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Volumn 47, Issue 1, 2000, Pages 11-22

Extracellular glutamate and other metabolites in and around RG2 rat glioma: An intracerebral microdialysis study

Author keywords

Amino acids; Glucose; Glutamate; In vivo microdialysis; Lactate; Rat glioma

Indexed keywords

ALANINE; ANTIOXIDANT; ARGININE; ASCORBIC ACID; ASPARTIC ACID; CITRULLINE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; LACTIC ACID; SERINE; TAURINE; THREONINE; TYROSINE; URIC ACID;

EID: 0033909858     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006426917654     Document Type: Article
Times cited : (83)

References (64)
  • 2
    • 0030774899 scopus 로고    scopus 로고
    • Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells
    • Klegeris A, Walker DG, McGeer PL: Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells. J Neuroimmunol 78: 152-161, 1997
    • (1997) J Neuroimmunol , vol.78 , pp. 152-161
    • Klegeris, A.1    Walker, D.G.2    McGeer, P.L.3
  • 3
    • 0343947821 scopus 로고    scopus 로고
    • Excitotoxicity of glutamate released from human glioma cells in vitro
    • Sontheimer H, Ye Z-C: Excitotoxicity of glutamate released from human glioma cells in vitro. Soc Neurosci Abstr 24: 179.5, 1998
    • (1998) Soc Neurosci Abstr , vol.24 , pp. 1795
    • Sontheimer, H.1    Ye, Z.-C.2
  • 4
    • 0028034176 scopus 로고
    • Levels of water-soluble antioxidants in astrocytoma and in adjacent tumor-free tissue
    • Landolt H, Langemann H, Probst A, Gratzl O: Levels of water-soluble antioxidants in astrocytoma and in adjacent tumor-free tissue. J Neuro-Oncol 21: 127-133, 1994
    • (1994) J Neuro-Oncol , vol.21 , pp. 127-133
    • Landolt, H.1    Langemann, H.2    Probst, A.3    Gratzl, O.4
  • 5
    • 0015406462 scopus 로고
    • Isogenic transplantation of ethylnitrosourea-induced tumors of the central and peripheral nervous system in two different inbred rat strains
    • Wechsler W, Ramadan MA, Gieseler A: Isogenic transplantation of ethylnitrosourea-induced tumors of the central and peripheral nervous system in two different inbred rat strains. Naturwissenschaften 59: 474, 1972
    • (1972) Naturwissenschaften , vol.59 , pp. 474
    • Wechsler, W.1    Ramadan, M.A.2    Gieseler, A.3
  • 6
    • 0018887347 scopus 로고
    • Morphological characterization of nitrosourea-induced glioma cell lines and clones
    • Berl
    • Ko L, Koestner A, Wechsler W: Morphological characterization of nitrosourea-induced glioma cell lines and clones. Acta Neuropathol (Berl) 51: 23-31, 1980
    • (1980) Acta Neuropathol , vol.51 , pp. 23-31
    • Ko, L.1    Koestner, A.2    Wechsler, W.3
  • 7
    • 0018928344 scopus 로고
    • Characterization of cell cycle and biological parameters of transplantable glioma cell lines and clones
    • Berl
    • Ko L, Koestner A, Wechsler W: Characterization of cell cycle and biological parameters of transplantable glioma cell lines and clones. Acta Neuropathol (Berl) 51: 107-111, 1980
    • (1980) Acta Neuropathol , vol.51 , pp. 107-111
    • Ko, L.1    Koestner, A.2    Wechsler, W.3
  • 9
    • 0032583783 scopus 로고    scopus 로고
    • Changes in blood-brain barrier permeability following neurotoxic lesions of rat brain can be visualised with trypan blue
    • Reynolds DS, Morton AJ: Changes in blood-brain barrier permeability following neurotoxic lesions of rat brain can be visualised with trypan blue. J Neurosci Meth 79: 115-121, 1998
    • (1998) J Neurosci Meth , vol.79 , pp. 115-121
    • Reynolds, D.S.1    Morton, A.J.2
  • 10
    • 0022472330 scopus 로고
    • In vivo measurement of regional brain and tumor pH using [14C]dimethyloxazolidinedione and quantitative autoradiography. II: Characterization of the extracellular fluid compartment using pH-sensitive microelectrodes and [14C]sucrose
