Vitamin D signalling in adipose tissue

British Journal of Nutrition

Volumn 108, Issue 11, 2012, Pages 1915-1923

  Ding, Cherlyn ^a   Gao, Dan ^a   Wilding, John ^a   Trayhurn, Paul ^a,b   Bing, Chen ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF BUCKINGHAM   (United Kingdom)

Author keywords

Adipocytes; Adipose tissue; Inflammation; Obesity; Vitamin D

Indexed keywords

ADIPOCYTOKINE; CALCIDIOL 1 MONOOXYGENASE; CALCIUM; COLECALCIFEROL; ERGOCALCIFEROL; INSULIN; LIPID; TRANSCRIPTION FACTOR; VITAMIN D; VITAMIN D RECEPTOR;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ARTICLE; BODY FAT; BONE METABOLISM; CALCIUM HOMEOSTASIS; DIET SUPPLEMENTATION; ENERGY BALANCE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID METABOLISM; LIPID STORAGE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PATHOGENESIS; PHYSIOLOGY; PREVALENCE; PUBLIC HEALTH; VITAMIN D DEFICIENCY; WHITE ADIPOSE TISSUE;

ADIPOGENESIS; ADIPOKINES; ADIPOSE TISSUE; ANIMALS; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; OBESITY; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; VITAMIN D; VITAMIN D DEFICIENCY;

MURINAE;

EID: 84871299721     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512003285     Document Type: Article

References (112)

