-
1
-
-
0035256772
-
Gliomagenesis: Genetic alterations and mouse models
-
Holland EC. Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2001;2:120-9.
-
(2001)
Nat Rev Genet
, vol.2
, pp. 120-129
-
-
Holland, E.C.1
-
2
-
-
0642336108
-
Glioblastoma multiforme: Introduction
-
Markert J. Glioblastoma multiforme: introduction. Cancer J 2003;9:148.
-
(2003)
Cancer J
, vol.9
, pp. 148
-
-
Markert, J.1
-
3
-
-
0038179723
-
Cost of migration: Invasion of malignant gliomas and implications for treatment
-
Giese A, Bjerkvig R, Berens ME, Westphal M. Cost of migration: invasion of malignant gliomas and implications for treatment. J Clin Oncol 2003;21:1624-36.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1624-1636
-
-
Giese, A.1
Bjerkvig, R.2
Berens, M.E.3
Westphal, M.4
-
4
-
-
0032477606
-
-
Haklai R, Gana-Weisz M, Elad G, et al. Dislodgment and accelerated degradation of Ras. Biochemistry 1998;37:1306-14.
-
Haklai R, Gana-Weisz M, Elad G, et al. Dislodgment and accelerated degradation of Ras. Biochemistry 1998;37:1306-14.
-
-
-
-
5
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature 1993;366:643-54.
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
6
-
-
0035844149
-
Differential activation of the Rac pathway by Ha-Ras and K-Ras
-
Walsh AB, Bar-Sagi D. Differential activation of the Rac pathway by Ha-Ras and K-Ras. J Biol Chem 2001;276:15609-15.
-
(2001)
J Biol Chem
, vol.276
, pp. 15609-15615
-
-
Walsh, A.B.1
Bar-Sagi, D.2
-
7
-
-
0030052368
-
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
-
Joneson T, White MA, Wigler MH, Bar Sagi D. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 1996;271:810-2.
-
(1996)
Science
, vol.271
, pp. 810-812
-
-
Joneson, T.1
White, M.A.2
Wigler, M.H.3
Bar Sagi, D.4
-
8
-
-
0031936353
-
Ras signalling and apoptosis
-
Downward J. Ras signalling and apoptosis. Curr Opin Genet Dev 1998;8:49-54.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 49-54
-
-
Downward, J.1
-
9
-
-
0032493812
-
Increasing complexity of the Ras signaling pathway
-
Vojtek AB, Der CJ. Increasing complexity of the Ras signaling pathway. J Biol Chem 1998;273:19925-8.
-
(1998)
J Biol Chem
, vol.273
, pp. 19925-19928
-
-
Vojtek, A.B.1
Der, C.J.2
-
10
-
-
0028241533
-
Activation of Raf as a result of recruitment to the plasma membrane
-
Stokoe D, Macdonald SG, Cadwallader K, Symons M, Hancock JF. Activation of Raf as a result of recruitment to the plasma membrane. Science 1994;264:1463-7.
-
(1994)
Science
, vol.264
, pp. 1463-1467
-
-
Stokoe, D.1
Macdonald, S.G.2
Cadwallader, K.3
Symons, M.4
Hancock, J.F.5
-
11
-
-
0028272507
-
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
-
Leevers SJ, Paterson HF, Marshall CJ. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 1994;369:411-4.
-
(1994)
Nature
, vol.369
, pp. 411-414
-
-
Leevers, S.J.1
Paterson, H.F.2
Marshall, C.J.3
-
12
-
-
0028074316
-
-
Rodriguez-Viciana P, Warne PH, Dhand R, et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 1994;370:527-32.
-
Rodriguez-Viciana P, Warne PH, Dhand R, et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 1994;370:527-32.
-
-
-
-
13
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-7.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
14
-
-
0033029811
-
Ras caught in another affair: The exchange factors for Ral
-
Wolthuis RM, Bos JL. Ras caught in another affair: the exchange factors for Ral. Curr Opin Genet Dev 1999;9:112-7.
-
(1999)
Curr Opin Genet Dev
, vol.9
, pp. 112-117
-
-
Wolthuis, R.M.1
Bos, J.L.2
-
15
-
-
0041846652
-
Ral-GTPases: Approaching their 15 minutes of fame
-
Feig LA. Ral-GTPases: approaching their 15 minutes of fame. Trends Cell Biol 2003;13:419-25.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 419-425
-
-
Feig, L.A.1
-
16
-
-
27844604200
-
GTPases and the control of cell behaviour
-
Hall A. Rho GTPases and the control of cell behaviour. Biochem Soc Trans 2005;33:891-5.
