N-acetylcysteine protects from glutathione depletion in rats exposed to hyperoxia

Journal of Parenteral and Enteral Nutrition

Volumn 22, Issue 4, 1998, Pages 228-233

  Shattuck, Karen E ^a   Rassin, David K ^a   Grinnell, Chali D ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; CYSTEINE; GLUTATHIONE;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; GLUTATHIONE METABOLISM; HYPEROXIA; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER PERFUSION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0031780624     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607198022004228     Document Type: Article

References (34)

1. Meister A, Anderson ME, Hwang O: Intracellular cysteine and glutathione delivery systems. J Am Coll Nutr 5:137-141, 1986
2. Kaplowitz N, Aw TY, Ookhtens H: The regulation of hepatic glutathione. Annu Rev Pharmacol Toxicol 25:715-744, 1985
3. Meister A: Glutathione deficiency produced by inhibition of its synthesis, and its reversal: Applications in research and therapy. Pharmacol Ther 51:155-194, 1991
4. Webster NR, Toothill C, Cowen PN: Tissue responses to hyperoxia: Biochemistry and pathology. Br J Anaesth 59:760-771, 1987
5. Husain K, Sugendran K, Pant SC, et al: Biochemical and pathological changes in response to hyperoxia and protection by antioxidants in rats. Indian J Physiol Pharmacol 36:97-100, 1992
6. 2-induced changes in lung and storage pool thiols in mice: Effect of superoxide dismutase. J Appl Physiol 74:989-997, 1991
7. Weber CA, Duncan CA, Lyons MJ, et al: Depletion of tissue glutathione with diethyl maleate enhances hyperbaric oxygen toxicity. Am J Physiol 258:L308-312, 1990
8. Droge W, Eck HP, Gmünder H, et al: Modulation role of lymphocyte functions and immune responses by cysteine and cysteine derivates. Am J Med 91:1405-1435, 1991
9. Langley SC, Kelly FJ: N-acetylcysteine ameliorates hyperoxic lung injury in the preterm guinea pig. Biochem Pharmacol 45:841-846, 1993
10. Lyon L, Studdiford JS, Sommaripa AM: Treatment of acetaminophen overdosage with N-acetylcysteine. N Engl J Med 296:174-175, 1977
11. Shattuck KE, Grinnell CD, Keeney SE, et al: Hyperoxia and glutathione in the isolated rat liver. J Invest Med 45: 576-583, 1997
12. Keeney SE, Brown SE, Cress SE, et al: The effect of hyperoxic exposure on antioxidant enzyme activities of alveolar type II cells in neonatal and adult rats. Pediatr Res 31:441-444, 1992
13. Keeney SE, Mathews MJ, Rassin DK: Antioxidant enzyme responses of preterm and term rats after prenatal dexamethasone administration. Pediatr Res 33:177-180, 1993
14. Keeney SE, Mathews MJ, Schmalstieg FC: Pulmonary inflammatory response of the neonatal rat to hyperoxic exposure (Abstr). Pediatr Res 33:331A, 1993
15. Shattuck KE, Grinnell CD, Rassin DK: Amino acid infusions induce reversible, dose-related decreases in bile flow in the isolated rat liver. JPEN 17:171-176, 1993
16. Shattuck KE, Grinnell CD, Rassin DK: Biliary amino acid secretion in response to amino acid infusion in the isolated rat liver. JPEN 18:119-127, 1993
17. Bergmeyer HV: Methoden der Enzymatischen Analyse, Verlag Chemie, Weinhein, 1970
18. Griffith OW: Determination of glutathione and glutathione disulfide using glutathione reductase acid 2-vinylpyridine. Anal Biochem 106:207-222, 1980
19. Tietze F: Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem 27:502-522, 1969
20. Smith PK, Krohn RI, Hermansen GT, et al: Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85, 1985
21. Buege JA, Aust SD: Microsomal lipid peroxidation. IN Methods in Enzymology, Fleischer S, Packer L (eds). Academic Press, New York, 1978, pp 302-310
22. DeLeve LD, Kaplowitz N: Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 52:287-305, 1991
23. Richman PG, Meister A: Regulation of γg-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. J Biol Chem 250:1422-1426, 1975
24. Thor H, Moldeús P, Orrenius S: Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes. Arch Biochem Biophys 192:405-413, 1979
25. Reed DJ, Orrenius S: The role of methionine in glutathione biosynthesis by isolated hepatocytes. Biochem Biophys Res Commun 77:1257-1264, 1977
26. Cotgreave I, Moldeus P, Schuppe I: The metabolism of N-acetylcysteine by human endothelial cells. Biochem Pharmacol 42:13-16, 1991
27. Critchley JAJH, Beeley JM, Clark RJ, et al: Evaluation of N-acetylcysteine and methylprednisolone as therapies for oxygen and acrolein-induced lung damage. Environ Health Perspect 85:89-94, 1990
28. Christman BW, Bernard GR: Antilipid mediator and antioxidant therapy in adult respiratory distress syndrome. New Horizons 1:623-630, 1993
29. Bernard GR: N-acetylcysteine in experimental and clinical acute lung injury. Am J Med 91 (Suppl 3C):54-59, 1991
30. Ballatori N, Truong AT, Ma AK, et al: Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver. Am J Physiol 256:G483-490, 1989
31. Lash LH, Hagen TM, Jones DP: Exogenous glutathione protects intestinal epithelial cells from oxidative injury. Proc Natl Acad Sci USA 983:4641-4645, 1986
32. Ma tensson J, Jain A, Meister A: Glutathione is required for intestinal function. Proc Natl Acad Sci USA 87:1715-1719, 1990
33. Graf J: Canalicular bile salt-independent bile formation: Concepts and clues from electrolyte transport in rat liver. Am J Physiol 244:G233-246, 1983
34. Frankel WL, Zhang W, Afonso J, et al: Glutamine enhancement of structure and function in transplanted small intestine in the rat. JPEN 17:47-55, 1993