1. Mellanby E (1976) Nutrition Classics. The Lancet 1: 407-12, 1919. An experimental investigation of rickets. Edward Mel-lanby. Nutr Rev 34, 338-340.
2. Boyle IT, Miravet L, Gray RW, et al. (1972) The response of intestinal calcium transport to 25-hydroxy and 1, 25-dihy-droxy vitamin D in nephrectomized rats. Endocrinology 90, 605-608.
3. 3 in the rat. Endocrinology 92, 417-422.
4. Liu PT, Stenger S, Li H, et al. (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311, 1770-1773.
5. 3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 173, 2909-2912.
6. Chen S, Law CS, Grigsby CL, et al. (2011) Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation 124, 1838-1847.
7. Zhang Y, Kong J, Deb DK, et al. (2010) Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angio-tensin system. J Am Soc Nephrol 21, 966-973.
8. Chiu KC, Chu A, Go VLW, et al. (2004) Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 79, 820-825.
9. Vrieling A, Hein R, Abbas S, et al. (2011) Serum 25-hydroxy-vitamin D and postmenopausal breast cancer survival: a prospective patient cohort study. Breast Cancer Res 13, R74.
10. Barchetta I, Angelico F, Del Ben M, et al. (2011) Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med 9, 85.
11. Osei K (2010) 25-OH vitamin D: is it the universal panacea for metabolic syndrome and type 2 diabetes? J Clin Endo-crinol Metab 95, 4220-4222.
12. Bell NH, Epstein S, Greene A, et al. (1985) Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 76, 370-373.
13. Wortsman J, Matsuoka LY, Chen TC, et al. (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72, 690-693.
14. Parikh SJ, Edelman M, Uwaifo GI, et al. (2004) The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 89, 1196-1199.
15. Snijder MB, van Dam RM, Visser M, et al. (2005) Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 90, 4119-4123.
16. Botella-Carretero JI, Alvarez-Blasco F, Villafruela JJ, et al. (2007) Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity. Clin Nutr 26, 573-580.
17. Goldner WS, Stoner JA, Thompson J, et al. (2008) Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls. Obes Surg 18, 145-150.
18. Blum M, Dolnikowski G, Seyoum E, et al. (2008) Vitamin D(3) in fat tissue. Endocrine 33, 90-94.
19. Ching S, Kashinkunti S, Niehaus MD, et al. (2011) Mammary adipocytes bioactivate 25-hydroxyvitamin D and signal via vitamin D receptor, modulating mammary epithelial cell growth. J Cell Biochem 112, 3393-3405.
20. Wong KE, Kong J, Zhang W, et al. (2011) Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J Biol Chem 286, 33804-33810.
21. Li J, Byrne ME, Chang E, et al. (2008) 1Alpha, 25-dihydrox-yvitamin D hydroxylase in adipocytes. J Steroid Biochem Mol Biol 112, 122-126.
22. 3 inhibition of adipogenesis in 3T3-L1 cells. Am J Physiol Endocrinol Metab 290, E916-E924.
23. Kamei Y, Kawada T, Kazuki R, et al. (1993) Vitamin D receptor gene expression is up-regulated by 1, 25-dihydrox-yvitamin D3 in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 193, 948-955.
24. 2). Justus Liebigs Annalen der Chemie 492, 226-241.
25. Windaus A, Schenck F & von Weder F (1936) Uber das antirachitisch wirksame bestrahlungs-produkt aus 7-dehydro-cholesterin (About the anti-rachitic effective irradiation-product of 7-dehydro-cholesterol). Hoppe-Seylers Z Physiol Chem 241, 100-103.
26. 3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse. Endocrinology 146, 825-834.
27. Xu Y, Hashizume T, Shuhart MC, et al. (2006) Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha, 25-dihy-droxyvitamin D(3): implications for drug-induced osteoma-lacia. Mol Pharmacol 69, 56-65.
28. Jones G, Strugnell SA & DeLuca HF (1998) Current understanding of the molecular actions of vitamin D. Physiol Rev 78, 1193-1231.
29. Demay MB (2006) Mechanism of vitamin D receptor action. Ann N Y Acad Sci 1068, 204-213.
30. Mangelsdorf DJ, Thummel C, Beato M, et al. (1995) The nuclear receptor superfamily: the second decade. Cell 83, 835-839.
31. Issa LL, Leong GM & Eisman JA (1998) Molecular mechanism of vitamin D receptor action. Inflamm Res 47, 451-475.
32. Carlberg C (2003) Current understanding of the function of the nuclear vitamin D receptor in response to its natural and synthetic ligands. Recent Results Cancer Res 164, 29-42.
33. Sutton ALM & MacDonald PN (2003) Vitamin D: more than a "bone-a-fide" hormone. Mol Endocrinol 17, 777-791.
34. 3 in vivo and in vitro. Mol Endocrinol 18, 2660-2671.
35. Norman AW (2006) Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 147, 5542-5548.
36. Plum LA & DeLuca HF (2010) Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov 9, 941-955.
37. Dretakis OE, Tsatsanis C, Fyrgadis A, et al. (2010) Correlation between serum 25-hydroxyvitamin D levels and quadriceps muscle strength in elderly Cretans. J Int Med Res 38, 1824-1834.
38. Baz-Hecht M & Goldfine AB (2010) The impact of vitamin D deficiency on diabetes and cardiovascular risk. Curr Opin Endocrinol Diabetes Obes 17, 113-119.
39. Yiu YF, Chan YH, Yiu KH, et al. (2011) Vitamin D deficiency is associated with depletion of circulating endo-thelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J Clin Endocrinol Metab 96, E830-E835.
40. Barth JH, Butler GE, Hammond PJ. (2008) Hypercalcaemia. In Biochemical Investigations in Laboratory Medicine. Leeds Teaching Hospitals. www.pathology.leedsth.nhs.uk
