Drug delivery characteristics of the progenitor bronchial epithelial cell line VA10

Pharmaceutical Research

Volumn 30, Issue 3, 2013, Pages 781-791

  Benediktsdóttir, Berglind Eva ^a   Arason, Ari Jón ^a,b   Halldórsson, Skarphédinn ^a   Gudjónsson, Thórarinn ^a,b   Másson, Már ^a   Baldursson, Ólafur ^b  

^a UNIVERSITY OF ICELAND   (Iceland)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

air liquid interface culture; airway permeability; differentiation; drug delivery; human bronchial epithelial cells

Indexed keywords

DEXTRAN; FLUORESCEIN SODIUM; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123;

AIR LIQUID INTERFACE CULTURE; ARTICLE; BRONCHUS MUCOSA; CELL DIFFERENTIATION; CELL GROWTH; CELL IMMORTALIZATION; CELL MEMBRANE PERMEABILITY; CELL SIZE; CELL STRUCTURE; CELL TRANSPORT; CELLULAR PARAMETERS; CULTURE MEDIUM; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; ELECTRON MICROSCOPY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; LIQUID COVERED CULTURE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSEPITHELIAL ELECTRICAL RESISTANCE;

ALCOHOLS; BRONCHI; CELL LINE; DEXTRANS; EPITHELIAL CELLS; HUMANS; P-GLYCOPROTEIN; PERMEABILITY; STEM CELLS;

EID: 84878870686     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0919-x     Document Type: Article

References (52)

