Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse

Molecular Neurodegeneration

Volumn 6, Issue 1, 2011, Pages

  Takamura, Ayumi ^a,b   Okamoto, Yasuhide ^a,c   Kawarabayashi, Takeshi ^b   Yokoseki, Tatsuki ^c   Shibata, Masao ^c   Mouri, Akihiko ^d   Nabeshima, Toshitaka ^d   Sun, Hui ^a   Abe, Koji ^e   Urisu, Tsuneo ^f   Yamamoto, Naoki ^a   Shoji, Mikio ^b   Yanagisawa, Katsuhiko ^a   Michikawa, Makoto ^a   Matsubara, Etsuro ^a,b  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

^c Immunas Pharma Incorporation   (Japan)

^d MEIJO UNIVERSITY   (Japan)

^e OKAYAMA UNIVERSITY   (Japan)

^f INSTITUTE FOR MOLECULAR SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; DIMER; HIGH MOLECULAR WEIGH AMYLOID BETA OLIGOMER; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1A9; MONOCLONAL ANTIBODY 2C3; OLIGOMER; TETRAMER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; FEMALE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; NERVE CELL DEGENERATION; NEUROBLASTOMA CELL; NONHUMAN; PERIKARYON; POLYACRYLAMIDE GEL ELECTROPHORESIS; PYRAMIDAL NERVE CELL;

MUS;

EID: 79952196722     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-6-20     Document Type: Article

References (36)

1. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. J Hardy D Allsop, Trends Pharmacol Sci 1991 12 383 388 10.1016/0165-6147(91)90609-V 1763432
2. Soluble amyloid peptide concentration as a predictor of synaptic change in Alzheimer's disease. LF Lue YM Kuo AE Roher L Brachova Y Shen L Sue T Beach JH Kurth RE Rydel J Rogers, Am J Pathol 1999 155 853 862 10.1016/S0002-9440(10) 65184-X 10487842 (Pubitemid 29426831)
3. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. CA McLean RA Cherny FW Fraser SJ Fuller MJ Smith K Beyreuther AI Bush CL Masters, Ann Neurol 1999 46 860 866 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M 10589538
4. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? WL Klein GA Krafft CE Finch, Trends Neurosci 2001 24 219 224 10.1016/S0166-2236(00)01749-5 11250006 (Pubitemid 32204378)
5. Alzheimer's disease is a synaptic failure. DJ Selkoe, Science 2002 298 789 791 10.1126/science.1074069 12399581 (Pubitemid 35231524)
6. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid -peptide. C Hass DJ Selkoe, Nat Rev Mol Cell Biol 2007 8 101 112 10.1038/nrm2101 17245412 (Pubitemid 46432529)
7. Inflammation and Alzheimer's disease. H Akiyama S Barger S Barnum B Bradt J Bauer GM Cole NR Cooper P Eikelenboom M Emmerling BL Fiebich CE Finch S Frautschy WS Griffin H Hampel M Hull G Landreth L Lue R Mrak IR Mackenzie PL McGeer MK O'Banion J Pachter G Pasinetti C Plata-Salaman J Rogers R Rydel Y Shen W Streit R Strohmeyer I Tooyoma FL Van Muiswinkel R Veerhuis D Walker S Webster B Wegrzyniak G Wenk T Wyss-Coray, Neurobiol Aging 2000 21 383 421 10.1016/S0197-4580(00)00124-X 10858586 (Pubitemid 30349107)
8. Alzheimer's disease: the amyloid cascade hypothesis. JA Hardy GA Higgins, Science 1992 256 184 185 10.1126/science.1566067 1566067
9. 1-42 are potent central nervous system neurotoxins. MP Lambert AK Barlow BA Chromy C Edwards R Freed M Liosatos TE Morgan I Rozovsky B Trommer KL Viola P Wals C Zhang CE Finch, Proc Natl Acad Sci USA 1998 95 6448 6453 10.1073/pnas.95.11.6448 9600986
10. Immunization reverses memory deficits without reducing brain A burden in Alzheimer's disease model. JC Dodart KR Bales KS Gannon SJ Greene RB DeMattos C Mathis CA DeLong S Wu X Wu DM Holtzman SM Paul, Nat Neurosci 2002 5 452 457 11941374 (Pubitemid 34454251)
11. 1-42 into globular neurotoxins. BA Chromy RJ Nowak MP Lambert KL Viola L Chang PT Velasco BW Jones SJ Fernandez PN Lacor P Horowitz CE Finch GA Krafft WL Klein, Biochemistry 2003 42 12749 12760 10.1021/bi030029q 14596589
12. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. R Kayed E Head JL Thompson TM Mclntire SC Milton CW Cotman CG Glabe, Science 2003 300 486 489 10.1126/science.1079469 12702875 (Pubitemid 36444329)
13. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. A Bayer RW Jones R Bullock S Love JW Neal E Zotova JA Nicoll, Lancet 2008 372 216 223 10.1016/S0140-6736(08)61075-2 18640458 (Pubitemid 351978111)
14. Naturally secreted oligomers of amyloid protein potently inhibit hippocampal long-term potentiation in vivo. DM Walsh I Klyubin JV Fadeeva WK Cullen R Anwyl MS Wolfe MJ Rowan DJ Selkoe, Nature 2002 16 535 539 10.1038/416535a (Pubitemid 34288854)
15. Amyloid-betaprotein dimers isolated directly from Alzheimer's brains impairsynaptic plasticity and memory. GM Shankar S Li TH Mehta A Garcia-Munoz NE Shepardson I Smith FM Brett MA Farrell MJ Rowan CA Lemere DM Walsh BL Sabatini DJ Selkoe, Nat Med 2008 14 837 842 10.1038/nm1782 18568035
16. Synaptic targeting by Alzheimer's-related amyloid oligomers. PN Lacor MC Buniel L Chang SJ Fernandez Y Gong KL Viola MP Lambert PT Velasco EH Bigio CE Finch GA Krafft WL Klein, J Neurosci 2004 24 10191 10200 10.1523/JNEUROSCI.3432- 04.2004 15537891 (Pubitemid 39492046)
17. Natural oligomers of the amyloid- protein specifically disrupt cognitive function. JP Cleary DM Walsh JJ Hofmeister GM Shankar MA Kuskowski DJ Selkoe KH Ashe, Nat Neurosci 2005 8 79 84 10.1038/nn1372 15608634 (Pubitemid 41236735)
18. A specific amyloid-beta protein assembly in the brain impairs memory. S Lesné MT Koh L Kotilinek R Kayed CG Glabe A Yang M Gallagher KH Ashe, Nature 2006 440 352 357 16541076
19. Alzheimer's disease-affected brain: presence of oligomeric A ligands (ADDLs) suggests a molecular basis for reversible memory loss. Y Gong L Chang KL Viola PN Lacor MP Lambert CE Finch GA Krafft WL Klein, Proc Natl Acad Sci USA 2003 100 10417 10422 10.1073/pnas.1834302100 12925731 (Pubitemid 37071893)
