Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy

Clinical and Experimental Nephrology

Volumn 12, Issue 5, 2008, Pages 332-338

  Narita, Ichiei ^a   Gejyo, Fumitake ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

IgA1; IgAN; Mucosal immunity; O galactosylation; O glycosylation; Pathogenesis

Indexed keywords

CHEMOKINE; CYTOKINE; GROWTH FACTOR; IMMUNOGLOBULIN A1; N ACETYLGALACTOSAMINE; POLYPEPTIDE; PROTEIN C1GALT1; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; B LYMPHOCYTE; DISEASE COURSE; DISEASE PREDISPOSITION; HUMAN; IMMUNE SYSTEM; IMMUNOGLOBULIN A NEPHROPATHY; MESANGIUM CELL; MUCOSAL IMMUNITY; PATHOGENESIS; PROTEIN GLYCOSYLATION; REVIEW; SIALYLATION;

ANIMALS; DISEASE PROGRESSION; GLOMERULAR MESANGIUM; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A;

EID: 51849102507     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-008-0054-5     Document Type: Review

References (66)

1. SN Emancipator 1994 IgA nephropathy: morphologic expression and pathogenesis Am J Kidney Dis 23 451 62
2. JV Donadio JP Grande 2002 IgA nephropathy N Engl J Med 347 738 48
3. BA Julian FB Waldo A Rifai 1988 IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States? Am J Med 84 129 32
4. M Levy J Berger 1988 Worldwide perspective of IgA nephropathy Am J Kidney Dis 12 340 7
5. A Koyama M Igarashi M Kobayashi 1997 Natural history and risk factors for immunoglobulin A nephropathy in Japan. Research group on progressive renal diseases Am J Kidney Dis 29 526 32
6. SI Hsu SB Ramirez MP Winn 2000 Evidence for genetic factors in the development and progression of IgA nephropathy Kidney Int 57 1818 35
7. HH Karnib S Sanna-Cherchi PA Zalloua 2007 Characterization of a large Lebanese family segregating IgA nephropathy Nephrol Dial Transplant 22 772 7
8. AG Gharavi Y Yan F Scolari 2000 IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23 Nat Genet 26 354 7
9. AD Paterson XQ Liu K Wang 2007 Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36 J Am Soc Nephrol 18 2408 15
10. C Ponticelli L Traversi A Feliciani 2001 Kidney transplantation in patients with IgA mesangial glomerulonephritis Kidney Int 60 1948 54
11. JH Galla 1995 IgA nephropathy Kidney Int 47 377 87
12. C Olive AC Allen SJ Harper 1997 Expression of the mucosal gamma delta T cell receptor V region repertoire in patients with IgA nephropathy Kidney Int 52 1047 53
13. L Layward AC Allen JM Hattersley 1993 Elevation of IgA in IgA nephropathy is localized in the serum and not saliva and is restricted to the IgA1 subclass Nephrol Dial Transplant 8 25 8
14. ME Conley MD Cooper AF Michael 1980 Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus J Clin Invest 66 1432 6
15. Y Tomino H Sakai M Miura 1982 Detection of polymeric IgA in glomeruli from patients with IgA nephropathy Clin Exp Immunol 49 419 25
16. JD Lomax-Smith LA Zabrowarny GS Howarth 1983 The immunochemical characterization of mesangial IgA deposits Am J Pathol 113 359 64
17. MA Kerr 1990 The structure and function of human IgA Biochem J 271 285 96
18. FW Putnam YS Liu TL Low 1979 Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain J Biol Chem 254 2865 74
19. RM Goldblum 1990 The role of IgA in local immune protection J Clin Immunol 10 64S 70S discussion 70S-1S
20. K Ohtsubo JD Marth 2006 Glycosylation in cellular mechanisms of health and disease Cell 126 855 67
21. JN Arnold MR Wormald RB Sim 2007 The impact of glycosylation on the biological function and structure of human immunoglobulins Annu Rev Immunol 25 21 50
22. T Nishie O Miyaishi H Azuma 2007 Development of immunoglobulin A nephropathy-like disease in beta-1,4-galactosyltransferase-I-deficient mice Am J Pathol 170 447 56
23. N Iwanami H Iwase N Takahashi 2008 Similarities between N-glycan glycoform of tonsillar IgA1 and that of aberran IgA1 abundant in IgA nephropathy patient serum J Nephrol 21 118 26
24. D Baharaki M Dueymes R Perrichot 1996 Aberrant glycosylation of IgA from patients with IgA nephropathy Glycoconj J 13 505 11
25. BD Oortwijn A Roos L Royle 2006 Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy J Am Soc Nephrol 17 3529 39
26. K Takahashi Y Hiki H Odani 2006 Structural analyses of O-glycan sugar chains on IgA1 hinge region using SELDI-TOFMS with various lectins Biochem Biophys Res Commun 350 580 7
27. BW Senior JM Woof 2005 The influences of hinge length and composition on the susceptibility of human IgA to cleavage by diverse bacterial IgA1 proteases J Immunol 174 7792 9
28. T Ju K Brewer A D'Souza 2002 Cloning and expression of human core 1 beta1,3-galactosyltransferase J Biol Chem 277 178 86
29. H Iwasaki Y Zhang K Tachibana 2003 Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-d- galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 J Biol Chem 278 5613 21
30. J Baenziger S Kornfeld 1974 Structure of the carbohydrate units of IgA1 immunoglobulin. I. Composition, glycopeptide isolation, and structure of the asparagine-linked oligosaccharide units J Biol Chem 249 7260 9
31. Y Hiki H Odani M Takahashi 2001 Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy Kidney Int 59 1077 85
32. M Tomana J Novak BA Julian 1999 Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies J Clin Invest 104 73 81
