Can scientific evidence support using Bangladeshi traditional medicinal plants in the treatment of diarrhoea? a review on seven plants

Nutrients

Volumn 5, Issue 5, 2013, Pages 1757-1800

  Wangensteen, Helle ^a   Klarpås, Line ^a   Alamgir, Mahiuddin ^b   Samuelsen, Anne B C ^a   Malterud, Karl E ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Bangladesh; Diarrhoea; Diospyros peregrina; Heritiera littoralis; Ixora coccinea; Mangrove plants; Pongamia pinnata; Rhizophora mucronata; Traditional medicine; Xylocarpus granatum; Xylocarpus moluccensis

Indexed keywords

ANTIDIARRHEAL AGENT; DIOSPYROS PEREGRINA EXTRACT; HERITIERA LITTORALIS EXTRACT; IXORA COCCINEA EXTRACT; PLANT EXTRACT; PONGAMIA PINNATA EXTRACT; RHIZOPHORA MUCRONATA EXTRACT; UNCLASSIFIED DRUG; XYLOCARPUS GRANATUM EXTRACT; XYLOCARPUS MOLUCCENSIS EXTRACT;

ANTHELMINTIC ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIDIARRHEAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; BANGLADESH; BARK; BIOCHEMICAL COMPOSITION; DIARRHEA; DIOSPYROS PEREGRINA; DRUG CYTOTOXICITY; DRUG STRUCTURE; DYSENTERY; GEOGRAPHIC DISTRIBUTION; HERITIERA LITTORALIS; HUMAN; IXORA COCCINEA; LD 50; MEDICINAL PLANT; NONHUMAN; PEPTIC ULCER; PLANT LEAF; PONGAMIA PINNATA; REVIEW; RHIZOPHORA MUCRONATA; TRADITIONAL MEDICINE; XYLOCARPUS GRANATUM; XYLOCARPUS MOLUCCENSIS;

EID: 84878206681     PISSN: 20726643     EISSN: None     Source Type: Journal    
DOI: 10.3390/nu5051757     Document Type: Review

References (277)

1. Kosek, M.; Bern, C.; Guerrant, R.L. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull. World Health Organ. 2003, 81, 197-204.
2. World Health Organization (WHO). The World Health Report 2005-Make Every Mother and Child Count; WHO: Geneva, Switzerlands, 2005.
3. World Health Organization (WHO). The World Health Report 2007-A Safer Future: Global Public Health in the 21st Century; WHO: Geneva, Switzerlands, 2007.
4. Lutterodt, G.D. Inhibition of microlax-induced experimental diarrhoea with narcotic-like extracts of Psidium guajava leaf in rats. J. Ethnopharmacol. 1992, 37, 151-157.
5. Albert, M.J.; Faruque, A.S.G.; Faruque, S.M.; Sack, R.B.; Mahalanabis, D. Case-control study of enteropathogens associated with childhood diarrhea in Dhaka, Bangladesh. J. Clin. Microbiol. 1999, 37, 3458-3464.
6. Sack, R.B.; Siddique, A.K.; Longini, I.M.; Nizam, A.; Yunus, M.; Islam, M.S.; Morris, J.G.; Ali, A.; Huq, A.; Nair, G.B.; et al. A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh. J. Infect. Dis. 2003, 187, 96-101.
7. Qadri, F.; Khan, A.I.; Faruque, A.S.G.; Begum, Y.A.; Chowdhury, F.; Nair, G.B.; Salam, M.A.; Sack, D.A.; Svennerholm, A.-M. Enterotoxigenic Escherichia coli and Vibrio cholerae diarrhea, Bangladesh, 2004. Emerg. Infect. Dis. 2005, 11, 1104-1107.
8. Palombo, E.A. Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function. Phytother. Res. 2006, 20, 717-724.
9. Barrett, M. The Handbook of Clinically Tested Herbal Remedies; Haworth Herbal Press: Binghamton, NY, USA, 2004.
10. Dillinger, T.L.; Barriga, P.; Escarcega, S.; Jimenez, M.; Lowe, D.S.; Grivetti, L.E. Food of the gods: cure for humanity? A cultural history of the medicinal and ritual use of chocolate. J. Nutr. 2000, 130, 2057S-2072S.
11. Alam, M.A.; Akter, R.; Subhan, N.; Rahman, M.M.; Majumder, M.M.; Nahar, L.; Sarker, S.D. Antidiarrhoeal property of the hydroethanolic extract of the flowering tops of Anthocephalus cadamba. Braz. J. Pharmacogn. 2008, 18, 155-159.
12. Bruins, M.J.; Cermak, R.; Kiers, J.L.; van der Meulen, J.; van Amelsvoort, J.M.M.; van Klinken, B.J.W. In vivo and in vitro effects of tea extracts on enterotoxigenic Escherichia coli-induced intestinal fluid loss in animal models. J. Pediat. Gastroenterol. Nutr. 2006, 43, 459-469.
13. Chen, J.-C.; Ho, T.-Y.; Chang, Y.-S.; Wu, S.-L.; Hsiang, C.-Y. Anti-diarrheal effect of Galla Chinensis on the Escherichia coli heat-labile enterotoxin and ganglioside interaction. J. Ethnopharmacol. 2006, 103, 385-391.
14. Chen, J.-C.; Huang, L.-J.; Wu, S.-L.; Kuo, S.-C.; Ho, T.-Y.; Hsiang, C.-Y. Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice. J. Agric. Food Chem. 2007, 55, 8390-8397.
15. Lakhsminarayana, M.; Shivkumar, H.; Rimaben, P.; Bhargava, V.K. Antidiarrhoeal activity of leaf extract of Moringa oleifera in experimentally induced diarrhoea in rats. Int. J. Phytomed. 2011, 3, 68-74.
16. Oi, H.; Matsuura, D.; Miyake, M.; Ueno, M.; Takai, I.; Yamamoto, T.; Kubo, M.; Moss, J.; Noda, M. Identification in traditional herbal medications and confirmation by synthesis of factors that inhibit cholera toxin-induced fluid accumulation. Proc. Natl. Acad. Sci. USA 2002, 99, 3042-3046.
17. Rahman, T.; Rahman, K.A.; Rajia, S.; Alamgir, M.; Khan, M.T.H.; Choudhuri, M.S.K. Evaluation of antidiarrhoeal activity of cardamom (Elettaria cardamomum) on mice models. Orient. Pharm. Exp. Med. 2008, 8, 130-134.
18. Asif, H.M.; Usmanghni, K.; Akram, M.; Akhtar, N.; Jabeen, Q.; Shah, S.M.A.; Rehman, R.; Ahmed, K.; Saeed, T. Herbal treatment of secretory diarrhea. Int. J. Phytomed. 2010, 2, 425-429.
19. Cai, Y.; Evans, F.J.; Roberts, M.F.; Phillipson, J.D.; Zenk, M.H.; Gleba, Y.Y. Biological and chemical investigation of dragon's blood from Croton species of South America. Part 1. Polyphenolic compounds from Croton lechleri. Phytochemistry 1991, 30, 2033-2040.
20. Lewis, W.H.; Elvin-Lewis, M.P.F. Medical Botany: Plants Affecting Human Health; Wiley: Hoboken, NJ, USA, 2003.
21. Fischer, H.; Machen, T.E.; Widdicombe, J.H.; Carlson, T.J.S.; King, S.R.; Chow, J.W.S.; Illek, B. A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells. J. Ethnopharmacol. 2004, 93, 351-357.
