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Volumn 368, Issue 3, 2002, Pages 855-864

Polyunsaturated fatty acids decrease the expression of sterol regulatory elernent-binding protein-1 in CaCo-2 cells: Effect on fatty acid synthesis and triacylglycerol transport

Author keywords

Apolipoprotein B; Cholesterol; Liver X receptor

Indexed keywords

BIOCHEMISTRY; ENZYME KINETICS; GENETIC ENGINEERING; GLYCEROL; PROTEINS; RNA; TRANSPORT PROPERTIES;

EID: 0037115762     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020731     Document Type: Article
Times cited : (64)

References (45)
  • 1
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown, M. S. and Goldstein, J. L. (1997) The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 2
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • Shimomura, I., Shimano, H., Horton, J. D., Goldstein, J. L. and Brown, M. S. (1997) Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99, 838-845
    • (1997) J. Clin. Invest. , vol.99 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 3
    • 0028960739 scopus 로고
    • Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBP1) and localization of SREBP1 and SREBP2 to chromosomes 17p11.2 and 22q13
    • Hua, X., Wu, J., Goldstein, J. L., Brown, M. S. and Hobbs, H. H. (1995) Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBP1) and localization of SREBP1 and SREBP2 to chromosomes 17p11.2 and 22q13. Genomics 25, 667-673
    • (1995) Genomics , vol.25 , pp. 667-673
    • Hua, X.1    Wu, J.2    Goldstein, J.L.3    Brown, M.S.4    Hobbs, H.H.5
  • 4
    • 0027139362 scopus 로고
    • SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
    • Hua, X., Yokoyama, C., Wu, J., Briggs, M. R., Brown, M. S., Goldstein, J. L. and Wang, X. (1993) SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. U.S.A. 90, 11603-11607
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 11603-11607
    • Hua, X.1    Yokoyama, C.2    Wu, J.3    Briggs, M.R.4    Brown, M.S.5    Goldstein, J.L.6    Wang, X.7
  • 5
    • 0033613147 scopus 로고    scopus 로고
    • A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
    • Brown, M. S. and Goldstein, J. L. (1999) A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci. U.S.A. 96, 11041-11048
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 11041-11048
    • Brown, M.S.1    Goldstein, J.L.2
  • 6
    • 0032892175 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis
    • Horton, J. D. and Shimomura, I. (1999) Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis. Curr. Opin. Lipidol. 10, 143-150
    • (1999) Curr. Opin. Lipidol. , vol.10 , pp. 143-150
    • Horton, J.D.1    Shimomura, I.2
  • 8
    • 0032489460 scopus 로고    scopus 로고
    • Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies
    • Sakai, J., Nohturfft, A., Goldstein, J. L. and Brown, M. S. (1998) Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. J. Biol. Chem. 273, 5785-5793
    • (1998) J. Biol. Chem. , vol.273 , pp. 5785-5793
    • Sakai, J.1    Nohturfft, A.2    Goldstein, J.L.3    Brown, M.S.4
  • 9
    • 0033613126 scopus 로고    scopus 로고
    • Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi
    • Nohturfft, A., DeBose-Boyd, R. A., Scheek, S., Goldstein, J. L. and Brown, M. S. (1999) Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc. Natl. Acad. Sci. U.S.A. 98, 11235-11240
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 11235-11240
    • Nohturfft, A.1    DeBose-Boyd, R.A.2    Scheek, S.3    Goldstein, J.L.4    Brown, M.S.5
  • 10
    • 0033599028 scopus 로고    scopus 로고
    • Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
    • DeBose-Boyd, R. A., Brown, M. S., Li, W. P., Nohturfft, A., Goldstein, J. L. and Espenshade, P. J. (1999) Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99, 703-712
    • (1999) Cell , vol.99 , pp. 703-712
    • DeBose-Boyd, R.A.1    Brown, M.S.2    Li, W.P.3    Nohturfft, A.4    Goldstein, J.L.5    Espenshade, P.J.6
  • 11
    • 0030907175 scopus 로고    scopus 로고
    • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
    • Shimano, H., Herren, J. D., Shimomura, I., Hammer, R. E., Brown, M. S. and Goldstein, J. L. (1997) Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Invest. 99, 846-854
    • (1997) J. Clin. Invest. , vol.99 , pp. 846-854
    • Shimano, H.1    Herren, J.D.2    Shimomura, I.3    Hammer, R.E.4    Brown, M.S.5    Goldstein, J.L.6
  • 12
    • 0028839010 scopus 로고
    • Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver
    • Sheng, Z., Otani, H., Brown, M. S. and Goldstein, J. L. (1995) Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. U.S.A. 92, 935-938
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 935-938
    • Sheng, Z.1    Otani, H.2    Brown, M.S.3    Goldstein, J.L.4
  • 14
    • 0032104180 scopus 로고    scopus 로고
    • Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
    • Horton, J. D., Shimomura, I., Brown, M. S., Hammer, R. E, Goldstein, J. L. and Shimano, H. (1998) Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J. Clin. Invest. 101, 2331-2339
    • (1998) J. Clin. Invest. , vol.101 , pp. 2331-2339
    • Horton, J.D.1    Shimomura, I.2    Brown, M.S.3    Hammer, R.E.4    Goldstein, J.L.5    Shimano, H.6
  • 15
    • 0034604350 scopus 로고    scopus 로고
    • Regulated step in cholesterol feedback localized to budding of SCAP from er membranes
    • Nohturfft, A., Yabe, D., Goldstein, J. L., Brown, M. S. and Espenshade, P. J. (2000) Regulated step in cholesterol feedback localized to budding of SCAP from er membranes. Cell 102, 315-323
    • (2000) Cell , vol.102 , pp. 315-323
    • Nohturfft, A.1    Yabe, D.2    Goldstein, J.L.3    Brown, M.S.4    Espenshade, P.J.5
  • 16
    • 0035137510 scopus 로고    scopus 로고
    • Gene expression of sterol regulatory element-binding proteins in hamster small intestine
    • Field, F. J., Born, E., Murthy, S. and Mathur, S. N. (2001) Gene expression of sterol regulatory element-binding proteins in hamster small intestine. J. Lipid Res. 42, 1-8
    • (2001) J. Lipid Res. , vol.42 , pp. 1-8
    • Field, F.J.1    Born, E.2    Murthy, S.3    Mathur, S.N.4
  • 17
    • 0034753564 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells
    • Field, F. J., Born, E., Murthy, S. and Mathur, S. N. (2001) Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells. J. Lipid Res. 42, 1687-1698
    • (2001) J. Lipid Res. , vol.42 , pp. 1687-1698
    • Field, F.J.1    Born, E.2    Murthy, S.3    Mathur, S.N.4
  • 18
    • 0035907298 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element-binding proteins in hamster intestine by changes in cholesterol flux
    • Field, F. J., Born, E., Murthy, S. and Mathur, S. N. (2001) Regulation of sterol regulatory element-binding proteins in hamster intestine by changes in cholesterol flux. J. Biol. Chem. 276, 17576-17583
    • (2001) J. Biol. Chem. , vol.276 , pp. 17576-17583
    • Field, F.J.1    Born, E.2    Murthy, S.3    Mathur, S.N.4
  • 19
    • 0032516931 scopus 로고    scopus 로고
    • Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins
    • Thewke, D. P., Panini, S. R. and Sinensky, M. (1998) Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins. J. Biol. Chem. 273, 21402-21407