33. AC Allen EM Bailey PE Brenchley 2001 Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients Kidney Int 60 969 73
34. Shimozato S, Hiki Y, Odani H, et al. Serum under-galactosylated IgA1 is increased in Japanese patients with IgA nephropathy. Nephrol Dial Transplant. (2008).
35. K Matousovic J Novak T Yanagihara 2006 IgA-containing immune complexes in the urine of IgA nephropathy patients Nephrol Dial Transplant 21 2478 84
36. T Kokubo Y Hiki H Iwase 1997 Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA1 interaction in IgA nephropathy J Am Soc Nephrol 8 915 9
37. T Kokubo Y Hiki H Iwase 1998 Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins J Am Soc Nephrol 9 2048 54
38. H Iwase A Tanaka Y Hiki 1999 Aggregated human serum immunoglobulin A1 induced by neuraminidase treatment had a lower number of O-linked sugar chains on the hinge portion J Chromatogr B Biomed Sci Appl 724 1 7
39. Y Yan LX Xu JJ Zhang 2006 Self-aggregated deglycosylated IgA1 with or without IgG were associated with the development of IgA nephropathy Clin Exp Immunol 144 17 24
40. R Coppo A Amore B Gianoglio 1993 Serum IgA and macromolecular IgA reacting with mesangial matrix components Contrib Nephrol 104 162 71
41. IC Moura M Arcos-Fajardo C Sadaka 2004 Glycosylation and size of IgA1 are essential for interaction with mesangial transferrin receptor in IgA nephropathy J Am Soc Nephrol. 15 622 34
42. J Novak M Tomana K Matousovic 2005 IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells Kidney Int 67 504 13
43. A Amore G Conti P Cirina 2000 Aberrantly glycosylated IgA molecules downregulate the synthesis and secretion of vascular endothelial growth factor in human mesangial cells Am J Kidney Dis 36 1242 52
44. L Peruzzi A Amore P Cirina 2000 Integrin expression and IgA nephropathy: in vitro modulation by IgA with altered glycosylation and macromolecular IgA Kidney Int 58 2331 40
45. Y Wang MH Zhao YK Zhang 2004 Binding capacity and pathophysiological effects of IgA1 from patients with IgA nephropathy on human glomerular mesangial cells Clin Exp Immunol 136 168 75
46. W Zhang PJ Lachmann 1994 Glycosylation of IgA is required for optimal activation of the alternative complement pathway by immune complexes Immunology 81 137 41
47. MT Linossier S Palle F Berthoux 2003 Different glycosylation profile of serum IgA1 in IgA nephropathy according to the glomerular basement membrane thickness: normal versus thin Am J Kidney Dis 41 558 64
48. LX Xu MH Zhao 2005 Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy Kidney Int 68 167 72
49. Y Hiki A Tanaka T Kokubo 1998 Analyses of IgA1 hinge glycopeptides in IgA nephropathy by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry J Am Soc Nephrol 9 577 82
50. MR Greer J Barratt SJ Harper 1998 The nucleotide sequence of the IgA1 hinge region in IgA nephropathy Nephrol Dial Transplant 13 1980 3
51. E Tarelli AC Smith BM Hendry 2004 Human serum IgA1 is substituted with up to six O-glycans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometry Carbohydr Res 339 2329 35
52. GS Li H Zhang JC Lv 2007 Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy Kidney Int 71 448 53
53. AC Smith JF de Wolff K Molyneux 2006 O-glycosylation of serum IgD in IgA nephropathy J Am Soc Nephrol 17 1192 9
54. J Barratt EM Bailey KS Buck 1999 Exaggerated systemic antibody response to mucosal Helicobacter pylori infection in IgA nephropathy Am J Kidney Dis 33 1049 57
55. L Layward AM Finnemore AC Allen 1993 Systemic and mucosal IgA responses to systemic antigen challenge in IgA nephropathy Clin Immunol Immunopathol 69 306 13
56. M Ots O Uibo K Metskula 1999 IgA-antigliadin antibodies in patients with IgA nephropathy: the secondary phenomenon? Am J Nephrol 19 453 8
57. L Layward AC Allen JM Hattersley 1994 Low antibody affinity restricted to the IgA isotype in IgA nephropathy Clin Exp Immunol 95 35 41
58. L Layward AC Allen SJ Harper 1992 Increased and prolonged production of specific polymeric IgA after systemic immunization with tetanus toxoid in IgA nephropathy Clin Exp Immunol 88 394 8
59. ME Lamm SN Emancipator 1987 The mucosal immune system and IgA nephropathy Semin Nephrol 7 280 2
60. L Royle A Roos DJ Harvey 2003 Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems J Biol Chem 278 20140 53
61. Smith AC, Molyneux K, Feehally J, et al. O-Glycosylation of Serum IgA1 Antibodies against Mucosal and Systemic Antigens in IgA Nephropathy. J Am Soc Nephrol. (2006).
62. Suzuki H, Moldoveanu Z, Hall S, et al. IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. J Clin Invest. (2008).
63. Oortwijn BD, Rastaldi MP, Roos A, et al. Demonstration of secretory IgA in kidneys of patients with IgA nephropathy. Nephrol Dial Transplant. (2007).
64. IC Moura M Arcos-Fajardo A Gdoura 2005 Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy J Am Soc Nephrol 16 2667 76
65. J Barratt MR Greer IZ Pawluczyk 2000 Identification of a novel Fcalpha receptor expressed by human mesangial cells Kidney Int 57 1936 48
66. Leung 2000 Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells J Am Soc Nephrol 11 241 9