Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643

Toxicology and Applied Pharmacology

Volumn 188, Issue 3, 2003, Pages 185-198

  Vanden Heuvel, John P ^a   Kreder, Dirk ^b,c   Belda, Benjamin ^a   Hannon, Daniel B ^a,d   Nugent, Courtney A ^a   Burns, Katherine A ^a   Taylor, Michael J ^b,e  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b ROCHE BIOSCIENCE   (United States)

^c Abgenix Inc   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e DURECT Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE; FATTY ACID; JANUS KINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE; PIRINIXIC ACID; PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CATABOLISM; CELL CYCLE; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ANALYSIS; HEPATOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BLOOD LEVEL; RAT; UNINDEXED SEQUENCE;

APOGON BRACHYGRAMMUS; JANUS; RODENTIA;

EID: 0242417493     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00015-2     Document Type: Article

References (81)

1. Adams M., Reginato M.J., Shao D., Lazar M.A., Chatterjee V.K. Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J. Biol. Chem. 272:1997;5128-5132.
2. Bayly A.C., French N.J., Dive C., Roberts R.A. Non-genotoxic hepatocarcinogenesis in vitro the FaO hepatoma line responds to peroxisome proliferators and retains the ability to undergo apoptosis . J. Cell Sci. 104:1993;307-315.
3. Bayly A.C., Roberts R.A., Dive C. Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin. J. Cell Biol. 125:1994;197-203.
4. Bojes H.K., Keller B.J., Thurman R.G. Wy-14,643 stimulates hepatic protein kinase C activity. Toxicol. Lett. 62:1992;317-322.
5. Bouras T., Southey M.C., Venter D.J. Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu. Cancer Res. 61:2001;903-907.
6. Byon J.C., Dadke S.S., Rulli S., Kusari A.B., Kusari J. Insulin regulates MAP kinase phosphatase-1 induction in Hire B cells via activation of both extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK). Mol. Cell. Biochem. 218:2001;131-138.
7. Camp H.S., Tafuri S.R. Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase. J. Biol. Chem. 272:1997;10811-10816.
8. Cattley R.C., DeLuca J., Elcombe C., Fenner-Crisp P., Lake B.G., Marsman D.S., Pastoor T.A., Popp J.A., Robinson D.E., Schwetz B., Tugwood J., Wahli W. Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans? Regul. Toxicol. Pharmacol. 27:1998;47-60.
9. Cherkaoui-Malki M., Meyer K., Cao W.Q., Latruffe N., Yeldandi A.V., Rao M.S., Bradfield C.A., Reddy J.K. Identification of novel peroxisome proliferator-activated receptor α (PPARα) target genes in mouse liver using cDNA microarray analysis. Gene Exp. 9:2001;291-304.
10. Citron M. Perplexing peroxisome proliferators. Environ. Health Perspect. 103:1995;232-235. [news].
11. Desbois-Mouthon C., Cadoret A., Blivet-Van Eggelpoel M.J., Bertrand F., Caron M., Atfi A., Cherqui G., Capeau J. Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase-and mitogen-activated protein kinase phosphatase-1-dependent pathway. Endocrinology. 141:2000;922-931.
12. Duclos S., Bride J., Ramirez L.C., Bournot P. Peroxisome proliferation and β-oxidation in Fao and MHIC1 rat hepatoma cells, HepG2 human hepatoblastoma cells and cultured human hepatocytes effect of ciprofibrate . Eur. J. Cell Biol. 72:1997;314-323.
13. Forman B.M., Chen J., Evans R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ Proc. Natl. Acad. Sci. USA. 94:1997;4312-4317.
14. Franklin C.C., Kraft A.S. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J. Biol. Chem. 272:1997;16917-16923.
15. Gervois P., Torra I.P., Chinetti G., Grotzinger T., Dubois G., Fruchart J.C., Fruchart-Najib J., Leitersdorf E., Staels B. A truncated human peroxisome proliferator-activated receptor α splice variant with dominant negative activity. Mol. Endocrinol. 13:1999;1535-1549.
16. Green S. Peroxisome proliferators a model for receptor mediated carcinogenesis . Cancer Surv. 14:1992;221-232.
