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Volumn 8, Issue 5, 2013, Pages

Synergistic Inhibition of Survival, Proliferation, and Migration of U87 Cells with a Combination of LY341495 and Iressa

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; AMPA RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; GLUTAMIC ACID; METABOTROPIC RECEPTOR 2; RILUZOLE; AMINO ACID; ANTINEOPLASTIC AGENT; QUINAZOLINE DERIVATIVE; XANTHENE DERIVATIVE;

EID: 84878306173     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064588     Document Type: Article
Times cited : (36)

References (54)
  • 2
    • 0034659906 scopus 로고    scopus 로고
    • World Health Organization classification of tumors
    • Kleihues P, Sobin LH, (2000) World Health Organization classification of tumors. Cancer 88: 2887.
    • (2000) Cancer , vol.88 , pp. 2887
    • Kleihues, P.1    Sobin, L.H.2
  • 4
    • 0036711589 scopus 로고    scopus 로고
    • Poor-prognosis high-grade gliomas: evolving an evidence-based standard of care
    • Gupta T, Sarin R, (2002) Poor-prognosis high-grade gliomas: evolving an evidence-based standard of care. Lancet Oncol 3: 557-564.
    • (2002) Lancet Oncol , vol.3 , pp. 557-564
    • Gupta, T.1    Sarin, R.2
  • 5
    • 44949158990 scopus 로고    scopus 로고
    • Improvement, clinical course, and quality of life after palliative radiotherapy for recurrent glioblastoma
    • Nieder C, Astner ST, Mehta MP, Grosu AL, Molls M, (2008) Improvement, clinical course, and quality of life after palliative radiotherapy for recurrent glioblastoma. Am J Clin Oncol 31: 300-305.
    • (2008) Am J Clin Oncol , vol.31 , pp. 300-305
    • Nieder, C.1    Astner, S.T.2    Mehta, M.P.3    Grosu, A.L.4    Molls, M.5
  • 6
    • 0033909858 scopus 로고    scopus 로고
    • Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study
    • Behrens PF, Langemann H, Strohschein R, Draeger J, Hennig J, (2000) Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study. J Neurooncol 47: 11-22.
    • (2000) J Neurooncol , vol.47 , pp. 11-22
    • Behrens, P.F.1    Langemann, H.2    Strohschein, R.3    Draeger, J.4    Hennig, J.5
  • 7
    • 0034800265 scopus 로고    scopus 로고
    • Glutamate release promotes growth of malignant gliomas
    • Takano T, Lin JH, Arcuino G, Gao Q, Yang J, et al. (2001) Glutamate release promotes growth of malignant gliomas. Nat Med 7: 1010-1015.
    • (2001) Nat Med , vol.7 , pp. 1010-1015
    • Takano, T.1    Lin, J.H.2    Arcuino, G.3    Gao, Q.4    Yang, J.5
  • 8
    • 0033573392 scopus 로고    scopus 로고
    • Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange
    • Ye ZC, Rothstein JD, Sontheimer H, (1999) Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. J Neurosci 19: 10767-10777.
    • (1999) J Neurosci , vol.19 , pp. 10767-10777
    • Ye, Z.C.1    Rothstein, J.D.2    Sontheimer, H.3
  • 9
    • 23144433297 scopus 로고    scopus 로고
    • Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo
    • Arcella A, Carpinelli G, Battaglia G, D'Onofrio M, Santoro F, et al. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro Oncol 7: 236-245.
    • (2005) Neuro Oncol , vol.7 , pp. 236-245
    • Arcella, A.1    Carpinelli, G.2    Battaglia, G.3    D'Onofrio, M.4    Santoro, F.5
  • 10
    • 73549104022 scopus 로고    scopus 로고
    • Molecular mechanisms of necrosis in glioblastoma: the role of glutamate excitotoxicity
    • Noch E, Khalili K, (2009) Molecular mechanisms of necrosis in glioblastoma: the role of glutamate excitotoxicity. Cancer Biol Ther 8: 1791-1797.
    • (2009) Cancer Biol Ther , vol.8 , pp. 1791-1797
    • Noch, E.1    Khalili, K.2
  • 12
    • 0141533202 scopus 로고    scopus 로고
    • Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage
    • Sontheimer H, (2003) Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage. Trends Neurosci 26: 543-549.
    • (2003) Trends Neurosci , vol.26 , pp. 543-549
    • Sontheimer, H.1
  • 13
    • 0036732391 scopus 로고    scopus 로고
    • Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells
    • Ishiuchi S, Tsuzuki K, Yoshida Y, Yamada N, Hagimura N, et al. (2002) Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells. Nat Med 8: 971-978.