41. Jones G (2008) Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 88, 582S-586S.
42. Holick MF (2009) Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 19, 73-78.
43. Holick MF (2011) Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets 12, 4-18.
44. Dawson-Hughes B, Heaney RP, Holick MF, et al. (2005) Estimates of optimal vitamin D status. Osteoporos Int 16, 713-716.
45. Khandalavala BN, Hibma PP & Fang X (2010) Prevalence and persistence of vitamin D deficiency in biliopancreatic diversion patients: a retrospective study. Obes Surg 20, 881-884.
46. Fish E, Beverstein G, Olson D, et al. (2010) Vitamin D status of morbidly obese bariatric surgery patients. J Surg Res 164, 198-202.
47. Ford ES, Ajani UA, McGuire LC, et al. (2005) Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care 28, 1228-1230.
48. Konradsen S, Ag H, Lindberg F, et al. (2008) Serum 1, 25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47, 87-91.
49. Cheng S, Massaro JM, Fox CS, et al. (2010) Adiposity, cardi-ometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes 59, 242-248.
50. Rajakumar K, de las Heras J, Chen TC, et al. (2011) Vitamin D status, adiposity, and lipids in black American and Caucasian children. J Clin Endocrinol Metab 96, 1560-1567.
51. Jorde R, Sneve M, Emaus N, et al. (2010) Cross-sectional and longitudinal relation between serum 25-hydroxyvita-min D and body mass index: the Tromso study. Eur J Nutr 49, 401-407.
52. Freedman BI, Wagenknecht LE, Hairston KG, et al. (2010) Vitamin D, adiposity, and calcified atherosclerotic plaque in African-Americans. J Clin Endocrinol Metab 95, 1076-1083.
53. Caron-Jobin M, Morisset AS, Tremblay A, et al. (2011) Elevated serum 25(OH)D concentrations, vitamin D, and calcium intakes are associated with reduced adipocyte size in women. Obesity (Silver Spring) 19, 1335-1341.
54. Rosenblum JL, Castro VM, Moore CE, et al. (2012) Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults. Am J Clin Nutr 95, 101-108.
55. Frost M, Abrahamsen B, Nielsen TL, et al. (2010) Vitamin D status and PTH in young men: a cross-sectional study on associations with bone mineral density, body composition and glucose metabolism. Clin Endocrinol (Oxf) 73, 573-580.
56. Kayaniyil S, Vieth R, Harris SB, et al. (2011) Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components. J Clin Endocri-nol Metab 96, 168-175.
57. Narvaez CJ, Matthews D, Broun E, et al. (2009) Lean pheno-type and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology 150, 651-661.
58. Ochs-Balcom HM, Chennamaneni R, Millen AE, et al. (2011) Vitamin D receptor gene polymorphisms are associated with adiposity phenotypes. Am J Clin Nutr 93, 5-10.
59. O'Hara A, Lim FL, Mazzatti DJ, et al. (2009) Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipo-cytes by macrophage-conditioned medium. Pflugers Arch 458, 1103-1114.
60. Trayhurn P, O'Hara A & Bing C (2011) Interrogation of microarray datasets indicates that macrophage-secreted factors stimulate the expression of genes associated with vitamin D metabolism (VDR and CYP27B1) in human adipocytes. Adipobiology 3, 29-34.
61. Querfeld U, Hoffmann MM, Klaus G, et al. (1999) Antagonistic effects of vitamin D and parathyroid hormone on lipo-protein lipase in cultured adipocytes. J Am Soc Nephrol 10, 2158-2164.
62. Bikle D (2009) Extra renal synthesis of 1, 25-dihydroxyvita-min D and its health implications. Clin Rev Bone Miner Metab 7, 114-125.
63. Xu H, Barnes GT, Yang Q, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112, 1821-1830.
64. Weisberg SP, McCann D, Desai M, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112, 1796-1808.
65. Blumberg JM, Tzameli I, Astapova I, et al. (2006) Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 Cells. J Biol Chem 281, 11205-11213.
66. Mandrup S & Lane MD (1997) Regulating adipogenesis. J Biol Chem 272, 5367-5370.
67. Christy RJ, Yang VW, Ntambi JM, et al. (1989) Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev 3, 1323-1335.
68. Dani C, Amri EZ, Bertrand B, et al. (1990) Expression and regulation of pOb24 and lipoprotein lipase genes during adipose conversion. J Cell Biochem 43, 103-110.
69. Madsen L, Petersen RK & Kristiansen K (2005) Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim Biophys Acta 1740, 266-286.
70. Lee S, Lee DK, Choi E, et al. (2005) Identification of a functional vitamin D response element in the murine Insig-2 promoter and its potential role in the differentiation of 3T3-L1 preadipocytes. Mol Endocrinol 19, 399-408.
71. Rayalam S, Della-Fera MA, Ambati S, et al. (2008) Enhanced effects of 1, 25(OH)(2)D(3) plus genistein on adipogenesis and apoptosis in 3T3-L1 adipocytes. Obesity (Silver Spring) 16, 539-546.
72. Wong KE, Szeto FL, Zhang W, et al. (2009) Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am J Physiol Endocrinol Metab 296, E820-E828.
73. Boon N, Hul GB, Sicard A, et al. (2006) The effects of increasing serum calcitriol on energy and fat metabolism and gene expression. Obesity (Silver Spring) 14, 1739-1746.
74. Trayhurn P, Bing C & Wood IS (2006) Adipose tissue and adipokines-energy regulation from the human perspective. J Nutr 136, 1935S-1939S.
75. Trayhurn P & Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92, 347-355.
76. Gannagé-Yared M-H, Chedid R, Khalife S, et al. (2009) Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young middle-eastern population. Eur J Endocrinol 160, 965-971.
