In situ visualization of intratumor growth factor signaling: Immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms

American Journal of Pathology

Volumn 153, Issue 5, 1998, Pages 1411-1423

  Mandell, James W ^a   Hussaini, Isa M ^a   Zecevic, Maja ^a   Weber, Michael J ^a   VandenBerg, Scott R ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

ARTICLE; ASTROCYTOMA; CELL CYCLE G0 PHASE; CELL POPULATION; CONTROLLED STUDY; ENZYME ACTIVATION; GLIOMA; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; OLIGODENDROGLIOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0031769940     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65728-8     Document Type: Article

References (44)

1. VandenBerg SR: Current diagnostic concepts of astrocytic tumors. J Neuropathol Exp Neurol 1992, 51:644-657
2. Louis DN: A molecular genetic model of astrocytoma histopathology. Brain Pathol 1997, 7:755-764
3. Fuller GN, Bigner SH: Amplified cellular oncogenes in neoplasms of the human central nervous system. Mutation Res 1992, 276:299-306
4. Nishikawa R, Ji XD, Harmon RC, Lazar CS, Gill GN, Cavenee WK, Huang HJ: A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA 1994, 91:7727-7731
5. Guha A, Dashner K, Black PM, Wagner JA, Stiles CD: Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer 1995, 60:168-173
6. Ohgaki H, Schauble B, zur Hausen A, von Ammon K, Kleihues P: Genetic alterations associated with the evolution and progression of astrocytic brain tumours. Virchows Arch 1995, 427:113-118
7. Westermark B, Nister M: Molecular genetics of human glioma. Curr Opin Oncol 1995, 7:220-225
8. Hermanson M, Funa K, Koopmann J, Maintz D, Waha A, Westermark B, Heldin CH, Wiestler OD, Louis DN, von Deimling A, Nister M: Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor α receptor expression in human malignant gliomas. Cancer Res 1996, 56:164-171
9. Ambrose D, Resnicoff M, Coppola D, Sell C, Miura M, Jameson S, Baserga R, Rubin R: Growth regulation of human glioblastoma T98G cells by insulin-like growth factor-1 and its receptor. J Cell Physiol 1994, 159:92-100
10. Cobb MH, Hepler JE, Cheng M, Robbins D: The mitogen-activated protein kinases, ERK1 and ERK2. Semin Cancer Biol 1994, 5:261-268
11. Marshall CJ: ERK/MAP kinase kinase kinase, ERK/MAP kinase kinase, and ERK/MAP kinase. Curr Opin Genet Dev 1994, 4:82-89
12. Seger R, Krebs EG: The MAPK signaling cascade. FASEB J 1995, 9:726-735
13. Mitra G, Weber M, Stacey D: Multiple pathways for activation of ERK/MAP kinases. Cell Mol Biol Res 1993, 39:517-523
14. Lopezilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R: Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ. Science 1997, 275:394-397
15. Cowley S, Paterson H, Kemp P, Marshall CJ: Activation of ERK/MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994, 77:841-852
16. Tournier C, Pomerance M, Gavaret JM, Pierre M: ERK/MAP kinase cascade in astrocytes. Glia 1994, 10:81-88
17. Roback JD, Marsh HN, Downen M, Palfrey HC, Wainer BH: BDNF-activated signal transduction in rat cortical glial cells. Eur J Neurosci 1995, 7:849-862
18. Gupta SK, Gallego C, Johnson GL, Heasley LE: ERK/MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. J Biol Chem 1992, 267:7987-7990
19. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, VandeWoude G, Ahn NG: Transformation of mammalian cells by constitutively active ERK/MAP kinase kinase. Science 1994, 265: 966-970
20. Okazaki K, Sagata N: ERK/MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos. Oncogene 1995, 10:1149-1157
21. Oldham SM, Clark GJ, Gangarosa LM, Coffey RJ, Der CJ: Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc Natl Acad Sci USA 1996, 93:6924-6928
22. Oka H, Chatani Y, Hoshino R, Ogawa O, Kakehi Y, Terachi T, Okada Y, Kawaichi M, Kohno M, Yoshida O: Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Cancer Res 1995, 55:4182-4187