    • (1998) J. Biol. Chem. , vol.273 , pp. 21402-21407
    • Thewke, D.P.1    Panini, S.R.2    Sinensky, M.3
  • 20
    • 0032475841 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein
    • Worgall, T. S., Sturley, S. L., Seo, T., Osborne, T. F. and Deckelbaum, R. J. (1998) Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J. Biol. Chem. 273, 25537-25540
    • (1998) J. Biol. Chem. , vol.273 , pp. 25537-25540
    • Worgall, T.S.1    Sturley, S.L.2    Seo, T.3    Osborne, T.F.4    Deckelbaum, R.J.5
  • 21
    • 0033551846 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
    • Xu, J., Nakamura, M. T., Cho, H. P. and Clarke, S. D. (1999) Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J. Biol. Chem. 274, 23577-23583
    • (1999) J. Biol. Chem. , vol.274 , pp. 23577-23583
    • Xu, J.1    Nakamura, M.T.2    Cho, H.P.3    Clarke, S.D.4
  • 22
    • 0033520484 scopus 로고    scopus 로고
    • Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs
    • Kim, H. J., Takahashi M. and Ezaki, O. (1999) Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs. J. Biol. Chem. 274, 25892-25898
    • (1999) J. Biol. Chem. , vol.274 , pp. 25892-25898
    • Kim, H.J.1    Takahashi, M.2    Ezaki, O.3
  • 23
    • 0035830840 scopus 로고    scopus 로고
    • Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells
    • Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L. and Brown, M. S. (2001) Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells. J. Biol. Chem. 276, 4365-4372
    • (2001) J. Biol. Chem. , vol.276 , pp. 4365-4372
    • Hannah, V.C.1    Ou, J.2    Luong, A.3    Goldstein, J.L.4    Brown, M.S.5
  • 24
    • 0035932990 scopus 로고    scopus 로고
    • Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
    • Ou, J., Tu, H., Shan, B., Luk, A., DeBose-Boyd, R. A., Bashmakov, Y., Goldstein, J. L. and Brown, M. S. (2001) Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc. Natl. Acad. Sci. U.S.A. 98, 6027-6032
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 6027-6032
    • Ou, J.1    Tu, H.2    Shan, B.3    Luk, A.4    DeBose-Boyd, R.A.5    Bashmakov, Y.6    Goldstein, J.L.7    Brown, M.S.8
  • 28
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R. and Mangelsdorf, D. J. (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature (London) 383, 728-731
    • (1996) Nature (London) , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 32
    • 0031042762 scopus 로고    scopus 로고
    • Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR
    • Willy, P. J. and Mangelsdorf, D. J. (1997) Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR. Genes Dev. 11, 289-298
    • (1997) Genes Dev. , vol.11 , pp. 289-298
    • Willy, P.J.1    Mangelsdorf, D.J.2
  • 33
    • 0036164154 scopus 로고    scopus 로고
    • Bareing it all. The adoption of LXR and FXR and their roles in lipid homeostasis
    • Edwards, P. A., Kast, H. R. and Anisfeld, A. M. (2002) Bareing it all. The adoption of LXR and FXR and their roles in lipid homeostasis. J. Lipid Res. 43, 2-12
    • (2002) J. Lipid Res. , vol.43 , pp. 2-12
    • Edwards, P.A.1    Kast, H.R.2    Anisfeld, A.M.3
  • 35
    • 0023176095 scopus 로고
    • Regulation of cholesterol esterification by micellar cholesterol in CaCo-2 cells
    • Field, F. J., Albright, E. and Mathur, S. N. (1987) Regulation of cholesterol esterification by micellar cholesterol in CaCo-2 cells. J. Lipid Res. 28, 1057-1066
    • (1987) J. Lipid Res. , vol.28 , pp. 1057-1066
    • Field, F.J.1    Albright, E.2    Mathur, S.N.3
  • 37
    • 0019345611 scopus 로고