    • (2002) Nat Med , vol.8 , pp. 971-978
    • Ishiuchi, S.1    Tsuzuki, K.2    Yoshida, Y.3    Yamada, N.4    Hagimura, N.5
  • 14
    • 0029089601 scopus 로고
    • Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
    • Geiger JR, Melcher T, Koh DS, Sakmann B, Seeburg PH, et al. (1995) Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 15: 193-204.
    • (1995) Neuron , vol.15 , pp. 193-204
    • Geiger, J.R.1    Melcher, T.2    Koh, D.S.3    Sakmann, B.4    Seeburg, P.H.5
  • 15
    • 0028988015 scopus 로고
    • Editing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR-B pre-mRNA in vitro reveals site-selective adenosine to inosine conversion
    • Melcher T, Maas S, Higuchi M, Keller W, Seeburg PH, (1995) Editing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR-B pre-mRNA in vitro reveals site-selective adenosine to inosine conversion. J Biol Chem 270: 8566-8570.
    • (1995) J Biol Chem , vol.270 , pp. 8566-8570
    • Melcher, T.1    Maas, S.2    Higuchi, M.3    Keller, W.4    Seeburg, P.H.5
  • 16
    • 16444366144 scopus 로고    scopus 로고
    • The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo
    • de Groot JF, Liu TJ, Fuller G, Yung WK, (2005) The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo. Cancer Res 65: 1934-1940.
    • (2005) Cancer Res , vol.65 , pp. 1934-1940
    • de Groot, J.F.1    Liu, T.J.2    Fuller, G.3    Yung, W.K.4
  • 17
    • 34547438107 scopus 로고    scopus 로고
    • Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation
    • Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, et al. (2007) Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci 27: 7987-8001.
    • (2007) J Neurosci , vol.27 , pp. 7987-8001
    • Ishiuchi, S.1    Yoshida, Y.2    Sugawara, K.3    Aihara, M.4    Ohtani, T.5
  • 19
    • 67650114955 scopus 로고    scopus 로고
    • Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment
    • van Vuurden DG, Yazdani M, Bosma I, Broekhuizen AJ, Postma TJ, et al. (2009) Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment. PLoS One 4: e5953.
    • (2009) PLoS One , vol.4
    • van Vuurden, D.G.1    Yazdani, M.2    Bosma, I.3    Broekhuizen, A.J.4    Postma, T.J.5
  • 20
    • 34250904342 scopus 로고    scopus 로고
    • Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2+-permeability
    • Mahajan SS, Ziff EB, (2007) Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2+-permeability. Mol Cell Neurosci 35: 470-481.
    • (2007) Mol Cell Neurosci , vol.35 , pp. 470-481
    • Mahajan, S.S.1    Ziff, E.B.2
  • 21
    • 79960918929 scopus 로고    scopus 로고
    • Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing
    • Mahajan SS, Thai KH, Chen K, Ziff E, (2011) Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience 189: 305-315.
    • (2011) Neuroscience , vol.189 , pp. 305-315
    • Mahajan, S.S.1    Thai, K.H.2    Chen, K.3    Ziff, E.4
  • 22
    • 33645794516 scopus 로고    scopus 로고
    • Serum-dependence of AMPA receptor-mediated proliferation in glioma cells
    • Yoshida Y, Tsuzuki K, Ishiuchi S, Ozawa S, (2006) Serum-dependence of AMPA receptor-mediated proliferation in glioma cells. Pathol Int 56: 262-271.
    • (2006) Pathol Int , vol.56 , pp. 262-271
    • Yoshida, Y.1    Tsuzuki, K.2    Ishiuchi, S.3    Ozawa, S.4
  • 23
    • 0035884505 scopus 로고    scopus 로고
    • Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma
    • Sonoda Y, Ozawa T, Aldape KD, Deen DF, Berger MS, et al. (2001) Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res 61: 6674-6678.
    • (2001) Cancer Res , vol.61 , pp. 6674-6678
    • Sonoda, Y.1    Ozawa, T.2    Aldape, K.D.3    Deen, D.F.4    Berger, M.S.5
  • 24
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, et al. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7: 261-269.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5
  • 25
    • 0032578999 scopus 로고    scopus 로고
    • Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
    • Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, et al. (1998) Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science. 279: 710-714.
    • (1998) Science , vol.279 , pp. 710-714
    • Stephens, L.1    Anderson, K.2    Stokoe, D.3    Erdjument-Bromage, H.4    Painter, G.F.5
  • 26
    • 0030799706 scopus 로고    scopus 로고
    • Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
    • Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, et al. (1997) Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 277: 567-570.
    • (1997) Science , vol.277 , pp. 567-570
    • Stokoe, D.1    Stephens, L.R.2    Copeland, T.3    Gaffney, P.R.4    Reese, C.B.5
  • 27
    • 0034653608 scopus 로고    scopus 로고
    • The PI3K-PDK1 connection: more than just a road to PKB
    • Vanhaesebroeck B, Alessi DR, (2000) The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346 Pt 3: 561-576.