22. Patz, J.A.; Campbell-Lendrum, D.; Holloway, T.; Foley, J.A. Impact of regional climate change on human health. Nature 2005, 438, 310-317.
23. Iftekhar, M.S.; Islam, M.R. Degeneration of Bangladesh's Sundarbans mangroves: A management issue. Int. Forestry Rev. 2004, 6, 123-135.
24. Mandal, R.N.; Das, C.S.; Naskar, K.R. Dwindling Indian sundarban mangrove: The way out. Sci. Cult. 2010, 76, 275-282.
25. Upadhyay, V.P.; Ranjan, R.; Singh, J.S. Human-mangrove conflicts: The way out. Curr. Sci. 2002, 83, 1328-1336.
26. Li, M.-Y.; Xiao, Q.; Pan, J.-Y.; Wu, J. Natural products from semi-mangrove flora: Source, chemistry and bioactivities. Nat. Prod. Rep. 2009, 26, 281-298.
27. Datta, D.; Chattopadhyay, R.N.; Deb, S. Prospective livelihood opportunities from mangroves of the Sunderbans, India. Res. J. Environ. Sci. 2011, 5, 536-543.
28. Kirtikar, K.R.; Basu, B.D. Indian Medicinal Plants; Lalit Mohan Basu: Allahabad, India, 1935.
29. Male Flowers of Diospyros malabarica from Ebenaceae. Rarely Seen in Cultivation. Available online: http://en.wikipedia.org/wiki/File:Malabar_Ebony.jpg (accessed on 4 April 2013).
30. Chopra, R.N.; Nayar, S.L.; Chopra, I.C. Glossary of Indian Medicinal Plants; Council of Scientific & Industrial Research: New Dehli, India, 1956.
31. Sinha, B.N.; Bansal, S.K. A review of phytochemical and biological studies of Diospyros species used in folklore medicine of Jharkand. J. Nat. Remedies 2008, 8, 11-17.
32. Misra, P.S.; Misra, G.; Nigam, S.K.; Mitra, C.R. Constituents of Diospyros peregrina fruit and seed. Phytochemistry 1971, 10, 904-905.
33. Chinsembu, K.C.; Hedimbi, M. An ethnobotanical survey of plants used to manage HIV/AIDS opportunistic infections in Katima Mulilo, Caprivi region, Namibia. J. Ethnobiol. Etnomed. 2010, 6, 25.
34. Kantamreddi, V.S.S.; Wright, C.V. Investigation of Diospyros species for antiplasmodial properties. Evid. Based Complement. Altern. Med. 2008, 5, 187-190.
35. Wagh, V.V.; Jain, A.K.; Kadel, C. Ethnomedicinal plants used for curing dysentery and diarrhea by tribals of Jhabua district (Madhya Pradesh). Indian J. Nat. Prod. Resour. 2011, 2, 256-260.
36. Gupta, R.K.; Tiwari, R.D. Chemical examination of the bark of Diospyros peregrina. Proc. Indian Nat. Sci. Acad. Sect. A 1964, 34, 180-181.
37. Sundararamaiah, T.; Ramraj, S.K.; Rao, K.L.; Vimalabai, V. Isolation of the lupeol group of triterpenes from Dillenia indica Linn. and Diospyros peregrina. J. Indian Chem. Soc. 1976, 53, 638.
38. Chauhan, J.S.; Kumari, G. A new leucoanthocyanin from the stem of Diospyros peregrina. J. Indian Chem. Soc. 1978, 55, 1068-1070.
39. Chauhan, J.S.; Kumari, G. Nonadecan-7-ol-2-one, an aliphatic ketol from Diospyros peregrina. Phytochemistry 1980, 19, 2637-2638.
40. Gupta, R.K.; Tiwari, R.D. Chemical examination of the leaves of Diospyros peregrina Gurke. Indian J. Chem. 1964, 2, 129-130.
41. Jain, N.; Alam, M.S.; Kamil, M.; Ilyas, M.; Ali, M. Peregrinol: A new lupene type triterpene from Diospyros peregrina. Pharmazie 1992, 47, 559-560.
42. Bhaumik, T.; Dey, A.K.; Das, P.C.; Mukhopadhyay, A.K.; Chatterjee, M.A. Triterpenes of Diospyros peregrina Gurke: Partial syntheses of olean-9(11),12-dien-3-one and ursan-9(11), 12-dien-3-one (marsformosanone). Indian J. Chem. Sect. B Org. Med. Chem. 1981, 20B, 664-668.
43. Pareek, R.B.; Vidyapati, T.J.; Bhutani, K.K. Chemical examination of the fruits of Diospyros peregrina. J. Teaching Res. Chem. 2008, 15, 6-11.
44. Jain, N.; Yadava, R. A novel chromenoflavone from the fruits of Diospyros peregrina. Fitoterapia 1996, 67, 348-350.
45. Sahu, R.; Dewanjee, S.; Dua, T.K.; Gangopadhyay, M.; Das, A.K.; Dey, S.P. Dereplication coupled with in vitro antioxidant assay of two flavonoid glycosides from Diospyros peregrine fruit. Nat. Prod. Res. 2012, 26, 454-459.
46. Sampurna, T.; Rao, T.S.S. Chemical examination of the fruits of Diospyros peregrina Gurke. Asian J. Chem. 2004, 16, 540-542.
47. Begum, S.A.; Hosain, M.M.; Ahmed, M.F.; Muttakin, M.A.; Rahman, M.M. Vitamin C content in tropical fruits and vegetables available in different districts of Bangladesh. J. Bangladesh Acad. Sci. 2009, 33, 231-234.
48. Chauhan, J.S.; Saraswat, M.; Kumari, G. Structure of a new dihydroflavonol glycoside from Diospyros peregrina roots. Planta Med. 1979, 35, 373-375.
49. Chauhan, J.S.; Saraswat, M.; Kumari, G. Structure of a new flavanone glycoside from Diospyros peregrina roots. Indian J. Chem. Sect. B Org. Med. Chem. 1982, 21B, 169-170.
50. Rouf, R.; Uddin, S.J.; Shilpi, J.A.; Toufiq-ur-rahman, M.; Ferdous, M.M.; Sarker, S.D. Anti-diarrhoeal properties of Diospyros peregrina in the castor oil-induced diarrhoea model in mice. Ars. Pharm. 2006, 47, 81-89.
51. Dewanjee, S.; Maiti, A.; Kundu, M.; Mandal, S.C. Evaluation of anthelmintic activity of extracts of Diospyros peregrina, Coccinia grandis and Schima wallichii. Dhaka Univ. J. Pharm. Sci. 2007, 6, 121-123.
52. Dewanjee, S.; Kundu, M.; Maiti, A.; Majumdar, R.; Majumdar, A.; Mandal, S.C. In vitro evaluation of antimicrobial activity of crude extract from plants Diospyros peregrina, Coccinia grandis and Swietenia macrophylla. Trop. J. Pharm. Res. 2007, 6, 773-778.
53. Dewanjee, S.; Maiti, A.; Mandal, S.C. Antioxidant activity of the methanol extract of Diospyros peregrina fruit in alloxan induced diabetic rats. Pharmacologyonline 2007, 3, 80-86.
