Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo

Neuro-Oncology

Volumn 7, Issue 3, 2005, Pages 236-245

  Arcella, Antonietta ^a   Carpinelli, Giulia ^b   Battaglia, Giuseppe ^a   D'Onofrio, Mara ^a,d   Santoro, Filippo ^b   Ngomba, Richard Teke ^a   Bruno, Valeria ^a,c   Casolini, Paola ^c   Giangaspero, Felice ^a,c   Nicoletti, Ferdinando ^a,c  

^a IRCCS NEUROMED   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

Author keywords

Antagonist; Glioma; Glutamate; Growth; MRI; Tumor

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; ALPHA ETHYLGLUTAMATE; ALPHA METHYL 4 TETRAZOLYLPHENYLGLYCINE; CYCLIN D1; CYCLIN D2; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR ANTAGONIST; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GRAFT; CANCER GROWTH; CANCER INHIBITION; CAUDATE NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUDE MOUSE; PROTEIN EXPRESSION; RECEPTOR BLOCKING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACIDS; ANIMALS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; CYCLINS; ENZYME ACTIVATION; EXCITATORY AMINO ACID ANTAGONISTS; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MAGNETIC RESONANCE IMAGING; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; RECEPTORS, METABOTROPIC GLUTAMATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; XANTHENES;

EID: 23144433297     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1215/S1152851704000961     Document Type: Article

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