메뉴 건너뛰기




Volumn 9, Issue 5, 2013, Pages

CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE DERIVATIVE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE 7; PROTEIN P21;

EID: 84878506959     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003546     Document Type: Article
Times cited : (57)

References (94)
  • 1
  • 2
    • 0030561571 scopus 로고    scopus 로고
    • The retinoblastoma protein pathway and the restriction point
    • Bartek J, Bartkova J, Lukas J, (1996) The retinoblastoma protein pathway and the restriction point. Curr Opin Cell Biol 8: 805-814.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 805-814
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 4
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg AS, Weinberg RA, (1998) Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 18: 753-761.
    • (1998) Mol Cell Biol , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 5
    • 43149108161 scopus 로고    scopus 로고
    • A bistable Rb-E2F switch underlies the restriction point
    • Yao G, Lee TJ, Mori S, Nevins JR, You L, (2008) A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol 10: 476-482.
    • (2008) Nat Cell Biol , vol.10 , pp. 476-482
    • Yao, G.1    Lee, T.J.2    Mori, S.3    Nevins, J.R.4    You, L.5
  • 6
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM, (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 7
    • 18344369616 scopus 로고    scopus 로고
    • Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues
    • Pei XH, Xiong Y, (2005) Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues. Oncogene 24: 2787-2795.
    • (2005) Oncogene , vol.24 , pp. 2787-2795
    • Pei, X.H.1    Xiong, Y.2
  • 8
    • 67649424560 scopus 로고    scopus 로고
    • p21 in cancer: intricate networks and multiple activities
    • Abbas T, Dutta A, (2009) p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 9: 400-414.
    • (2009) Nat Rev Cancer , vol.9 , pp. 400-414
    • Abbas, T.1    Dutta, A.2
  • 9
    • 0032535375 scopus 로고    scopus 로고
    • Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1)
    • Hengst L, Gopfert U, Lashuel HA, Reed SI, (1998) Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1). Genes Dev 12: 3882-3888.
    • (1998) Genes Dev , vol.12 , pp. 3882-3888
    • Hengst, L.1    Gopfert, U.2    Lashuel, H.A.3    Reed, S.I.4
  • 11
    • 0030845187 scopus 로고    scopus 로고
    • Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4
    • Blain SW, Montalvo E, Massague J, (1997) Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J Biol Chem 272: 25863-25872.
    • (1997) J Biol Chem , vol.272 , pp. 25863-25872
    • Blain, S.W.1    Montalvo, E.2    Massague, J.3
  • 13
    • 33846321913 scopus 로고    scopus 로고
    • Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
    • Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, et al. (2007) Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell 128: 269-280.
    • (2007) Cell , vol.128 , pp. 269-280
    • Grimmler, M.1    Wang, Y.2    Mund, T.3    Cilensek, Z.4    Keidel, E.M.5
  • 14
    • 33846268807 scopus 로고    scopus 로고
    • p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    • Chu I, Sun J, Arnaout A, Kahn H, Hanna W, et al. (2007) p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 128: 281-294.
    • (2007) Cell , vol.128 , pp. 281-294
    • Chu, I.1    Sun, J.2    Arnaout, A.3    Kahn, H.4    Hanna, W.5
  • 15
    • 59449106702 scopus 로고    scopus 로고
    • p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes
    • Ray A, James MK, Larochelle S, Fisher RP, Blain SW, (2009) p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. Mol Cell Biol 29: 986-999.
    • (2009) Mol Cell Biol , vol.29 , pp. 986-999
    • Ray, A.1    James, M.K.2    Larochelle, S.3    Fisher, R.P.4    Blain, S.W.5
  • 16
    • 84860168892 scopus 로고    scopus 로고
    • Mechanism of cell cycle entry mediated by the intrinsically disordered protein p27(Kip1)
    • Ou L, Waddell MB, Kriwacki RW, (2012) Mechanism of cell cycle entry mediated by the intrinsically disordered protein p27(Kip1). ACS Chem Biol 7: 678-682.
    • (2012) ACS Chem Biol , vol.7 , pp. 678-682
    • Ou, L.1    Waddell, M.B.2    Kriwacki, R.W.3
  • 17
    • 84861371005 scopus 로고    scopus 로고
    • Regulation of p27 (Kip1) by mitogen-induced tyrosine phosphorylation
    • Jakel H, Peschel I, Kunze C, Weinl C, Hengst L, (2012) Regulation of p27 (Kip1) by mitogen-induced tyrosine phosphorylation. Cell Cycle 11: 1910-1917.