23. Sivaraman VS, Wang H, Nuovo GJ, Malbon CC: Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest 1997, 99:1478-1483
24. Davis F, Tsao T, Fowler S, Rao P: Monoclonal antibodies to mitotic cells. Proc Natl Acad Sci USA 1983, 80:2926-2930
25. Mandell JW, Banker GA: A spatial gradient of tau protein phospnorylation in nascent axons. J Neurosci 1996, 16:5727-5740
26. Garver TD, Harris KA, Lehman RA, Lee VM, Trojanowski JQ, Billingsley ML: Tau phosphorylation in human, primate, and rat brain: evidence that a pool of tau is highly phosphorylated in vivo and is rapidly dephosphorylated in vitro. J Neurochem 1994, 63:2279-2287
27. Matsuo ES, Shin RW, Billingsley ML, Van deVoorde A, O'Connor M, Trojanowski JQ, Lee VM: Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 1994, 13:989-1002
28. Smith PF, Keefer DA: Acrolein/glutaraldehyde as a fixative for combined light and electron microscopic immunocytochemical detection of pituitary hormones in immersion-fixed tissue. J Histochem Cytochem 1982, 30:1307-1310
29. Hyman BT, Elvhage TE, Reiter J: Extracellular signal regulated kinases: localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease. Am J Pathol 1994, 144:565-572
30. Westermark B, Heldin CH, Nister M: Platelet-derived growth factor in human gliomas. Glia 1995, 15:257-263
31. Shamah SM, Stiles CD, Guha A: Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol Cell Biol 1993, 13:7203-7212
32. Edwards NA: Insulin-like growth factor-I receptors in human glial tumors. J Clin Endocrinol Metab 1990, 71:199-209
33. Unterman TG, Glick RP, Waites GT, Bell SC: Production of insulin-like growth factor-binding proteins by human central nervous system tumors. Cancer Res 1991, 51:3030-3036
34. Morford LA, Boghaert ER, Brooks WH, Roszman TL: Insulin-like growth factors (IGF) enhance three-dimensional (3D) growth of human glioblastomas. Cancer Lett 115:81-90
35. Hussaini IM, Lopes MBS, Musante DB, Karns LR, VandenBerg SR: Expression of IGF-1 and IGF-1R in reactive astrocytes and astrocytic tumors. J Neuropathol Exp Neurol 1996, 55:606
36. Rosen LB, Ginty DD, Weber MJ, Greenberg ME: Membrane depolarization and calcium influx stimulate MEK and ERK/MAP kinase via activation of Ras. Neuron 1994, 12:1207-1221
37. Silliman CC, Sturgill TW: Phosphorylation of microtubule-associated protein 2 by MAP kinase primarily involves the projection domain. Biochem Biophys Res Commun 1989, 160:993-998
38. Morishima-Kawashima M, Kosik KS: The pool of MAP kinase associated with microtubules is small but constitutively active. Mol Biol Cell 1996, 7:893-905
39. Klemke RL, Cai, Giannini AL, Gallagher PJ, de Lanerolle P, Cheresh DA: Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol 1997, 137:481-492
40. Montgomery RB, Moscatello DK, Wong AJ, Cooper JA, Stahl WL: Differential modulation of mitogen-activated protein (MAP) kinase/ extracellular signal-related kinase kinase and ERK/MAP kinase activities by a mutant epidermal growth factor receptor. J Biol Chem 1995, 270:30562-30566
41. Pelicci G, Lanfrancone L, Salcini AE, Romano A, Mele S, Grazia BM, Segatto O, Di Fiore P, Pelicci PG: Constitutive phosphorylation of Shc proteins in human tumors. Oncogene 1995, 11:899-907
42. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, Mccombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947
43. Steck PA, Pershouse MA, Jasser SA, Yung W, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng D, Tavtigian SV: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nature Genet 1997, 15:356-362
44. Lavoie JN, Lallemain G, Brunet A, Muller R, Pouyssegur J: Cyclin D1 expression is regulated positively by the p42/p44(mapk) and negatively by the p38/hog(mapk) pathway. J Biol Chem 1996, 271:20608-20616