A genome-wide methylation study of severe vitamin d deficiency in African American adolescents

Journal of Pediatrics

Volumn 162, Issue 5, 2013, Pages

  Zhu, Haidong ^a   Wang, Xiaoling ^a   Shi, Huidong ^a   Su, Shaoyong ^a   Harshfield, Gregory A ^a   Gutin, Bernard ^a,b   Snieder, Harold ^c   Dong, Yanbin ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b IL   (United States)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CYP24A1 PROTEIN; CYP2R1 PROTEIN; CYTOCHROME; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AFRICAN AMERICAN; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DNA METHYLATION; EPIGENETICS; GENETIC ASSOCIATION; HUMAN; IMMUNOCOMPETENT CELL; MALE; PHENOTYPE; PRIORITY JOURNAL; SELF REPORT; SYSTOLIC BLOOD PRESSURE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN METABOLISM;

EID: 84876681149     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2012.10.059     Document Type: Article

References (47)

1. C.M. Veldman, M.T. Cantorna, and H.F. DeLuca Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system Arch Biochem Biophys 374 2000 334 338
2. M.F. Holick Vitamin D deficiency N Engl J Med 357 2007 266 281
3. J.H. Lee, J.H. O'Keefe, D. Bell, D.D. Hensrud, and M.F. Holick Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 52 2008 1949 1956
4. A. Woloszynska-Read, C.S. Johnson, and D.L. Trump Vitamin D and cancer: clinical aspects Best Pract Res Clin Endocrinol Metab 25 2011 605 615
5. V. Ganji, X. Zhang, N. Shaikh, and V. Tangpricha Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001-2006 Am J Clin Nutr 94 2011 225 233
6. A.A. Ginde, M.C. Liu, and C.A. Camargo Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004 Arch Intern Med 169 2009 626 632
7. Y. Dong, N. Pollock, I.S. Stallmann-Jorgensen, B. Gutin, L. Lan, and T.C. Chen Low 25-hydroxyvitamin D levels in adolescents: race, season, adiposity, physical activity, and fitness Pediatrics 125 2010 1104 1111
8. D.M. Provvedini, C.D. Tsoukas, L.J. Deftos, and S.C. Manolagas 1,25-Dihydroxyvitamin D3 receptors in human leukocytes Science 221 1983 1181 1183
9. A. Bellia, C. Garcovich, M. D'Adamo, M. Lombardo, M. Tesauro, and G. Donadel Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects Intern Emerg Med 2011
10. S.S. Schleithoff, A. Zittermann, G. Tenderich, H.K. Berthold, P. Stehle, and R. Koerfer Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial Am J Clin Nutr 83 2006 754 759
11. C. Mathieu, and L. Adorini The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents Trends Mol Med 8 2002 174 179
12. T.P. Nguyen, M. Scotti, M.J. Morine, and C. Priami Model-based clustering reveals vitamin D dependent multi-centrality hubs in a network of vitamin-related proteins BMC Syst Biol 5 2011 195
13. A. Petronis Epigenetics as a unifying principle in the aetiology of complex traits and diseases Nature 465 2010 721 727
14. P. Gynther, S. Toropainen, J.M. Matilainen, S. Seuter, C. Carlberg, and S. Vaisanen Mechanism of 1α,25-dihydroxyvitamin D(3)-dependent repression of interleukin-12B Biochim Biophys Acta 1813 2011 810 818
15. J. Ahn, K. Yu, R. Stolzenberg-Solomon, K.C. Simon, M.L. McCullough, and L. Gallicchio Genome-wide association study of circulating vitamin D levels Hum Mol Genet 19 2010 2739 2745
16. T.J. Wang, F. Zhang, J.B. Richards, B. Kestenbaum, J.B. van Meurs, and D. Berry Common genetic determinants of vitamin D insufficiency: a genome-wide association study Lancet 376 2010 180 188
17. K.H. Petty, K. Li, Y. Dong, J. Fortenberry, I. Stallmann-Jorgensen, and D. Guo Sex dimorphisms in inflammatory markers and adiposity in African merican youth Int J Pediatr Obes 5 2010 327 333
18. T.C. Chen, A.K. Turner, and M.F. Holick Methods for the determination of the circulating concentration of 25-hydroxyvitamin D J Nutr Biochem 1 1990 315 319
19. A.M. Wallace, S. Gibson, A. de la Hunty, C. Lamberg-Allardt, and M. Ashwell Measurement of 25-hydroxyvitamin D in the clinical laboratory: current procedures, performance characteristics and limitations Steroids 75 2010 477 488
20. G.K. Smyth Linear models and empirical bayes methods for assessing differential expression in microarray experiments Statistical applications in genetics and molecular biology 3 2004 Article3
