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Volumn 54, Issue 1, 2011, Pages 168-179

Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse

Author keywords

Extracellular signal regulated kinase; Inflammation; Insulin resistance; Toll like receptor 2

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 79953653547     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1931-5     Document Type: Article
Times cited : (66)

References (43)
  • 4
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • DOI 10.1038/nm1166
    • Cai D, Yuan M, Frantz DF et al (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NFkappaB. Nat Med 11:183-190 (Pubitemid 40321354) (Pubitemid 40321354)
    • (2005) Nature Medicine , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 5
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKKbeta/IkappaB/NF-kappaB axis in obesity- And diet-induced insulin resistance
    • DOI 10.1038/sj.ijo.0802501
    • Shoelson SE, Lee J, Yuan M (2003) Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 27(Suppl 3): S49-S52 (Pubitemid 38019189) (Pubitemid 38019189)
    • (2003) International Journal of Obesity , vol.27 , Issue.SUPPL. 3
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 6
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- And diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
    • DOI 10.1126/science.1061620
    • Yuan M, Konstantopoulos N, Lee J et al (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 293:1673-1677 (Pubitemid 32807849) (Pubitemid 32807849)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.-W.5    Karin, M.6    Shoelson, S.E.7
  • 7
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappaB kinase complex
    • DOI 10.1074/jbc.M209459200
    • Gao Z, Hwang D, Bataille F et al (2002) Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 277:48115-48121 (Pubitemid 35470759) (Pubitemid 35470759)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.50 , pp. 48115-48121
    • Gao, Z.1    Hwang, D.2    Bataille, F.3    Lefevre, M.4    York, D.5    Quon, M.J.6    Ye, J.7
  • 8
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • Aguirre V, Uchida T, Yenush L, Davis R, White MF (2000) The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-9054
    • (2000) J Biol Chem , vol.275 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 9
    • 0031465447 scopus 로고    scopus 로고
    • Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase
    • DOI 10.1074/jbc.272.50.31400
    • De Fea K, Roth RA (1997) Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase. J Biol Chem 272:31400-31406 (Pubitemid 28013276) (Pubitemid 28013276)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.50 , pp. 31400-31406
    • De Fea, K.1    Roth, R.A.2
  • 10
    • 84944284695 scopus 로고
    • Weight and blood pressure. Findings in hypertension screening of 1 million Americans
    • Stamler R, Stamler J, Riedlinger WF, Algera G, Roberts RH (1978) Weight and blood pressure. Findings in hypertension screening of 1 million Americans. JAMA 240:1607-1610
    • (1978) JAMA , vol.240 , pp. 1607-1610
    • Stamler, R.1    Stamler, J.2    Riedlinger, W.F.3    Algera, G.4    Roberts, R.H.5
  • 13
    • 4644338458 scopus 로고    scopus 로고
    • Circulating mononuclear cells in the obese are in a proinflammatory state
    • DOI 10.1161/01.CIR.0000142055.53122.FA
    • Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P (2004) Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 110:1564-1571 (Pubitemid 39297977) (Pubitemid 39297977)
    • (2004) Circulation , vol.110 , Issue.12 , pp. 1564-1571
    • Ghanim, H.1    Aljada, A.2    Hofmeyer, D.3    Syed, T.4    Mohanty, P.5    Dandona, P.6
  • 14
    • 22144498471 scopus 로고    scopus 로고
    • Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor B activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells
    • DOI 10.1210/en.2004-1560
    • Jove M, Planavila A, Laguna JC, Vazquez-Carrera M (2005) Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells. Endocrinology 146:3087-3095 (Pubitemid 41002818) (Pubitemid 41002818)
    • (2005) Endocrinology , vol.146 , Issue.7 , pp. 3087-3095