17. Grimshaw M.J., Balkwill F.R. Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - a potential mechanism. Eur. J. Immunol. 31:2001;480-489.
18. Guo Y.L., Kang B., Williamson J.R. Resistance to TNF-alpha cytotoxicity can be achieved through different signaling pathways in rat mesangial cells. Am. J. Physiol. 276:1999;C435-C441.
19. Hamadeh H.K., Bushel P.R., Jayadev S., Martin K., DiSorbo O., Sieber S., Bennett L., Tennant R., Stoll R., Barrett J.C., Blanchard K., Paules R.S., Afshari C.A. Gene expression analysis reveals chemical-specific profiles. Toxicol. Sci. 67:2002;219-231.
20. Hasmall S., Orphanides G., James N., Pennie W., Hedley K., Soames A., Kimber I., Roberts R. Downregulation of lactoferrin by PPARalpha ligands role in perturbation of hepatocyte proliferation and apoptosis . Toxicol. Sci. 68:2002;304-313.
21. Hofken T., Keller N., Fleischer F., Goke B., Wagner A.C. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Biochem. Biophys. Res. Commun. 276:2000;680-685.
22. Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347:1990;645-650. [see comments].
23. Kato S., Endoh H., Masuhiro Y., Kitamoto T., Uchiyama S., Sasaki H., Masushige S., Gotoh Y., Nishida E., Kawashima H., Metzer D., Chambon P. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science. 270:1995;1491-1494.
24. Kersten S., Mandard S., Escher P., Gonzalez F.J., Tafuri S., Desvergne B., Wahli W. The peroxisome proliferator-activated receptor α regulates amino acid metabolism. FASEB J. 15:2001;1971-1978.
25. Kliewer S.A., Sundseth S.S., Jones S.A., Brown P.J., Wisely G.B., Koble C.S., Devchand P., Wahli W., Willson T.M., Lenhard J.M., Lehmann J.M. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ Proc. Natl. Acad. Sci. USA. 94:1997;4318-4323.
26. Kliewer S.A., Umesono K., Noonan D.J., Heyman R.A., Evans R.M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature. 358:1992;771-774.
27. Kojima S., Yanagihara I., Kono G., Sugahara T., Nasu H., Kijima M., Hattori A., Kodama T., Nagayama K.I., Honda T. mkp-1 encoding mitogen-activated protein kinase phosphatase 1, a verotoxin 1 responsive gene, detected by differential display reverse transcription-PCR in Caco-2 cells. Infect. Immun. 68:2000;2791-2796.
28. Krey G., Braissant O., L'Horset F., Kalkhoven E., Perroud M., Parker M.G., Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11:1997;779-791.
29. Kusari A.B., Byon J., Bandyopadhyay D., Kenner K.A., Kusari J. Insulin-induced mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) attenuates insulin-stimulated MAP kinase activity a mechanism for the feedback inhibition of insulin signaling . Mol. Endocrinol. 11:1997;1532-1543.
30. Laderoute K.R., Mendonca H.L., Calaoagan J.M., Knapp A.M., Giaccia A.J., Stork P.J. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J. Biol. Chem. 274:1999;12890-12897.
31. Lazennec G., Canaple L., Saugy D., Wahli W. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol. Endocrinol. 14:2000;1962-1975.
32. Li Y., Lau L.F. Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation. Endocrinology. 138:1997;4138-4146.
33. Lin W.W., Hsu Y.W. Cycloheximide-induced cPLA(2) activation is via the MKP-1 down-regulation and ERK activation. Cell. Signal. 12:2000;457-461.
34. Lock E.A., Mitchell A.M., Elcombe C.R. Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annu. Rev. Pharmacol. Toxicol. 29:1989;145-163.
35. Long W.P., Pray-Grant M., Tsai J.C., Perdew G.H. Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction. Mol. Pharmacol. 53:1998;691-700.
36. Manteuffel-Cymborowska M. Nuclear receptors, their coactivators and modulation of transcription. Acta Biochim. Pol. 46:1999;77-89.
37. Marcus S.L., Miyata K.S., Zhang B., Subramani S., Rachubinski R.A., Capone J.P. Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Proc. Natl. Acad. Sci. USA. 90:1993;5723-5727.
38. Mendelson K.G., Contois L.R., Tevosian S.G., Davis R.J., Paulson K.E. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proc. Natl. Acad. Sci. USA. 93:1996;12908-12913.