    • (2012) Cell Cycle , vol.11 , pp. 1910-1917
    • Jakel, H.1    Peschel, I.2    Kunze, C.3    Weinl, C.4    Hengst, L.5
  • 18
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr CJ, McCormick F, (2002) The RB and p53 pathways in cancer. Cancer Cell 2: 103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 20
    • 4444307411 scopus 로고    scopus 로고
    • Mouse development and cell proliferation in the absence of D-cyclins
    • Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, et al. (2004) Mouse development and cell proliferation in the absence of D-cyclins. Cell 118: 477-491.
    • (2004) Cell , vol.118 , pp. 477-491
    • Kozar, K.1    Ciemerych, M.A.2    Rebel, V.I.3    Shigematsu, H.4    Zagozdzon, A.5
  • 21
    • 4344631708 scopus 로고    scopus 로고
    • Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues
    • Miliani de Marval PL, Macias E, Rounbehler R, Sicinski P, Kiyokawa H, et al. (2004) Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. Mol Cell Biol 24: 7538-7547.
    • (2004) Mol Cell Biol , vol.24 , pp. 7538-7547
    • Miliani de Marval, P.L.1    Macias, E.2    Rounbehler, R.3    Sicinski, P.4    Kiyokawa, H.5
  • 22
    • 0036965836 scopus 로고    scopus 로고
    • Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation
    • Rodriguez-Puebla ML, Miliani de Marval PL, LaCava M, Moons DS, Kiyokawa H, et al. (2002) Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation. Am J Pathol 161: 405-411.
    • (2002) Am J Pathol , vol.161 , pp. 405-411
    • Rodriguez-Puebla, M.L.1    Miliani de Marval, P.L.2    LaCava, M.3    Moons, D.S.4    Kiyokawa, H.5
  • 23
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: a changing paradigm
    • Malumbres M, Barbacid M, (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9: 153-166.
    • (2009) Nat Rev Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 24
    • 77954279920 scopus 로고    scopus 로고
    • A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma
    • Puyol M, Martin A, Dubus P, Mulero F, Pizcueta P, et al. (2010) A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 18: 63-73.
    • (2010) Cancer Cell , vol.18 , pp. 63-73
    • Puyol, M.1    Martin, A.2    Dubus, P.3    Mulero, F.4    Pizcueta, P.5
  • 25
    • 84867618851 scopus 로고    scopus 로고
    • The requirement for cyclin D function in tumor maintenance
    • Choi YJ, Li X, Hydbring P, Sanda T, Stefano J, et al. (2012) The requirement for cyclin D function in tumor maintenance. Cancer Cell 22: 438-451.
    • (2012) Cancer Cell , vol.22 , pp. 438-451
    • Choi, Y.J.1    Li, X.2    Hydbring, P.3    Sanda, T.4    Stefano, J.5
  • 26
    • 34548838818 scopus 로고    scopus 로고
    • Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia
    • Wang L, Wang J, Blaser BW, Duchemin AM, Kusewitt DF, et al. (2007) Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia. Blood 110: 2075-2083.
    • (2007) Blood , vol.110 , pp. 2075-2083
    • Wang, L.1    Wang, J.2    Blaser, B.W.3    Duchemin, A.M.4    Kusewitt, D.F.5
  • 27
    • 33747872306 scopus 로고    scopus 로고
    • A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
    • Baughn LB, Di Liberto M, Wu K, Toogood PL, Louie T, et al. (2006) A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6. Cancer Res 66: 7661-7667.
    • (2006) Cancer Res , vol.66 , pp. 7661-7667
    • Baughn, L.B.1    Di Liberto, M.2    Wu, K.3    Toogood, P.L.4    Louie, T.5
  • 28
    • 77951082119 scopus 로고    scopus 로고
    • Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts
    • Michaud K, Solomon DA, Oermann E, Kim JS, Zhong WZ, et al. (2010) Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res 70: 3228-3238.