    • Fatty acid synthase from lactating bovine mammary gland
    • Kumar, S. and Dodds, P. F. (1981) Fatty acid synthase from lactating bovine mammary gland. Methods Enzymol. 71, 86-97
    • (1981) Methods Enzymol. , vol.71 , pp. 86-97
    • Kumar, S.1    Dodds, P.F.2
  • 38
    • 0025352716 scopus 로고
    • Effect of eicosapentaenoic acid on triacylglycerol transport in CaCo-2 cells
    • Murthy, S., Albright, E., Mathur, S. N. and Field, F. J. (1990) Effect of eicosapentaenoic acid on triacylglycerol transport in CaCo-2 cells. Biochim. Biophys. Acta 1045, 147-155
    • (1990) Biochim. Biophys. Acta , vol.1045 , pp. 147-155
    • Murthy, S.1    Albright, E.2    Mathur, S.N.3    Field, F.J.4
  • 39
    • 0030007427 scopus 로고    scopus 로고
    • ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
    • Kim, J. B. and Spiegelman, B. M. (1996) ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10, 1096-1107
    • (1996) Genes Dev. , vol.10 , pp. 1096-1107
    • Kim, J.B.1    Spiegelman, B.M.2
  • 40
    • 0028875426 scopus 로고
    • Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways
    • Bennett, M. K., Lopez, J. M., Sanchez, H. B. and Osborne, T. F. (1995) Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways. J Biol. Chem. 270, 25578-25583
    • (1995) J Biol. Chem. , vol.270 , pp. 25578-25583
    • Bennett, M.K.1    Lopez, J.M.2    Sanchez, H.B.3    Osborne, T.F.4
  • 41
    • 0024214567 scopus 로고
    • Regulation of triglyceride-rich lipoprotein secretion by fatty acids in CaCo-2 cells
    • Field, F. J., Albright, E. and Mathur, S. N. (1988) Regulation of triglyceride-rich lipoprotein secretion by fatty acids in CaCo-2 cells. J. Lipid Res. 29, 1427-1437
    • (1988) J. Lipid Res. , vol.29 , pp. 1427-1437
    • Field, F.J.1    Albright, E.2    Mathur, S.N.3
  • 42
    • 0026655389 scopus 로고
    • Apolipoprotein B mRNA abundance is decreased by eicosapentaenoic acid in CaCo-2 cells. Effect on the synthesis and secretion of apolipoprotein B
    • Murthy, S., Albright, E., Mathur, S. N., Davidson, N. O. and Field, F. J. (1992) Apolipoprotein B mRNA abundance is decreased by eicosapentaenoic acid in CaCo-2 cells. Effect on the synthesis and secretion of apolipoprotein B. Arterioscler. Thromb. 12, 691-700
    • (1992) Arterioscler. Thromb. , vol.12 , pp. 691-700
    • Murthy, S.1    Albright, E.2    Mathur, S.N.3    Davidson, N.O.4    Field, F.J.5
  • 43
    • 0023490564 scopus 로고
    • Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell line
    • Traber, M. G., Kayden, H. J. and Rindler, M. J. (1987) Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell line. J. Lipid Res. 28, 1350-1363
    • (1987) J. Lipid Res. , vol.28 , pp. 1350-1363
    • Traber, M.G.1    Kayden, H.J.2    Rindler, M.J.3
  • 44
    • 0025022294 scopus 로고
    • Increased production of apolipoprotein B and its lipoproteins by oleic acid in Caco-2 cells
    • Dashti, N., Smith, E. A. and Alaupovic, P. (1990) Increased production of apolipoprotein B and its lipoproteins by oleic acid in Caco-2 cells. J. Lipid Res. 31, 113-123
    • (1990) J. Lipid Res. , vol.31 , pp. 113-123
    • Dashti, N.1    Smith, E.A.2    Alaupovic, P.3
  • 45
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    • Liang, G., Yang, J., Horton, J. D., Hammer. R. E., Goldstein, J. L. and Brown, M. S. (2002) Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J. Biol. Chem. 277, 9520-9528
    • (2002) J. Biol. Chem. , vol.277 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.D.3    Hammer, R.E.4    Goldstein, J.L.5    Brown, M.S.6


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