Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy

Journal of International Medical Research

Volumn 35, Issue 3, 2007, Pages 338-345

  Tian, J ^a   Wang, H Ping ^a   Mao, Y Ying ^a   Jin, J ^a   Chen, Jiang Hua ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Glomerular protein 1; Immunoglobulin A nephropathy; Podocyte

Indexed keywords

ALBUMIN; CREATININE; GLOMERULAR EPITHELIAL PROTEIN 1; IMMUNOGLOBULIN A; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ALBUMIN BLOOD LEVEL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CYTOPATHOLOGY; DIAGNOSTIC VALUE; DISEASE MARKER; DISEASE SEVERITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; PODOCYTE; PREDICTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEINURIA; TRANSMISSION ELECTRON MICROSCOPY;

EID: 34250791563     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000703500308     Document Type: Article

References (28)

1. Daskalakis N, Winn MP: Focal and segmental glomerulosclerosis: varying biologic mechanisms underlie a final histopathologic end point. Semin Nephrol 2006; 26: 89-94.
2. Hara M, Yanagihara T, Kihara I: Urinary podocytes in primary focal segmental glomerulosclerosis. Nepron 2001; 89: 342-347.
3. Chen CA, Hwang JC, Guh JY, et al: Reduced podocyte expression of alpha3beta1 integrins and podocyte depletion in patients with primary focal segmental glomerulosclerosis and chronic PAN-treated rats. J Lab Clin Med 2006; 147: 74-82.
4. Kaplan JM, Kim SH, North KN, et al: Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 2000; 24: 251-256.
5. White KE, Bilous RW, for the Diabiopsies Study Group: Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients. Nephrol Dial Transplant 2004; 19: 1437-1440.
6. Patrakka J, Lahdenkari AT, Koskimies O, et al: The number of podocyte slit diaphragms is decreased in minimal change nephrotic syndrome. Pediatr Res 2002; 52: 349-355.
7. Kim YH, Goyal M, Wharram B, et al: GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury. Nephron 2002; 90: 471-476.
8. Sharif K, Goyal M, Kershaw D, et al: Podocyte phenotypes as defined by expression and distribution of GLEPP1 in the developing glomerulus and in nephrotic glomeruli from MCD, CNF, and FSGS. A dedifferentiation hypothesis for the nephrotic syndrome. Exp Nephrol 1998; 6: 234-244.
9. Lee SM: Prognostic indicators of progressive renal disease in IgA nephropathy: emergence of a new histologic grading system: Am J Kidney Dis 1997; 29: 953-958.
10. Eikmans M, Baelde HJ, de Heer E, et al: Effect of age and biopsy site on extracellular matrix mRNA and protein levels in human kidney biopsies. Kidney Int 2001; 60: 974-981.
11. Srivastava T, Garola RE, Whiting JM, et al: Synaptopodin expression in idiopathic nephrotic syndrome of childhood. Kidney Int 2001; 59: 118-125.
12. Drumond MC, Kristal B Myers BD, et al: Structural basis for reduced glomerular filtration capacity in nephrotic humans. J Clin Invest 1994; 94: 1187-1195.
13. Kriz W, Hackenthal E, Nobiling R, et al: A role for podocytes to counteract capillary wall distension. Kidney Int 1994; 45: 369-376.
14. Gagliardini E, Benigni A, Tomasoni S, et al: Targeted downregulation of extracellular nephrin in human IgA nephropathy. Am J Nephrol 2003; 23: 277-286.
15. Qiu LQ, Sinniah R, I-Hong Hsu S: Downregulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy. J Am Soc Nephrol 2004; 15: 79-90.
16. Wagrowska-Danilewicz M, Stasikowska O, Danilewicz M: Immunoexpression of podocyte-associated proteins in acquired human glomerulopathies with nephrotic syndrome. Pol J Pathol 2006; 57: 17-21.
17. Asanuma K, Mundel P: The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 2003; 7: 255-259.
18. Lemley KV, Lafayette RA, Safai M, et al: Podocytopenia and disease severity in IgA nephropathy. Kidney Int 2002; 61: 1475-1485.
19. Hishiki T, Shirato I, Takahashi Y, et al: Podocyte injury predicts prognosis in patients with IgA nephropathy using a small amount of renal biopsy tissue. Kidney Blood Press Res 2001; 24: 99-104.
20. Wiggins RC, Wiggins JE, Goyal M, et al: Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. Genomics 1995; 27: 174-181.
21. Yang DH, Goyal M, Sharif K, et al: Glomerular epithelial protein 1 and podocalyxin-like protein 1 in inflammatory glomerular disease (crescentic nephritis) in rabbit and man. Lab Invest 1996; 74: 571-584.
22. Thomas PE, Wharram BL, Goyal M, et al: GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit. J Biol Chem 1994; 269: 19953-19962.
23. Wharram BL, Goyal M, Gillespie PJ, et al: Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest 2000; 106: 1281-1290.
24. Koop K, Eikmans M, Baelde HJ, et al: Expression of podocyte-associated molecules in acquired human kidney diseases. J Am Soc Nephrol 2003; 14: 2063-2071.
25. Wharram BL, Goyal M, Wiggins JE, et al: Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005; 16: 2941-2952.
26. Hirakawa M, Tsuruya K, Yotsueda H, et al: Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis. Life Sci 2006; 79: 757-763.
27. Nakamura T, Ushiyama C, Suzuki S, et al: Effects of angiotensin-converting enzyme inhibitor, angiotensin II receptor antagonist and calcium antagonist on urinary podocytes in patients with IgA nephropathy. Am J Nephrol 2000; 20: 373-379.
28. Bartosik LP, Lajoie G, Sugar L, et al: Predicting progression in IgA nephropathy. Am J Kidney Dis 2001; 38: 728-735.