    • (2010) Cancer Res , vol.70 , pp. 3228-3238
    • Michaud, K.1    Solomon, D.A.2    Oermann, E.3    Kim, J.S.4    Zhong, W.Z.5
  • 30
    • 0028270189 scopus 로고
    • Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase
    • Kato JY, Matsuoka M, Strom DK, Sherr CJ, (1994) Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol Cell Biol 14: 2713-2721.
    • (1994) Mol Cell Biol , vol.14 , pp. 2713-2721
    • Kato, J.Y.1    Matsuoka, M.2    Strom, D.K.3    Sherr, C.J.4
  • 31
    • 33745470981 scopus 로고    scopus 로고
    • Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"
    • Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, et al. (2006) Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol 26: 5070-5085.
    • (2006) Mol Cell Biol , vol.26 , pp. 5070-5085
    • Bockstaele, L.1    Kooken, H.2    Libert, F.3    Paternot, S.4    Dumont, J.E.5
  • 32
    • 0031686960 scopus 로고    scopus 로고
    • Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities
    • Kaldis P, Russo AA, Chou HS, Pavletich NP, Solomon MJ, (1998) Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities. Mol Biol Cell 9: 2545-2560.
    • (1998) Mol Biol Cell , vol.9 , pp. 2545-2560
    • Kaldis, P.1    Russo, A.A.2    Chou, H.S.3    Pavletich, N.P.4    Solomon, M.J.5
  • 33
    • 67651233668 scopus 로고    scopus 로고
    • Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation
    • Bockstaele L, Bisteau X, Paternot S, Roger PP, (2009) Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. Mol Cell Biol 29: 4188-4200.
    • (2009) Mol Cell Biol , vol.29 , pp. 4188-4200
    • Bockstaele, L.1    Bisteau, X.2    Paternot, S.3    Roger, P.P.4
  • 34
    • 18344381018 scopus 로고    scopus 로고
    • Cyclin E in normal and neoplastic cell cycles
    • Hwang HC, Clurman BE, (2005) Cyclin E in normal and neoplastic cell cycles. Oncogene 24: 2776-2786.
    • (2005) Oncogene , vol.24 , pp. 2776-2786
    • Hwang, H.C.1    Clurman, B.E.2
  • 35
    • 77953153764 scopus 로고    scopus 로고
    • Rb inactivation in cell cycle and cancer: The puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase
    • Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K, et al. (2010) Rb inactivation in cell cycle and cancer: The puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase. Cell Cycle 9: 689-699.
    • (2010) Cell Cycle , vol.9 , pp. 689-699
    • Paternot, S.1    Bockstaele, L.2    Bisteau, X.3    Kooken, H.4    Coulonval, K.5
  • 36
    • 58149306363 scopus 로고    scopus 로고
    • Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation
    • Rocha AS, Paternot S, Coulonval K, Dumont JE, Soares P, et al. (2008) Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation. Mol Biol Cell 19: 4814-4825.
    • (2008) Mol Biol Cell , vol.19 , pp. 4814-4825
    • Rocha, A.S.1    Paternot, S.2    Coulonval, K.3    Dumont, J.E.4    Soares, P.5
  • 37
    • 66349086978 scopus 로고    scopus 로고
    • Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation
    • Paternot S, Roger PP, (2009) Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation. Cancer Res 69: 4577-4581.
    • (2009) Cancer Res , vol.69 , pp. 4577-4581
    • Paternot, S.1    Roger, P.P.2
  • 38
    • 77954830905 scopus 로고    scopus 로고
    • Cyclic AMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4
    • Blancquaert S, Wang L, Paternot S, Coulonval K, Dumont JE, et al. (2010) Cyclic AMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. Mol Endocrinol 24: 1453-1468.
    • (2010) Mol Endocrinol , vol.24 , pp. 1453-1468
    • Blancquaert, S.1    Wang, L.2    Paternot, S.3    Coulonval, K.4    Dumont, J.E.5
  • 39
    • 0038036033 scopus 로고    scopus 로고
    • Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells
    • Paternot S, Coulonval K, Dumont JE, Roger PP, (2003) Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells. J Biol Chem 278: 26533-26540.
    • (2003) J Biol Chem , vol.278 , pp. 26533-26540
    • Paternot, S.1    Coulonval, K.2    Dumont, J.E.3    Roger, P.P.4
  • 40
    • 0346101798 scopus 로고    scopus 로고
    • Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis
    • Coulonval K, Bockstaele L, Paternot S, Roger PP, (2003) Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis. J Biol Chem 278: 52052-52060.