54. Dewanjee, S.; Bose, S.K.; Sahu, R.; Mandal, S.C. Antidiabetic effect of matured fruits of Diospyros peregrina in alloxan-induced diabetic rats. Int. J. Green. Pharm. 2008, 2, 95-99.
55. Dewanjee, S.; Sahu, R.; Mandal, V.; Maiti, A.; Mandal, S.C. Antidiabetic and antioxidant activity of the methanol extract of Diospyros peregrina fruit on type I diabetic rats. Pharm. Biol. 2009, 47, 1149-1153.
56. Dewanjee, S.; Gangopadhyay, M.; Das, A.K. Multimodal approaches of the hydroalcoholic extract of fruits in diabetic therapy. Nat. Prod. Res. 2011, 25, 827-833.
57. Dewanjee, S.; Maiti, A.; Sahu, R.; Dua, T.K.; Mandal, V. Effective control of type 2 diabetes through antioxidant defense by edible fruits of Diospyros peregrina. Evid. Based Complement. Altern. Med. 2011, 2011, 675397; doi:10.1093/ecam/nep080.
58. Kumar, K.E.; Mastan, S.K.; Sreekanth, N.; Chaitanya, G.; Sumalatha, G.; Krishna, P.V. Hypoglycemic and antihyperglycemic activity of aqueous extract of Diospyros peregrina fruits in normal and alloxan-induced diabetic rabbits. Pharmacologyonline 2008, 3, 250-256.
59. Venu Gopal, Y.; Ravindranath, A.; Kalpana, G.; Raju, A.B.; Reddy, P. Antitumor activity of Diospyros peregrina on Ehrlich ascites carcinoma in mice. J. Sci. Res. 2011, 3, 413-419.
60. Hussan Reza, K.; Jeevanandham, S.; Kumervelrajen, R. Evaluation of Diospyros peregrina gum as a novel binder in tablet formulation. Int. Res. J. Pharm. Appl. Sci. 2012, 2, 53-60.
61. Singh, N.; Nath, R.; Gupta, M.L. A pharmacological evaluation of anti-stress activity of Diospyros peregrina Gurke. Indian J. Pharm. 1988, 20, 102-108.
62. Tomlinson, P.B. The Botany of Mangroves; Cambridge University Press: Cambridge, UK, 1986.
63. Heritiera littoralis (Green Fruit). Location: Oahu, Keehi Lagoon. Available online: http://en.wikipedia.org/wiki/File:Starr_080530-4634_Heritiera_littoralis.jpg (accessed on 14 April 2013).
64. Daengrot, C.; Ponglimanont, C.; Karalai, C. Chemical Constituents from the Barks of Heritiera Littoralis. In Proceedings of the 31st Annual Congress on Science and Technology of Thailand, Suranaree, Thailand, 18-20 October 2005.
65. Bandaranayake, W.M. Traditional and medicinal uses of mangroves. Mangroves Salt Marshes 1998, 2, 133-148.
66. Bandaranayake, W.M. Bioactivities, bioactive compounds and chemical constitutions of mangrove plants. Wetlands Ecol. Manag. 2002, 10, 451-452.
67. Pattanaik, C.; Reddy, C.S.; Dhal, N.K.; Das, R. Utilisation of mangrove forests in Bhitarkanika wildlife sanctuary, Orissa. Indian J. Tradit. Knowl. 2008, 7, 598-603.
68. Miles, D.H.; Lho, D.S.; de la Cruz, A.A.; Gomez, E.D.; Weeks, J.A.; Atwood, J.L. Toxicants from mangrove plants. 3. Heritol, a novel ichthyotoxin from the mangrove plant Heritiera littoralis. J. Org. Chem. 1987, 52, 2930-2932.
69. Bhargava, N. Ethnobotanical studies of the tribes of Andaman and Nicobar Islands, India. I. Onge. Econ. Bot. 1983, 37, 110-119.
70. Dahdouh-Guebas, F.; Collin, S.; lo Seen, D.; Rönnbäck, P.; Depommier, D.; Ravishankar, T.; Koedam, N. Analysing ethnobotanical and fishery-related importance of mangroves of the East-Godavari Delta (Andhra Pradesh, India) for conservation and management purposes. J. Ethnobiol. Ethnomed. 2006, 2, 24.
71. Tewtrakul, S.; Tansakul, P.; Daengrot, C.; Ponglimanont, C.; Karalai, C. Anti-inflammatory principles from Heritiera littoralis bark. Phytomedicine 2010, 17, 851-855.
72. Balasooriya, S.J.; Sotheeswaran, S. Economically useful plants of Sri Lanka. Part IV. Screening of Sri Lanka plants for tannins. J. Natl. Sci. Counc. Sri Lanka 1982, 10, 213-219.
73. Tian, Y.; Wu, J.; Zhang, S. Flavonoids from leaves of Heritiera littoralis D. J. Chin. Pharm. Sci. 2004, 13, 214-216.
74. Takeda, Y.; Miyazaki, K.; Shimizu, H.; Masuda, T.; Hirata, E.; Takushi, A.; Shinzato, T.; Otsuka, H. A new phenylpropanoid-glycerol conjugate from Heritiera littoralis Dryand. Nat. Med. 2000, 54, 22-25.
75. Gaydou, E.M.; Ramanoelina, A.R.P.; Rasoarahona, J.R.E.; Combres, A. Fatty acid composition of Sterculia seeds and oils from Madagascar. J. Agric. Food Chem. 1993, 41, 64-66.
76. Miles, D.H.; Chittawong, V.; Lho, D.-S.; Payne, A.M.; de la Cruz, A.A.; Gomez, E.D.; Weeks, J.A.; Atwood, J.L. Toxicants from mangrove plants, VII. Vallapin and vallapianin, novel sesquiterpene lactones from the mangrove plant Heritiera littoralis. J. Nat. Prod. 1991, 54, 286-289.
77. Miles, D.H.; de la Cruz, A.A.; Ly, A.-M.; Lho, D.S.; Gomez, E.D.; Weeks, J.A.; Atwood, J.L. Toxicants from mangrove plants. Ichthyotoxins from the Philippine plant Heritiera littoralis. Am. Chem. Soc. Symp. Ser. 1987, 330, 491-501.
78. Miles, D.H.; Ly, A.-M.; Chittawong, V.; de la Cruz, A.A.; Gomez, E.D. Toxicants from mangrove plants, VI. Heritonin, a new piscicide from the mangrove plant Heritiera littoralis. J. Nat. Prod. 1989, 52, 896-898.
79. Dang, H.C.T. Antioxidants in Heritiera fomes, a Medicinal Plant from the Mangrove Forest of Bangladesh (in Norwegian). Master Thesis, School of Pharmacy, University of Oslo, Oslo, Norway, 2007.
80. Tao, W.Q.; Xu, M.B.; Huang, L.Y.; Miao, S.Y. Antibacterial activity of extracts from four mangrove species in vitro. Med. Plant 2012, 3, 38-41.
81. Latha, P.G.; Panikkar, K.R.; Suja, S.R.; Abraham, A.; Rajasekharan, S. Chemistry, pharmacognosy, pharmacology and botany of Ixora coccinea-A review. J. Med. Arom. Plant Sci. 2001, 23, 670-676.
