MEK1 and MEK2 differentially control the duration and amplitude of the ERK cascade response

Physical Biology

Volumn 10, Issue 3, 2013, Pages

  Kocieniewski, Pawel ^a   Lipniacki, Tomasz ^a,b  

^a INSTITUTE OF FUNDAMENTAL TECHNOLOGICAL RESEARCH   (Poland)

^b Rice University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2;

ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; HUMAN; METABOLISM; PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ARTICLE;

ANIMALS; COMPUTER SIMULATION; HUMANS; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN INTERACTION MAPS; PROTEIN ISOFORMS;

EID: 84878883842     PISSN: 14783967     EISSN: 14783975     Source Type: Journal    
DOI: 10.1088/1478-3975/10/3/035006     Document Type: Article

References (53)

1. McKay M M and Morrison D K 2007 Integrating signals from RTKs to ERK/MAPK Oncogene 26 3113-21 (Pubitemid 46763008)
2. Roskoski R Jr 2012 MEK1/2 dual-specificity protein kinases: structure and regulation Biochem. Biophys. Res. Commun. 417 5-10
3. Roskoski R Jr 2012 ERK1/2 MAP kinases: structure, function, and regulation Pharmacol. Res. 66 105-43
4. Kim E K and Choi E J 2010 Pathological roles of MAPK signaling pathways in human diseases Biochim. Biophys. Acta 1802 396-405
5. Bentires-Alj M, Kontaridis M I and Neel B G 2006 Stops along the RAS pathway in human genetic disease Nature Med. 12 283-5 (Pubitemid 43355073)
6. Roskoski R Jr 2010 RAF protein-serine/threonine kinases: structure and regulation Biochem. Biophys. Res. Commun. 399 313-7
7. Orton R J, Sturm O E, Vyshemirsky V, Calder M, Gilbert D R and Kolch W 2005 Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway Biochem. J. 392 249-61 (Pubitemid 41796513)
8. Kholodenko B N and Birtwistle M R 2009 Four-dimensional dynamics of MAPK information processing systems Interdiscip. Rev. Syst. Biol. Med. 1 28-44
9. Huang C Y and Ferrell J E Jr 1996 Ultrasensitivity in the mitogen-activated protein kinase cascade Proc. Natl Acad. Sci. USA 93 10078-83 (Pubitemid 26314577)
10. Ferrell J E Jr and Machleder E M 1998 The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes Science 280 895-8 (Pubitemid 28215598)
11. Kholodenko B N, Demin O V, Moehren G and Hoek J B 1999 Quantification of short term signaling by the epidermal growth factor receptor J. Biol. Chem. 274 30169-81 (Pubitemid 29483404)
12. Schoeberl B, Eichler-Jonsson C, Gilles E D and Mller G 2002 Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors Nature Biotechnol. 20 370-5 (Pubitemid 34286330)
13. Chen W W, Schoeberl B, Jasper P J, Niepel M, Nielsen U B, Lauffenburger D A and Sorger P K 2009 Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data Mol. Syst. Biol. 5 239
14. Kholodenko B N 2000 Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades Eur. J. Biochem. 267 1583-8 (Pubitemid 30165509)
15. Qiao L, Nachbar R B, Kevrekidis I G and Shvartsman S Y 2007 Bistability and oscillations in the Huang-Ferrell model of MAPK signaling PLoS Comput. Biol. 3 1819-26 (Pubitemid 47502986)
16. Sasagawa S, Ozaki Y, Fujita K and Kuroda S 2005 Prediction and validation of the distinct dynamics of transient and sustained ERK activation Nature Cell Biol. 7 365-73 (Pubitemid 40533125)
17. Markevich N I, Hoek J B and Kholodenko B N 2004 Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades J. Cell Biol. 164 353-9 (Pubitemid 38174763)
18. Cirit M, Wang C C and Haugh J M 2012 Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network J. Biol. Chem. 285 36736-44
19. Sturm O E, Orton R, Grindlay J, Birtwistle M, Vyshemirsky V, Gilbert D, Calder M, Pitt A, Kholodenko B and Kolch W 2010 The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier Sci. Signal. 3 90
20. Shankaran H and Wiley H S 2009 Oscillatory dynamics of the extracellular signal-regulated kinase pathway Curr. Opin. Genet. Dev. 20 650-5
21. Harrington H A, Komorowski M, Beguerisse-Daz M, Ratto G M and Stumpf M P 2012 Mathematical modeling reveals the functional implications of the different nuclear shuttling rates of Erk1 and Erk2 Phys. Biol. 9 036001
22. Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann W D, Timmer J and Klingmüller U 2009 Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions Mol. Syst. Biol. 5 334
23. Robubi A, Mueller T, Fueller J, Hekman M, Rapp U R and Dandekar T 2005 B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade Biol. Chem. 386 1165-71 (Pubitemid 41705371)
24. Charron J, Bissonauth V and Nadeau V 2012 Implication of MEK1 and MEK2 in the establishment of the blood-placenta barrier during placentogenesis in mouse Reprod. Biomed. Online 25 58-67
