The Glomerular Response to IgA Deposition in IgA Nephropathy

Seminars in Nephrology

Volumn 28, Issue 1, 2008, Pages 88-95

  Moura, Ivan C ^a,b   Benhamou, Marc ^a,b   Launay, Pierre ^a,b   Vrtovsnik, François ^a,b   Blank, Ulrich ^a,b   Monteiro, Renato C ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

CD71; CD89; Fc receptor; IgA; mesangial cells; transferrin receptor

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN RECEPTOR;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; BONE MARROW CELL; CELL ACTIVATION; CHRONICITY; CROSS LINKING; CYTOKINE PRODUCTION; DISEASE COURSE; GLOMERULAR STRUCTURE; IMMUNOGLOBULIN A NEPHROPATHY; LEUKOCYTE; MESANGIUM CELL; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, CD; DISEASE MODELS, ANIMAL; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOGLOBULIN A; INFLAMMATION; MESANGIAL CELLS; MICE; RECEPTORS, FC; RECEPTORS, TRANSFERRIN;

EID: 38349116876     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2007.10.010     Document Type: Article

References (53)

1. Conley M.E., Cooper M.D., and Michael A.F. Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus. J Clin Invest 66 (1980) 1432-1436
2. Lomax-Smith J.D., Zabrowarny L.A., Howarth G.S., et al. The immunochemical characterization of mesangial IgA deposits. Am J Pathol 113 (1983) 359-364
3. Hisano S., Matsushita M., Fujita T., et al. Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am J Kidney Dis 38 (2001) 1082-1088
4. Tomino Y., Sakai H., Miura M., et al. Detection of polymeric IgA in glomeruli from patients with IgA nephropathy. Clin Exp Immunol 49 (1982) 419-425
5. Monteiro R.C., Halbwachs-Mecarelli L., Roque-Barreira M.C., et al. Charge and size of mesangial IgA in IgA nephropathy. Kidney Int 28 (1985) 666-671
6. Allen A.C., Bailey E.M., Brenchley P.E., et al. Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients. Kidney Int 60 (2001) 969-973
7. Hiki Y., Odani H., Takahashi M., et al. Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney Int 59 (2001) 1077-1085
8. Kokubo T., Hiki Y., Iwase H., et al. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol 9 (1998) 2048-2054
9. Tomana M., Novak J., Julian B.A., et al. Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 104 (1999) 73-81
10. Almogren A., Kerr M.A., et al. Irreversible aggregation of the Fc fragment derived from polymeric but not monomeric serum IgA1-Implications in IgA-mediated disease. Mol Immunol 45 (2008) 87-94
11. van der Boog P.J., van Kooten C., de Fijter J.W., et al. Role of macromolecular IgA in IgA nephropathy. Kidney Int 67 (2005) 813-821
12. Olas K., Butterweck H., Teschner W., et al. Immunomodulatory properties of human serum immunoglobulin A: anti-inflammatory and pro-inflammatory activities in human monocytes and peripheral blood mononuclear cells. Clin Exp Immunol 140 (2005) 478-490
13. Pasquier B., Launay P., Kanamaru Y., et al. Identification of FcαRI as an inhibitory receptor that controls inflammation: dual role of FcRγ ITAM. Immunity 22 (2005) 31-42
14. Monteiro R.C., Moura I.C., Launay P., et al. Pathogenic significance of IgA receptor interactions in IgA nephropathy. Trends Mol Med 8 (2002) 464-468
15. Monteiro R.C., and Van De Winkel J.G. IgA Fc receptors. Annu Rev Immunol 21 (2003) 177-204
16. Grossetete B., Launay P., Lehuen A., et al. Down-regulation of Fcα receptors on blood cells of IgA nephropathy patients: evidence for a negative regulatory role of serum IgA. Kidney Int 53 (1998) 1321-1335
17. Launay P., Grossetete B., Arcos-Fajardo M., et al. Fcα receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-IgA complexes in patients and CD89 transgenic mice. J Exp Med 191 (2000) 1999-2009
18. van Dijk T.B., Caldenhoven E., Raaijmakers J.A., et al. Cloning and characterization of FcαRb, a novel Fcα receptor (CD89) isoform expressed in eosinophils and neutrophils. Blood 88 (1996) 4229-4238
19. van Zandbergen G., Westerhuis R., Mohamad N.K., et al. Crosslinking of the human Fc receptor for IgA (FcαRI/CD89) triggers FcRγ-chain-dependent shedding of soluble CD89. J Immunol 163 (1999) 5806-5812
20. van der Boog P.J., van Zandbergen G., de Fijter J.W., et al. FcαRI/CD89 circulates in human serum covalently linked to IgA in a polymeric state. J Immunol 168 (2002) 1252-1258
21. van der Boog P.J., De Fijter J.W., Van Kooten C., et al. Complexes of IgA with FcαRI/CD89 are not specific for primary IgA nephropathy. Kidney Int 63 (2003) 514-521
22. Kanamaru Y., Arcos-Fajardo M., Moura I.C., et al. Fcα receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcRγ adaptor. Eur J Immunol 37 (2007) 1116-1128
23. van der Boog P.J., van Kooten C., van Zandbergen G., et al. Injection of recombinant FcαRI/CD89 in mice does not induce mesangial IgA deposition. Nephrol Dial Transplant 19 (2004) 2729-2736