1. Sakagami M. In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Adv Drug Delivery Rev. 2006;58(9-10):1030-60.
2. Guidance for industry: Waiver of in vivo bioavailability and bioequivalence studies for immediate-release solid oral dosage forms based on a biopharmaceutics classification system. August 2000, CDER/FDA.
3. Note for guidance on the investigation of bioavailability and bioequivalence. December 2000, EMEA.
4. Forbes B, Ehrhardt C. Human respiratory epithelial cell culture for drug delivery applications. Eur J Pharm Biopharm. 2005;60(2):193-205.
5. Sporty JL, Horalkova L, Ehrhardt C. In vitro cell culture models for the assessment of pulmonary drug disposition. Expert Opin Drug Metab Toxicol. 2008;4(4):333-45.
6. Shen BQ, Finkbeiner WE, Wine JJ, Mrsny RJ, Widdicombe JH. Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion. Am J Physiol Lung Cell Mol Physiol. 1994;266(5):L493-501.
7. Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, Eng K, et al. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol. 1994;10(1):38-47.
8. Wan H, Winton H, Soeller C, Stewart G, Thompson P, Gruenert D, et al. Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o. Eur Respir J. 2000;15(6):1058-68.
9. Manford F, Tronde A, Jeppsson A-B, Patel N, Johansson F, Forbes B. Drug permeability in 16HBE14o- airway cell layers correlates with absorption from the isolated perfused rat lung. Eur J Pharm Sci. 2005;26(5):414-20.
10. Mathias NR, Timoszyk J, Stetsko PI, Megill JR, Smith RL, Wall DA. Permeability characteristics of Calu-3 human bronchial epithelial cells: In vitro-in vivo correlation to predict lung absorption in rats. J Drug Target. 2002;10(1):31-40.
11. Fogh J, Fogh JM, Orfeo T. 127 Cultured human tumor-cell lines producing tumors in nude mice. J Natl Cancer Inst. 1977;59(1):221-6.
12. Florea BI, Cassara ML, Junginger HE, Borchard G. Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3. J Control Release. 2003;87(1-3):131-8.
13. Fiegel J, Ehrhardt C, Schaefer UF, Lehr C-M, Hanes J. Large porous particle impingement on lung epithelial cell monolayers - Toward improved particle characterization in the lung. Pharm Res. 2003;20(5):788-96.
14. Stentebjerg-Andersen A, Notlevsen IV, Brodin B, Nielsen CU. Calu-3 cells grown under AIC and LCC conditions: Implications for dipeptide uptake and transepithelial transport of substances. Eur J Pharm Biopharm. 2011;78(1):19-26.
15. Grainger C, Greenwell L, Lockley D, Martin G, Forbes B. Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier. Pharm Res. 2006;23(7):1482-90.
16. Haghi M, Young PM, Traini D, Jaiswal R, Gong J, Bebawy M. Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model. Drug Dev Ind Pharm. 2010;36(10):1207-14.
17. Finkbeiner WE, Carrier SD, Teresi CE. Reverse transcription-polymerase chain reaction (RT-PCR) phenotypic analysis of cell cultures of human tracheal epithelium, tracheobronchial glands, and lung carcinomas. Am J Respir Cell Mol Biol. 1993;9(5):547-56.
18. Ehrhardt C, Forbes B, Kim K-J. In vitro models of the tracheo-bronchial epithelium. In: Ehrhardt C, Kim K-J, editors. Drug absorption studies: in situ, in vitro and in silico models. New York: Springer US; 2008. p. 235-57.
19. Ehrhardt C, Kneuer C, Fiegel J, Hanes J, Schaefer U, Kim K-J, et al. Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o- implications for the use of this cell line as an in vitro model for bronchial drug absorption studies. Cell Tissue Res. 2002;308(3):391-400.
20. Pohl C, Hermanns MI, Uboldi C, Bock M, Fuchs S, Dei-Anang J, et al. Barrier functions and paracellular integrity in human cell culture models of the proximal respiratory unit. Eur J Pharm Biopharm. 2009;72(2):339-49.
21. Halldorsson S, Asgrimsson V, Axelsson I, Gudmundsson GH, Steinarsdottir M, Baldursson O, et al. Differentiation potential of a basal epithelial cell line established from human bronchial explant. In Vitro Cell Dev Biol Anim. 2007;43(8-9):283-9.
22. Franzdottir S, Axelsson I, Arason A, Baldursson O, Gudjonsson T, Magnusson M. Airway branching morphogenesis in three dimensional culture. Respir Res. 2010;11(1):162.
23. Gudjonsson T, Villadsen R, Nielsen HL, Rønnov-Jessen L, Bissell MJ, Petersen OW. Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev. 2002;16(6):693-706.
24. Gudjonsson T, Villadsen R, Rønnov-Jessen L, Petersen OW. Immortalization protocols used in cell culture models of human breast morphogenesis. Cell Mol Life Sci. 2004;61(19):2523-34.
25. Zabner J, Karp P, Seiler M, Phillips SL, Mitchell CJ, Saavedra M, et al. Development of cystic fibrosis and noncystic fibrosis airway cell lines. Am J Physiol Lung Cell Mol Physiol. 2003;284(5):L844-54.