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 891-895
-
-
Rho, H.A.1
-
17
-
-
0024376173
-
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
-
-
-
-
18
-
-
0031465906
-
Proliferation of human malignant astrocytomas is dependent on Ras activation
-
Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 1997;15:2755-65.
-
(1997)
Oncogene
, vol.15
, pp. 2755-2765
-
-
Guha, A.1
Feldkamp, M.M.2
Lau, N.3
Boss, G.4
Pawson, A.5
-
19
-
-
13444283313
-
Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1α, causing glycolysis shutdown and cell death
-
Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G, Kloog Y. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1α, causing glycolysis shutdown and cell death. Cancer Res 2005;65:999-1006.
-
(2005)
Cancer Res
, vol.65
, pp. 999-1006
-
-
Blum, R.1
Jacob-Hirsch, J.2
Amariglio, N.3
Rechavi, G.4
Kloog, Y.5
-
20
-
-
33745472798
-
E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition
-
Blum R, Nakdimon I, Goldberg L, Shamir R, Rechavi G, Kloog Y. E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition. Int J Cancer 2006;119:527-38.
-
(2006)
Int J Cancer
, vol.119
, pp. 527-538
-
-
Blum, R.1
Nakdimon, I.2
Goldberg, L.3
Shamir, R.4
Rechavi, G.5
Kloog, Y.6
-
21
-
-
0028959539
-
Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth
-
Marciano D, Ben-Baruch G, Marom M, Egozi Y, Haklai R, Kloog Y. Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. J Med Chem 1995;38:1267-72.
-
(1995)
J Med Chem
, vol.38
, pp. 1267-1272
-
-
Marciano, D.1
Ben-Baruch, G.2
Marom, M.3
Egozi, Y.4
Haklai, R.5
Kloog, Y.6
-
22
-
-
32144442590
-
In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization
-
Etienne-Manneville S. In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization. Methods Enzymol 2006;406:565-78.
-
(2006)
Methods Enzymol
, vol.406
, pp. 565-578
-
-
Etienne-Manneville, S.1
-
23
-
-
0031055415
-
-
de Rooij J, Bos JL. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 1997;14:623-5.
-
de Rooij J, Bos JL. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 1997;14:623-5.
-
-
-
-
24
-
-
0031944085
-
Activation of the small GTPase Ral in platelets
-
Wolthuis RM, Franke B, van Triest M, et al. Activation of the small GTPase Ral in platelets. Mol Cell Biol 1998;18:2486-91.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2486-2491
-
-
Wolthuis, R.M.1
Franke, B.2
van Triest, M.3
-
25
-
-
0033531955
-
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
-
Benard V, Bohl BP, Bokoch GM. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem 1999;274:13198-204.
-
(1999)
J Biol Chem
, vol.274
, pp. 13198-13204
-
-
Benard, V.1
Bohl, B.P.2
Bokoch, G.M.3
-
26
-
-
33645516549
-
PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility
-
Fiordalisi JJ, Keller PJ, Cox AD. PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. Cancer Res 2006;66:3153-61.
-
(2006)
Cancer Res
, vol.66
, pp. 3153-3161
-
-
Fiordalisi, J.J.1
Keller, P.J.2
Cox, A.D.3
-
27
-
-
33749576587
-
Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis
-
Blum R, Jacob-Hirsch J, Rechavi G, Kloog Y. Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis. Mol Cancer Ther 2006;5:2337-47.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2337-2347
-
-
Blum, R.1
Jacob-Hirsch, J.2
Rechavi, G.3
Kloog, Y.4
-
28
-
-
0742306777
-
Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor
-
Shalom-Feuerstein R, Lindenboim L, Stein R, Cox AD, Kloog Y. Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor. Cell Death Differ 2004;11:244-7.
-
(2004)
Cell Death Differ
, vol.11
, pp. 244-247
-
-
Shalom-Feuerstein, R.1
Lindenboim, L.2
Stein, R.3
Cox, A.D.4
Kloog, Y.5
-
29
-
-
0036051325
-
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
-
Lambert JM, Lambert QT, Reuther GW, et al. Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol 2002;4:621-5.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 621-625
-
-
Lambert, J.M.1
Lambert, Q.T.2
Reuther, G.W.3
-
30
-
-
0033575885
-
-
Scita G, Nordstrom J, Carbone R, et al. EPS8 and E3B1 transduce signals from Ras to Rac. Nature 1999;401:290-3.
-
Scita G, Nordstrom J, Carbone R, et al. EPS8 and E3B1 transduce signals from Ras to Rac. Nature 1999;401:290-3.
-
-
-
-
31
-
-
0029588356
-
A putative effector of Ral has homology to Rho/Rac GTPase activating proteins
-
Park SH, Weinberg RA. A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene 1995;11:2349-55.
