Mesangial medium with IgA1 from IgA nephropathy inhibits nephrin expression in mouse podocytes

European Journal of Clinical Investigation

Volumn 39, Issue 7, 2009, Pages 561-567

  Wang, C ^a   Liu, X ^a   Ye, Z ^a   Zhang, J ^a   Tang, H ^a   Chen, Z ^a   Zhang, H ^b   Lou, T ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

IgA nephropathy; IgA1; Medium; Mesangial cell; Nephrin; Podocyte

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN II; ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE; ENALAPRILAT; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A1; MESSENGER RNA; NEPHRIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; VALSARTAN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOSTIMULATION; MESANGIUM CELL; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANIMALS; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOGLOBULIN A; MEMBRANE PROTEINS; MESANGIAL CELLS; MICE; PODOCYTES; REFERENCE VALUES; RENIN-ANGIOTENSIN SYSTEM;

EID: 66849124727     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2009.02135.x     Document Type: Article

References (22)

1. Li Ls, Liu Zh. Epidemiologic data of renal diseases from a single unit in China: analysis based on 13,519 renal biopsies. Kidney Int 2004 66 : 920 3.
2. Nartia I, Gejyo F. Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy. Clin Exp Nephrol 2008 12 : 332 8.
3. van der Boog PJ, van Kooten C, de Fijter JW, De Fijter JW, Daha MR. Role of macromolecular IgA in IgA nephropathy. Kidney Int 2005 67 : 813 21.
4. Giannakakis K, Feriozzi S, Perez M, Faraggiana T, Muda AO. Aberrantly glycosylated IgA1 in glomerular immune deposits of IgA nephropathy. J Am Soc Nephrol 2007 18 : 3139 46.
5. Xu LX, Zhao MH. Aberrantly glycosylated IgA1 are closed associated with pathologic phenotype of IgA nephropathy. Kidney Int 2005 68 : 167 72.
6. Ding JX, Xu LX, Lv JC, Zhao MH, Zhang H, Wang HY. Aberrant sialylation of serum IgA1 was associated with prognosis of patients with IgA nephropathy. Clin Immunol 2007 125 : 268 74.
7. Peng AI, Gu Y, Xiao T, Zhu KY, Zhang M, Yang HC et al. Clinicopathological characteristics of IgA nephropathy with urinary podocyte excretion. Chin J Nephrol 2007 23 : 283 5.
8. Lemley KV, Lafayette RA, Safai M, Derby G, Blouch K, Squarer A et al. Podocytopenia and disease severity in IgA nephropathy. Kidney Int 2002 61 : 1475 85.
9. Tomino Y. Pathogenesis of IgA nephropathy. Contrib Nephrol 2007 157 : 1 7.
10. Luimula P, Ahola H, Wang SX, Aaltonen P, Tikkanen I, Kerjaschki D et al. Nephrin in experimental glomerular disease. Kidney Int 2000 58 : 1461 8.
11. Doublier S, Ruostalainen V, Salvidlo G, Lupia E, Biancone L, Conaldi PG et al. Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephritic syndrome. Am J Pathol 2001 158 : 1723 31.
12. Wang CH, Peng H, Tang H, Liu X, Chen Z, Lou T et al. Serum IgA1 from IgA nephropathy induces apoptosis in podocytes through direct and indirect pathway. Clin Invest Med 2007 30 : E240 9.
13. Wang CH, Ye ZH, Peng H, Tang H, Liu X, Chen Z et al. Effect of aggregated immunoglobulin A1 from immunoglobulin A nephropathy patients on nephrin expression in podocytes. Nephrology (Carlton) 2008 [Epub ahead of print].
14. Coppo R, Peruzzi L, Amore A, Piccoli A, Cochat P, Stone R et al. IgACE: a placebo-controlled, randomized trial of angiotensin-converting enzyme inhibitors in children and young people with IgA nephropathy and moderate proteinuria. J Am Soc Nephrol 2007 18 : 1880 8.
15. Blanco S, Bonet J, Lopez D, Casas I, Romero R. ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis. Kidney Int Suppl 2005 93 : S10 4.
16. Wang Y, Zhao Mh, Zhang YK, Li XM, Wang HY. Binding capacity and pathophysiological effects of IgA1 from patients with IgA nephropathy on human glomerular mesangial cells. Clin Exp Immunol 2004 136 : 168 75.
17. Wang Y, Zhao MH, Zhang Y, Li X, Wang HY. Serum IgA(1) from patients with IgA nephropathy induces phosphorylation of extracellular signal-regulated kinase and proliferation of human mesangial cells. Zhonghua Yi Xue Za Zhi 2002 82 : 1406 9.
18. To WY, Leung JC, Lai KN. Identification and characterization of human serum alpha2-HS glycoprotein as a jacalin-bound protein. Biochim Biophys Acta 1995 1249 : 58 64.
19. Jia J, Ding G, Zhu J, Chen C, Liang W, Franki N et al. Angiotensin II infusion induces nephrin expression changes and podocyte apoptosis. Am J Nephrol 2008 28 : 500 7.
20. Benigni A, Tomasoni S, Gagliardini E, Zoja C, Grunkemeyer JA, Kalluri R et al. Blocking angiotensin II synthesis/activity preserves glomerular nephrin in rats with severe nephrosis. J Am Soc Nephrol 2001 12 : 941 8.
21. Oottwijn BD, Roos A, Royle L, van Gijlswijk-Janssen DJ, Faber-Krol MC, Eijgenraam JW et al. Differential glycosylation of ploymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy. J Am Soc Nephrol 2006 17 : 3529 39.
22. Lai KN, Leung JC, Chan LY, Saleem MA, Mathieson PW, Lai FM et al. Activation of podocytes by mesangial derived TNF-alpha glomerulo-podocytic communication in IgA nephropathy. Am J Physiol Renal Physiol 2008 294 : F945 55.