    • Arnold JB, Kraig RP, Rottenberg DA: In vivo measurement of regional brain and tumor pH using [14C]dimethyloxazolidinedione and quantitative autoradiography. II: Characterization of the extracellular fluid compartment using pH-sensitive microelectrodes and [14C]sucrose. J Cereb Blood Flow Metab 6: 435-440, 1986
    • (1986) J Cereb Blood Flow Metab , vol.6 , pp. 435-440
    • Arnold, J.B.1    Kraig, R.P.2    Rottenberg, D.A.3
  • 11
    • 0342641794 scopus 로고
    • Mass transfer in brain dialysis devices - A new method for the estimation of extracellular amino acids concentration
    • Jacobson I, Sandberg M, Hamberger A: Mass transfer in brain dialysis devices - a new method for the estimation of extracellular amino acids concentration. J Neurochem 52: 1741-1750, 1985
    • (1985) J Neurochem , vol.52 , pp. 1741-1750
    • Jacobson, I.1    Sandberg, M.2    Hamberger, A.3
  • 12
    • 0021284732 scopus 로고
    • Measurement of free amino acids in human biological fluids by high-performance liquid chromatography
    • Godel H, Graser T, Foldi P, Furst P: Measurement of free amino acids in human biological fluids by high-performance liquid chromatography. J Chromatogr 297: 49-61, 1984
    • (1984) J Chromatogr , vol.297 , pp. 49-61
    • Godel, H.1    Graser, T.2    Foldi, P.3    Furst, P.4
  • 13
    • 0022426930 scopus 로고
    • An ultra rapid and sensitive high-performance liquid chromatographic method for determination of tissue and plasma free amino acids
    • Graser T, Godel HG, Albers S, Foldi P, Furst P: An ultra rapid and sensitive high-performance liquid chromatographic method for determination of tissue and plasma free amino acids. Anal Biochem 151: 142-152, 1985
    • (1985) Anal Biochem , vol.151 , pp. 142-152
    • Graser, T.1    Godel, H.G.2    Albers, S.3    Foldi, P.4    Furst, P.5
  • 15
    • 0031776473 scopus 로고    scopus 로고
    • Rat brain tumor models in experimental neurooncology: The 9L, C6, F98 RG2 (D74), RT-2 and CNS-1 gliomas
    • Barth R: Rat brain tumor models in experimental neurooncology: the 9L, C6, F98 RG2 (D74), RT-2 and CNS-1 gliomas. J Neuro-Oncol 36: 91-102, 1998
    • (1998) J Neuro-Oncol , vol.36 , pp. 91-102
    • Barth, R.1
  • 19
    • 0029090135 scopus 로고
    • The effects of dexamethasone on experimental brain tumors: I. Transcapillary transport and blood flow in RG-2 rat gliomas
    • Molnar P, Lapin GD, Groothuis DR: The effects of dexamethasone on experimental brain tumors: I. Transcapillary transport and blood flow in RG-2 rat gliomas. J Neuro-Oncol 25: 19-28, 1995
    • (1995) J Neuro-Oncol , vol.25 , pp. 19-28
    • Molnar, P.1    Lapin, G.D.2    Groothuis, D.R.3
  • 21
    • 0024390845 scopus 로고
    • Determination of brain interstitial concentrations by microdialysis
    • Benveniste H, Hansen AJ, Ottosen NS: Determination of brain interstitial concentrations by microdialysis. J Neurochem 52: 1741-1750, 1989
    • (1989) J Neurochem , vol.52 , pp. 1741-1750
    • Benveniste, H.1    Hansen, A.J.2    Ottosen, N.S.3
  • 24
    • 0025052336 scopus 로고
    • The release and uptake of excitatory amino acids
    • Nicholls D, Attwell D: The release and uptake of excitatory amino acids. Trends Pharmacol Sci 11: 462-468, 1990
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 462-468
    • Nicholls, D.1    Attwell, D.2
  • 25
    • 0032032480 scopus 로고    scopus 로고
    • Astrocytes protect neurons from neurotoxic injury by serum glutamate
    • Ye ZC, Sontheimer H: Astrocytes protect neurons from neurotoxic injury by serum glutamate. GLIA 22: 237-248, 1998
    • (1998) GLIA , vol.22 , pp. 237-248
    • Ye, Z.C.1    Sontheimer, H.2
  • 27
    • 0011323738 scopus 로고    scopus 로고
    • Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system
    • Robinson MB, Dowd LA: Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system. Adv Pharmacol 37: 69-115, 1997
    • (1997) Adv Pharmacol , vol.37 , pp. 69-115
    • Robinson, M.B.1    Dowd, L.A.2
  • 28
    • 0031833248 scopus 로고    scopus 로고
    • Molecular pharmacology and physiology of glutamate transporters in the central nervous system