20. Conformational Abs recognizing a generic amyloid fibril epitope. B O'Nuallain R Wetzel, Proc Natl Acad Sci USA 2002 99 1485 1490 11818542 (Pubitemid 34136519)
21. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. R Kayed E Head F Sarsoza T Saing CW Cotman M Necula L Margol J Wu L Breydo JL Thompson S Rasool T Gurlo P Butler CG Glabe, Mol Neurodeg 2007 2 18 28 10.1186/1750-1326-2-18 (Pubitemid 350209643)
22. A ganglioside-induced toxic soluble A assembly. Its enhanced formation from A bearing the Arctic mutation. N Yamamoto E Matsubara S Maeda H Minagawa A Takashima W Maruyama M Michikawa K Yanagisawa, J Biol Chem 2007 282 2646 2655 10.1074/jbc.M606202200 17135262 (Pubitemid 47076773)
23. Spherical aggregates of -amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3 M Hoshi M Sato S Matsumoto A Noguchi K Yasutake N Yoshida K Sato, Proc Natl Acad Sci USA 2003 100 6370 6375 10.1073/pnas.1237107100 12750461 (Pubitemid 36666588)
24. Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. A Noguchi S Matsumura M Dezawa M Tada M Yanazawa A Ito M Akioka S Kikuchi M Sato S Ideno M Noda A Fukunari S Muramatsu Y Itokazu K Sato H Takahashi DB Teplow Y Nabeshima A Kakita K Imahori M Hoshi, J Biol Chem 2009 284 32895 905 10.1074/jbc.M109. 000208 19759000
25. Lipid membrane formation by vesicle fusion on silicon dioide surfaces modified with alkyl self-assembled monolayer islands. R Tero M Takizawa YJ Li M Yamazaki T Urisu, Langmuir 2004 20 7526 7531 10.1021/la0400306 15323498
26. Reversible memory loss in a mouse model of Alzheimer's disease. LA Kotilinek B Bacskai M Westerman T Kawarabayashi L Younkin BT Hyman S Younkin KH Ashe, J Neurosci 2002 22 6331 6335 12151510 (Pubitemid 35386387)
27. Targeting amyloid- peptide (A) oligomers by passive immunization with a conformation-selective monoclonal antibodies improves learning and memory in A precursor protein (APP) transgenic mice. EB Lee LZ Leng B Zhang L Kwong JQ Trojanowski VM Lee, J Biol Chem 2006 281 4292 4299 10.1074/jbc.M511018200 16361260 (Pubitemid 43847859)
28. Oral vaccination with a viral vector containing A cDNA attenuates age-related A accumulation and memory deficits without causing inflammation in a mouse Alzheimer model. A Mouri Y Noda H Hara H Mizoguchi T Tabira T Nabeshim, FASEB J 2007 21 2135 2148 10.1096/fj.06-7685com 17341681 (Pubitemid 47026449)
29. A high affinity fluorescent marker for the localization of neuronal degeneration. LC Schmued KJ Hopkins B Fluoro-Jade, Brain Res 2000 874 123 130 10.1016/S0006-8993(00)02513-0 10960596
30. Vaccination with soluble A oligomers generates toxicity-neutralizing antibodies. MP Lambert KL Viola BA Chromy L Chang TE Morgan J Yu DL Venton GA Krafft CE Finch WL Klein, J Neurochem 2001 79 595 605 10.1046/j.1471-4159.2001. 00592.x 11701763 (Pubitemid 33029933)
31. Monoclonal antibodies that target pathological assemblies of A MP Lambert AK Barlow BA Chromy C Edwards R Freed M Liosatos TE Morgan I Rozovsky B Trommer KL Viola P Wals C Zhang CE Finch MP Lambert PT Velasco L Chang KL Viola S Fernandez PN Lacor D Khuon Y Gong EH Bigio P Shaw FG De Felice GA Krafft WL Klein, J Neurochem 2007 100 23 35 10.1111/j.1471-4159.2006.04157.x 17116235 (Pubitemid 46085837)
32. Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. T Kawarabayashi M Shoji LH Younkin L Wen-Lang DW Dickson T Murakami E Matsubara K Abe KH Ashe SG Younkin, J Neurosci 2004 24 3801 3809 10.1523/JNEUROSCI.5543-03.2004 15084661 (Pubitemid 38509410)
33. Intraneuronal A42 accumulation in Down syndrome brain. C Mori ET Spooner KE Wisniewsk TM Wisniewski H Yamaguch TC Saido DR Tolan DJ Selkoe CA Lemere, Amyloid 2002 9 88 102 12440481 (Pubitemid 34787802)
34. Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. X Hu SL Crick G Bu C Frieden RV Pappu JM Lee, Proc Natl Acad Sci USA 2009 106 20324 20329 10.1073/pnas.0911281106 19910533
35. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. T Tomiyama S Matsuyama H Iso T Umeda H Takuma K Ohnishi K Ishibashi R Teraoka N Sakama T Yamashita K Nishitsuji K Ito H Shimada MP Lambert WL Klein H Mori, J Neurosci 2010 30 4845 56 10.1523/JNEUROSCI.5825-09.2010 20371804
36. Characterization of apolipoprotein J-Alzheimer's A beta interaction. E Matsubara B Frangione J Ghiso, J Biol Chem 1995 270 7563 7567 10.1074/jbc.270.13.7563 7706304