39. Metzler B., Hu Y., Sturm G., Wick G., Xu Q. Induction of mitogen-activated protein kinase phosphatase-1 by arachidonic acid in vascular smooth muscle cells. J. Biol. Chem. 273:1998;33320-33326.
40. Moody D.E., Reddy J.K., Lake B.G., Popp J.A., Reese D.H. Peroxisome proliferation and nongenotoxic carcinogenesis commentary on a symposium . Fundam. Appl. Toxicol. 16:1991;233-248.
41. Motojima K., Goto S. A protein histidine kinase induced in rat liver by peroxisome proliferators. In vitro activation by Ras protein and guanine nucleotides. FEBS Lett. 319:1993;75-79.
42. Motojima K., Passilly P., Jannin B., Latruffe N. Protein phosphorylation by peroxisome proliferators species-specific stimulation of protein kinases and its role in PP-induced transcriptional activation . Ann. N.Y. Acad. Sci. 804:1996;413-423.
43. Moya-Camarena S.Y., Vanden Heuvel J.P., Blanchard S.G., Leesnitzer L.A., Belury M.A. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα J. Lipid Res. 40:1999;1426-1433.
44. Murakami K., Ide T., Suzuki M., Mochizuki T., Kadowaki T. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor α Biochem. Biophys. Res. Commun. 260:1999;609-613.
45. Nuwaysir E.F., Bittner M., Trent J., Barrett J.C., Afshari C.A. Microarrays and toxicology the advent of toxicogenomics . Mol. Carcinogen. 24:1999;153-159.
46. Orellana A., Holuigue L., Hidalgo P.C., Faundez V., Gonzalez A., Bronfman M. Ciprofibrate, a carcinogenic peroxisome proliferator, increases the phosphorylation of epidermal-growth-factor receptor in isolated rat hepatocytes. Eur. J. Biochem. 215:1993;903-906.
47. Palmer C.N., Hsu M.H., Griffin K.J., Raucy J.L., Johnson E.F. Peroxisome proliferator activated receptor-alpha expression in human liver. Mol. Pharmacol. 53:1998;14-22.
48. Passilly P., Jannin B., Hassell S.J., Latruffe N. Human HepG2 and rat Fao hepatic-derived cell lines show different responses to ciprofibrate, a peroxisome proliferator analysis by flow cytometry . Exp. Cell Res. 223:1996;436-442.
49. Passilly P., Jannin B., Latruffe N. Influence of peroxisome proliferators on phosphoprotein levels in human and rat hepatic-derived cell lines. Eur. J. Biochem. 230:1995;316-321.
50. Peters J.M., Cattley R.C., Gonzalez F.J. Role of PPAR α in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis. 18:1997;2029-2033.
51. Roberts R.A., James N.H., Hasmall S.C., Holden P.R., Lambe K., Macdonald N., West D., Woodyatt N.J., Whitcome D. Apoptosis and proliferation in nongenotoxic carcinogenesis species differences and role of PPARα Toxicol. Lett. 112-113:2000;49-57.
52. Rockett J.C., Dix D.J. Application of DNA arrays to toxicology. Environ. Health Perspect. 107:1999;681-685.
53. Rodi C.P., Bunch R.T., Curtiss S.W., Kier L.D., Cabonce M.A., Davila J.C., Mitchell M.D., Alden C.L., Morris D.L. Revolution through genomics in investigative and discovery toxicology. Toxicol. Pathol. 27:1999;107-110.
54. Rodriguez C., Noe V., Cabrero A., Ciudad C.J., Laguna J.C. Differences in the formation of PPARα-RXR/acoPPRE complexes between responsive and nonresponsive species upon fibrate administration. Mol. Pharmacol. 58:2000;185-193.
55. Rokos C.L., Ledwith B.J. Peroxisome proliferators activate extracellular signal-regulated kinases in immortalized mouse liver cells. J. Biol. Chem. 272:1997;13452-13457.
56. Rumora L., Shaver A., Zanic Grubisic T., Maysinger D. MKP-1 as a target for pharmacological manipulations in PC12 cell survival. Neurochem. Int. 39:2001;25-32.
57. Ryser S., Tortola S., van Haasteren G., Muda M., Li S., Schlegel W. MAP kinase phosphatase-1 gene transcription in rat neuroendocrine cells is modulated by a calcium-sensitive block to elongation in the first exon. J. Biol. Chem. 276:2001;33319-33327.
58. Sadar M.D. Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways. J. Biol. Chem. 274:1999;7777-7783.