    • Vandenberg RA: Molecular pharmacology and physiology of glutamate transporters in the central nervous system. Clin Exp Pharmacol Physiol 25: 393-400, 1998
    • (1998) Clin Exp Pharmacol Physiol , vol.25 , pp. 393-400
    • Vandenberg, R.A.1
  • 29
    • 0029984610 scopus 로고    scopus 로고
    • Rat C6 and human astrocytic tumor cells express a neuronal type of glutamate transporter
    • Palos TP, Ramachandran B, Boado R, Howard BD: Rat C6 and human astrocytic tumor cells express a neuronal type of glutamate transporter. Brain Res 37: 297-303, 1996
    • (1996) Brain Res , vol.37 , pp. 297-303
    • Palos, T.P.1    Ramachandran, B.2    Boado, R.3    Howard, B.D.4
  • 30
    • 0032053985 scopus 로고    scopus 로고
    • Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma
    • Davis KE, Straff DA, Weinstein EA, Bannerman PG, Correale DM, Rothstein JD, Robinson MB: Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. J Neurosci 18: 2475-2485, 1998
    • (1998) J Neurosci , vol.18 , pp. 2475-2485
    • Davis, K.E.1    Straff, D.A.2    Weinstein, E.A.3    Bannerman, P.G.4    Correale, D.M.5    Rothstein, J.D.6    Robinson, M.B.7
  • 31
    • 0343947810 scopus 로고    scopus 로고
    • Evaluation of 1-glutamate transport in the human astrocytoma cell lines U87, U118, U138 and U373
    • Dunlop J, Lou Z, and McIlvain HB: Evaluation of 1-glutamate transport in the human astrocytoma cell lines U87, U118, U138 and U373. Soc Neurosci Abstr 24: 826.6, 1998
    • (1998) Soc Neurosci Abstr , vol.24 , pp. 8266
    • Dunlop, J.1    Lou, Z.2    McIlvain, H.B.3
  • 32
    • 0025570260 scopus 로고
    • Uptake of glutamate and cysteine in C-6 glioma cells and in cultured astrocytes
    • Cho Y, Bannai S: Uptake of glutamate and cysteine in C-6 glioma cells and in cultured astrocytes. J Neurochem 55: 2091-2097, 1990
    • (1990) J Neurochem , vol.55 , pp. 2091-2097
    • Cho, Y.1    Bannai, S.2
  • 34
    • 0023754192 scopus 로고
    • Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
    • Kleckner NW, Dingledine R: Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science 241: 835-837, 1988
    • (1988) Science , vol.241 , pp. 835-837
    • Kleckner, N.W.1    Dingledine, R.2
  • 35
    • 0017238493 scopus 로고
    • Amino acid assignment to one of three blood-brain barrier amino acid carriers
    • Oldendorf WH, Szabo J: Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am J Physiol 230: 94-98, 1976
    • (1976) Am J Physiol , vol.230 , pp. 94-98
    • Oldendorf, W.H.1    Szabo, J.2
  • 36
    • 0029884574 scopus 로고    scopus 로고
    • Glutamate is transported across the rat blood-brain barrier by a sodium-independent system
    • Benrabh H, Lefauconnier JM: Glutamate is transported across the rat blood-brain barrier by a sodium-independent system. Neurosci Lett 210: 9-12, 1996
    • (1996) Neurosci Lett , vol.210 , pp. 9-12
    • Benrabh, H.1    Lefauconnier, J.M.2
  • 37
    • 0031239010 scopus 로고    scopus 로고
    • Brain metabolism of branched-chain amino acids
    • Yudkoff M: Brain metabolism of branched-chain amino acids. GLIA 21: 92-98, 1997
    • (1997) GLIA , vol.21 , pp. 92-98
    • Yudkoff, M.1
  • 38
    • 0029059287 scopus 로고
    • Regional brain glutamate transport in rats at normal and raised concentrations of circulating glutamate
    • Hawkins RA, DeJoseph MR, Hawkins PA: Regional brain glutamate transport in rats at normal and raised concentrations of circulating glutamate. Cell Tissue Res 281: 207-214, 1995
    • (1995) Cell Tissue Res , vol.281 , pp. 207-214
    • Hawkins, R.A.1    DeJoseph, M.R.2    Hawkins, P.A.3
  • 39
    • 0026326378 scopus 로고
    • Blood flow and blood-to-tissue transport in 9L gliosarcomas: The role of the brain tumor model in drug delivery research
    • Fross RD, Warnke PC, Groothuis DR: Blood flow and blood-to-tissue transport in 9L gliosarcomas: the role of the brain tumor model in drug delivery research. J Neuro-Oncol 11: 185-197, 1991
