Beneficial effects of flaxseed oil and fish oil diet are through modulation of different hepatic genes involved in lipid metabolism in streptozotocin- nicotinamide induced diabetic rats

Genes and Nutrition

Volumn 8, Issue 3, 2013, Pages 329-342

  Devarshi, Prasad P ^a   Jangale, Nivedita M ^b   Ghule, Arvindkumar E ^b   Bodhankar, Subhash L ^b   Harsulkar, Abhay M ^b  

^a Bharati Vidyapeeth Deemed University   (India)

^b BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

Desaturases; Fish oil; Flaxseed oil; PPAR ; SREBP 1; Streptozotocin

Indexed keywords

DESATURASE; FATTY ACID BINDING PROTEIN; FISH OIL; FLAXSEED OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 3 FATTY ACID; OXYGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VEGETABLE OIL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DYSLIPIDEMIA; ENZYME ACTIVATION; ERYTHROCYTE; FATTY ACID OXIDATION; LIPID METABOLISM; LIPOGENESIS; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84879080558     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-012-0326-2     Document Type: Article

References (73)

1. Bao Y, Lu Z, Zhou M, Li H, Wang Y, Gao M, Wei M, Jia W (2011) Serum levels of adipocyte fatty acid-binding protein are associated with the severity of coronary artery disease in Chinese women. PLoS ONE 6:e19115
2. Bassett CM, Rodriguez-Leyva D, Pierce GN (2009) Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed. Appl Physiol Nutr Metab 34:965-974
3. Boden G (2003) Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes. Exp Clin Endocrinol Diabetes 111:121-124
4. Boord JB, Fazio S, Linton MF (2002) Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis. Curr Opin Lipidol 13:141-147
5. Calon F, Cole G (2007) Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostaglandins Leukot Essent Fatty Acids 77:287-293
6. Chen L, Frister A, Wang S, Ludwig A, Behr H, Pippig S, Li B, Simm A, Hofmann B, Pilowski C, Koch S, Buerke M, Rose-John S, Werdan K, Loppnow H (2009a) Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production. Am J Physiol Heart Circ Physiol 296:H987-H996
7. Chen X, Xun K, Chen L, Wang Y (2009b) TNF-alpha, a potent lipid metabolism regulator. Cell Biochem Funct 27:407-416
8. Connor WE (2000) Importance of n-3 fatty acids in health and disease. Am J Clin Nutr 71(1 Suppl):171S-175S
9. Das UN (2007) A defect in the activity of Delta6 and Delta5 desaturases may be a factor in the initiation and progression of atherosclerosis. Prostaglandins Leukot Essent Fatty Acids 76:251-268
10. Davidson MH (2006) Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids. Am J Cardiol 98(4A):27-33
11. De Caterina R, Massaro M (2005) Omega-3 fatty acids and the regulation of expression of endothelial pro-atherogenic and pro-inflammatory genes. J Membr Biol 206:103-116
12. Deckelbaum RJ, Worgall TS, Seo T (2006) n-3 Fatty acids and gene expression. Am J Clin Nutr 83(6 Suppl):1520S-1525S
13. Djoussé L, Pankow JS, Eckfeldt JH, Folsom AR, Hopkins PN, Province MA, Hong Y, Ellison RC (2001) Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr 74:612-619
14. Dutta-Roy AK (2000) Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. Am J Clin Nutr 71(1 Suppl):315S-322S
15. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
16. Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS (2007) Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447:959-965
17. Ginsberg HN (1996) Diabetic dyslipidemia: basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels. Diabetes 45(Suppl 3):S27-S30
18. Gougeon R, Pencharz PB, Marliss EB (1994) Effect of NIDDM on the kinetics of whole-body protein metabolism. Diabetes 43:318-328
19. Hardman WE (2002) Omega-3 fatty acids to augment cancer therapy. J Nutr 132(11 Suppl):3508S-3512S
20. Hendrich S (2010) (n-3) Fatty acids: clinical trials in people with type 2 diabetes. Adv Nutr 1:3-7
21. Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N, Kohjima M, Kotoh K, Nakamuta M, Takayanagi R, Enjoji M (2008) Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 38:1122-1129
22. Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-1131
23. Huang T, Wahlqvist ML, Xu T, Xu A, Zhang A, Li D (2010) Increased plasma n-3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China. Mol Nutr Food Res 54(Suppl 1):S112-S119
24. Innis SM (2004) Polyunsaturated fatty acids in human milk: an essential role in infant development. Adv Exp Med Biol 554:27-43
25. Jana M, Jana A, Liu X, Ghosh S, Pahan K (2007) Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B α in anti-inflammatory effect of gemfibrozil in microglia. J Immunol 179:4142-4152
26. Kaithwas G, Majumdar D (2012) In-vitro antioxidant and in vivo antidiabetic, antihyperlipidemic activity of linseed oil against streptozotocin-induced toxicity in albino rats. Eur J Lipid Sci Technol. doi: 10.1002/ejlt.201100263
27. Keller H, Wahli W (1993) Peroxisome proliferator-activated receptors A link between endocrinology and nutrition? Trends Endocrinol Metab 4:291-296
28. Koh JH, Shin YG, Nam SM, Lee MY, Chung CH, Shin JY (2009) Serum adipocyte fatty acid-binding protein levels are associated with nonalcoholic fatty liver disease in type 2 diabetic patients. Diabetes Care 32:147-152
29. Krauss RM (2004) Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care 27:1496-1504
30. Kris-Etherton PM, Harris WS, Appel LJ, AHA Nutrition Committee American Heart Association (2003) Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 23:151-152
31. Kroger J, Schulze MB (2012) Recent insights into the relation of Δ5 desaturase and Δ6 desaturase activity to the development of type 2 diabetes. Curr Opin Lipidol 23:4-10
32. Mahmud I, Hossain A, Hossain S, Hannan A, Ali L, Hashimoto M (2004) Effects of Hilsa ilisa fish oil on the atherogenic lipid profile and glycaemic status of streptozotocin-treated type 1 diabetic rats. Clin Exp Pharmacol Physiol 31(1-2):76-81
33. Manku MS, Horrobin DF, Huang S, Morse N (1983) Fatty acids in plasma and red cell membranes. Lipids 18:906-908
34. Mansouri RM, Baugé E, Staels B, Gervois P (2008) Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-α control of the acute-phase response. Endocrinology 149:3215-3223
35. Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire-Buys D, Novelli M, Ribes G (1998) Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 47:224-229
36. McKenney JM, Sica D (2007) Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. Pharmacotherapy 27:715-728
37. Meyer C, Stumvoll M, Nadkarni V, Dostou J, Mitrakou A, Gerich J (1998) Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. J Clin Invest 102:619-624
38. Montori VM, Farmer A, Wollan PC, Dinneen SF (2000) Fish oil supplementation in type 2 diabetes: a quantitative systematic review. Diabetes Care 23:1407-1415
39. Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD (2012) The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab 15:240-246
40. Mori TA, Beilin LJ (2004) Omega-3 fatty acids and inflammation. Curr Atheroscler Rep 6:461-467
41. Murugan P, Pari L (2007) Protective role of tetrahydrocurcumin on changes in the fatty acid composition in streptozotocin-nicotinamide induced type 2 diabetic rats. J Appl Biomed 5:31-38
42. Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, Romanelli AJ, Rossbacher JC, Moore IK, Regittnig W, Munoz DS, Kim JH, Shulman GI (2007) n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-α-dependent manner. Diabetes 56:1034-1041
43. Newberry EP, Xie Y, Kennedy S, Han X, Buhman KK, Luo J, Gross RW, Davidson NO (2003) Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J Biol Chem 278:51664-51672
44. Pari L, Murugan P (2007) Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats. J Med Food 10:323-329
45. Pelsers MM, Hermens WT, Glatz JF (2005) Fatty acid-binding proteins as plasma markers of tissue injury. Clin Chim Acta 352:15-35