    • Jove, M.1    Planavila, A.2    Laguna, J.C.3    Vazquez-Carrera, M.4
  • 15
    • 33845533359 scopus 로고    scopus 로고
    • Fat fuels insulin resistance through Toll-like receptors
    • DOI 10.1038/nm1206-1359, PII NM12061359
    • Tschop M, Thomas G (2006) Fat fuels insulin resistance through Toll-like receptors. Nat Med 12:1359-1361 (Pubitemid 44924493) (Pubitemid 44924493)
    • (2006) Nature Medicine , vol.12 , Issue.12 , pp. 1359-1361
    • Tschop, M.1    Thomas, G.2
  • 16
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • DOI 10.1038/90609
    • Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2:675-680 (Pubitemid 32747155) (Pubitemid 32747155)
    • (2001) Nature Immunology , vol.2 , Issue.8 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 17
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R (2001) Toll-like receptors and innate immunity. Nat Rev Immunol 1:135-145
    • (2001) Nat Rev Immunol , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 18
    • 0037290876 scopus 로고    scopus 로고
    • Mammalian toll-like receptors
    • Akira S (2003) Mammalian toll-like receptors. Curr Opin Immunol 15:5-11
    • (2003) Curr Opin Immunol , vol.15 , pp. 5-11
    • Akira, S.1
  • 19
    • 29144490013 scopus 로고    scopus 로고
    • Lipopeptide structure determines TLR2 dependent cell activation level
    • DOI 10.1111/j.1742-4658.2005.05029.x
    • Buwitt-Beckmann U, Heine H, Wiesmuller KH, Jung G, Brock R, Ulmer AJ (2005) Lipopeptide structure determines TLR2 dependent cell activation level. FEBS J 272:6354-6364 (Pubitemid 41815623) (Pubitemid 41815623)
    • (2005) FEBS Journal , vol.272 , Issue.24 , pp. 6354-6364
    • Buwitt-Beckmann, U.1    Heine, H.2    Wiesmuller, K.-H.3    Jung, G.4    Brock, R.5    Ulmer, A.J.6
  • 21
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    • Senn JJ (2006) Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J Biol Chem 281:26865-26875
    • (2006) J Biol Chem , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 22
    • 33846610092 scopus 로고    scopus 로고
    • High fat intake induces a population of adipocytes to co-express TLR2 and TNFalpha in mice with insulin resistance
    • DOI 10.1016/j.bbrc.2007.01.039, PII S0006291X07000769
    • Murakami K, Bujo H, Unoki H, Saito Y (2007) High fat intake induces a population of adipocytes to co-express TLR2 and TNFalpha in mice with insulin resistance. Biochem Biophys Res Commun 354:727-734 (Pubitemid 46186245)
    • (2007) Biochemical and Biophysical Research Communications , vol.354 , Issue.3 , pp. 727-734
    • Murakami, K.1    Bujo, H.2    Unoki, H.3    Saito, Y.4
  • 24
    • 0034637439 scopus 로고    scopus 로고
    • The lipopolysaccharide-activated Toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
    • DOI 10.1074/jbc.M002137200
    • Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, Scherer PE (2000) The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem 275:24255-24263 (Pubitemid 30626513)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.32 , pp. 24255-24263
    • Lin, Y.1    Lee, H.2    Berg, A.H.3    Lisanti, M.P.4    Shapiro, L.5    Scherer, P.E.6
  • 25
    • 0142064412 scopus 로고    scopus 로고
    • Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle
    • Lang CH, Silvis C, Deshpande N, Nystrom G, Frost RA (2003) Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle. Shock 19:538-546
    • (2003) Shock , vol.19 , pp. 538-546
    • Lang, C.H.1    Silvis, C.2    Deshpande, N.3    Nystrom, G.4    Frost, R.A.5
  • 26
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • DOI 10.1016/S1074-7613(00)80119-3
    • Takeuchi O, Hoshino K, Kawai T et al (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443-451 (Pubitemid 29504199) (Pubitemid 29504199)
    • (1999) Immunity , vol.11 , Issue.4 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 28
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • DOI 10.1038/nature05483, PII NATURE05483
    • Rosen ED, Spiegelman BM (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444:847-853 (Pubitemid 46024991)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 29
