Vitamin D and maternal and child health: Overview and implications for dietary requirements

Birth Defects Research Part C - Embryo Today: Reviews

Volumn 99, Issue 1, 2013, Pages 24-44

  Uriu Adams, Janet Y ^a   Obican, Sarah G ^b   Keen, Carl L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Preeclampsia; Pregnancy; Rickets; Vitamin D; Vitamin D deficiency; Vitamin D toxicity

Indexed keywords

25 HYDROXYVITAMIN D; 7 DEHYDROCHOLESTEROL; ALKALINE PHOSPHATASE; CALCIUM; COLECALCIFEROL; ERGOCALCIFEROL; GLUCOSE; LIVER RECEPTOR HOMOLOG 1; PARATHYROID HORMONE; PHENOBARBITAL; PHENYTOIN; PHOSPHORUS; RETINOID X RECEPTOR; SUNSCREEN; VITAMIN D; VITAMIN D RECEPTOR;

ADAPTIVE IMMUNITY; ALCOHOL CONSUMPTION; ALLERGIC ENCEPHALOMYELITIS; ALLERGY; ANKYLOSING SPONDYLITIS; ASTHMA; BONE DENSITY; BONE DISEASE; CHRONIC DISEASE; DEMYELINATION; DIET SUPPLEMENTATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DOPAMINERGIC NERVE CELL; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENE EXPRESSION; GENE MUTATION; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HYPERTENSION; IMMUNOPATHOLOGY; INCIDENCE; INFANCY; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY DISEASE; LIFESTYLE; LIVER DISEASE; MALABSORPTION; MATERNAL WELFARE; META ANALYSIS (TOPIC); METHYLATION; MILK; MULTIPLE SCLEROSIS; MYCOBACTERIUM TUBERCULOSIS; NEUROPROTECTION; NUTRITIONAL REQUIREMENT; OBESITY; OSTEOMALACIA; POLLUTION; PREECLAMPSIA; PREGNANT WOMAN; PREVALENCE; PRIORITY JOURNAL; PROGENY; PROTECTIVE CLOTHING; PROTEIN EXPRESSION; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RHEUMATIC DISEASE; RICKETS; RISK FACTOR; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN PIGMENTATION; SMOKING; SURVIVAL; SYSTEMIC LUPUS ERYTHEMATOSUS; ULTRAVIOLET B RADIATION; VASCULAR DISEASE; VITAMIN D DEFICIENCY; VITAMIN D METABOLISM; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION;

ADOLESCENT; ADULT; AGED; CHILD; CHILD WELFARE; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MATERNAL WELFARE; MIDDLE AGED; NUTRITIONAL REQUIREMENTS; PRE-ECLAMPSIA; PREGNANCY; RICKETS; VITAMIN D; VITAMIN D DEFICIENCY; YOUNG ADULT;

EID: 84878456109     PISSN: 1542975X     EISSN: 15429768     Source Type: Journal    
DOI: 10.1002/bdrc.21031     Document Type: Review

References (193)

1. Adams JS, Hewison M. 2012. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Arch Biochem Biophys 523:95-102.
2. Agarwal N, Arya SC. 2011. Vitamin D levels in pregnant women and newborns at a private tertiary care hospital in Delhi, India. Int J Gynaecol Obstet 113:240-241.
3. Ahmed SF, Franey C, McDevitt H, et al. 2011. Recent trends and clinical features of childhood vitamin D deficiency presenting to a children's hospital in Glasgow. Arch Dis Child 96:694-696.
4. Ala-Houhala M, Koskinen T, Terho A, et al. 1986. Maternal compared with infant vitamin D supplementation. Arch Dis Child 61:1159-1163.
5. Amato R, Pinelli M, Monticelli A, et al. 2010. Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation. BMC Evol Biol 10:351.
6. Amer M, Qayyum R. 2012. Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006). Am J Cardiol 109:226-230.
7. American Academy of Pediatrics Council on Environmental Health. 2011. Ultraviolet radiation: a hazard to children and adolescents. Pediatrics 127:588-597.