    • (2003) J Biol Chem , vol.278 , pp. 52052-52060
    • Coulonval, K.1    Bockstaele, L.2    Paternot, S.3    Roger, P.P.4
  • 41
    • 80655149445 scopus 로고    scopus 로고
    • Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation
    • Coulonval K, Kooken H, Roger PP, (2011) Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation. Mol Biol Cell 22: 3971-3985.
    • (2011) Mol Biol Cell , vol.22 , pp. 3971-3985
    • Coulonval, K.1    Kooken, H.2    Roger, P.P.3
  • 42
    • 0027994603 scopus 로고
    • A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
    • Fisher RP, Morgan DO, (1994) A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724.
    • (1994) Cell , vol.78 , pp. 713-724
    • Fisher, R.P.1    Morgan, D.O.2
  • 43
    • 0028807103 scopus 로고
    • Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase
    • Fisher RP, Jin P, Chamberlin HM, Morgan DO, (1995) Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell 83: 47-57.
    • (1995) Cell , vol.83 , pp. 47-57
    • Fisher, R.P.1    Jin, P.2    Chamberlin, H.M.3    Morgan, D.O.4
  • 44
    • 0033022375 scopus 로고    scopus 로고
    • The cdk-activating kinase (CAK): from yeast to mammals
    • Kaldis P, (1999) The cdk-activating kinase (CAK): from yeast to mammals. Cell Mol Life Sci 55: 284-296.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 284-296
    • Kaldis, P.1
  • 45
    • 0028089946 scopus 로고
    • Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)
    • Tassan JP, Schultz SJ, Bartek J, Nigg EA, (1994) Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). J Cell Biol 127: 467-478.
    • (1994) J Cell Biol , vol.127 , pp. 467-478
    • Tassan, J.P.1    Schultz, S.J.2    Bartek, J.3    Nigg, E.A.4
  • 46
    • 0027943714 scopus 로고
    • Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase
    • Matsuoka M, Kato JY, Fisher RP, Morgan DO, Sherr CJ, (1994) Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase. Mol Cell Biol 14: 7265-7275.
    • (1994) Mol Cell Biol , vol.14 , pp. 7265-7275
    • Matsuoka, M.1    Kato, J.Y.2    Fisher, R.P.3    Morgan, D.O.4    Sherr, C.J.5
  • 47
    • 33751522249 scopus 로고    scopus 로고
    • Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations of human thyrocytes by growth factors and TSH
    • Paternot S, Dumont JE, Roger PP, (2006) Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations of human thyrocytes by growth factors and TSH. Mol Endocrinol 20: 3279-3292.
    • (2006) Mol Endocrinol , vol.20 , pp. 3279-3292
    • Paternot, S.1    Dumont, J.E.2    Roger, P.P.3
  • 48
    • 0027973043 scopus 로고
    • Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation
    • Kato JY, Matsuoka M, Polyak K, Massague J, Sherr CJ, (1994) Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Cell 79: 487-496.
    • (1994) Cell , vol.79 , pp. 487-496
    • Kato, J.Y.1    Matsuoka, M.2    Polyak, K.3    Massague, J.4    Sherr, C.J.5
  • 49
    • 30044438459 scopus 로고    scopus 로고
    • Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics
    • Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, et al. (2006) Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol 13: 55-62.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 55-62
    • Larochelle, S.1    Batliner, J.2    Gamble, M.J.3    Barboza, N.M.4    Kraybill, B.C.5
  • 50
    • 29244468847 scopus 로고    scopus 로고
    • Secrets of a double agent: CDK7 in cell-cycle control and transcription
    • Fisher RP, (2005) Secrets of a double agent: CDK7 in cell-cycle control and transcription. J Cell Sci 118: 5171-5180.
    • (2005) J Cell Sci , vol.118 , pp. 5171-5180
    • Fisher, R.P.1
  • 51
    • 0034747803 scopus 로고    scopus 로고
    • Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop
    • Garrett S, Barton WA, Knights R, Jin P, Morgan DO, et al. (2001) Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Mol Cell Biol 21: 88-99.