-
(1995)
Oncogene
, vol.11
, pp. 2349-2355
-
-
Park, S.H.1
Weinberg, R.A.2
-
32
-
-
25444528940
-
Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1
-
Salhia B, Rutten F, Nakada M, et al. Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1. Cancer Res 2005;65:8792-800.
-
(2005)
Cancer Res
, vol.65
, pp. 8792-8800
-
-
Salhia, B.1
Rutten, F.2
Nakada, M.3
-
33
-
-
0033577975
-
Interplay between Rac and Rho in the control of substrate contact dynamics
-
Rottner K, Hall A, Small JV. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol 1999;9:640-8.
-
(1999)
Curr Biol
, vol.9
, pp. 640-648
-
-
Rottner, K.1
Hall, A.2
Small, J.V.3
-
34
-
-
0033531237
-
A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival
-
Moorman JP, Luu D, Wickham J, Bobak DA, Hahn CS. A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival. Oncogene 1999;18:47-57.
-
(1999)
Oncogene
, vol.18
, pp. 47-57
-
-
Moorman, J.P.1
Luu, D.2
Wickham, J.3
Bobak, D.A.4
Hahn, C.S.5
-
35
-
-
0033529620
-
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
-
Maekawa M, Ishizaki T, Boku S, et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 1999;285:895-8.
-
(1999)
Science
, vol.285
, pp. 895-898
-
-
Maekawa, M.1
Ishizaki, T.2
Boku, S.3
-
36
-
-
0345731237
-
Cell migration: Rho GTPases lead the way
-
Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004;265:23-32.
-
(2004)
Dev Biol
, vol.265
, pp. 23-32
-
-
Raftopoulou, M.1
Hall, A.2
-
37
-
-
33646552096
-
Role of vinculin in regulating focal adhesion turnover
-
Saunders RM, Holt MR, Jennings L, et al. Role of vinculin in regulating focal adhesion turnover. Eur J Cell Biol 2006;185:487-500.
-
(2006)
Eur J Cell Biol
, vol.185
, pp. 487-500
-
-
Saunders, R.M.1
Holt, M.R.2
Jennings, L.3
-
38
-
-
27644570788
-
Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397
-
Hamadi A, Bouali M, Dontenwill M, Stoeckel H, Takeda K, Ronde P. Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397. J Cell Sci 2005;118:4415-25.
-
(2005)
J Cell Sci
, vol.118
, pp. 4415-4425
-
-
Hamadi, A.1
Bouali, M.2
Dontenwill, M.3
Stoeckel, H.4
Takeda, K.5
Ronde, P.6
-
39
-
-
33645238619
-
Dominant-negative Rac increases both inherent and ionizing radiation-induced cell migration in C6 rat glioma cells
-
Hwang SY, Jung JW, Jeong JS, et al. Dominant-negative Rac increases both inherent and ionizing radiation-induced cell migration in C6 rat glioma cells. Int J Cancer 2006;118:2056-63.
-
(2006)
Int J Cancer
, vol.118
, pp. 2056-2063
-
-
Hwang, S.Y.1
Jung, J.W.2
Jeong, J.S.3
-
40
-
-
33644815892
-
Tailoring Ras-pathway-inhibitor combinations fo cancer therapy
-
Blum R, Kloog Y. Tailoring Ras-pathway-inhibitor combinations fo cancer therapy. Drug Resist Updat 2005;8:369-80.
-
(2005)
Drug Resist Updat
, vol.8
, pp. 369-380
-
-
Blum, R.1
Kloog, Y.2
-
41
-
-
12344318372
-
Context, tissue plasticity, and cancer: Are tumor stem cells also regulated by the microenvironment?
-
Bissell MJ, Labarge MA. Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment? Cancer Cell 2005;7:17-23.
-
(2005)
Cancer Cell
, vol.7
, pp. 17-23
-
-
Bissell, M.J.1
Labarge, M.A.2
-
42
-
-
20444438759
-
Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest
-
Yaari S, Jacob-Hirsch J, Amariglio N, Haklai R, Rechavi G, Kloog Y. Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest. Clin Cancer Res 2005;11:4321-30.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4321-4330
-
-
Yaari, S.1
Jacob-Hirsch, J.2
Amariglio, N.3
Haklai, R.4
Rechavi, G.5
Kloog, Y.6
-
44
-
-
0038796537
-
The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model
-
Shohami E, Yatsiv I, Alexandrovich A, et al. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. J Cereb Blood Flow Metab 2003;23:728-38.
-
(2003)
J Cereb Blood Flow Metab
, vol.23
, pp. 728-738
-
-
Shohami, E.1
Yatsiv, I.2
Alexandrovich, A.3
|