8. Andersen L, Abrahamsen B, Dalgård C, Kyhl H, Beck-Nielsen S, Frost-Nielsen M, Jørgensen J, Barington T, Christesen H. Parity and tanned white skin as novel predictors of vitamin D status in early pregnancy: a population-based cohort study. Clin Endocrinol (Oxf) 2013. doi: 10.1111/cen.12147. [Epub ahead of print].
9. Andraweera PH, Dekker GA, Laurence JA, et al. 2012. Placental expression of VEGF family mRNA in adverse pregnancy outcomes. Placenta 33:467-472.
10. Ariyuki F. 1987. Growth retardation induced in rat fetuses by maternal fasting and massive doses of ergocalciferol. J Nutr 117:342-348.
11. Arora CP, Hobel CJ. 2010. Vitamin D-a novel role in pregnancy. Biopolymers and Cell 26:1-8.
12. Bang UC, Semb S, Nordgaard-Lassen I, et al. 2009. A descriptive cross-sectional study of the prevalence of 25-hydroxyvitamin D deficiency and association with bone markers in a hospitalized population. Nutr Res 29:671-675.
13. Barger-Lux MJ, Heaney RP. 2002. Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. J Clin Endocrinol Metab 87:4952-4956.
14. Barrera D, Avila E, Hernandez G, et al. 2008. Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts. Reprod Biol Endocrinol 6:3.
15. Basile LA, Taylor SN, Wagner CL, et al. 2006. The effect of high-dose vitamin D supplementation on serum vitamin D levels and milk calcium concentration in lactating women and their infants. Breastfeed Med 1:27-35.
16. Belderbos ME, Houben ML, Wilbrink B, et al. 2011. Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics 127:e1513-1520.
17. Bjorn Jensen C, Thorne-Lyman AL, Vadgard Hansen L, et al. 2013. Development and validation of a vitamin D status prediction model in Danish pregnant women: a study of the Danish National Birth Cohort. PLoS One 8:e53059.
18. Blumfield ML, Hure AJ, Macdonald-Wicks L, et al. 2013. A systematic review and meta-analysis of micronutrient intakes during pregnancy in developed countries. Nutr Rev 71:118-132.
19. Bodnar LM, Catov JM, Simhan HN, et al. 2007a. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 92:3517-3522.
20. Bodnar LM, Catov JM, Zmuda JM, et al. 2010. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr 140:999-1006.
21. Bodnar LM, Krohn MA, Simhan HN. 2009. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr 139:1157-1161.
22. Bodnar LM, Simhan HN. 2010. Vitamin D may be a link to black-white disparities in adverse birth outcomes. Obstet Gynecol Surv 65:273-284.
23. Bodnar LM, Simhan HN, Powers RW, et al. 2007b. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr 137:447-452.
24. Bolen JW. 1973. Hypoparathyroidism in pregnancy. Am J Obstet Gynecol 117:178-179.
25. Brannon PM, Picciano MF. 2011. Vitamin D in pregnancy and lactation in humans. Annu Rev Nutr 31:89-115.
26. Brannon PM, Yetley EA, Bailey RL, et al. 2008. Overview of the conference "Vitamin D and Health in the 21st Century: an Update". Am J Clin Nutr 88:483S-490S.
27. Brehm JM, Acosta-Perez E, Klei L, et al. 2012. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med 186:140-146.
28. Brehm JM, Schuemann B, Fuhlbrigge AL, et al. 2010. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol 126:52-58.
29. Brembeck P, Winkvist A, Olausson H. 2013. Determinants of vitamin D status in pregnant fair-skinned women in Sweden. Br J Nutr 1-9.
30. Bu FX, Armas L, Lappe J, et al. 2010. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet 128:549-556.
31. Calvo MS, Whiting SJ, Barton CN. 2004. Vitamin D fortification in the United States and Canada: current status and data needs. Am J Clin Nutr 80:1710S-1716S.
32. Camadoo L, Tibbott R, Isaza F. 2007. Maternal vitamin D deficiency associated with neonatal hypocalcaemic convulsions. Nutr J 6:23-24.
33. Camargo CA Jr, Rifas-Shiman SL, Litonjua AA, et al. 2007. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr 85:788-795.
34. Cardus A, Panizo S, Encinas M, et al. 2009. 1, 25-dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter. Atherosclerosis 204:85-89.
