Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy

Nephrology Dialysis Transplantation

Volumn 24, Issue 1, 2009, Pages 62-72

  Lai, Kar Neng ^a   Leung, Joseph C K ^a   Chan, Loretta Y Y ^a   Saleem, Moin A ^b   Mathieson, Peter W ^b   Tam, Ka Ying ^a   Xiao, Jing ^a   Lai, Fernand M ^c   Tang, Sydney C W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

IgA nephropathy; Podocytes; Slit diaphragm; Transforming growth factor ; Tumour necrosis factor

Indexed keywords

EZRIN; IMMUNOGLOBULIN A; NEPHRIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING AFFINITY; CELL DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN A NEPHROPATHY; IN VITRO STUDY; KIDNEY FUNCTION; MALE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

APOPTOSIS; BASE SEQUENCE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; CYTOSKELETAL PROTEINS; DNA PRIMERS; FEMALE; GENE EXPRESSION; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOGLOBULIN A; LYMPHOTOXIN-ALPHA; MALE; MEMBRANE PROTEINS; MESANGIAL CELLS; OSTEONECTIN; PODOCYTES; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 3; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 58049206800     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn441     Document Type: Article

References (20)

1. Radford MG Jr, Donadio JV Jr, Bergstralh EJ et al. Predicting renal outcome in IgA nephropathy. J Am Soc Nephrol 1997; 8: 199-207
2. Chan LY, Leung JC, Tsang AW et al. Activation of tubular epithelial cells by mesangial-derived TNF-a: glomerulo-tubular communication in IgA nephropathy. Kidney Int 2005; 67: 602-612
3. Lai KN, Chan LY, Tang SC et al. Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1. Kidney Int 2004; 66: 1403-1416
4. Chan LY, Leung JC, Tang SC et al. Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy. J Am Soc Nephrol 2005; 16: 2306-2317
5. Saleem MA, O'Hare MJ, Reiser J et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 2002; 13: 630-638
6. Leung JC, Chan LY, Tang SC et al. Glycosylation profile of differently charge IgA1 and their binding characteristics to cultured mesangial cells in IgA nephropathy. Nephron 2007: 107: e107-e118
7. Lai KN, Leung JC, Chan LY et al. Activation of podocytes by mesangial-derived TNF-a: glomerulo-podocytic communication in IgA nephropathy. Am J Physiol Renal Physiol 2008; 294: F945-F955
8. Ng WL, Chan KW, Yeung CK et al. Peripheral glomerular capillary wall lesions in IgA nephropathy and their implications. Pathology 1984; 16: 324-330
9. Lemley KV, Lafayette RA, Safai M et al. Podocytopenia and disease severity in IgA nephropathy. Kidney Int 2002; 61: 1475-1485
10. Hara M, Yanagihara T, Kihara I. Cumulative excretion of urinary podocytes reflects disease progression in IgA nephropathy and Schonlein-Henoch purpura nephritis. Clin J Am Soc Nephrol 2007; 2: 231-238
11. Gagliardini E, Benigni A, Tomasoni S et al. Targeted downregulation of extracellular nephrin in human IgA nephropathy. Am J Nephrol 2003; 23: 277-286
12. Doublier S, Ruotsalainen V, Salvidio G et al. Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome. Am J Pathol 2001; 158: 1723-1731
13. Wang C, Peng H, Tang H et al. Serum IgA1 from IgA nephropathy patients induces apoptosis in podocytes through direct and indirect pathways. Clin Invest Med 2007; 30: E240-E249
14. Ostalska-Nowicka D, Zachwieja J, Nowicki M et al. Ezrin - a useful factor in the prognosis of nephrotic syndrome in children: an immunohistochemical approach. J Clin Pathol 2006; 59: 916-920
15. Tian J, Wang HP, Mao YY et al. Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy. J Int Med Res 2007; 35: 338-345
16. Bradshaw AD, Sage EH. SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J Clin Invest 2001; 107: 1049-1054
17. Alpers CE, Hudkins KL, Segerer S et al. Localization of SPARC in developing, mature, and chronically injured human allograft kidneys. Kidney Int 2002; 62: 2073-2086
18. van den Berg JG, van den Bergh Weerman MA, Assmann KJ et al. Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulonephritis. Kidney Int 2004; 66: 1901-1906
19. Sever S, Altintas MM, Nankoe SR et al. Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. J Clin Invest 2007; 117: 2095-2104
20. Takano Y, Yamauchi K, Hayakawa K et al. Transcriptional suppression of nephrin in podocytes by macrophages: role of inflammatory cytokines and involvement of the P13K/Akt pathway. FEBS Lett 2007; 581: 421-426