Podocyte number predicts progression of proteinuria in IgA nephropathy

Modern Pathology

Volumn 23, Issue 9, 2010, Pages 1241-1250

  Xu, Lan ^a   Yang, Hai Chun ^a,b   Hao, Chuan Ming ^a,c   Lin, Shan Tan ^a   Gu, Yong ^a   Ma, Ji ^a,d  

^a FUDAN UNIVERSITY   (China)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d MONROE CARELL JR CHILDREN S HOSPITAL AT VANDERBILT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT MEMBRANE ATTACK COMPLEX; NESTIN; PROTEIN P27;

ADULT; ARTICLE; CANCER SURGERY; CELL DAMAGE; CELL DENSITY; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY CARCINOMA; KIDNEY INJURY; KIDNEY PARENCHYMA; MALE; MESANGIUM CELL; MORPHOMETRICS; PODOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEINURIA;

ADULT; DISEASE PROGRESSION; FEMALE; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY GLOMERULUS; MALE; PODOCYTES; PROTEINURIA;

EID: 77956295977     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2010.110     Document Type: Article

References (57)

1. DAmico G, Minetti L, Ponticelli C, et al. Prognostic indicators in idiopathic IgA mesangial nephropathy. Q J Med 1986;59:363-378.
2. Alamartine E, Sabatier JC, Guerin C, et al. Prognostic factors in mesangial IgA glomerulonephritis: an extensive study with univariate and multivariate analyses. Am J Kidney Dis 1991;18:12-19.
3. Katafuchi R, Oh Y, Hori K, et al. An important role of glomerular segmental lesions on progression of IgA nephropathy: a multivariate analysis. Clin Nephrol 1994;41:191-198.
4. Bartosik LP, Lajoie G, Sugar L, et al. Predicting progression in IgA nephropathy. Am J Kidney Dis 2001;38:728-735.
5. Morigi M, Macconi D, Zoja C, et al. Protein overloadinduced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. J Am Soc Nephrol 2002;13:1179-1189.
6. Zoja C, Benigni A, Remuzzi G. Cellular responses to protein overload: key event in renal disease progression. Curr Opin Nephrol Hypertens 2004;13:31-33
7. Tang S, Leung JC, Abe K, et al. Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest 2003;111: 515-527.
8. Jafar TH, Stark PC, Schmid CH, et al. Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis. Ann Intern Med 2003;139:244-252.
9. Donadio JV, Bergstralh EJ, Grande JP, et al. Proteinuria patterns and their association with subsequent endstage renal disease in IgA nephropathy. Nephrol Dial Transplant 2002;17:1197-1203.
10. Szeto CC, Lai FM, To KF, et al. The natural history of immunoglobulin a nephropathy among patients with hematuria and minimal proteinuria. Am J Med 2001;110:434-437.
11. Radford Jr MG, Donadio Jr JV, Bergstralh EJ. Predicting renal outcome in IgA nephropathy. J Am Soc Nephrol 1997;8:199-207.
12. Eiro M, Katoh T, Kuriki M, et al. The product of duration and amount of proteinuria (proteinuria index) is a possible marker for glomerular and tubulointerstitial damage in IgA nephropathy. Nephron 2002; 90:432-441.
13. Reich HN, Troyanov S, Scholey JW, et al. Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol 2007;18:3177-3183.
14. Coppo R, DAmico G. Factors predicting progression of IgA nephropathies. J Nephrol 2005;18:503-512.
15. Tian J, Wang HP, Mao YY, Jin J, et al. Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy. J Int Med Res 2007;35:338-345.
16. Lai KN, Leung JC, Chan LY, et al. Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy. Nephrol Dial Transplant 2009;24: 62-72.
17. Gagliardini E, Benigni A, Tomasoni S, et al. Targeted downregulation of extracellular nephrin in human IgA nephropathy. Am J Nephrol 2003;23:277-286.
18. Ng WL, Chan KW, Yeung CK, et al. Peripheral glomerular capillary wall lesions in IgA nephropathy and their implications. Pathology 1984;16:324-330.
19. Hishiki T, Shirato I, Takahashi Y, et al. Podocyte injury predicts prognosis in patients with IgA nephropathy using a small amount of renal biopsy tissue. Kidney Blood Press Res 2001;24:99-104.
20. Lemley KV, Lafayette RA, Safai M, et al. Podocytopenia and disease severity in IgA nephropathy. Kidney Int 2002;61:1475-1485.
21. Giannakakis K, Feriozzi S, Perez M, et al. Aberrantly glycosylated IgA1 in glomerular immune deposits of IgA nephropathy. J Am Soc Nephrol 2007;18: 3139-3146.
22. Duque N, Gomez-Guerrero C, Egido J. Interaction of IgA with Fc alpha receptors of human mesangial cells activates transcription factor nuclear factor-kappa B and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10. J Immunol 1997;159:3474-3482.
23. Lai KN, Tang SC, Guh JY, et al. Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system. J Am Soc Nephrol 2003;14: 3127-3137.
24. Bogers WM, Stad RK, van Es LA, et al. Immunoglobulin A: interaction with complement, phagocytic cells and endothelial cells. Complement Inflamm 1991; 8:347-358.