82. A Specimen of Ixora coccinea, Also Known as the Jungle Flame, Shot in Miami, Florida. Available online: http://en.wikipedia.org/wiki/File:IxoraCoccineaMiami.JPG (accessed on 14 April 2013).
83. Nayak, S.; Udupa, L.; Udupa, S. Altered antioxidant enzyme profile in wound healing. Indian J. Clin. Biochem. 2003, 18, 75-79.
84. Ragasa, C.Y.; Tiu, F.; Rideout, J.A. New cycloartenol esters from Ixora coccinea. Nat. Prod. Res. 2004, 18, 319-323.
85. Ratnasooriya, W.D.; Deraniyagala, S.A.; Bathige, S.D.N.K.; Goonasekara, C.L.; Jayakody, J.R.A.C. Antinociceptive action of aqueous extract of the leaves of Ixora coccinea. Acta Biol. Hung. 2005, 56, 21-34.
86. Khare, C.P. Indian Medicinal Plants: An Illustrated Dictionary; Springer: New York, NY, USA, 2007.
87. Alam, M.K. Medical ethnobotany of the Marma tribe of Bangladesh. Econ. Bot. 1992, 46, 330-335.
88. Baliga, M.S.; Kurian, P.J. Ixora coccinea Linn.: Traditional uses, phytochemistry and pharmacology. Chin. J. Integr. Med. 2012, 18, 72-79.
89. Zachariah, R.; Nair, C.R.S.; Panicker, P.V. Anti-inflammatory and anti-mitotic activities of lupeol isolated from the leaves of Ixora coccinea Linn. Indian J. Pharm. Sci. 1994, 56, 129-131.
90. Idowu, T.O.; Ogundaini, A.O.; Salau, A.O.; Obuotor, E.M.; Bezabih, M.; Abegaz, B.M. Doubly linked, A-type proanthocyanidins trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties. Phytochemistry 2010, 71, 2092-2098.
91. Sumathy, H.; Sangeetha, J.; Vijayalakhsmi, K. Chromatographic fingerprint analysis of Ixora coccinea methanolic flower extract. Int. J. Pharm. Sci. Drug Res. 2011, 3, 327-330.
92. Lee, C.-L.; Liao, Y.-C.; Hwang, T.-L.; Wu, C.-C.; Chang, F.-R.; Wu, Y.-C. Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea. Bioorg. Med. Chem. Lett. 2010, 20, 7354-7357.
93. Yadava, R.N. Analysis of the fixed oil from the roots of Ixora coccinea Linn. Asian J. Chem. 1989, 1, 307-308.
94. Srinivasan, G.V.; Sharanappa, P.; Udayan, P.S.; Leela, N.K.; Vijayan, K.K. Chemical composition and antimicrobial activity of the essential oil of Ixora coccinea L. root. J. Med. Arom. Plant Sci. 2010, 32, 27-30.
95. Maniyar, Y.; Bhixavatimath, P.; Agashikar, N.V. Antidiarrheal activity of Ixora coccinea Linn. in rats. J. Ayurveda Integr. Med. 2010, 1, 287-291.
96. Annapurna, J.; Amarnath, P.V.S.; Amar Kumar, D.; Ramakrishna, S.V.; Raghavan, K.V. Antimicrobial activity of Ixora coccinea leaves. Fitoterapia 2003, 74, 291-293.
97. Sasidharan, V.K. Search for antibacterial and antifungal activity of some plants of Kerala. Acta Pharm. 1997, 47, 47-51.
98. Selvaraj, N.; Lakshmanan, B.; Mazumder, P.M.; Karuppusamy, M.; Jena, S.S.; Pattnaik, A.K. Evaluation of wound healing and antimicrobial potentials of Ixora coccinea root extract. Asia Pac. J. Trop. Med. 2011, 959-963.
99. Shyamal, S.; Latha, P.G.; Suja, S.R.; Shine, V.J.; Anuja, G.I.; Sini, S.; Pradeep, S.; Shikha, P.; Rajasekharan, S. Hepatoprotective effect of three herbal extracts on aflatoxin B1-intoxicated rat liver. Singap. Med. J. 2010, 51, 326-331.
100. Torey, A.; Sasidharan, S.; Latha, L.Y.; Sudhakaran, S.; Ramanathan, S. Antioxidant activity and total phenolic content of methanol extracts of Ixora coccinea. Pharm. Biol. 2010, 48, 1119-1123.
101. Momin, F.N.; Kalai, B.R.; Shikalgar, T.S.; Naikwade, N.S. Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats. Indian J. Pharmacol. 2012, 44, 178-183.
102. Haridass, S.; Sekar, S.; Vijayan, R.; Jayakumar, S.; Thtmizharasu, S.; Krishnamurthy, V.; Chidambaram, S.B. Relative antioxidant and cytotoxic activities of Ixora coccinea flower extracts. J. Pharm. Res. 2012, 5, 1403-1408.
103. Wongwattanasathien, O.; Kangsadalampai, K.; Tongyonk, L. Antimutagenicity of some flowers grown in Thailand. Food Chem. Toxicol. 2010, 48, 1045-1051.
104. Maniyar, Y.; Bhixavatimath, P. Evaluation of the hypoglycaemic and hypolipidaemic activities of the aqueous extract of the leaves of Ixora coccinea Linn in diabetic rats. J. Clin. Diagnost. Res. 2011, 5, 1381-1384.
105. Bhattacharya, A.; Kar, D.R.; Sengupta, A.; Ghosh, G.; Mishra, S.K. Evaluation of anti-inflammatory and analgesic activity of Ixora coccinea flower extract. Asian J. Chem. 2011, 23, 4369-4372.
106. Kensa, V.M. Larvicidal effects of selected plant leaves extract against Anopheles mosquitoes. Ecol. Environ. Conserv. Paper 2011, 17, 375-380.
107. Seetha, D.B.; Sudhakaran-Nair, C.R.; Velayudha-Panicker, P. Pharmacognostical and pharmacological studies on the root of Ixora coccinea Linn. (Rubicaceae). Indian J. Pharm. Sci. 1991, 53, 92-93.
108. Latha, P.G.; Panikkar, K.R. Inhibition of chemical carcinogenesis in mice by Ixora coccinea flowers. Pharm. Biol. 2000, 38, 152-156.
109. Atiq-Ur-Rahman; Taqvi, S.I.H.; Versiani, M.A.; Ikram, A.; Ahmed, S.K. Effects of whole flower and fractions from Ixora coccinea Linn. on cardiovascular system: A preliminary report. J. Chem. Soc. Pak. 2012, 34, 758-766.
110. Howell, A.B.; Reed, J.D.; Krueger, C.G.; Winterbottom, R.; Cunningham, D.G.; Leahy, M. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry 2005, 66, 2281-2291.
111. Chopade, V.V.; Tankar, A.N.; Pande, V.V.; Tekade, A.R.; Gowekar, N.M.; Bhandari, S.R.; Khandake, S.N. Pongamia pinnata: Phytochemical constituents, traditional uses and pharmacological properties: A review. Int. J. Green Pharm. 2008, 2, 72-75.
112. Pandey, A.; Khatri, P.; Patel, P.; Jakhetia, V.; Sharma, S. Phytopharmacognostic and pharmacological review of Pongamia pinnata family Fabaceae. J. Global Pharm. Technol. 2009, 3, 1-6.