35. Carlson CR, Uriu-Adams JY, Chambers CD, et al. 2012. Low Vitamin D status is a common finding in a population of pregnant women enrolled in a nutrition intervention study in the Ukraine. FASEB J 26:lb281.
36. Carroll KN, Gebretsadik T, Larkin EK, et al. 2011. Relationship of maternal vitamin D level with maternal and infant respiratory disease. Am J Obstet Gynecol 205:215 e211-215 e217.
37. Chan GM, Buchino JJ, Mehlhorn D, et al. 1979. Effect of vitamin D on pregnant rabbits and their offspring. Pediatr Res 13:121-126.
38. Chesney RW. 2012. Theobald Palm and his remarkable observation: how the sunshine vitamin came to be recognized. Nutrients 4:42-51.
39. Chesney RW, Hedberg G. 2010. Metabolic bone disease in lion cubs at the London Zoo in 1889: the original animal model of rickets. J Biomed Sci 17 (Suppl 1):S36-S39.
40. Christakos S, DeLuca HF. 2011. Minireview: vitamin D: is there a role in extraskeletal health? Endocrinology 152:2930-2936.
41. Clarke NM, Page JE. 2012. Vitamin D deficiency: a paediatric orthopaedic perspective. Curr Opin Pediatr 24:46-49.
42. Crozier SR, Harvey NC, Inskip HM, et al. 2012. Maternal vitamin D status in pregnancy is associated with adiposity in the offspring: findings from the Southampton Women's Survey. Am J Clin Nutr 96:57-63.
43. Cui X, Pelekanos M, Burne TH, et al. 2010. Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon. Neurosci Lett 486:220-223.
44. Cui X, Pelekanos M, Liu PY, et al. 2013. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience 236:77-87.
45. Dealberto MJ. 2010. Ethnic origin and increased risk for schizophrenia in immigrants to countries of recent and longstanding immigration. Acta Psychiatr Scand 121:325-339.
46. Dealberto MJ. 2011. Prevalence of autism according to maternal immigrant status and ethnic origin. Acta Psychiatr Scand 123:339-348.
47. Devereux G, Litonjua AA, Turner SW, et al. 2007. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr 85:853-859.
48. Di Rosa M, Malaguarnera M, Nicoletti F, et al. 2011. Vitamin D3: a helpful immuno-modulator. Immunology 134:123-139.
49. Diaz L, Arranz C, Avila E, et al. 2002. Expression and activity of 25-hydroxyvitamin D-1 alpha-hydroxylase are restricted in cultures of human syncytiotrophoblast cells from preeclamptic pregnancies. J Clin Endocrinol Metab 87:3876-3882.
50. Ding C, Gao D, Wilding J, et al. 2012. Vitamin D signalling in adipose tissue. Br J Nutr 108:1915-1923.
51. Dobson R, Giovannoni G, Ramagopalan S. 2013. The month of birth effect in multiple sclerosis: systematic review, meta-analysis and effect of latitude. J Neurol Neurosurg Psychiatry 84:427-432.
52. Dong J, Wong SL, Lau CW, et al. 2012. Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J 33:2980-2990.
53. Dong Y, Stallmann-Jorgensen IS, Pollock NK, et al. 2010. A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J Clin Endocrinol Metab 95:4584-4591.
54. Dror DK, Allen LH. 2010. Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutr Rev 68:465-477.
55. Dror DK, King JC, Durand DJ, et al. 2011. Association of modifiable and nonmodifiable factors with vitamin D status in pregnant women and neonates in Oakland, CA. J Am Diet Assoc 111:111-116.
56. Dusso AS, Brown AJ, Slatopolsky E. 2005. Vitamin D. Am J Physiol Renal Physiol 289:F8-F28.
57. Erkkola M, Kaila M, Nwaru BI, et al. 2009. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy 39:875-882.
58. Erten S, Kucuksahin O, Sahin A, et al. 2013. Decreased plasma vitamin D levels in patients with undifferentiated spondyloarthritis and ankylosing spondylitis. Intern Med 52:339-344.
59. Evans KN, Bulmer JN, Kilby MD, et al. 2004. Vitamin D and placental-decidual function. J Soc Gynecol Investig 11:263-271.