    • 34548857335 scopus 로고    scopus 로고
    • Inside, outside, upside down: Damage-associated molecular-pattern molecules (DAMPs) and redox
    • DOI 10.1016/j.it.2007.08.004, PII S1471490607002074
    • Rubartelli A, Lotze MT (2007) Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol 28:429-436 (Pubitemid 47444554)
    • (2007) Trends in Immunology , vol.28 , Issue.10 , pp. 429-436
    • Rubartelli, A.1    Lotze, M.T.2
  • 30
    • 0033618562 scopus 로고    scopus 로고
    • Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
    • Brightbill HD, Libraty DH, Krutzik SR et al (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285:732-736
    • (1999) Science , vol.285 , pp. 732-736
    • Brightbill, H.D.1    Libraty, D.H.2    Krutzik, S.R.3
  • 31
    • 0141886177 scopus 로고    scopus 로고
    • Involvement of leucine residues at positions 107, 112, and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and lipopeptides and Staphylococcus aureus peptidoglycans
    • Fujita M, Into T, Yasuda M et al (2003) Involvement of leucine residues at positions 107, 112, and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and lipopeptides and Staphylococcus aureus peptidoglycans. J Immunol 171:3675-3683 (Pubitemid 37254571) (Pubitemid 37254571)
    • (2003) Journal of Immunology , vol.171 , Issue.7 , pp. 3675-3683
    • Fujita, M.1    Into, T.2    Yasuda, M.3    Okusawa, T.4    Hamahira, S.5    Kuroki, Y.6    Eto, A.7    Nisizawa, T.8    Morita, M.9    Shibata, K.-I.10
  • 32
    • 0345671672 scopus 로고    scopus 로고
    • Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration
    • DOI 10.1084/jem.185.11.1951
    • Muhlradt PF, Kiess M, Meyer H, Sussmuth R, Jung G (1997) Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J Exp Med 185:1951-1958 (Pubitemid 27247081) (Pubitemid 27247081)
    • (1997) Journal of Experimental Medicine , vol.185 , Issue.11 , pp. 1951-1958
    • Muhlradt, P.F.1    Kiess, M.2    Meyer, H.3    Sussmuth, R.4    Jung, G.5
  • 34
    • 14544271905 scopus 로고    scopus 로고
    • Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    • DOI 10.1016/j.biochi.2004.10.019
    • Gual P, Le Marchand-Brustel Y, Tanti JF (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87:99-109 (Pubitemid 40298772) (Pubitemid 40298772)
    • (2005) Biochimie , vol.87 , Issue.1 SPEC. ISS , pp. 99-109
    • Gual, P.1    Le, M.-B.Y.2    Tanti, J.-F.3
  • 35
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • DOI 10.1038/nrm1837, PII NRM1837
    • Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96 (Pubitemid 43278292) (Pubitemid 43278292)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 36
    • 0037424466 scopus 로고    scopus 로고
    • Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation
    • DOI 10.1074/jbc.M209153200
    • Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA (2003) Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. J Biol Chem 278:8199-8211 (Pubitemid 36800563) (Pubitemid 36800563)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8199-8211
    • Greene, M.W.1    Sakaue, H.2    Wang, L.3    Alessi, D.R.4    Roth, R.A.5
  • 37
    • 15844389443 scopus 로고    scopus 로고
    • Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action
    • Mothe I, Van Obberghen E (1996) Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem 271:11222-11227
    • (1996) J Biol Chem , vol.271 , pp. 11222-11227
    • Mothe, I.1    Van Obberghen, E.2
  • 38
    • 57449083385 scopus 로고    scopus 로고
    • Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet
    • Caricilli AM, Nascimento PH, Pauli JR et al (2008) Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. J Endocrinol 199:399-406
    • (2008) J Endocrinol , vol.199 , pp. 399-406
    • Caricilli, A.M.1    Nascimento, P.H.2    Pauli, J.R.3
  • 39
    • 77952315676 scopus 로고    scopus 로고
    • Tlr2 is critical for diet-induced metabolic syndrome in a murine model
    • Himes RW, Smith CW (2010) Tlr2 is critical for diet-induced metabolic syndrome in a murine model. FASEB J 24:731-739
    • (2010) FASEB J , vol.24 , pp. 731-739
    • Himes, R.W.1    Smith, C.W.2


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