113. Satish Kumar, B.N. Phytochemistry and pharmacological studies of Pongamia pinnata (Linn.) Pierre. Int. J. Pharm. Sci. Rev. Res. 2011, 9, 12-19.
114. Khatri, P.; Patel, R. A phytochemical overview of various parts of Pongamia pinnata (Karanj). World J. Pharm. Res. 2013, 2, 146-165.
115. Pongamia pinnata-Karanj, Indian Beech Tree, Honge Tree, Pongam Tree or Panigrahi at Deer Park in Shamirpet, Rangareddy District, Andhra Pradesh, India. Available online: http://en.wikipedia.org/wiki/File:Pongamia_pinnata_%28Karanj%29_near_Hyderabad_W_IMG_7633.jpg (accessed on 14 April 2013).
116. Muthu, C.; Ayyanar, M.; Raja, N.; Ignacimuthu, S. Medicinal plants used by traditional healers in Kancheepuram district of Tamil Nadu, India. J. Ethnobiol. Ethnomed. 2006, 2, 43.
117. Pandikumar, P.; Chellappandian, M.; Mutheeswaran, S.; Ignacimuthu, S. Consensus of local knowledge on medicinal plants amongst traditional healers in Mayialadumparai block of Theni district, Tamil Nadu, India. J. Ethnopharmacol. 2011, 134, 354-362.
118. Ragupathy, S.; Newmaster, S.G. Valorizing the "Irulas" traditional knowledge of medicinal plants in the Kodiakkal Reserve Forest, India. J. Ethnobiol. Ethnomed. 2009, 5, 10.
119. Awashti, A.K. Ethnobotanical studies of the Negrito islanders of Andaman islands, India-The great Andamanese. Econ. Bot. 1991, 45, 274-280.
120. Kumar, A.; Pandey, V.C.; Tewari, D.D. Documentation and determination of consensus about phytotherapeutic veterinary practices among the Tharu tribal community of Uttar Pradesh, India. Trop. Animal Health Prod. 2012, 44, 863-872.
121. Jain, S.K. Medicinal plant lore of the tribals of Bastar. Econ. Bot. 1965, 19, 236-250.
122. Garg, G.P. A new component from leaves of Pongamia glabra. Planta Med. 1979, 37, 73-74.
123. Mahey, S.; Sharma, P.; Seshadri, T.R.; Mukerjee, T.R. Structure & synthesis of glabrachromene, a new constituent of Pongamia glabra. Indian J. Chem. 1972, 10, 585-588.
124. Malik, S.B.; Seshadri, T.R.; Sharma, P. Minor components of the leaves of Pongamia glabra. Indian J. Chem. 1976, 14, 229-230.
125. Malik, S.B.; Sharma, P.; Seshadri, T.R. Furanoflavonoids from the leaves of Pongamia glabra. Indian J. Chem. 1977, 15, 536-538.
126. Sagwan, S.; Rao, D.V.; Sharma, R.A. Studies on GC/MS spectroscopic analysis of some different in vivo plant extracts of (Karanj) Pongamia pinnata (L.) Pierre. J. Global Pharma Technol. 2012, 8, 1-10.
127. Talapatra, B.; Mallik, A.K.; Talapatra, S.K. Triterpenoids and flavonoids from the leaves of Pongamia glabra Vent. Demethylation studies on 5-methoxy-furanoflavones. J. Indian Chem. Soc. 1985, 62, 408-409.
128. Shoba, F.G.; Thomas, M. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J. Ethnopharmacol. 2001, 76, 73-76.
129. Brijesh, S.; Daswani, P.G.; Tetali, P.; Rojatkar, S.R.; Antia, N.H.; Birdi, T.J. Studies on Pongamia pinnata (L.) Pierre leaves: Understanding the mechanism(s) of action in infectious diarrhea. J. Zhejiang Univ. Sci. B 2006, 7, 665-674.
130. Dahikar, S.B.; Arote, S.R.; Tambekar, D.H.; Yeole, P.G.; Bhutada, S.A. Antibacterial properties of Pongamia pinnata Linn. (Fabaceae) against enteric bacterial pathogens. Biotechnol. Indian J. 2009, 3, 35-38.
131. Johnson, D.B.; Shringi, B.N.; Patidar, D.K.; Chalichem, N.S.S.; Javvadi, A.K. Screening of antimicrobial activity of alcoholic & aqueous extracts of some indigenous plants. Indo-Global J. Pharm. Sci. 2011, 1, 186-193.
132. Ramesh, K.; Gifson Gnanadhas, Y.; Karthick, N.; Umamaheswari, S. Plasmid mediated drug resistance and anti-MRSA activity of Pongamia glabra and Ocimum basilicum. J. Pharm. Res. 2011, 4, 2466-2467.
133. Sumathi, R.; Pavni, S.; Sivakumar, T. Antimicrobial evaluation of lipid extract of Pongamia pinnata leaves. Res. J. Pharm. Technol. 2009, 2, 714-718.
134. Sajid, Z.I.; Anwar, F.; Shabir, G.; Rasul, G.; Alkharfy, K.M.; Gilani, A.-H. Antioxidant, antimicrobial properties and phenolics of different solvent extracts from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. Molecules 2012, 17, 3917-3932.
135. Sharma, A.; Tyagi, S.; Nag, R.; Chaturvedi, A.; Nag, T.N. Antimicrobial activity and cellular toxicity of flavonoid extracts from Pongamia pinnata and Vitex negundo. Rom. Biotechnol. Lett. 2011, 16, 6396-6400.
136. Umera Begam, A.K.; Manoharan, N.; Sirajudeen, J.; Abdul Jameel, A. Effect of some Indian traditional plants on few common pathogens. Adv. Appl. Sci. Res. 2010, 1, 205-211.
137. Gupta, V.; Sharma, M. In vitro antioxidant studies on methanolic extracts of Pongamia pinnata (L.) Pierre: A great versatile leguminous plant. J. Pharm. Res. 2011, 4, 2241-2244.
138. Badole, S.L.; Bodhankar, S.L. Antihyperglycemic activity of cycloart-23-ene-3β, 25-diol isolated from stem bark of Pongamia pinnata in alloxan induced diabetic mice. Res. J. Phytochem. 2009, 3, 18-24.
139. Badole, S.L.; Bodhankar, S.L. Investigation of antihyperglycaemic activity of aqueous and petroleum ether extract of stem bark of Pongamia pinnata on serum glucose level in diabetic mice. J. Ethnopharmacol. 2009, 123, 115-120.
140. Badole, S.L.; Bodhankar, S.L. Antidiabetic activity of cycloart-23-ene-3β, 25-diol isolated from Pongamia pinnata (L. Pierre) in streptozocine-nicotinamide induced diabetic mice. Eur. J. Pharmacol. 2010, 632, 103-109.
141. Sikarwar, M.S.; Patil, M.B. Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats. Int. J. Ayurveda Res. 2010, 1, 199-204.
142. Badole, S.L.; Zanwar, A.A.; Khopade, A.N.; Bodhankar, S.L. In vitro antioxidant and antimicrobial activity cycloart-23-ene-3β, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre). Asia Pac. J. Trop. Med. 2011, 4, 910-916.
143. Jaiswal, N.; Yadav, P.P.; Maurya, R.; Srivastava, A.K.; Tamrakar, A.K. Karanjin from Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a phosphatidylinositol-3-kinase-independent manner. Eur. J. Pharmacol. 2011, 670, 22-28.