26. Forbes B, Shah A, Martin GP, Lansley AB. The human bronchial epithelial cell line 16HBE14o-as a model system of the airways for studying drug transport. Int J Pharm. 2003;257(1-2):161-7.
27. Dorscheid D, Conforti A, Hamann K, Rabe K, White S. Characterization of cell surface lectin-binding patterns of human airway epithelium. Histochem J. 1999;31(3):145-51.
28. Rojas A, Gonzalez I, Figueroa H. Cell line cross-contamination in biomedical research: a call to prevent unawareness. Acta Pharmacol Sin. 2008;29(7):877-80.
29. Nardone R. Eradication of cross-contaminated cell lines: a call for action. Cell Biol Toxicol. 2007;23(6):367-72.
30. Otton A. Cell culture forensics of Calu-3: a human lung epithelial cell line. Ethn Dis. 2009;19(2):S78-9.
31. Boers JE, Ambergen AW, Thunnissen FBJM. Number and proliferation of basal and parabasal cells in normal human airway epithelium. Am J Respir Crit Care Med. 1998;157(6):2000-6.
32. Rock JR, Onaitis MW, Rawlins EL, Lu Y, Clark CP, Xue Y, et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci. 2009;106(31):12771-5.
33. Dvorak A, Tilley AE, Shaykhiev R, Wang R, Crystal RG. Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol. 2011;44(4):465-73.
34. Halldorsson S, Gudjonsson T, Gottfredsson M, Singh PK, Gudmundsson GH, Baldursson O. Azithromycin maintains airway epithelial integrity during pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol. 2010;42(1):62-8.
35. Mathias NR, Kim K-J, Robison TW, Lee VHL. Development and characterization of rabbit tracheal epithelial cell monolayer models for drug transport studies. Pharm Res. 1995;12(10):1499-505.
36. Yamaya M, Finkbeiner WE, Chun SY, Widdicombe JH. Differentiated structure and function of cultures from human tracheal epithelium. Am J Physiol Lung Cell Mol Physiol. 1992;262(6):L713-24.
37. Clary-Meinesz C, Mouroux J, Huitorel P, Cosson J, Schoevaert D, Blaive B. Ciliary beat frequency in human bronchi and bronchioles. CHEST J. 1997;111(3):692-7.
38. Clary-Meinesz C, Mouroux J, Cosson J, Huitorel P, Blaive B. Influence of external pH on ciliary beat frequency in human bronchi and bronchioles. Eur Respir J. 1998;11(2):330-3.
39. Rutland J, Griffin WM, Cole PJ. Human ciliary beat frequency in epithelium from intrathoracic and extrathoracic airways. Am Rev Respir Dis. 1982;125(1):100-5.
40. Asgrimsson V, Gudjonsson T, Gudmundsson GH, Baldursson O. Novel effects of azithromycin on tight junction proteins in human airway epithelia. Antimicrob Agents Chemother. 2006;50(5):1805-12.
41. Kim K-J. Bioelectrical characterization of cultured epithelial cell (mono)layers and excised tissues. In: Lehr CM, editor. Cell culture models of biological barriers. CRC Press; 2002. p. 41-51.
42. Ehrhardt C, Fiegel J, Fuchs S, Abu-Dahab R, Schaefer UF, Hanes J, et al. Drug absorption by the respiratory mucosa: cell culture models and particulate drug carriers. J Aerosol Med. 2002;15(2):131-9.
43. Lin H, Li H, Cho H-J, Bian S, Roh H-J, Lee M-K, et al. Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies. J Pharm Sci. 2007;96(2):341-50.
44. Foster KA, Avery ML, Yazdanian M, Audus KL. Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery. Int J Pharm. 2000;208(1-2):1-11.
45. Tronde A, Norden B, Jeppsson AB, Brunmark P, Nilsson E, Lennernas H, et al. Drug absorption from the isolated perfused rat lung-correlations with drug physicochemical properties and epithelial permeability. J Drug Target. 2003;11(1):61-74.
46. Conradi RA, Burton PS, Borchardt RT. Physico-chemical and biological factors that influence a drug's cellular permeability by passive diffusion. In: Pliška V, Testa B, van de Waterbeemd H, editors. Lipophilicity in drug action and toxicology. Weinheim: Wiley-VCH Verlag GmbH; 2008. p. 233-52.
47. Clark DE. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption. J Pharm Sci. 1999;88(8):807-14.
48. Balimane PV, Han YH, Chong SH. Current industrial practices of assessing permeability and P-glycoprotein interaction. AAPS J. 2006;8(1):E1-E13.
49. Hamilton KO, Topp E, Makagiansar I, Siahaan T, Yazdanian M, Audus KL. Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001;298(3):1199-205.
50. Ehrhardt C, Kneuer C, Laue M, Schaefer UF, Kim K-J, Lehr C-M. 16HBE14o-human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1. Pharm Res. 2003;20(4):545-51.
51. Lechapt-Zalcman E, Hurbain I, Lacave R, Commo F, Urban T, Antoine M, et al. MDR1-Pgp 170 expression in human bronchus. Eur Respir J. 1997;10(8):1837-43.
52. Madlova M, Bosquillon C, Asker D, Dolezal P, Forbes B. In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity. J Pharm Pharmacol. 2009;61(3):293-301.