    • (2001) Mol Cell Biol , vol.21 , pp. 88-99
    • Garrett, S.1    Barton, W.A.2    Knights, R.3    Jin, P.4    Morgan, D.O.5
  • 52
    • 34248583324 scopus 로고    scopus 로고
    • Recognition of Cdk2 by Cdk7
    • Lolli G, Johnson LN, (2007) Recognition of Cdk2 by Cdk7. Proteins 67: 1048-1059.
    • (2007) Proteins , vol.67 , pp. 1048-1059
    • Lolli, G.1    Johnson, L.N.2
  • 53
    • 33947424005 scopus 로고    scopus 로고
    • Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
    • Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, et al. (2007) Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell 25: 839-850.
    • (2007) Mol Cell , vol.25 , pp. 839-850
    • Larochelle, S.1    Merrick, K.A.2    Terret, M.E.3    Wohlbold, L.4    Barboza, N.M.5
  • 54
    • 26444470797 scopus 로고    scopus 로고
    • Control of cell division and transcription by cyclin-dependent kinase-activating kinases in plants
    • Umeda M, Shimotohno A, Yamaguchi M, (2005) Control of cell division and transcription by cyclin-dependent kinase-activating kinases in plants. Plant Cell Physiol 46: 1437-1442.
    • (2005) Plant Cell Physiol , vol.46 , pp. 1437-1442
    • Umeda, M.1    Shimotohno, A.2    Yamaguchi, M.3
  • 55
    • 0033919678 scopus 로고    scopus 로고
    • Analysis of CAK activities from human cells
    • Kaldis P, Solomon MJ, (2000) Analysis of CAK activities from human cells. Eur J Biochem 267: 4213-4221.
    • (2000) Eur J Biochem , vol.267 , pp. 4213-4221
    • Kaldis, P.1    Solomon, M.J.2
  • 56
    • 0032004973 scopus 로고    scopus 로고
    • The role of Cdk7 in CAK function, a retro-retrospective
    • Harper JW, Elledge SJ, (1998) The role of Cdk7 in CAK function, a retro-retrospective. Genes Dev 12: 285-289.
    • (1998) Genes Dev , vol.12 , pp. 285-289
    • Harper, J.W.1    Elledge, S.J.2
  • 57
    • 84864390302 scopus 로고    scopus 로고
    • Why minimal is not optimal: Driving the mammalian cell cycle-and drug discovery-with a physiologic CDK control network
    • Merrick KA, Fisher RP, (2012) Why minimal is not optimal: Driving the mammalian cell cycle-and drug discovery-with a physiologic CDK control network. Cell Cycle 11: 2600-2605.
    • (2012) Cell Cycle , vol.11 , pp. 2600-2605
    • Merrick, K.A.1    Fisher, R.P.2
  • 58
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, et al. (1999) The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 18: 1571-1583.
    • (1999) EMBO J , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5
  • 59
    • 0141529760 scopus 로고    scopus 로고
    • P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes
    • Bagui TK, Mohapatra S, Haura E, Pledger WJ, (2003) P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Mol Cell Biol 23: 7285-7290.
    • (2003) Mol Cell Biol , vol.23 , pp. 7285-7290
    • Bagui, T.K.1    Mohapatra, S.2    Haura, E.3    Pledger, W.J.4
  • 60
    • 0037153424 scopus 로고    scopus 로고
    • Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1)
    • Sugimoto M, Martin N, Wilks DP, Tamai K, Huot TJ, et al. (2002) Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1). Oncogene 21: 8067-8074.
    • (2002) Oncogene , vol.21 , pp. 8067-8074
    • Sugimoto, M.1    Martin, N.2    Wilks, D.P.3    Tamai, K.4    Huot, T.J.5
  • 61
    • 23844462834 scopus 로고    scopus 로고
    • Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif
    • Zhu H, Nie L, Maki CG, (2005) Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif. J Biol Chem 280: 29282-29288.
    • (2005) J Biol Chem , vol.280 , pp. 29282-29288
    • Zhu, H.1    Nie, L.2    Maki, C.G.3
  • 62
    • 0038152755 scopus 로고    scopus 로고
    • Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
    • Bornstein G, Bloom J, Sitry-Shevah D, Nakayama K, Pagano M, et al. (2003) Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem 278: 25752-25757.