77. Sun X & Zemel MB (2008) Calcitriol and calcium regulate cytokine production and adipocyte-macrophage crosstalk. J Nutr Biochem 19, 392-399.
78. 3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation. Lipids Health Dis 10, 37.
79. Lorente-Cebrian S, Eriksson A, Dunlop T, et al. (2011) Differential effects of 1alpha, 25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adi-pocytes. Eur J Nutr 51, 335-342.
80. 3 on inflammatory responses in psoriasis. Eur J Dermatol 8, 16-20.
81. Do JE, Kwon SY, Park S, et al. (2008) Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. Rheumatology (Oxford) 47, 840-848.
82. Martinesi M, Treves C, d'Albasio G, et al. (2008) Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients. Inflamm Bowel Dis 14, 597-604.
83. Zhang Y, Leung DY, Richers BN, et al. (2012) Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol 188, 2127-2135.
84. Bruce D, Yu S, Ooi JH, et al. (2011) Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling. Int Immunol 23, 519-528.
85. Yu S, Bruce D, Froicu M, et al. (2008) Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc Natl Acad Sci U S A 105, 20834-20839.
86. Giulietti A, van Etten E, Overbergh L, et al. (2007) Mono-cytes from type 2 diabetic patients have a pro-inflammatory profile. 1, 25-Dihydroxyvitamin D(3) works as anti-inflammatory. Diabetes Res Clin Pract 77, 47-57.
87. Lee V, Rekhi E, Kam JH, et al. (2012) Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function. Neurobiol Aging 33, 2382-2389.
88. Fontana L, Eagon JC, Trujillo ME, et al. (2007) Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56, 1010-1013.
89. Skurk T, Alberti-Huber C, Herder C, et al. (2007) Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92, 1023-1033.
90. Cinti S, Mitchell G, Barbatelli G, et al. (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46, 2347-2355.
91. Lolmede K, Duffaut C, Zakaroff-Girard A, et al. (2011) Immune cells in adipose tissue: key players in metabolic disorders. Diabetes Metab 37, 283-290.
92. Lacasa D, Taleb S, Keophiphath M, et al. (2007) Macro-phage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148, 868-877.
93. Keophiphath M, Achard V, Henegar C, et al. (2009) Macro-phage-secreted factors promote a profibrotic phenotype in human preadipocytes. Mol Endocrinol 23, 11-24.
94. Gao D, Trayhurn P & Bing C (2010) Macrophage-secreted factors inhibit ZAG expression and secretion by human adi-pocytes. Mol Cell Endocrinol 325, 135-142.
95. Gao D & Bing C (2011) Macrophage-induced expression and release of matrix metalloproteinase 1 and 3 by human preadipocytes is mediated by IL-1b via activation of MAPK signaling. J Cell Physiol 226, 2869-2880.
96. 3 inhibits the cytokine-induced secretion ofMCP-1 and reduces monocyte recruitment by human preadipocytes. Int J Obes (Lond) (Epublication ahead of print version 17 April 2012).
97. Fujihara CK, Antunes GR, Mattar AL, et al. (2007) Chronic inhibition of nuclear factor-kB attenuates renal injury in the 5/6 renal ablation model. Am J Physiol Renal Physiol 292, F92-F99.
98. 3 suppresses inflammation-induced expression of plasmi-nogen activator inhibitor-1 by blocking nuclear factor-kB activation. Arch Biochem Biophys 507, 241-247.
99. Bonizzi G & Karin M (2004) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25, 280-288.
100. 3 targeting of NF-kappaB suppresses high glucose-induced MCP-1 expression in mesangial cells. Kidney Int 72, 193-201.
101. 3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res Clin Pract 27, 181-188.
102. Parikh S, Guo D-H, Pollock NK, et al. (2012) Circulating 25-hydroxyvitamin D concentrations are correlated with cardi-ometabolic risk among American Black and White adolescents living in a year-round sunny climate. Diabetes Care 35, 1133-1138.
103. Olson ML, Maalouf NM, Oden JD, et al. (2012) Vitamin D deficiency in obese children and its relationship to glucose homeostasis. J Clin Endocrinol Metab 97, 279-285.
104. Kayaniyil S, Retnakaran R, Harris SB, et al. (2011) Prospective associations of vitamin D with b-cell function and gly-cemia. Diabetes 60, 2947-2953.
105. 3 on insulin release and calcium handling via the phospholipid pathway in islets from vitamin D-deficient rats. J Endocrinol Invest 18, 673-682.
106. 3 of insulin secretion and glucose tolerance in the vitamin D-deficient rat. Endocrinology 120, 1490-1497.
107. Mitri J, Dawson-Hughes B, Hu FB, et al. (2011) Effects of vitamin D and calcium supplementation on pancreatic beta cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr 94, 486-494.
108. Nikooyeh B, Neyestani TR, Farvid M, et al. (2011) Daily consumption of vitamin D 2 or vitamin D calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr 93, 764-771.
109. Maestro B, Molero S, Bajo S, et al. (2002) Transcriptional activation of the human insulin receptor gene by 1, 25-dihy-droxyvitamin D(3). Cell Biochem Funct 20, 227-232.
110. Hotamisligil GS (2000) Molecular mechanisms of insulin resistance and the role of the adipocyte. Int J Obes Relat Metab Disord 24, Suppl. 4, S23-S27.
111. Smith U (2002) Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance-is insulin resistance initiated in the adipose tissue? Int J Obes Relat Metab Disord 26, 897-904.
112. 3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozo-tocin-induced diabetic rats. BMC Mol Biol 9, 65.