60. Eyles D, Burne T, McGrath J. 2011. Vitamin D in fetal brain development. Semin Cell Dev Biol 22:629-636.
61. Gale CR, Robinson SM, Harvey NC, et al. 2008. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62:68-77.
62. Garg S, Sabri D, Kanji J, et al. 2013. Evaluation of vitamin D medicines and dietary supplements and the physicochemical analysis of selected formulations. J Nutr Health Aging 17:158-161.
63. Gaultier C, Harf A, Balmain N, et al. 1984. Lung mechanics in rachitic rats. Am Rev Respir Dis 130:1108-1110.
64. Gernand AD, Simhan HN, Klebanoff MA, et al. 2013. Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a U.S. multicenter cohort study. J Clin Endocrinol Metab 98:398-404.
65. Gezmish O, Tare M, Parkington HC, et al. 2010. Maternal vitamin D deficiency leads to cardiac hypertrophy in rat offspring. Reprod Sci 17:168-176.
66. Giguere Y, Charland M, Theriault S, et al. 2012. Linking preeclampsia and cardiovascular disease later in life. Clin Chem Lab Med 50:985-993.
67. Goodenday LS, Gordon GS. 1971. No risk from vitamin D in pregnancy. Ann Intern Med 75:807-808.
68. Gordon NP, Caan BJ, Asgari MM. 2012. Variation in vitamin D supplementation among adults in a multi-race/ethnic health plan population, 2008. Nutr J 11:104.
69. Greer FR. 2008. 25-Hydroxyvitamin D: functional outcomes in infants and young children. Am J Clin Nutr 88:529S-533S.
70. Gregori S, Giarratana N, Smiroldo S, et al. 2002. A 1alpha, 25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 51:1367-1374.
71. Grundmann M, Haidar M, Placzko S, et al. 2012. Vitamin D improves the angiogenic properties of endothelial progenitor cells. Am J Physiol Cell Physiol 303:C954-C962.
72. Halicioglu O, Aksit S, Koc F, et al. 2012. Vitamin D deficiency in pregnant women and their neonates in spring time in western Turkey. Paediatr Perinat Epidemiol 26:53-60.
73. Hamilton SA, McNeil R, Hollis BW, et al. 2010. Profound vitamin D deficiency in a diverse group of women during pregnancy living in a sun-rich environment at latitude 32 degrees N. Int J Endocrinol 2010:917428.
74. Hanson C, Armas L, Lyden E, et al. 2011. Vitamin D status and associations in newborn formula-fed infants during initial hospitalization. J Am Diet Assoc 111:1836-1843.
75. Harms LR, Eyles DW, McGrath JJ, et al. 2008. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice. Behav Brain Res 187:343-350.
76. Harris RA, Pedersen-White J, Guo DH, et al. 2011. Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults. Am J Hypertens 24:557-562.
77. Harris SS. 2006. Vitamin D and African Americans. J Nutr 136:1126-1129.
78. Hathcock JN, Shao A, Vieth R, et al. 2007. Risk assessment for vitamin D. Am J Clin Nutr 85:6-18.
79. Hatun S, Islam O, Cizmecioglu F, et al. 2005. Subclinical vitamin D deficiency is increased in adolescent girls who wear concealing clothing. J Nutr 135:218-222.
80. Hatun S, Ozkan B, Bereket A. 2011. Vitamin D deficiency and prevention: Turkish experience. Acta Paediatr 100:1195-1199.
81. Haugen M, Brantsaeter AL, Trogstad L, et al. 2009. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology 20:720-726.
82. Hensel KJ, Randis TM, Gelber SE, et al. 2011. Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis. Am J Obstet Gynecol 204:41.e41-49.
83. Hill KM, Jonnalagadda SS, Albertson AM, et al. 2012. Top food sources contributing to vitamin D intake and the association of ready-to-eat cereal and breakfast consumption habits to vitamin D intake in Canadians and United States Americans. J Food Sci 77:H170-H175.
84. Holick MF. 2004. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80:1678S-1688S.
85. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. 2011. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911-1930.
86. Hollis BW, Johnson D, Hulsey TC, et al. 2011. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 26:2341-2357.
87. Hollis BW, Pittard WB III, Reinhardt TA. 1986. Relationships among vitamin D, 25-hydroxyvitamin D, and vitamin D-binding protein concentrations in the plasma and milk of human subjects. J Clin Endocrinol Metab 62:41-44.