    • (2003) J Biol Chem , vol.278 , pp. 25752-25757
    • Bornstein, G.1    Bloom, J.2    Sitry-Shevah, D.3    Nakayama, K.4    Pagano, M.5
  • 63
    • 1642378661 scopus 로고    scopus 로고
    • Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase
    • Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M, (2004) Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428: 190-193.
    • (2004) Nature , vol.428 , pp. 190-193
    • Bashir, T.1    Dorrello, N.V.2    Amador, V.3    Guardavaccaro, D.4    Pagano, M.5
  • 64
    • 0029784513 scopus 로고    scopus 로고
    • Cyclin-binding motifs are essential for the function of p21CIP1
    • Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A, (1996) Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol 16: 4673-4682.
    • (1996) Mol Cell Biol , vol.16 , pp. 4673-4682
    • Chen, J.1    Saha, P.2    Kornbluth, S.3    Dynlacht, B.D.4    Dutta, A.5
  • 65
    • 0037155824 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation
    • Rossig L, Badorff C, Holzmann Y, Zeiher AM, Dimmeler S, (2002) Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J Biol Chem 277: 9684-9689.
    • (2002) J Biol Chem , vol.277 , pp. 9684-9689
    • Rossig, L.1    Badorff, C.2    Holzmann, Y.3    Zeiher, A.M.4    Dimmeler, S.5
  • 66
    • 24744437350 scopus 로고    scopus 로고
    • Roscovitine targets, protein kinases and pyridoxal kinase
    • Bach S, Knockaert M, Reinhardt J, Lozach O, Schmitt S, et al. (2005) Roscovitine targets, protein kinases and pyridoxal kinase. J Biol Chem 280: 31208-31219.
    • (2005) J Biol Chem , vol.280 , pp. 31208-31219
    • Bach, S.1    Knockaert, M.2    Reinhardt, J.3    Lozach, O.4    Schmitt, S.5
  • 67
    • 74049087952 scopus 로고    scopus 로고
    • Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential
    • Wesierska-Gadek J, Borza A, Komina O, Maurer M, (2009) Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential. Acta Biochim Pol 56: 495-501.
    • (2009) Acta Biochim Pol , vol.56 , pp. 495-501
    • Wesierska-Gadek, J.1    Borza, A.2    Komina, O.3    Maurer, M.4
  • 68
    • 53249149292 scopus 로고    scopus 로고
    • CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases
    • Bettayeb K, Oumata N, Echalier A, Ferandin Y, Endicott JA, et al. (2008) CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene 27: 5797-5807.
    • (2008) Oncogene , vol.27 , pp. 5797-5807
    • Bettayeb, K.1    Oumata, N.2    Echalier, A.3    Ferandin, Y.4    Endicott, J.A.5
  • 69
    • 0038157142 scopus 로고    scopus 로고
    • Xpd/Ercc2 regulates CAK activity and mitotic progression
    • Chen J, Larochelle S, Li X, Suter B, (2003) Xpd/Ercc2 regulates CAK activity and mitotic progression. Nature 424: 228-232.
    • (2003) Nature , vol.424 , pp. 228-232
    • Chen, J.1    Larochelle, S.2    Li, X.3    Suter, B.4
  • 70
    • 20244365948 scopus 로고    scopus 로고
    • Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6
    • Toogood PL, Harvey PJ, Repine JT, Sheehan DJ, VanderWel SN, et al. (2005) Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. J Med Chem 48: 2388-2406.
    • (2005) J Med Chem , vol.48 , pp. 2388-2406
    • Toogood, P.L.1    Harvey, P.J.2    Repine, J.T.3    Sheehan, D.J.4    VanderWel, S.N.5
  • 71
    • 79952959945 scopus 로고    scopus 로고
    • Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21
    • Wang Y, Fisher JC, Mathew R, Ou L, Otieno S, et al. (2011) Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21. Nat Chem Biol 7: 214-221.
    • (2011) Nat Chem Biol , vol.7 , pp. 214-221
    • Wang, Y.1    Fisher, J.C.2    Mathew, R.3    Ou, L.4    Otieno, S.5
  • 73
    • 56849109923 scopus 로고    scopus 로고
    • Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells
    • Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, et al. (2008) Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. Mol Cell 32: 662-672.