25. Hisano S, Matsushita M, Fujita T, et al. Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am J Kidney Dis 2001;38:1082-1088.
26. Abe K, Miyazaki M, Koji T, et al. Intraglomerular synthesis of complement C3 and its activation products in IgA nephropathy. Nephron 2001;87:231-239.
27. Espinosa M, Ortega R, Gomez-Carrasco JM, et al. Mesangial C4d deposition: a new prognostic factor in IgA nephropathy. Nephrol Dial Transplant 2009; 24:886-891.
28. Abe K, Miyazaki M, Koji T, et al. Expression of decay accelerating factor mRNA and complement C3 mRNA in human diseased kidney. Kidney Int 1998;54: 120-130.
29. Kelly LJ, Vicario PP, Thompson GM, et al. Peroxisome proliferator- activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology 1998;139:4920-4927.
30. Lee HS, Lee MS, Lee SM, et al. Histological grading of IgA nephropathy predicting renal outcome: revisiting HS Lees glomerular grading system. Nephrol Dial Transplant 2005;20:342-348.
31. Roberts IS, Cook HT, Troyanov S, et al. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int 2009;76:546-556.
32. Weibel E. Stereologic Methods. Practical Methods for Biological. Academic Press: London, 1979, pp 415.
33. White KE, Bilous RW. Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients. Nephrol Dial Transplant 2004;19:1437-1440.
34. White KE, Bilous RW, Marshall SM, et al. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes 2002;51:3083-3089.
35. van den Berg JG, van den Bergh Weerman MA, Assmann KJ, et al. Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies. Kidney Int 2004;66:1901-1906.
36. Nagata M, Nakayama K, Terada Y, et al. Cell cycle regulation and differentiation in the human podocyte lineage. Am J Pathol 1998;153:1511-1520.
37. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage? J Am Soc Nephrol 2006;17:2974-2984.
38. Jalanko H, Patrakka J, Tryggvason K, et al. Genetic kidney diseases disclose the pathogenesis of proteinuria. Ann Med 2001;33:526-533.
39. Shankland SJ. The podocytes response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006;69:2131-2147.
40. Matsusaka T, Xin J, Niwa S, et al. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. J Am Soc Nephrol 2005;16:1013-1023.
41. Wharram BL, Goyal M, Wiggins JE, et al. Podocyte depletion causes glomerulosclerosis: diphtheria toxininduced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005;16:2941-2952.
42. Hara M, Yanagihara T, Kihara I. Cumulative excretion of urinary podocytes reflects disease progression in IgA nephropathy and Schonlein-Henoch purpura nephritis. Clin J Am Soc Nephrol 2007;2:231-238.
43. Ransom RF, Vega-Warner V, Smoyer WE, et al. Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes. Kidney Int 2005;67:1275-1285.
44. Wada T, Pippin JW, Marshall CB, et al. Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins. J Am Soc Nephrol 2005;16:2615-2625.
45. Kim YH, Goyal M, Kurnit D, et al. Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 2001;60:957-968.
46. Lai KN, Leung JC, Chan LY, et al. Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy. Am J Physiol Renal Physiol 2008;294:F945-F955.
47. Endlich N, Kress KR, Reiser J, et al. Podocytes respond to mechanical stress in vitro. J Am Soc Nephrol 2001;12:413-422.
48. Durvasula RV, Petermann AT, Hiromura K, et al. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int 2004;65:30-39.
49. Ding G, Reddy K, Kapasi AA, et al. Angiotensin II induces apoptosis in rat glomerular epithelial cells. Am J Physiol Renal Physiol 2002;283:F173-F180.
50. Nangaku M, Alpers CE, Pippin J, et al. CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats. J Am Soc Nephrol 1998;9:590-597.
51. Torbohm I, Schonermark M, Wingen AM, et al. C5b-8 and C5b-9 modulate the collagen release of human glomerular epithelial cells. Kidney Int 1990;37: 1098-1104.
52. Topham PS, Haydar SA, Kuphal R, et al. Complementmediated injury reversibly disrupts glomerular epithelial cell actin microfilaments and focal adhesions. Kidney Int 1999;55:1763-1775.
53. Takano T, Cybulsky AV. Complement C5b-9-mediated arachidonic acid metabolism in glomerular epithelial cells : role of cyclooxygenase-1 and-2. Am J Pathol 2000;156:2091-2101.
54. Pippin JW, Durvasula R, Petermann A, et al. DNA damage is a novel response to sublytic complement C5b-9-induced injury in podocytes. J Clin Invest 2003;111:877-885.
55. Puri TS, Quigg RJ. The many effects of complement C3-and C5-binding proteins in renal injury. Semin Nephrol 2007;27:321-337.
56. Moll S, Miot S, Sadallah S, et al. No complement receptor 1 stumps on podocytes in human glomerulopathies. Kidney Int 2001;59:160-168.
57. Teixeira JE, Costa RS, Lachmann PJ, et al. CR1 stump peptide and terminal complement complexes are found in the glomeruli of lupus nephritis patients. Clin Exp Immunol 1996;105:497-503.