88. Hollis BW, Wagner CL. 2011. Vitamin D requirements and supplementation during pregnancy. Curr Opin Endocrinol Diabetes Obes 18:371-375.
89. Hoogenboezem T, Degenhart HJ, de Muinck Keizer-Schrama SM, et al. 1989. Vitamin D metabolism in breast-fed infants and their mothers. Pediatr Res 25:623-628.
90. Hossain N, Khanani R, Hussain-Kanani F, et al. 2011. High prevalence of vitamin D deficiency in Pakistani mothers and their newborns. Int J Gynaecol Obstet 112:229-233.
91. Hossein-nezhad A, Holick MF. 2012. Optimize dietary intake of vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care 15:567-579.
92. Hughes AM, Lucas RM, Ponsonby AL, et al. 2011. The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma and hayfever: an Australian multicenter study. Pediatr Allergy Immunol 22:327-333.
93. Hypponen E. 2011. Preventing vitamin D deficiency in pregnancy: importance for the mother and child. Ann Nutr Metab 59:28-31.
94. Hypponen E, Berry DJ, Wjst M, et al. 2009. Serum 25-hydroxyvitamin D and IgE-a significant but nonlinear relationship. Allergy 64:613-620.
95. Hypponen E, Laara E, Reunanen A, et al. 2001. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358:1500-1503.
96. Institute of Medicine. 1997. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D and fluoride. Washington, D.C.: National Academies Press. p. 1-522.
97. Institute of Medicine. 2011. In: Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary reference intakes for calcium and vitamin D. Washington, D.C.: The National Academies Press.
98. Johnson DD, Wagner CL, Hulsey TC, et al. 2011. Vitamin D deficiency and insufficiency is common during pregnancy. Am J Perinatol 28:7-12.
99. Kalra P, Das V, Agarwal A, et al. 2012. Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant. Br J Nutr 108:1052-1058.
100. Karohl C, Vaccarino V, Veledar E, et al. 2012. Vitamin D status and coronary flow reserve measured by positron emission tomography: a Co-Twin Control study. J Clin Endocrinol Metab 98:389-397.
101. Kehler L, Verma S, Krone R, Roper E. 2012. Vitamin D deficiency in children presenting to the emergency department: a growing concern. Vitamin D deficiency in Birmingham's children: presentation to the emergency department. Emerg Med J 0:1-3. doi:10.1136/emermed-2012-201473.
102. Koch MW, Metz LM, Agrawal SM, et al. 2013. Environmental factors and their regulation of immunity in multiple sclerosis. J Neurol Sci 324:10-16.
103. Kupferschmidt K. 2012. Uncertain verdict as vitamin D goes on trial. Science 337:1476-1478.
104. Larriba MJ, Ordonez-Moran P, Chicote I, et al. 2011. Vitamin D receptor deficiency enhances Wnt/beta-catenin signaling and tumor burden in colon cancer. PLoS One 6:e23524.
105. Lau SL, Gunton JE, Athayde NP, et al. 2011. Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus. Med J Aust 194:334-337.
106. Leffelaar ER, Vrijkotte TG, van Eijsden M. 2010. Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and their Development cohort. Br J Nutr 104:108-117.
107. Liu J. 2012. Vitamin D content of food and its contribution to vitamin D status: a brief overview and Australian focus. Photochem Photobiol Sci 11:1802-1807.
108. Liu N, Kaplan AT, Low J, et al. 2009. Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway. Biol Reprod 80:398-406.
109. Liu NQ, Hewison M. 2011. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys 523:37-47.
110. Liu NQ, Kaplan AT, Lagishetty V, et al. 2011. Vitamin D and the regulation of placental inflammation. J Immunol 186:5968-5974.
111. Liu PT, Stenger S, Li H, et al. 2006. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1770-1773.
112. Louw JA, Werbeck A, Louw ME, et al. 1992. Blood vitamin concentrations during the acute-phase response. Crit Care Med 20:934-941.
113. MacLaughlin J, Holick MF. 1985. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536-1538.
114. Maiya S, Sullivan I, Allgrove J, et al. 2008. Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure. Heart 94:581-584.