    • (2008) Mol Cell , vol.32 , pp. 662-672
    • Merrick, K.A.1    Larochelle, S.2    Zhang, C.3    Allen, J.J.4    Shokat, K.M.5
  • 74
    • 84861871242 scopus 로고    scopus 로고
    • Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion
    • Ganuza M, Saiz-Ladera C, Canamero M, Gomez G, Schneider R, et al. (2012) Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J 31: 2498-2510.
    • (2012) EMBO J , vol.31 , pp. 2498-2510
    • Ganuza, M.1    Saiz-Ladera, C.2    Canamero, M.3    Gomez, G.4    Schneider, R.5
  • 75
  • 76
    • 0028099631 scopus 로고
    • Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase
    • Darbon JM, Devault A, Taviaux S, Fesquet D, Martinez AM, et al. (1994) Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase. Oncogene 9: 3127-3138.
    • (1994) Oncogene , vol.9 , pp. 3127-3138
    • Darbon, J.M.1    Devault, A.2    Taviaux, S.3    Fesquet, D.4    Martinez, A.M.5
  • 77
    • 0030714114 scopus 로고    scopus 로고
    • Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes
    • Muller D, Bouchard C, Rudolph B, Steiner P, Stuckmann I, et al. (1997) Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes. Oncogene 15: 2561-2576.
    • (1997) Oncogene , vol.15 , pp. 2561-2576
    • Muller, D.1    Bouchard, C.2    Rudolph, B.3    Steiner, P.4    Stuckmann, I.5
  • 78
    • 0041836324 scopus 로고    scopus 로고
    • Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation
    • Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, et al. (2003) Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci U S A 100: 10231-10236.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10231-10236
    • Kamura, T.1    Hara, T.2    Kotoshiba, S.3    Yada, M.4    Ishida, N.5
  • 79
    • 33644747700 scopus 로고    scopus 로고
    • Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest
    • Jarviluoma A, Child ES, Sarek G, Sirimongkolkasem P, Peters G, et al. (2006) Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest. Mol Cell Biol 26: 2430-2440.
    • (2006) Mol Cell Biol , vol.26 , pp. 2430-2440
    • Jarviluoma, A.1    Child, E.S.2    Sarek, G.3    Sirimongkolkasem, P.4    Peters, G.5
  • 80
    • 0028169236 scopus 로고
    • p21-containing cyclin kinases exist in both active and inactive states
    • Zhang H, Hannon GJ, Beach D, (1994) p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8: 1750-1758.
    • (1994) Genes Dev , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3
  • 81
    • 0029928180 scopus 로고    scopus 로고
    • Analysis of wild-type and mutant p21WAF-1 gene activities
    • Lin J, Reichner C, Wu X, Levine AJ, (1996) Analysis of wild-type and mutant p21WAF-1 gene activities. Mol Cell Biol 16: 1786-1793.
    • (1996) Mol Cell Biol , vol.16 , pp. 1786-1793
    • Lin, J.1    Reichner, C.2    Wu, X.3    Levine, A.J.4
  • 82
    • 34247577963 scopus 로고    scopus 로고
    • Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo
    • Zhan J, Easton JB, Huang S, Mishra A, Xiao L, et al. (2007) Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo. Mol Cell Biol 27: 3530-3541.
    • (2007) Mol Cell Biol , vol.27 , pp. 3530-3541
    • Zhan, J.1    Easton, J.B.2    Huang, S.3    Mishra, A.4    Xiao, L.5
  • 83
    • 0033532558 scopus 로고    scopus 로고
    • Mathematical analysis of binary activation of a cell cycle kinase which down-regulates its own inhibitor
    • Thron CD, (1999) Mathematical analysis of binary activation of a cell cycle kinase which down-regulates its own inhibitor. Biophys Chem 79: 95-106.
    • (1999) Biophys Chem , vol.79 , pp. 95-106
    • Thron, C.D.1
  • 84
    • 0030767422 scopus 로고    scopus 로고
    • Bistable biochemical switching and the control of the events of the cell cycle
    • Thron CD, (1997) Bistable biochemical switching and the control of the events of the cell cycle. Oncogene 15: 317-325.