144. Tamrakar, A.K.; Jaiswal, N.; Yadav, P.P.; Maurya, R.; Srivastava, A.K. Pongamol from Pongamia pinnata stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle. Mol. Cell. Endocrinol. 2011, 339, 98-104.
145. Tamrakar, A.K.; Yadav, P.P.; Tiwari, P.; Maurya, R.; Srivastava, A.K. Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. J. Ethnopharmacol. 2008, 118, 435-439.
146. Prabha, T.; Dorababu, M.; Goel, S.; Agarwal, P.K.; Singh, A.; Joshi, V.K.; Goel, R.K. Effect of methanolic extract of Pongamia pinnata Linn seed on gastro-duodenal ulceration and mucosal offensive and defensive factors in rats. Indian J. Exp. Biol. 2009, 47, 649-659.
147. +-ATPase inhibitor. Evid. Based Complement. Altern. Med. 2011, doi:10.1093/ecam/neq027.
148. Bhatia, G.; Puri, A.; Maurya, R.; Yadav, P.P.; Khan, M.M.; Khanna, A.K.; Saxena, J.K. Anti-dyslipidemic and antioxidant activities of different fractions of Pongamia pinnata (Lin.) fruits. Med. Chem. Res. 2008, 17, 281-289.
149. Sagar, S.K.; Sehgal, S.S. Effects of aqueous extract of deoiled neem (Azadirachta indica A. Juss) seed kernel and karanja (Pongamia glabra Vent) seed kernel against Culex quinquefasciatus. J. Commun. Dis. 1996, 28, 260-269.
150. Sagar, S.K.; Sehgal, S.S.; Agarwala, S.P. Bioactivity of ethanol extract of Karanja (Pongamia glabra Vent) seed coat against mosquitoes. J. Commun. Dis. 1999, 31, 107-111.
151. Abdul Rahuman, A.; Bagavan, A.; Kamaraj, C.; Vadivelu, M.; Zahir, A.A.; Elango, G.; Pandiyan, G. Evaluation of indigenous plant extracts against larvae of Culex quinquefasciatus Say (Diptera: Culicidae). Parasitol. Res. 2009, 104, 637-643.
152. Swathi, S.; Murugananthan, G.; Ghosh, S.K. Oviposition deterrent activity from the ethanolic extract of Pongamia pinnata, Coleus forskohlii, and Datura stramonium leaves against Aedes aegypti and Culex quinquefasciatus. Pharmacogn. Mag. 2010, 6, 320-322.
153. Samuel, A.J.S.J.; Radhamani, S.; Gopinath, R.; Kalusalingam, A.; Vimala, A.G.K.A.; Husain, H.A. In vitro screening of anti-lice activity of Pongamia pinnata leaves. Korean J. Parasitol. 2009, 47, 377-380.
154. Shanthi, S.; Elamathy, S.; Panneerselvam, A.; Radha, N. Antixanthomonas activity of Pongamia pinnata Linn. leaves-Cow urine extract-Natural cost effective ecofriendly remedy to bacterial leaf blight of paddy (BLB). J. Pharm. Res. 2011, 4, 650-652.
155. Srinivasan, K.; Muruganandan, S.; Lal, J.; Chandra, S.; Tandan, S.K.; Prakash, V.R. Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats. J. Ethnopharmacol. 2001, 78, 151-157.
156. Baki, M.A.; Khan, A.; Al-Bari, M.A.A.; Mosaddik, A.; Sadik, G.; Mondal, K.A.M.S.H. Sub-acute toxicological studies of pongamol isolated from Pongamia pinnata. Res. J. Med. Med. Sci. 2007, 2, 53-57.
157. Rhizophora mucronata Propagules at Iriomote is. Okinawa, Japan. Available online: http://en.wikipedia.org/wiki/File:Rhizophora_mucronata_Propagules.jpg (accessed on 14 April 2013).
158. Patra, J.K.; Thatoi, H.N. Metabolic diversity and bioactivity screening of mangrove plants: A review. Acta Physiol. Plant. 2011, 33, 1051-1061.
159. Nurulhuda, M.N.; Chew, L.T.; Mohd, N.M.Y.; Abdul, R.M.A. Tannin properties of Rhizophora mucronata barks of different ages. Holz Roh Werkst. 1990, 48, 381-383.
160. Shinoda, Y.; Ogisu, M.; Iwata, S.; Tajima, T. The chemical composition of mangroves II. Gifu Daigaku Nogakubu Kenkyu Hokoku 1985, 50, 155-165.
161. Rohini, R.M.; Das, A.K. Antidiarrheal and anti-inflammatory activities of lupeol, quercetin, β-sitosterol, adene-5-3-ol and caffeic acid isolated from Rhizophora mucronata bark. Pharm. Lett. 2010, 2, 95-101.
162. Rohini, R.M.; Das, A.K. Triterpenoids from the stem bark of Rhizophora mucronata. Nat. Prod. Res. 2010, 24, 197-202.
163. Rohini, R.M.; Das, A.K. Determination of lupeol, β-sitosterol and quercetin from ethyl acetate extract of Rhizophora mucronata bark by HPTLC technique. Asian J. Pharm. Clin. Res. 2011, 4, 103-105.
164. Saha, P.K.; Ganguly, T.; Ganguly, S.N.; Sircar, S.M. Rhizophorine, a new indole acid plant growth inhibitor from Rhizophora mucronata. Plant Biochem. J. 1978, 5, 65-68.
165. Ganguly, S.N.; Sircar, S.M. Gibberellins from mangrove plants. Phytochemistry 1974, 13, 1911-1913.
166. Joel, E.L.; Bhimba, V. Isolation and characterization of secondary metabolites from the mangrove plant Rhizophora mucronata. Asia Pac. J. Trop. Med. 2010, 602-604.
167. Hogg, R.W.; Gillan, F.T. Fatty acids, sterols and hydrocarbons in the leaves from eleven species of mangrove. Phytochemistry 1984, 23, 93-97.
168. Chandrasekaran, M.; Kumar, A.S.; Kannathasan, K.; Venkatesalu, V. Fatty-acid composition of some mangroves. Chem. Nat. Comp. 2010, 46, 92-94.
169. Lakshmi, V.; Misra, A. The novel 1-hydroxy-5-oxobicyclo[6.4.0]dodecane from Rhizophora mucronata. Planta Med. 1995, 61, 382-383.
170. Puspitasar, Y.E.; Hartiati, A.M.; Suprayitno, E. The potency of Rhizophora mucronata leaf extract as antidiarrhea. J. Appl. Sci. Res. 2012, 8, 1180-1185.
171. Laphookhieo, S.; Karalai, C.; Ponglimanont, C. New sesquiterpenoid and triterpenoids from the fruits of Rhizophora mucronata. Chem. Pharm. Bull. 2004, 52, 883-885.
172. Anjaneyulu, A.S.R.; Anjaneyulu, V.; Rao, V.L. New beyerane and isopimarane diterpenoids from Rhizophora mucronata. J. Asian Nat. Prod. Res. 2002, 4, 53-61.
173. Anjaneyulu, A.S.R.; Anjaneyulu, V.; Rao, V.L. Rhizophorin B: A novel beyerane diterpenoid from the Indian mangrove plant Rhizophora mucronata. Indian J. Chem. Sect. B 2000, 39B, 803-807.