115. Malham M, Jorgensen SP, Ott P, et al. 2011. Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology. World J Gastroenterol 17:922-925.
116. Marya RK, Rathee S, Manrow M. 1987. Effect of calcium and vitamin D supplementation on toxaemia of pregnancy. Gynecol Obstet Invest 24:38-42.
117. McAree T, Jacobs B, Manickavasagar T, et al. 2013. Vitamin D deficiency in pregnancy-still a public health issue. Matern Child Nutr 9:23-30.
118. McCollum EV, Simmonds N, Becker JE. 1922. Nutrition classics from The Journal of Biological Chemistry 53:293-312, 1922. Studies of experimental rickets. XXI. An experimental demonstration of the existence of a vitamin which promotes calcium depositor. Nutr Rev (1975) 33:48-50.
119. McGrath J, Saari K, Hakko H, et al. 2004. Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study. Schizophr Res 67:237-245.
120. McGrath JJ, Burne TH, Feron F, et al. 2010. Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr Bull 36:1073-1078.
121. Mensink GB, Fletcher R, Gurinovic M, et al. 2013. Mapping low intake of micronutrients across Europe. Br J Nutr Jan 14:1-19.
122. Milne M, Baran DT. 1985. Inhibitory effect of maternal alcohol ingestion on rat pup hepatic 25-hydroxyvitamin D production. Pediatr Res 19:102-104.
123. Moore CE, Murphy MM, Holick MF. 2005. Vitamin D intakes by children and adults in the United States differ among ethnic groups. J Nutr 135:2478-2485.
124. Mosekilde L. 2005. Vitamin D and the elderly. Clin Endocrinol (Oxf) 62:265-281.
125. Mostafa GA, Al-Ayadhi LY. 2012. Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity. J Neuroinflammation 9:201.
126. National Institutes of Health State-of-the-Science Panel. 2007. National Institutes of Health State-of-the-Science Conference Statement: multivitamin/mineral supplements and chronic disease prevention. Am J Clin Nutr 85:257S-264S.
127. Nesby-O'Dell S, Scanlon KS, Cogswell ME, et al. 2002. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 76:187-192.
128. Novakovic B, Galati JC, Chen A, et al. 2012. Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations. Am J Clin Nutr 96:188-195.
129. Nowson CA, Margerison C. 2002. Vitamin D intake and vitamin D status of Australians. Med J Aust 177:149-152.
130. Nurmatov U, Devereux G, Sheikh A. 2011. Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol 127:724-733 e721-e730.
131. O'Loan J, Eyles DW, Kesby J, et al. 2007. Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring. Psychoneuroendocrinology 32:227-234.
132. Obican SG, Jahnke GD, Soldin OP, et al. 2012. Teratology Public Affairs Committee position paper: iodine deficiency in pregnancy. Birth Defects Res A Clin Mol Teratol 94:677-682.
133. Oken E, Ning Y, Rifas-Shiman SL, et al. 2007. Diet during pregnancy and risk of preeclampsia or gestational hypertension. Ann Epidemiol 17:663-668.
134. Ozkan S, Jindal S, Greenseid K, et al. 2010. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril 94:1314-1319.
135. Palm TA. 1888. Letter to the editor. Br Med J 2:1247.
136. Pandita KK, Razdan S, Kudyar RP, et al. 2012. "Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. Clin Cases Miner Bone Metab 9:118-120.
137. Pani MA, Knapp M, Donner H, et al. 2000. Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans. Diabetes 49:504-507.
138. Patterson KY, Phillips KM, Horst RL, et al. 2010. Vitamin D content and variability in fluid milks from a US Department of Agriculture nationwide sampling to update values in the National Nutrient Database for Standard Reference. J Dairy Sci 93:5082-5090.
139. Paul G, Brehm JM, Alcorn JF, et al. 2012. Vitamin D and asthma. Am J Respir Crit Care Med 185:124-132.
140. Pawley N, Bishop NJ. 2004. Prenatal and infant predictors of bone health: the influence of vitamin D. Am J Clin Nutr 80:1748S-1751S.
141. Pereira F, Barbachano A, Singh PK, et al. 2012. Vitamin D has wide regulatory effects on histone demethylase genes. Cell Cycle 11:1081-1089.