    • (1997) Oncogene , vol.15 , pp. 317-325
    • Thron, C.D.1
  • 85
    • 32244445684 scopus 로고    scopus 로고
    • Distinct Specificities of pRb Phosphorylation by CDK4 Activated by Cyclin D1 or Cyclin D3: Differential Involvement in the Distinct Mitogenic Modes of Thyroid Epithelial Cells
    • Paternot S, Arsenijevic T, Coulonval K, Bockstaele L, Dumont JE, et al. (2006) Distinct Specificities of pRb Phosphorylation by CDK4 Activated by Cyclin D1 or Cyclin D3: Differential Involvement in the Distinct Mitogenic Modes of Thyroid Epithelial Cells. Cell Cycle 5: 61-70.
    • (2006) Cell Cycle , vol.5 , pp. 61-70
    • Paternot, S.1    Arsenijevic, T.2    Coulonval, K.3    Bockstaele, L.4    Dumont, J.E.5
  • 86
    • 67649205804 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1
    • Hwang CY, Lee C, Kwon KS, (2009) Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1. Mol Cell Biol 29: 3379-3389.
    • (2009) Mol Cell Biol , vol.29 , pp. 3379-3389
    • Hwang, C.Y.1    Lee, C.2    Kwon, K.S.3
  • 87
    • 76749104377 scopus 로고    scopus 로고
    • Targeting the RB-pathway in cancer therapy
    • Knudsen ES, Wang JY, (2010) Targeting the RB-pathway in cancer therapy. Clin Cancer Res 16: 1094-1099.
    • (2010) Clin Cancer Res , vol.16 , pp. 1094-1099
    • Knudsen, E.S.1    Wang, J.Y.2
  • 88
    • 84870289371 scopus 로고    scopus 로고
    • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
    • Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, et al. (2012) Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med 18: 1503-1510.
    • (2012) Nat Med , vol.18 , pp. 1503-1510
    • Kwong, L.N.1    Costello, J.C.2    Liu, H.3    Jiang, S.4    Helms, T.L.5
  • 89
    • 0242365407 scopus 로고    scopus 로고
    • The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis
    • Coulonval K, Bockstaele L, Paternot S, Dumont JE, Roger PP, (2003) The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis. Exp Cell Res 291: 135-149.
    • (2003) Exp Cell Res , vol.291 , pp. 135-149
    • Coulonval, K.1    Bockstaele, L.2    Paternot, S.3    Dumont, J.E.4    Roger, P.P.5
  • 90
    • 0029957947 scopus 로고    scopus 로고
    • Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation
    • Clurman BE, Sheaff RJ, Thress K, Groudine M, Roberts JM, (1996) Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev 10: 1979-1990.
    • (1996) Genes Dev , vol.10 , pp. 1979-1990
    • Clurman, B.E.1    Sheaff, R.J.2    Thress, K.3    Groudine, M.4    Roberts, J.M.5
  • 91
    • 0035848706 scopus 로고    scopus 로고
    • Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence
    • Lin J, Jinno S, Okayama H, (2001) Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence. Oncogene 20: 2000-2009.
    • (2001) Oncogene , vol.20 , pp. 2000-2009
    • Lin, J.1    Jinno, S.2    Okayama, H.3
  • 92
    • 0035898652 scopus 로고    scopus 로고
    • T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity
    • Larochelle S, Chen J, Knights R, Pandur J, Morcillo P, et al. (2001) T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. EMBO J 20: 3749-3759.
    • (2001) EMBO J , vol.20 , pp. 3749-3759
    • Larochelle, S.1    Chen, J.2    Knights, R.3    Pandur, J.4    Morcillo, P.5
  • 93
    • 70350442978 scopus 로고    scopus 로고
    • TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II
    • Glover-Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, et al. (2009) TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Mol Cell Biol 29: 5455-5464.
    • (2009) Mol Cell Biol , vol.29 , pp. 5455-5464
    • Glover-Cutter, K.1    Larochelle, S.2    Erickson, B.3    Zhang, C.4    Shokat, K.5
  • 94
    • 79952837100 scopus 로고    scopus 로고
    • CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
    • Bettayeb K, Baunbaek D, Delehouze C, Loaec N, Hole AJ, et al. (2010) CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells. Genes Cancer 1: 369-380.
    • (2010) Genes Cancer , vol.1 , pp. 369-380
    • Bettayeb, K.1    Baunbaek, D.2    Delehouze, C.3    Loaec, N.4    Hole, A.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.