    • (2000) Biochem J , vol.346 , Issue.Pt 3 , pp. 561-576
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 28
    • 0034644523 scopus 로고    scopus 로고
    • Cellular signaling: pivoting around PDK-1
    • Toker A, Newton AC, (2000) Cellular signaling: pivoting around PDK-1. Cell 103: 185-188.
    • (2000) Cell , vol.103 , pp. 185-188
    • Toker, A.1    Newton, A.C.2
  • 29
    • 0034708482 scopus 로고    scopus 로고
    • Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
    • Toker A, Newton AC, (2000) Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem 275: 8271-8274.
    • (2000) J Biol Chem , vol.275 , pp. 8271-8274
    • Toker, A.1    Newton, A.C.2
  • 30
    • 77955709724 scopus 로고    scopus 로고
    • Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line
    • Schunemann DP, Grivicich I, Regner A, Leal LF, de Araujo DR, et al. (2010) Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line. Pathol Oncol Res 16: 285-293.
    • (2010) Pathol Oncol Res , vol.16 , pp. 285-293
    • Schunemann, D.P.1    Grivicich, I.2    Regner, A.3    Leal, L.F.4    de Araujo, D.R.5
  • 31
    • 0028909618 scopus 로고
    • The role of the epidermal growth factor receptor in human gliomas: I. The control of cell growth
    • Hoi Sang U, Espiritu OD, Kelley PY, Klauber MR, Hatton JD, (1995) The role of the epidermal growth factor receptor in human gliomas: I. The control of cell growth. J Neurosurg 82: 841-846.
    • (1995) J Neurosurg , vol.82 , pp. 841-846
    • Hoi Sang, U.1    Espiritu, O.D.2    Kelley, P.Y.3    Klauber, M.R.4    Hatton, J.D.5
  • 32
    • 0142188691 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
    • Shinojima N, Tada K, Shiraishi S, Kamiryo T, Kochi M, et al. (2003) Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res 63: 6962-6970.
    • (2003) Cancer Res , vol.63 , pp. 6962-6970
    • Shinojima, N.1    Tada, K.2    Shiraishi, S.3    Kamiryo, T.4    Kochi, M.5
  • 33
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE, (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 34
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC, Neel BG, (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 96: 4240-4245.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 35
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo
    • Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, et al. (2003) Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 63: 2742-2746.
    • (2003) Cancer Res , vol.63 , pp. 2742-2746
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3    Crosby, K.4    Seligson, D.5
  • 36
    • 27744535984 scopus 로고    scopus 로고
    • PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells
    • Ghosh MK, Sharma P, Harbor PC, Rahaman SO, Haque SJ, (2005) PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene 24: 7290-7300.
    • (2005) Oncogene , vol.24 , pp. 7290-7300
    • Ghosh, M.K.1    Sharma, P.2    Harbor, P.C.3    Rahaman, S.O.4    Haque, S.J.5
  • 37
    • 0029162564 scopus 로고
    • Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3
    • Wallasch C, Weiss FU, Niederfellner G, Jallal B, Issing W, et al. (1995) Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J 14: 4267-4275.
    • (1995) EMBO J , vol.14 , pp. 4267-4275
    • Wallasch, C.1    Weiss, F.U.2    Niederfellner, G.3    Jallal, B.4    Issing, W.5
  • 38
    • 3042691035 scopus 로고    scopus 로고
    • AKT status controls susceptibility of malignant keratinocytes to the early-activated and UVB-induced apoptotic pathway
    • Decraene D, Van Laethem A, Agostinis P, De Peuter L, Degreef H, et al. (2004) AKT status controls susceptibility of malignant keratinocytes to the early-activated and UVB-induced apoptotic pathway. J Invest Dermatol 123: 207-212.
    • (2004) J Invest Dermatol , vol.123 , pp. 207-212
    • Decraene, D.1    Van Laethem, A.2    Agostinis, P.3    De Peuter, L.4    Degreef, H.5
  • 40
    • 0031769940 scopus 로고    scopus 로고
    • In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
    • Mandell JW, Hussaini IM, Zecevic M, Weber MJ, VandenBerg SR, (1998) In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms. Am J Pathol 153: 1411-1423.
    • (1998) Am J Pathol , vol.153 , pp. 1411-1423
    • Mandell, J.W.1    Hussaini, I.M.2    Zecevic, M.3    Weber, M.J.4    VandenBerg, S.R.5
  • 41
  • 42
    • 0037343943 scopus 로고    scopus 로고
    • Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells
    • D'Onofrio M, Arcella A, Bruno V, Ngomba RT, Battaglia G, et al. (2003) Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells. J Neurochem 84: 1288-1295.