142. Poel YH, Hummel P, Lips P, et al. 2012. Vitamin D and gestational diabetes: a systematic review and meta-analysis. Eur J Intern Med 23:465-469.
143. Powe CE, Seely EW, Rana S, et al. 2010. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension 56:758-763.
144. Prentice A. 2008. Vitamin D deficiency: a global perspective. Nutr Rev 66:S153-S164.
145. Ralph AR, Lucas RM, Norval M. 2013. Vitamin D and solar ultraviolet radiation in the risk and treatment of tuberculosis. Lancet Infect Dis 13:77-88.
146. Ramagopalan SV, Dyment DA, Cader MZ, et al. 2011. Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol 70:881-886.
147. Rawson JB, Sun Z, Dicks E, et al. 2012. Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients. Nutr Cancer 64:919-928.
148. Reinholz M, Ruzicka T, Schauber J. 2011. Vitamin D and its role in allergic disease. Clin Exp Allergy 42:817-826.
149. Reis JP, von Muhlen D, Miller ER III, et al. 2009. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics 124:e371-e379.
150. Robinson CJ, Alanis MC, Wagner CL, et al. 2010. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol 203:366 e361-366 e366.
151. Robinson CJ, Wagner CL, Hollis BW, et al. 2011. Maternal vitamin D and fetal growth in early-onset severe preeclampsia. Am J Obstet Gynecol 204:556 e551-556 e554.
152. Rosen CJ, Adams JS, Bikle DD, et al. 2012. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev 33:456-492.
153. Roth DE. 2011. Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trials. J Perinatol 31:449-459.
154. Sabetta JR, DePetrillo P, Cipriani RJ, et al. 2010. Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One 5:e11088.
155. Sahu M, Das V, Aggarwal A, et al. 2009. Vitamin D replacement in pregnant women in rural north India: a pilot study. Eur J Clin Nutr 63:1157-1159.
156. Saijo T, Ito M, Takeda E, et al. 1991. A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection. Am J Hum Genet 49:668-673.
157. Sanders KM, Nicholson GC, Ebeling PR. 2013. Is High Dose Vitamin D Harmful? Calcif Tissue Int 92:191-206.
158. Soliman AT, El-Dabbagh M, Adel A, et al. 2010. Clinical responses to a mega-dose of vitamin D3 in infants and toddlers with vitamin D deficiency rickets. J Trop Pediatr 56:19-26.
159. Sundar IK, Rahman I. 2011. Vitamin D and susceptibility of chronic lung diseases: role of epigenetics. Front Pharmacol 2:50.
160. Swamy GK, Garrett ME, Miranda ML, et al. 2011. Maternal vitamin D receptor genetic variation contributes to infant birthweight among black mothers. Am J Med Genet A 155:1264-1271.
161. Tare M, Emmett SJ, Coleman HA, et al. 2011. Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats. J Physiol 589:4777-4786.
162. Thomas GN, o Hartaigh B, Bosch JA, et al. 2012. Vitamin D levels predict all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. Diabetes Care 35:1158-1164.
163. Thorne-Lyman A, Fawzi WW. 2012. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol 26 (Suppl 1):75-90.
164. Tshibangu K, Oosterwijck K, Doumont-Meyvis M. 1975. Effects of massive doses of ergocalciferol plus cholesterol on pregnant rats and their offspring. J Nutr 105:741-758.
165. Tsiaras WG, Weinstock MA. 2011. Factors influencing vitamin D status. Acta Derm Venereol 91:115-124.
166. Urashima M, Segawa T, Okazaki M, et al. 2010. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 91:1255-1260.
167. Uriu-Adams JY, Keen CL. 2010. Zinc and reproduction: effects of zinc deficiency on prenatal and early postnatal development. Birth Defects Res B Dev Reprod Toxicol 89:313-325.
168. Urrutia RP, Thorp JM. 2012. Vitamin D in pregnancy: current concepts. Curr Opin Obstet Gynecol 24:57-64.
169. Uysal S, Kalayci AG, Baysal K. 1999. Cardiac functions in children with vitamin D deficiency rickets. Pediatr Cardiol 20:283-286.