    • (1991) J Neuro-Oncol , vol.11 , pp. 185-197
    • Fross, R.D.1    Warnke, P.C.2    Groothuis, D.R.3
  • 41
    • 0026666213 scopus 로고
    • Capillary NMDA receptors regulate blood-brain barrier function and breakdown
    • Koenig H, Trout JJ, Goldstone AD, Lu CY: Capillary NMDA receptors regulate blood-brain barrier function and breakdown. Brain Res 588: 297-303, 1992
    • (1992) Brain Res , vol.588 , pp. 297-303
    • Koenig, H.1    Trout, J.J.2    Goldstone, A.D.3    Lu, C.Y.4
  • 42
    • 0027275979 scopus 로고
    • Blockade of AMPA receptors reduces brain edema following opening of the blood-brain barrier
    • Westergren I, Johansson BB: Blockade of AMPA receptors reduces brain edema following opening of the blood-brain barrier. J Cereb Blood Flow Metab 13: 603-608, 1993
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 603-608
    • Westergren, I.1    Johansson, B.B.2
  • 43
    • 0028009515 scopus 로고
    • Concentrations of amino acids in extracellular fluid after opening of the blood-brain barrier by intracarotid infusion of protamine sulfate
    • Westergren I, Nystrom B, Hamberger A, Nordborg C, Johansson BB: Concentrations of amino acids in extracellular fluid after opening of the blood-brain barrier by intracarotid infusion of protamine sulfate. J Neurochem 62: 159-165, 1994
    • (1994) J Neurochem , vol.62 , pp. 159-165
    • Westergren, I.1    Nystrom, B.2    Hamberger, A.3    Nordborg, C.4    Johansson, B.B.5
  • 44
    • 0029879746 scopus 로고    scopus 로고
    • Glutamate-induced disruption of the blood-brain barrier in rats. Role of nitric oxide
    • Mayhan WG, Didion SP: Glutamate-induced disruption of the blood-brain barrier in rats. Role of nitric oxide. Stroke 27: 965-969, 1996
    • (1996) Stroke , vol.27 , pp. 965-969
    • Mayhan, W.G.1    Didion, S.P.2
  • 45
    • 0029988688 scopus 로고    scopus 로고
    • NMDA- and endothelin-1-induced increases in blood-brain barrier permeability quantitated with Lucifer yellow
    • Miller RD, Monsul NT, Vender JR, Lehmann JC: NMDA- and endothelin-1-induced increases in blood-brain barrier permeability quantitated with Lucifer yellow. J Neurol Sci 136: 37-40, 1996
    • (1996) J Neurol Sci , vol.136 , pp. 37-40
    • Miller, R.D.1    Monsul, N.T.2    Vender, J.R.3    Lehmann, J.C.4
  • 47
    • 0032583237 scopus 로고    scopus 로고
    • Lack of evidence for direct involvement of NMDA receptors or polyamines in blood-brain barrier injury after cerebral ischemia in rats
    • Preston E, Webster J, Palmer GC: Lack of evidence for direct involvement of NMDA receptors or polyamines in blood-brain barrier injury after cerebral ischemia in rats. Brain Res 813: 191-194, 1998
    • (1998) Brain Res , vol.813 , pp. 191-194
    • Preston, E.1    Webster, J.2    Palmer, G.C.3
  • 48
    • 0028932763 scopus 로고
    • Astrocytic swelling due to hypotonie or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release
    • Kimelberg HK, Rutledge E, Goderie S, Charniga C: Astrocytic swelling due to hypotonie or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release. J Cereb Blood Flow Metab 15: 409-416, 1995
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 409-416
    • Kimelberg, H.K.1    Rutledge, E.2    Goderie, S.3    Charniga, C.4
  • 49
    • 0029588463 scopus 로고
    • Current concepts of brain edema. Review of laboratory investigations
    • Kimelberg HK: Current concepts of brain edema. Review of laboratory investigations. J Neurosurg 83: 1051-1059, 1995
    • (1995) J Neurosurg , vol.83 , pp. 1051-1059
    • Kimelberg, H.K.1
  • 51
    • 0030028586 scopus 로고    scopus 로고
    • Simultaneous measurement of salicylate hydroxylation and glutamate release in the penumbral cortex following transient middle cerebral artery occlusion in rats
    • Morimoto T, Globus MY, Busto R, Martinez E, Ginsberg MD: Simultaneous measurement of salicylate hydroxylation and glutamate release in the penumbral cortex following transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 16: 92-99, 1996