21. Y. Hochberg, and Y. Benjamini More powerful procedures for multiple significance testing Stat Med 9 1990 811 818
22. N.L. Smith, L.A. Hindorff, S.R. Heckbert, R.N. Lemaitre, K.D. Marciante, and K. Rice Association of genetic variations with nonfatal venous thrombosis in postmenopausal women JAMA 297 2007 489 498
23. F. Al-Shahrour, R. Diaz-Uriarte, and J. Dopazo FatiGO: a web tool for finding significant associations of gene ontology terms with groups of genes Bioinformatics 20 2004 578 580
24. E.E. Morrison Action and interactions at microtubule ends Cell Mol Life Sci 64 2007 307 317
25. A. Musch Microtubule organization and function in epithelial cells Traffic 5 2004 1 9
26. O. Valiron, N. Caudron, and D. Job Microtubule dynamics Cell Mol Life Sci 58 2001 2069 2084
27. P. Carvalho, J.S. Tirnauer, and D. Pellman Surfing on microtubule ends Trends Cell Biol 13 2003 229 237
28. C. Renner, J.P. Pfitzenmeier, K. Gerlach, G. Held, S. Ohnesorge, and U. Sahin RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells J Immunol 159 1997 1276 1283
29. Y. Wang, X. Zhou, H. Zhu, S. Liu, C. Zhou, and G. Zhang Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating β-catenin/TCF pathway Oncogene 24 2005 6637 6645
30. K. Kelly, and U. Siebenlist Immediate-early genes induced by antigen receptor stimulation Curr Opin Immunol 7 1995 327 332
31. I. Abiatari, S. Gillen, T. DeOliveira, T. Klose, K. Bo, and N.A. Giese The microtubule-associated protein MAPRE2 is involved in perineural invasion of pancreatic cancer cells Int J Oncol 35 2009 1111 1116
32. A. Hernandez, M.E. Martinez, S. Fiering, V.A. Galton, and D. St Germain Type 3 deiodinase is critical for the maturation and function of the thyroid axis J Clin Invest 116 2006 476 484
33. I. Meulenbelt, S.D. Bos, K. Chapman, R. van der Breggen, J.J. Houwing-Duistermaat, and D. Kremer Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility Ann Rheum Dis 70 2011 164 167
34. J.I. Martin-Subero, O. Ammerpohl, M. Bibikova, E. Wickham-Garcia, X. Agirre, and S. Alvarez A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms PLoS One 4 2009 e6986
35. M.E. Figueroa, B.J. Wouters, L. Skrabanek, J. Glass, Y. Li, and C.A. Erpelinck-Verschueren Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features Blood 113 2009 2795 2804
36. R. Bouillon, G. Carmeliet, L. Verlinden, E. van Etten, A. Verstuyf, and H.F. Luderer Vitamin D and human health: lessons from vitamin D receptor null mice Endocr Rev 29 2008 726 776
37. J.E. Manson Vitamin D and the heart: why we need large-scale clinical trials Cleve Clin J Med 77 2010 903 910
38. C. Carlberg, and S. Seuter Dynamics of nuclear receptor target gene regulation Chromosoma 119 2010 479 484
39. J.W. Pike Genome-wide principles of gene regulation by the vitamin D receptor and its activating ligand Mol Cell Endocrinol 347 2011 3 10
40. M.S. Kim, T. Kondo, I. Takada, M.Y. Youn, Y. Yamamoto, and S. Takahashi DNA demethylation in hormone-induced transcriptional derepression Nature 461 2009 1007 1012
41. I. Rhee, K.E. Bachman, B.H. Park, K.W. Jair, R.W. Yen, and K.E. Schuebel DNMT1 and DNMT3b cooperate to silence genes in human cancer cells Nature 416 2002 552 556
42. H.G. Palmer, M. Sanchez-Carbayo, P. Ordonez-Moran, M.J. Larriba, C. Cordon-Cardo, and A. Munoz Genetic signatures of differentiation induced by 1α,25-dihydroxyvitamin D3 in human colon cancer cells Cancer Res 63 2003 7799 7806
43. M.J. Larriba, P. Ordonez-Moran, I. Chicote, G. Martin-Fernandez, I. Puig, and A. Munoz Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer PLoS One 6 2011 e23524
44. E. Ramos-Lopez, P. Bruck, T. Jansen, J. Herwig, and K. Badenhoop CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans Diabetes Metab Res Rev 23 2007 631 636
45. J.B. Cheng, M.A. Levine, N.H. Bell, D.J. Mangelsdorf, and D.W. Russell Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase Proc Natl Acad Sci U.S.A 101 2004 7711 7715
46. X. Wang, H. Zhu, H. Snieder, S. Su, D. Munn, and G. Harshfield Obesity related methylation changes in DNA of peripheral blood leukocytes BMC Med 8 2010 87
47. G. Toperoff, D. Aran, J.D. Kark, M. Rosenberg, T. Dubnikov, and B. Nissan Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood Hum Mol Genet 21 2012 371 383