25. Zhou L, Tan X, Kamohara H, Wang W, Wang B, Liu J, Egami H, Baba H and Dai X 2010 MEK1 and MEK2 isoforms regulate distinct functions in pancreatic cancer cells Oncol. Rep. 24 251-5
26. Scholl F A, Dumesic P A, Barragan D I, Harada K, Charron J and Khavari P A 2009 Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia Cancer Res. 69 3772-8
27. Voisin L et al 2008 Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors BMC Cancer 8 337
28. Skarpen E, Flinder L I, Rosseland C M, Orstavik S, Wierod L, Oksvold M P, Skalhegg B S and Huitfeldt H S 2008 MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments FASEB J 22 466-76 (Pubitemid 351225583)
29. Di Benedetto B, Hitz C, Hlter S M, Khn R, Vogt Weisenhorn D M and Wurst W 2007 Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain J. Comp. Neurol. 500 542-56
30. Ussar S and Voss T 2004 MEK1 and MEK2, different regulators of the G1/S transition J. Biol. Chem. 279 43861-9 (Pubitemid 39390693)
31. Robinson F L, Whitehurst A W, Raman M and Cobb M H 2002 Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1 J. Biol. Chem. 277 14844-52 (Pubitemid 34952557)
32. Alessandrini A, Brott B K and Erikson R L 1997 Differential expression of MEK1 and MEK2 during mouse development Cell Growth Differ. 8 505-11 (Pubitemid 27273061)
33. Brott B K, Alessandrini A, Largaespada D A, Copeland N G, Jenkins N A, Crews C M and Erikson R L 1993 MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues Cell Growth Differ. 4 921-9
34. Giroux S et al 1999 Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta Curr. Biol. 9 369-72 (Pubitemid 29194878)
35. Blanger L F, Roy S, Tremblay M, Brott B, Steff A M, Mourad W, Hugo P, Erikson R and Charron J 2003 Mek2 is dispensable for mouse growth and development Mol. Cell. Biol. 23 4778-87 (Pubitemid 36793325)
36. Zheng C F and Guan K L 1993 Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2 J. Biol. Chem. 268 11435-9
37. Park E R, Eblen S T and Catling A D 2007 MEK1 activation by PAK: a novel mechanism Cell. Signal. 19 1488-96 (Pubitemid 46818914)
38. Catalanotti F, Reyes G, Jesenberger V, Galabova-Kovacs G, de Matos Simoes R, Carugo O and Baccarini M 2009 A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal Nature Struct. Mol. Biol. 16 294-303
39. Faeder J R, Blinov M L and Hlavacek W S 2009 Rule-based modeling of biochemical systems with BioNetGen Methods Mol. Biol. 500 113-67
40. Kamioka Y, Yasuda S, Fujita Y, Aoki K and Matsuda M 2010 Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK J. Biol. Chem. 285 33540-8
41. Endres N F, Engel K, Das R, Kovacs E and Kuriyan J 2011 Regulation of the catalytic activity of the EGF receptor Curr. Opin. Struct. Biol. 6 777-84
42. Hubbard S R, Mohammadi M and Schlessinger J 1998 Autoregulatory mechanisms in protein-tyrosine kinases J. Biol. Chem. 273 11987-90 (Pubitemid 28240552)
43. Egan S E, Giddings B W, Brooks M W, Buday L, Sizeland A M and Weinberg R A 1993 Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation Nature 363 45-51 (Pubitemid 23144959)
44. Burke P, Schooler K and Wiley H S 2001 Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking Mol. Biol. Cell 6 1897-910 (Pubitemid 33049739)
45. Alessi D R, Saito Y, Campbell D G, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall C J and Cowley S 1994 Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1 EMBO J 13 1610-9
46. Zheng C F and Guan K L 1995 Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues EMBO J 5 1123-31
47. Ohren J F et al 2004 Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition Nature Struct. Mol. Biol. 11 1192-7
48. Burack W R and Sturgill T W 1997 The activating dual phosphorylation of MAPK by MEK is nonprocessive Biochemistry 36 5929-33 (Pubitemid 27257857)
49. Buday L, Warne P H and Downward J 1995 Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos Oncogene 11 1327-31
50. Zmajkovicova K, Jesenberger V, Catalanotti F, Baumgartner C, Reyes G and Baccarini M 2013 MEK1 is required for PTEN membrane recruitment, AKT regulation and the maintenance of peripheral tolerance Mol. Cell 50 43-55
51. Marais R, Light Y, Paterson H F, Mason C S and Marshall C J 1997 Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases J. Biol. Chem. 272 4378-83 (Pubitemid 27078513)
52. Ritt D A, Monson D M, Specht S I and Morrison D K 2010 Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling Mol. Cell. Biol. 30 806-19
53. Hatakeyama M et al 2003 A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling Biochem. J. 373 451-63 (Pubitemid 36897847)