174. Anjaneyulu, A.S.R.; Rao, V.L. Rhizophorin A, a novel secolabdane diterpenoid from the Indian mangrove plant Rhizophora mucronata. Nat. Prod. Lett. 2001, 15, 13-19.
175. Richter, A.; Thonke, B.; Popp, M. 1D-1-O-Methyl-muco-inositol in Viscum album and members of the Rhizophoraceae. Phytochemistry 1990, 29, 1785-1786.
176. Ahmed, S.S.; Hiader, S.I.; Rabbani, M.M. 25-S-Spirost-5-ene-3β, 14β-diol from Rhizophora mucronata. Fitoterapia 1988, 59, 79.
177. Premanathan, M.; Kathiresan, K.; Chandra, K. Antiviral evaluation of some marine plants against Semliki forest virus. Pharm. Biol. 1995, 33, 75-77.
178. Premanathan, M.; Kathiresan, K.; Yamamoto, N.; Nakashima, H. In vitro anti-human immunodeficiency virus activity of polysaccharide from Rhizophora mucronata Poir. Biosci. Biotechnol. Biochem. 1999, 63, 1187-1191.
179. Premnathan, M.; Chandra, K.; Bajpai, S.K.; Kathiresan, K. A survey of some Indian marine plants for antiviral activity. Bot. Mar. 1992, 35, 321-324.
180. Baskaran, R.; Mohan, P.M. In vitro antibacterial activity of leaf extracts of Rhizophora mucronata L. against multi drug resistant Vibrio spp. isolated from marine water lobster's larvae hatcheries. Indian J. Geo-Mar. Sci. 2012, 41, 218-222.
181. Chandrasekaran, M.; Venkatesalu, V.; Sivasankari, S.; Kannathasan, K.; Sajit Khan, A.K.; Prabhakar, K.; Rajendran, S.; Lakhsmi Sarayu, Y. Antibacterial activity of certain mangroves against methicillin resistant Staphylococcus aureus. Seaweed Res. Util. 2006, 28, 165-170.
182. Rajaretinam, R.K.; PrakashVincent, S.G. Isolation of a novel bioactive compound from Rhizophora mucronata for methicillin resistant Staphylococcus aureus (MRSA) and compound toxicity assessment in zebra fish embryos. J. Pharm. Res. 2010, 3, 2000-2003.
183. Kusuma, S.; Anil Kumar, P.; Boopalan, K. Potent antimicrobial activity of Rhizophora mucronata. J. Ecobiotechnol. 2011, 3, 40-41.
184. Ravikumar, S.; Inbaneson, S.J.; Suganthi, P.; Guanadesigan, M. In vitro antiplasmodial activity of ethanolic extracts of mangrove plants from South East coast of India against chloroquine-sensitive Plasmodium falciparum. Parasitol. Res. 2011, 108, 873-878.
185. Ravikumar, S.; Inbaneson, S.J.; Suganthi, P.; Venkatesan, M.; Ramu, A. Mangrove plants as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India. Parasitol. Res. 2011, 108, 1405-1410.
186. Agoramoorthy, G.; Chen, F.A.; Venkatesalu, V.; Kuo, D.H.; Shea, P.C. Evaluation of antioxidant polyphenols from selected mangrove plants of India. Asian J. Chem. 2008, 20, 1311-1322.
187. Vadlapudi, V.; Naidu, K.C. Evaluation of antioxidant potential of selected mangrove plants. J. Pharm. Res. 2009, 2, 1742-1745.
188. Johnson, T. CRC Ethnobotany Desk Reference; CRC Press: Boca Raton, FL, USA, 1999.
189. Cannonball Mangrove (Xylocarpus granatum) in a Mangrove Swamp in the Daintree Region of Queensland, Australia. Located on the Mardjja Botanical Walk (Coordinates Imprecise). Available online: http://en.wikipedia.org/wiki/File:Xylocarpus_granatum.jpg (accessed on 14 April 2013).
190. Alvi, K.A.; Crews, P.; Aalbersberg, B.; Prasad, R. Limonoids from the Fijian medicinal plant dabi (Xylocarpus). Tetrahedron 1991, 47, 8943-8948.
191. Weiner, M.A. Ethnomedicine in Tonga. Econ. Bot. 1971, 25, 423-450.
192. Rouf, R.; Uddin, S.J.; Shilpi, J.A.; Alamgir, M. Assessment of antidiarrhoeal activity of the methanol extract of Xylocarpus granatum bark in mice model. J. Ethnopharmacol. 2007, 109, 539-542.
193. Uddin, S.J.; Shilpi, J.A.; Delazar, A.; Nahar, L.; Sarker, S.D. Free radical scavenging activity of some Bangladeshi plant extracts. Orient. Pharm. Exp. Med. 2004, 4, 187-195.
194. Wiart, C. Medicinal Plants of Asia and the Pacific; Taylor & Francis: Boca Raton, FL, USA, 2006.
195. Lakhsmi, V.; Saxena, A.; Singh, S.; Pal, R.; Srivastava, S.; Srivastava, M.N. A Process for the Isolation of Standardized Antidiarrhoeal Fraction and Its Active Compounds from the Fruit Seed Coat of Xylocarpus granatum Koen and Its Use Thereof. Indian Pat. Appl. No. 1937/DEL/ 2006 A, 2006.
196. Zaridah, M.Z.; Idid, S.Z.; Wan Omar, A.; Khozirah, S. In vitro antifilarial effects of three plant species against adult worms of subperiodic Brugia malayi. J. Ethnopharmacol. 2001, 78, 79-84.
197. Wangensteen, H.; Alamgir, M.; Duong, G.M.; Grønhaug, T.E.; Samuelsen, A.B.; Malterud, K.E. Chemical and Biological Studies of Medicinal Plants from the Sundarbans Mangrove Forest. In Advances in Phytotherapy Research; Eddouks, M., Ed.; Research Signpost: Trivandrum, India, 2009; pp. 59-78.
198. Wangensteen, H.; Duong, G.M.; Alamgir, M.; Sarder, M.; Samuelsen, A.B.; Malterud, K.E. Biological activities of limonoids, catechins, procyanidins and extracts from Xylocarpus granatum. Nat. Prod. Commun. 2006, 1, 985-990.
199. Cui, J.; Deng, Z.; Li, J.; Fu, H.; Proksch, P.; Lin, W. Phragmalin-type limonoids from the mangrove plant Xylocarpus granatum. Phytochemistry 2005, 66, 2334-2339.
200. Wu, J.; Xiao, Q.; Huang, J.S.; Xiao, Z.H.; Qi, S.H.; Li, Q.X.; Zhang, S. Xyloccensins O and P, unique 8,9,30-phragmalin ortho esters from Xylocarpus granatum. Org. Lett. 2004, 6, 1841-1844.
201. Wu, J.; Xiao, Q.; Zhang, S.; Li, X.; Xiao, Z.H.; Ding, H.X.; Li, Q.X. Xyloccensins Q-V, six new 8,9,30-phragmalin ortho ester antifeedants from the Chinese mangrove Xylocarpus granatum. Tetrahedron 2005, 61, 8382-8389.
202. Wu, J.; Zhang, S.; Xiao, Q.; Li, Q.; Huang, J.; Xiao, Z.; Long, L. Xyloccensin M and N, two new B, D-seco limonoids from Xylocarpus granatum. Z. Naturforsch. Sect. B 2003, 58, 1216-1219.