46. Pickup JC, Mattock MB, Chusney GD, Burt D (1997) NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40:1286-1292
47. Pickup JC, Chusney GD, Thomas SM, Burt D (2000) Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci 67:291-300
48. Popa C, Netea MG, van Riel PL, van der Meer JW, Stalenhoef AF (2007) The role of TNF-α in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res 48:751-762
49. Price PT, Nelson CM, Clarke SD (2000) Omega-3 polyunsaturated fatty acid regulation of gene expression. Curr Opin Lipidol 11:3-7
50. Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD (1988) Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37:1020-1024
51. Reiffel JA, McDonald A (2006) Antiarrhythmic effects of omega-3 fatty acids. Am J Cardiol 98:50-60
52. Riediger ND, Othman R, Fitz E, Pierce GN, Suh M, Moghadasian MH (2008) Low n-6: n-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in mice. Eur J Nutr 47:153-160
53. Rivellese AA, Maffettone A, Iovine C, Di Marino L, Annuzzi G, Mancini M, Riccardi G (1996) Long-term effects of fish oil on insulin resistance and plasma lipoproteins in NIDDM patients with hypertriglyceridemia. Diabetes Care 19:1207-1213
54. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101-1108
55. Schoonjans K, Staels B, Auwerx J (1996) The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1302:93-109
56. Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL (1996) Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98:1575-1584
57. Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL (1997) Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 99:846-854
58. Shimomura I, Bashmakov Y, Horton JD (1999) Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274:30028-30032
59. Siddiqui RA, Shaikh SR, Sech LA, Yount HR, Stillwell W, Zaloga GP (2004) Omega 3-fatty acids: health benefits and cellular mechanisms of action. Mini Rev Med Chem 4:859-871
60. Simopoulos AP (1991) Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54:438-463
61. Simopoulos AP (2002) Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 21:495-505
62. Singer P, Shapiro H, Theilla M, Anbar R, Singer J, Cohen J (2008) Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective. Intensive Care Med 34:1580-1592
63. Song He W, Nara TY, Nakamura MT (2002) Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator. Biochem Biophys Res Commun 299:832-838
64. Szkudelski T (2012) Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model. Exp Biol Med 237:481-490
65. Tkac I, Kimball BP, Lewis G, Uffelman K, Steiner G (1997) The severity of coronary atherosclerosis in type 2 diabetes mellitus is related to the number of circulating triglyceride-rich lipoprotein particles. Arterioscler Thromb Vasc Biol 17:3633-3638
66. Tso AW, Xu A, Sham PC, Wat NM, Wang Y, Fong CH, Cheung BM, Janus ED, Lam KS (2007) Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care 30:2667-2672
67. Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS (2006) A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA 103:6970-6975
68. Veerkamp JH, van Moerkerk HT (1993) Fatty acid-binding protein and its relation to fatty acid oxidation. Mol Cell Biochem 123:101-106
69. Vijaimohan K, Jainu M, Sabitha KE, Subramaniyam S, Anandhan C, Shyamala Devi CS (2006) Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. Life Sci 79:448-454
70. Wakutsu M, Tsunoda N, Shiba S, Muraki E, Kasono K (2010) Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice. Lipids Health Dis 9:101
71. Wallace JM, Schwarz M, Coward P, Houze J, Sawyer JK, Kelley KL, Chai A, Rudel LL (2005) Effects of peroxisome proliferator-activated receptor α/delta agonists on HDL-cholesterol in vervet monkeys. J Lipid Res 46:1009-1016
72. Wolfrum C, Borrmann CM, Borchers T, Spener F (2001) Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus. Proc Natl Acad Sci USA 98:2323-2328
73. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V (2000) Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148:209-214