CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats

Xenobiotica

Volumn 43, Issue 7, 2013, Pages 571-578

  Reisman, Scott A ^a   Ward, Keith W ^a   Klaassen, Curtis D ^b   Meyer, Colin J ^a  

^a Reata Pharmaceuticals Inc   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Glutathione; Liver; Nrf2; Synthetic triterpenoid

Indexed keywords

AMIDE; BILE ACID; CDDO 9; CHOLESTEROL; EPOXIDE HYDROLASE; GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; HEME OXYGENASE 1; MESSENGER RNA; PHOSPHOLIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THIOREDOXIN REDUCTASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE DUCT; BILE FLOW; BILIARY EXCRETION; CATALYSIS; CELL PROTECTION; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; HISTOLOGY; LIVER; LIVER CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SUBUNIT; RAT; TREATMENT DURATION;

ANIMALS; BILE; CYTOPROTECTION; GLUTATHIONE; HEME OXYGENASE-1; LIVER; MALE; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OLEANOLIC ACID; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; THIOREDOXIN-DISULFIDE REDUCTASE;

RATTUS;

EID: 84878834284     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.750022     Document Type: Article

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