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 92-99
    • Morimoto, T.1    Globus, M.Y.2    Busto, R.3    Martinez, E.4    Ginsberg, M.D.5
  • 54
    • 0028271350 scopus 로고
    • Glutamate-mediated injury in focal cerebral ischemia: The excitotoxin hypothesis revised
    • Hossmann KA: Glutamate-mediated injury in focal cerebral ischemia: the excitotoxin hypothesis revised. Brain Pathol 4: 23-36, 1994
    • (1994) Brain Pathol , vol.4 , pp. 23-36
    • Hossmann, K.A.1
  • 55
    • 0028535070 scopus 로고
    • The role of glutamate in epilepsy and other CNS disorders
    • Meldrum BS: The role of glutamate in epilepsy and other CNS disorders. Neurology 44: S14-S23, 1994
    • (1994) Neurology , vol.44
    • Meldrum, B.S.1
  • 56
    • 0030569028 scopus 로고    scopus 로고
    • Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER)
    • Kanda T, Kurokawa M, Tamura S, Nakamura J, Ishii A, Kuwana Y, Serikawa T, Yamada J, Ishihara K, Sasa M: Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER). Life Sci 59: 1607-1616, 1996
    • (1996) Life Sci , vol.59 , pp. 1607-1616
    • Kanda, T.1    Kurokawa, M.2    Tamura, S.3    Nakamura, J.4    Ishii, A.5    Kuwana, Y.6    Serikawa, T.7    Yamada, J.8    Ishihara, K.9    Sasa, M.10
  • 58
    • 0024389770 scopus 로고
    • Effects of microdialysis-perfusion with anisoosmotic media on extracellular amino acids in the rat hippocampus and skeletal muscle
    • Lehmann A: Effects of microdialysis-perfusion with anisoosmotic media on extracellular amino acids in the rat hippocampus and skeletal muscle. J Neurochem 53: 525-535, 1989
    • (1989) J Neurochem , vol.53 , pp. 525-535
    • Lehmann, A.1
  • 59
    • 0029893380 scopus 로고    scopus 로고
    • Taurine as osmoregulator and neuro-modulator in the brain
    • Oja SS, Saransaari P: Taurine as osmoregulator and neuro-modulator in the brain. Metab Brain Dis 11: 153-164, 1996
    • (1996) Metab Brain Dis , vol.11 , pp. 153-164
    • Oja, S.S.1    Saransaari, P.2
  • 61
    • 0030207099 scopus 로고    scopus 로고
    • Relationships among lactate concentration, blood flow and histopathologic profiles in rat C6 glioma
    • Terpstra M, High WB, Luo Y, de Graaf RA, Merkle H, Garwood M: Relationships among lactate concentration, blood flow and histopathologic profiles in rat C6 glioma. NMR Biomed 9: 185-194, 1996
    • (1996) NMR Biomed , vol.9 , pp. 185-194
    • Terpstra, M.1    High, W.B.2    Luo, Y.3    De Graaf, R.A.4    Merkle, H.5    Garwood, M.6
  • 62
    • 0030763027 scopus 로고    scopus 로고
    • Gliomas are driven by glycolysis: Putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure
    • Oudard S, Boitier E, Miccoli L, Rousset S, Dutrillaux B, Poupon MF: Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure. Anticancer Res 17: 1903-1911, 1997
    • (1997) Anticancer Res , vol.17 , pp. 1903-1911
    • Oudard, S.1    Boitier, E.2    Miccoli, L.3    Rousset, S.4    Dutrillaux, B.5    Poupon, M.F.6
  • 63
    • 0031302533 scopus 로고    scopus 로고
    • The origin of lactate in peritumoral edema as measured by proton magnetic resonance spectroscopic imaging
    • Wien
    • Go KG, Krikke AP, Kamman RL, Heesters MA: The origin of lactate in peritumoral edema as measured by proton magnetic resonance spectroscopic imaging. Acta Neurochir Suppl (Wien) 70: 173-175, 1997
    • (1997) Acta Neurochir Suppl , vol.70 , pp. 173-175
    • Go, K.G.1    Krikke, A.P.2    Kamman, R.L.3    Heesters, M.A.4
  • 64
    • 0031041053 scopus 로고    scopus 로고
    • Inhibition of lactate export by quercetin acidifies rat glial cells in vitro
    • Volk C, Kempski B, Kempski OS: Inhibition of lactate export by quercetin acidifies rat glial cells in vitro. Neurosci Lett 223: 121-124, 1997
    • (1997) Neurosci Lett , vol.223 , pp. 121-124
    • Volk, C.1    Kempski, B.2    Kempski, O.S.3


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