170. Vandevijvere S, Amsalkhir S, Van Oyen H, et al. 2012. High prevalence of vitamin D deficiency in pregnant women: A National Cross-Sectional Survey. PLoS One 7:e43868.
171. Vidailhet M, Mallet E, Bocquet A, et al. 2012. Vitamin D: still a topical matter in children and adolescents. A position paper by the Committee on Nutrition of the French Society of Paediatrics. Arch Pediatr 19:316-328.
172. Vieth R. 1999. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69:842-856.
173. Viljakainen HT, Korhonen T, Hytinantti T, et al. 2011. Maternal vitamin D status affects bone growth in early childhood-a prospective cohort study. Osteoporos Int 22:883-891.
174. Viljakainen HT, Saarnio E, Hytinantti T, et al. 2010. Maternal vitamin D status determines bone variables in the newborn. J Clin Endocrinol Metab 95:1749-1757.
175. Wagner CL, Hulsey TC, Fanning D, et al. 2006. High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. Breastfeed Med 1:59-70.
176. Wagner CL, McNeil RB, Johnson DD, Hulsey TC, Ebeling M, Robinson C, Hamilton SA, Hollis BW. Health characteristics and outcomes of two randomized vitamin D supplementation trials during pregnancy: a combined analysis. J Steroid Biochem Mol Biol 2013 pii: S0960-0760(13)00006-X. doi: 10.1016/j.jsbmb.2013.01.002.
177. Walker VP, Zhang X, Rastegar I, et al. 2011. Cord blood vitamin D status impacts innate immune responses. J Clin Endocrinol Metab 96:1835-1843.
178. Wang L, Ma J, Manson JE, Buring JE, Gaziano JM, Sesso HD. A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men. Eur J Nutr 2012. doi: 10.1007/s00394-012-0480-8.
179. Wang L, Song Y, Manson JE, et al. 2012. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes 5:819-829.
180. Wang TJ, Zhang F, Richards JB, et al. 2010. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376:180-188.
181. Wei SQ, Qi HP, Luo ZC, Fraser WD. 2013. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2013 [Epub ahead of print].
182. Weisberg P, Scanlon KS, Li R, et al. 2004. Nutritional rickets among children in the United States: review of cases reported between 1986 and 2003. Am J Clin Nutr 80:1697S-1705S.
183. Weisse K, Winkler S, Hirche F, et al. 2013. Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy 68:220-228.
184. Wijnia JW, Wielders JP, Lips P, et al. 2013. Is vitamin D deficiency a confounder in alcoholic skeletal muscle myopathy? Alcohol Clin Exp Res 37 (Suppl 1):E209-E215.
185. Willer CJ, Dyment DA, Sadovnick AD, et al. 2005. Timing of birth and risk of multiple sclerosis: population based study. BMJ 330:120.
186. Winzenberg TM, Powell S, Shaw KA, Jones G. 2010. Vitamin D supplementation for improving bone mineral density in children. Cochrane Database Syst Rev 2010;CD006944. doi: 10.1002/14651858.CD006944.pub2.
187. Wortsman J, Matsuoka LY, Chen TC, et al. 2000. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:690-693.
188. Yorifuji J, Yorifuji T, Tachibana K, et al. 2008. Craniotabes in normal newborns: the earliest sign of subclinical vitamin D deficiency. J Clin Endocrinol Metab 93:1784-1788.
189. Yoshizawa T, Handa Y, Uematsu Y, et al. 1997. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16:391-396.
190. Yu CK, Sykes L, Sethi M, et al. 2009. Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol (Oxf) 70:685-690.
191. Zhu H, Wang X, Shi H, Su S, Harshfield GA, Gutin B, Snieder H, Dong Y. A Genome-wide methylation study of severe vitamin D deficiency in African American adolescents. J Pediatr 2012. pii: S0022-3476(12)01272-3. doi: 10.1016/j.jpeds.2012.10.059.
192. Ziaei S, Norrozi M, Faghihzadeh S, et al. 2007. A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin>or=13.2 g/dl. BJOG 114:684-688.
193. Zosky GR, Berry LJ, Elliot JG, et al. 2011. Vitamin D deficiency causes deficits in lung function and alters lung structure. Am J Respir Crit Care Med 183:1336-1343.