59. Schena M., Heller R.A., Theriault T.P., Konrad K., Lachenmeier E., Davis R.W. Microarrays biotechnology's discovery platform for functional genomics . Trends Biotechnol. 16:1998;301-306. [see comments].
60. Schliess F., Kurz A.K., Haussinger D. Glucagon-induced expression of the MAP kinase phosphatase MKP-1 in rat hepatocytes. Gastroenterology. 118:2000;929-936.
61. Seta K.A., Kim R., Kim H.W., Millhorn D.E., Beitner-Johnson D. Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis. J. Biol. Chem. 276:2001;44405-44412.
62. Shalev A., Siegrist-Kaiser C.A., Yen P.M., Wahli W., Burger A.G., Chin W.W., Meier C.A. The peroxisome proliferator-activated receptor α is a phosphoprotein regulation by insulin . Endocrinology. 137:1996;4499-4502.
63. Slack D.N., Seternes O.M., Gabrielsen M., Keyse S.M. Distinct binding determinants for ERK2/p38α and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. J. Biol. Chem. 276:2001;16491-16500.
64. Sterchele P.F., Sun H., Peterson R.E., Vanden Heuvel J.P. Regulation of peroxisome proliferator-activated receptor-α mRNA in rat liver. Arch. Biochem. Biophys. 326:1996;281-289.
65. Stott W.T. Regulatory implications of peroxisome proliferation an industrial perspective . Ann. N.Y. Acad. Sci. 804:1996;641-648.
66. Sun H., Charles C.H., Lau L.F., Tonks N.K. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 75:1993;487-493.
67. Tugwood J.D., Issemann I., Anderson R.G., Bundell K.R., McPheat W.L., Green S. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J. 11:1992;433-439.
68. Valledor A.F., Xaus J., Comalada M., Soler C., Celada A. Protein kinase Cε is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J. Immunol. 164:2000;29-37.
69. Valledor A.F., Xaus J., Marques L., Celada A. Macrophage colony-stimulating factor induces the expression of mitogen-activated protein kinase phosphatase-1 through a protein kinase C-dependent pathway. J. Immunol. 163:1999;2452-2462.
70. Vanden Heuvel J.P. Approaches for the identification of xenobiotic-inducible genes. Denison M.S., Helferich W.G. Toxicant-Receptor Interactions. 1998;217-235 Taylor and Francis, Philadelphia.
71. Vanden Heuvel J.P. Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis. Toxicol. Sci. 47:1999;1-8.
72. Vanden Heuvel J.P. Peroxisome proliferator-activated receptors a critical link among fatty acids, gene expression and carcinogenesis . J. Nutr. 129:1999;575-580.
73. Vanden Heuvel J.P., Holden P., Tugwood J., Ingle C., Yen W.Y., Galjart N., Greenlee W.F. Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37. Toxicol. Appl. Pharmacol. 152:1998;107-118.
74. Vanden Heuvel J.P., Peters J.M. Biology of the PPAR family of receptors. Comments Toxicol. 7:2001;233-257.
75. Williams G.M., Iatropoulos M.J., Weisburger J.H. Chemical carcinogen mechanisms of action and implications for testing methodology. Exp. Toxicol. Pathol. 48:1996;101-111.
76. Wong J.S., Ye X., Muhlenkamp C.R., Gill S.S. Effect of a peroxisome proliferator on 3β-hydroxysteroid dehydrogenase. Biochem. Biophys. Res. Commun. 293:2002;549-553.
77. Yamazaki K., Kuromitsu J., Tanaka I. Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor α agonists. Biochem. Biophys. Res. Commun. 290:2002;1114-1122.
78. Zhang B., Berger J., Zhou G., Elbrecht A., Biswas S., White-Carrington S., Szalkowski D., Moller D.E. Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ J. Biol. Chem. 271:1996;31771-31774.
79. Zhang B., Marcus S.L., Sajjadi F.G., Alvares K., Reddy J.K., Subramani S., Rachubinski R.A., Capone J.P. Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc. Natl. Acad. Sci. USA. 89:1992;7541-7545.
80. Zhou Y.C., Waxman D.J. Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-α (PPARα) signaling pathways. Growth hormone inhibition of PPARα transcriptional activity mediated by STAT5b. J. Biol. Chem. 274:1999;2672-2681.
81. Zhou Y.C., Waxman D.J. STAT5b down-regulates peroxisome proliferator-activated receptor α-transcription by inhibition of ligand-independent activation function region-1 trans-activation domain. J. Biol. Chem. 274:1999;29874-29882.