    • (2003) J Neurochem , vol.84 , pp. 1288-1295
    • D'Onofrio, M.1    Arcella, A.2    Bruno, V.3    Ngomba, R.T.4    Battaglia, G.5
  • 44
    • 33846205171 scopus 로고    scopus 로고
    • A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration
    • Goldberg L, Kloog Y, (2006) A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration. Cancer Res 66: 11709-11717.
    • (2006) Cancer Res , vol.66 , pp. 11709-11717
    • Goldberg, L.1    Kloog, Y.2
  • 45
    • 37349063346 scopus 로고    scopus 로고
    • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1
    • Fumagalli E, Funicello M, Rauen T, Gobbi M, Mennini T, (2008) Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur J Pharmacol 578: 171-176.
    • (2008) Eur J Pharmacol , vol.578 , pp. 171-176
    • Fumagalli, E.1    Funicello, M.2    Rauen, T.3    Gobbi, M.4    Mennini, T.5
  • 46
    • 67650901985 scopus 로고    scopus 로고
    • Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress
    • Akamatsu K, Shibata MA, Ito Y, Sohma Y, Azuma H, et al. (2009) Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress. Anticancer Res 29: 2195-2204.
    • (2009) Anticancer Res , vol.29 , pp. 2195-2204
    • Akamatsu, K.1    Shibata, M.A.2    Ito, Y.3    Sohma, Y.4    Azuma, H.5
  • 47
    • 84859107394 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer
    • Speyer CL, Smith JS, Banda M, DeVries JA, Mekani T, et al. (2012) Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. Breast Cancer Res Treat 132: 565-573.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 565-573
    • Speyer, C.L.1    Smith, J.S.2    Banda, M.3    DeVries, J.A.4    Mekani, T.5
  • 48
    • 67649871267 scopus 로고    scopus 로고
    • The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells
    • Beretta F, Bassani S, Binda E, Verpelli C, Bello L, et al. (2009) The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells. Eur J Neurosci 30: 25-34.
    • (2009) Eur J Neurosci , vol.30 , pp. 25-34
    • Beretta, F.1    Bassani, S.2    Binda, E.3    Verpelli, C.4    Bello, L.5
  • 49
    • 0035807807 scopus 로고    scopus 로고
    • Underediting of glutamate receptor GluR-B mRNA in malignant gliomas
    • Maas S, Patt S, Schrey M, Rich A, (2001) Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc Natl Acad Sci U S A 98: 14687-14692.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14687-14692
    • Maas, S.1    Patt, S.2    Schrey, M.3    Rich, A.4
  • 50
    • 0028008825 scopus 로고
    • Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction
    • Xue D, Huang ZG, Barnes K, Lesiuk HJ, Smith KE, et al. (1994) Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction. J Cereb Blood Flow Metab 14: 251-261.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 251-261
    • Xue, D.1    Huang, Z.G.2    Barnes, K.3    Lesiuk, H.J.4    Smith, K.E.5
  • 51
    • 0037387875 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism
    • El-Kholy W, Macdonald PE, Lin JH, Wang J, Fox JM, et al. (2003) The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J 17: 720-722.
    • (2003) FASEB J , vol.17 , pp. 720-722
    • El-Kholy, W.1    Macdonald, P.E.2    Lin, J.H.3    Wang, J.4    Fox, J.M.5
  • 52
    • 3042818148 scopus 로고    scopus 로고
    • Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+-dependent divergences
    • Nauc V, De Lamirande E, Leclerc P, Gagnon C, (2004) Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+-dependent divergences. J Androl 25: 573-585.
    • (2004) J Androl , vol.25 , pp. 573-585
    • Nauc, V.1    De Lamirande, E.2    Leclerc, P.3    Gagnon, C.4
  • 53
    • 84862801899 scopus 로고    scopus 로고
    • Differential effects of LY294002 and wortmannin on inducible nitric oxide synthase expression in glomerular mesangial cells
    • Tsai KD, Chang WW, Lin CC, Hsu SC, Lee YJ, et al. (2012) Differential effects of LY294002 and wortmannin on inducible nitric oxide synthase expression in glomerular mesangial cells. Int Immunopharmacol 12: 471-480.
    • (2012) Int Immunopharmacol , vol.12 , pp. 471-480
    • Tsai, K.D.1    Chang, W.W.2    Lin, C.C.3    Hsu, S.C.4    Lee, Y.J.5
  • 54
    • 18044389786 scopus 로고    scopus 로고
    • Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor
    • McKillop D, Partridge EA, Kemp JV, Spence MP, Kendrew J, et al. (2005) Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor. Mol Cancer Ther 4: 641-649.
    • (2005) Mol Cancer Ther , vol.4 , pp. 641-649
    • McKillop, D.1    Partridge, E.A.2    Kemp, J.V.3    Spence, M.P.4    Kendrew, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.