The microenvironment for erythropoiesis is regulated by HIF-2ά through VCAM-1 in endothelial cells

Blood

Volumn 112, Issue 4, 2008, Pages 1482-1492

  Yamashita, Toshiharu ^a   Ohneda, Osamu ^a   Sakiyama, Ai ^a   Iwata, Fumiko ^a   Ohneda, Kinuko ^b   Fujii Kuriyama, Yoshiaki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TAKASAKI UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2 ALPHA; MESSENGER RNA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; OXYGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; ERYTHROBLAST; ERYTHROPOIESIS; HEMATOPOIETIC CELL; IMMUNOPRECIPITATION; MICROCIRCULATION; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANEMIA; ANIMAL; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MOUSE MUTANT; PHYSIOLOGY;

ANEMIA; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; ENDOTHELIAL CELLS; ERYTHROPOIESIS; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MICE; MICE, KNOCKOUT; OXYGEN; TRANSCRIPTION, GENETIC; VASCULAR CELL ADHESION MOLECULE-1;

EID: 51649104761     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-11-122648     Document Type: Article

References (47)

1. Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem. 1995;270:1230-1237.
2. Gu YZ, Moran SM, Hogenesch JB, et al. Molecular characterization and chromosomal localization of third α-class hypoxia inducible factor subunit, HIF-3α. Gene Expr. 1998;7:205-213.
3. Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 1997;11:72-82.
4. Wang GL. Semenza GL. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood. 1993;15:3610-3615.
5. Peng J, Zhang L. Drysdale L, et al. The transcription factor EPAS-1/hypoxia-inducible factor-2α plays an important role in vascular remodeling. Proc Natl Acad Sci USA. 2000;97:8386-8391.
6. Tian H, Hammer RE, Matsumoto AM, et al. The hypoxia-responsive transcription factor EPAS-1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 1998;12:3320-3324.
7. -I- mice. Nat Genet. 2003;35:331-340.
8. Scortegagna M, Morris MA, Oktay Y, et al. The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice. Blood. 2003;102: 1634-1640.
9. Jelkmann W. Erythropoietin after a century of research: younger than ever. Eur J Haematol. 2007;78:183-205.
10. Koury ST Bondurant MC, Koury MJ. Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood. 1988;71:524- 527.
11. Semenza GL, Koury ST, Nejfelt MK, et al. Cell- type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci U S A. 1991 ;88:8725- 8729.
12. Maxwell PH, Osmond MK, Pugh CW, et al. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int. 1993;44:1149- 1162.
13. Wintour EM, Butkus A, Esrnest L, et al. The erythropoietin gene is expressed strongly in the mammalian mesonephric kidney. Blood. 1996;88: 3349-3353.
14. Obara N, Suzuki N, Kim K, et al. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood. 2008;111: 5223-5232.
15. Lin CS, Lim SK, D'Agati V, et al. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996;15:154-164.
16. Scortegagna M, Ding K, Zhang Q. et al. HIF-2α regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood. 2005;105:3133-3140.
17. Gruber M, Hu G-J, Johnson RS. et al. Acute postnatal ablation of HlF-2α results in anemia. Proc Natl Acad Sci USA. 2007;104:2301-2306.
18. Rankin EB, Biju MP. Liu Q, et al. Hypoxia- inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117:1068- 1077.
19. Trentin JJ. Determination of bone marrow stem cell differentiation by stromal hemopoietic inductive microenvironments (HIM). Am J Pathol. 1971; 65:621-628.
20. Gordon MY. Clarke D, Atkinson J, et al. Hemopoietic progenitor cell binding to the stromal micro- environment in vitro. Exp Hematol. 1990;18:837-842.
21. Ohneda O, Yanai N, Obinata M. Microenviron- ment created by stromal cells is essential for a rapid expansion of erythroid cells in mouse fetal liver. Development. 1990;110:379-384.