24. van den Wall Bake A.W., Kirk K.A., Gay R.E., et al. Binding of serum immunoglobulins to collagens in IgA nephropathy and HIV infection. Kidney Int 42 (1992) 374-382
25. Coppo R., Amore A., Gianoglio B., et al. Serum IgA and macromolecular IgA reacting with mesangial matrix components. Contrib Nephrol 104 (1993) 162-171
26. Cederholm B., Wieslander J., Bygren P., et al. Circulating complexes containing IgA and fibronectin in patients with primary IgA nephropathy. Proc Natl Acad Sci U S A 85 (1988) 4865-4868
27. Shinkai Y., Karai M., Osawa G., et al. Antimouse laminin antibodies in IgA nephropathy and various glomerular diseases. Nephron 56 (1990) 285-296
28. Zheng F., Kundu G.C., Zhang Z., et al. Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice. Nat Med 5 (1999) 1018-1025
29. Coppo R., Chiesa M., Cirina P., et al. In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice. Am J Kidney Dis 40 (2002) 495-503
30. Endo M., Ohi H., Ohsawa I., et al. Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy. Nephrol Dial Transplant 13 (1998) 1984-1990
31. Roos A., Rastaldi M.P., Calvaresi N., et al. Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J Am Soc Nephrol 17 (2006) 1724-1734
32. 2+ mobilization in rat and human mesangial cells. J Immunol 156 (1996) 4369-4376
33. Gomez-Guerrero C., Lopez-Armada M.J., Gonzalez E., et al. Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-α and IL-6, and proliferation. J Immunol 153 (1994) 5247-5255
34. Diven S.C., Caflisch C.R., Hammond D.K., et al. IgA induced activation of human mesangial cells: independent of FcαR1 (CD 89). Kidney Int 54 (1998) 837-847
35. Moura I.C., Arcos-Fajardo M., Gdoura A., et al. Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy. J Am Soc Nephrol 16 (2005) 2667-2676
36. Amore A., Cirina P., Conti G., et al. Glycosylation of circulating IgA in patients with IgA nephropathy modulates proliferation and apoptosis of mesangial cells. J Am Soc Nephrol 12 (2001) 1862-1871
37. Stockert R.J., Kressner M.S., Collins J.C., et al. IgA interaction with the asialoglycoprotein receptor. Proc Natl Acad Sci U S A 79 (1982) 6229-6231
38. Monteiro R.C., Kubagawa H., and Cooper M.D. Cellular distribution, regulation, and biochemical nature of an Fcα receptor in humans. J Exp Med 171 (1990) 597-613
39. Mostov K.E., Friedlander M., and Blobel G. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature 308 (1984) 37-43
40. Shibuya A., Sakamoto N., Shimizu Y., et al. Fcα/μ receptor mediates endocytosis of IgM-coated microbes. Nat Immunol 1 (2000) 441-446
41. Moura I.C., Centelles M.N., Arcos-Fajardo M., et al. Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. J Exp Med 194 (2001) 417-425
42. Novak J., Vu H.L., Novak L., et al. Interactions of human mesangial cells with IgA and IgA-containing immune complexes. Kidney Int 62 (2002) 465-475
43. Barratt J., Greer M.R., Pawluczyk I.Z., et al. Identification of a novel Fcα receptor expressed by human mesangial cells. Kidney Int 57 (2000) 1936-1948
44. Westerhuis R., Van Zandbergen G., Verhagen N.A., et al. Human mesangial cells in culture and in kidney sections fail to express Fcα receptor (CD89). J Am Soc Nephrol 10 (1999) 770-778
45. Leung J.C., Tsang A.W., Chan D.T., et al. Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells. J Am Soc Nephrol 11 (2000) 241-249
46. McDonald K.J., Cameron A.J., Allen J.M., et al. Expression of Fcα/μ receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy. Biochem Biophys Res Commun 290 (2002) 438-442
47. Moura I.C., Arcos-Fajardo M., Sadaka C., et al. Glycosylation and size of IgA1 are essential for interaction with mesangial transferrin receptor in IgA nephropathy. J Am Soc Nephrol 15 (2004) 622-634
48. Haddad E., Moura I.C., Arcos-Fajardo M., et al. Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schonlein nephritis: association between CD71 expression and IgA deposits. J Am Soc Nephrol 14 (2003) 327-337
49. Arima S., Nakayama M., Naito M., et al. Significance of mononuclear phagocytes in IgA nephropathy. Kidney Int 39 (1991) 684-692
50. Falk M.C., Ng G., Zhang G.Y., et al. Infiltration of the kidney by αβ and γδ T cells: effect on progression in IgA nephropathy. Kidney Int 47 (1995) 177-185
51. Kashem A., Endoh M., Yano N., et al. Glomerular FcαR expression and disease activity in IgA nephropathy. Am J Kidney Dis 30 (1997) 389-396
52. Lai K.N., Chan L.Y., Tang S.C., et al. Characteristics of polymeric λ-IgA binding to leukocytes in IgA nephropathy. J Am Soc Nephrol 13 (2002) 2309-2319
53. Roos A., Bouwman L.H., van Gijlswijk-Janssen D.J., et al. Human IgA activates the complement system via the mannan-binding lectin pathway. J Immunol 167 (2001) 2861-2868