22. Rafii S, Mohle R, Shapiro R et al. Regulation of hematopoiesis by microvascular endothelium. Leuk Lymphoma. 1997;27:375-386.
23. 23.Morita M, Ohneda O, Yamashita T, et al. HLF/ HIF-2α is key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 2003; 22:1134-1146.
24. Kameoka J, Yanai N, Obinata M. Bone marrow stromal cells selectively stimulate the rapid expansion of lineage-restricted myeloid progenitors. J Cell Physiol. 1995;164:55-64.
25. Suzuki M, Ohneda K, Hosoya-Ohmura S, et al. Real-time monitoring of stress erythropoiesis in vivo using Gatal and beta-globin LCR luciferase transgenic mice. Blood. 2006;108:726-733.
26. Hosoya-Ohmura S, Mochizuki N, Suzuki M, et al. GATA-4 incompletely substitutes for GATA-1 in promoting both primitive and definitive erythropoiesis in vivo. J Biol Chem. 2006;281:32820-32830.
27. Ohneda O. Fennie C, Zheng Z. et al. Hematopoietic stem cell maintenance and differentiation are supported by embryonic aorta-gonad- mesonephros region-derived endothelium. Blood. 1998;92:908-919.
28. Yanai N, Matsuya Y Obinata M. Spleen stromal cell lines selectively support erythroid colony formation. Blood. 1989;74:2391-2397.
29. Yanai N, Sekine C, Yagita H, et al. Roles for inte- grin very late activation antigen-4 in stroma- dependent erythropoiesis. Blood. 1994;83:2844- 2850.
30. Ohneda O, Ohneda K, Arai F et al. ALGAM (CD166): its role in hematopoietic and endothelial development. Blood. 2001 ;98:2134-2142.
31. Nagano M. Yamashita T, Hamada H. et al. Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Blood. 2007;110: 151-160.
32. Yamashita T, Ohneda O, Nagano M, et al. Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS. Mol Cell Biol. 2008;28:1285-1297.
33. Zhang J, Socolovsky M, Gross AW, et al. Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood. 2003;102:3938-3946.
34. Gustafsson E, Brakebusch C, Hietanen K, et al. Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transenic mice. J Cell Sci. 2001 ;114:671-676.
35. Leavesley Dl, Oliver JM, Swart BW, et al. Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells. J Immunol. 1994;153:4673-4683.
36. Ye ZO, Burkholder JK, Qiu P, et al. Establishment of an adherent cell feeder layer from human umbilical cord blood for support of long-term hematopoietic progenitor cell growth. Proc Natl Acad Sci U SA. 1994;91:12140-12144.
37. Fraser ST, Ogawa M, Yu RT, et al. Definitive hematopoietic commitment within the embryonic vascular endothelial-cadherin(+) population. Exp Hematol. 2002;30:1070-1078.
38. Kappel A, Rönicke V, Damaert A, et al. Identification of vascular endothelial growth factor (VEGF) receptor-2 (flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell- specific transcription in transgenic mice. Blood. 1999;93:4284-4292.
39. Duan LJ. Zhang-Benoit Y, Fong GH. Endothelium- intrinsic requirement for Hif-2alpha during vascular development. Circulation. 2005;111:2227-2232.
40. Ohneda O. Yanai N, Obinata M. Combined action of c-kit and erythropoietin on erythroid progenitor cells. Development. 1992;114:245-252.
41. Papayannopoulou T, Brice M. Integrin expression profiles during erythroid differentiation. Blood. 1992;79:1686-1694.
42. Hamamura K, Matsuda H, Takeuchi Y et al. A critical role of VLA-4 in erythropoiesis in vivo. Blood. 1996;87:2513-2517.
43. Wu H, Liu X, Jaenisch R, et al. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995;83:59-67.
44. Li H, Cybulsky Ml, Gimbrone MA, et al. Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma. Am J Pathol. 1993;143: 1551-1559.
45. Miyake K, Medina K, Ishihara K, et al. A VCAM- like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. J Gell Biol. 1991 ;114:557-565.
46. Quesenberry PJ, Becker PS. Stem cell homing: rolling, crawling, and nesting. Proc Natl Acad Sci USA. 1998;95:15155-15157.
47. Verfaillie CM. Adhesion receptors as regulators of the hematopoietic process. Blood. 1998;92: 2609-2612.