203. Wu, J.; Zhang, S.; Xiao, Q.; Li, Q.X.; Huang, H.S.; Long, L.J.; Huang, L.M. Xyloccensin L, a novel limonoid from Xylocarpus granatum. Tetrahedron Lett. 2004, 45, 591-593.
204. Sundarasivarao, B.; Nazma; Madhusudhanarao, J. Antifungal activity of gedunin. Curr. Sci. 1977, 46, 714-716.
205. Du, S.; Wang, M.; Zhu, W.; Qin, Z. A new fungicidal lactone from Xylocarpus granatum (Meliaceae). Nat. Prod. Res. 2009, 23, 1316-1321.
206. Hu, W.-M.; Wu, J. Protoxylogranatin B, a key biosynthetic intermediate from Xylocarpus granatum: Suggesting an oxidative cleavage biogenetic pathway to limonoid. Open Nat. Prod. J. 2010, 3, 1-5.
207. Huo, C.; Guo, D.; Shen, L.; Wang, W.; Zhang, Q.; Zhang, M.; Shi, Q. One new limonoid from seeds of Xylocarpus granatum. Zhongcaoyao 2010, 41, 176-178.
208. Huo, C.-H.; Dong, C.; Shen, L.-R.; Yin, B.-W.; Sauriol, F.; Li, L.-G.; Zhang, M.-L.; Shi, Q.-W.; Kiyota, H. Xylocarpanoids A and B, unique C28 skeleton limonoids from Xylocarpus granatum. Tetrahedron Lett. 2010, 51, 754-757.
209. Kokpol, U.; Chavasiri, W.; Tip-pyang, S.; Veerachato, G.; Zhao, F.L.; Simpson, J.; Weavers, R.T. A limonoid from Xylocarpus granatum. Phytochemistry 1996, 41, 903-905.
210. Li, M.-Y.; Wu, J.; Zhang, S.; Xiao, Q.; Li, Q.-X. The absolute stereochemistry of protoxylogranatin A-A new protolimonoid from the seeds of Chinese mangrove Xylocarpus granatum. J. Asian Nat. Prod. 2008, 10, 503-508.
211. Li, M.-Y.; Yang, X.-B.; Pan, J.-Y.; Feng, G.; Xiao, Q.; Sinkkonen, J.; Satyanandamurty, T.; Wu, J. Granatumins A-G, limonoids from the seeds of a Krishna mangrove, Xylocarpus granatum. J. Nat. Prod. 2009, 72, 2110-2114.
212. Ng, A.S.; Fallis, A.G. Comment: 7α-Acetoxydihydronomilin and mexicanolide: Limonoids from Xylocarpus granatum (Koenig). Can. J. Chem. 1979, 57, 3088-3089.
213. Okorie, D.A.; Taylor, D.A.H. Limonoids from Xylocarpus granatum Koenig. J. Chem. Soc. C 1970, 211-213.
214. Pan, J.-Y.; Chen, S.-L.; Li, M.-Y.; Li, J.; Yang, M.-H.; Wu, J. Limonoids from the seeds of a Hainan mangrove, Xylocarpus granatum. J. Nat. Prod. 2010, 73, 1672-1679.
215. Pudhom, K.; Sommit, D.; Nuclear, P.; Ngamrojanavanich, N.; Petsom, A. Protoxylocarpins F-H, protolimonoids from seed kernels of Xylocarpus granatum. J. Nat. Prod. 2009, 72, 2188-2191.
216. Shen, L.; Guo, D.; Yin, B.; Zhang, Q.; Zhao, L.; Huo, C.; Zhang, M.; Shi, Q.; Wang, Y. Chemical constituents of Xylocarpus granatum Koenig. Zhongcaoyao 2009, 40, 1201-1204.
217. Waratchareeyakul, W.; Chantrapromma, S.; Fun, H.-K.; Razak, I.A; Karalai, C.; Ponglimanont, C. 7-Oxogedunin. Acta Crystallogr. Sect. E 2004, E60, o1964-o1966.
218. Wu, J.; Li, M.Y.; Zhang, S.; Xiao, Q.; Li, Q.X. Two new limonoids with a 3-O-β-tigloyl group from the seeds of the Chinese mangrove Xylocarpus granatum. Z. Naturforsch. Sect. B 2007, B62, 859-862.
219. Wu, J.; Zhang, Z.; Bruhn, T.; Xiao, Q.; Ding, H.; Bringmann, G. Xylogranatins F-R: Antifeedants from the Chinese mangrove, Xylocarpus granatum, a new biogenetic pathway to triterpenoids. Chem. Eur. J. 2008, 14, 1129-1144.
220. Yang, X.; Yang, S.; Li, M.; Pan, J.; Zheng, Y.; Wu, J. Chemical constituents in seeds of Indian mangrove, Xylocarpus granatum. Zhongcaoyao 2010, 41, 846-851.
221. Yin, S.; Fan, C.-Q.; Wang, X.-N.; Lin, L.-P.; Ding, J.; Yue, J.-M. Xylogranatins A-D: Novel tetranortriterpenoids with an unusual 9,10-seco scaffold from marine mangrove Xylocarpus granatum. Org. Lett. 2006, 8, 4935-4938.
222. Yin, S.; Wang, X.-N.; Fan, C.-Q.; Lin, L.-P.; Ding, J.; Yue, J.-M. Limonoids from the seeds of the marine mangrove Xylocarpus granatum. J. Nat. Prod. 2007, 70, 682-685.
223. Yin, B.; Huo, C.; Shen, L.; Wang, C.; Zhao, L.; Wang, Y.; Shi, Q. Protolimonoids from the seeds of Xylocarpus granatum. Biochem. Syst. Ecol. 2009, 37, 218-220.
224. Cheng, F.; Zhou, Y.; Wu, J. Chemical constituents of fruit of Xylocarpus granatum. Zhongyaocai 2009, 32, 1220-1223.
225. Cui, J.X.; Wu, J.; Deng, Z.W.; Proksch, P.; Lin, W.H. Xylocarpins A-I, limonoids from the Chinese mangrove plant Xylocarpus granatum. J. Nat. Prod. 2007, 70, 772-778.
226. Cui, J.; Ouyang, J.; Deng, Z.; Lin, W. Structure elucidation of an unprecedented alkaloid and a new limonoid from Xylocarpus granatum. Magn. Res. Chem. 2008, 46, 894-897.
227. Cui, J.; Deng, Z.; Xu, M.; Proksch, P.; Li, Q.; Liu, W. Protolimonoids and limonoids from the Chinese mangrove plant Xylocarpus granatum. Helv. Chim. Acta 2009, 92, 139-150.
228. 29, from the fruit of a Chinese mangrove Xylocarpus granatum. Z. Naturforsch. Sect. B 2007, B 62, 569-572.
229. Wu, J.; Li, M.Y.; Xiao, Z.H.; Zhou, Y.A. Butyrospermol fatty acid esters from the fruit of a Chinese mangrove Xylocarpus granatum. Z. Naturforsch. Sect. B 2006, B61, 1447-1449.
230. Wu, J.; Zhang, S.; Li, M.Y.; Zhou, Y.; Xiao, Q. Xylogranatins A-D, new mexicanolides from the fruit of a Chinese mangrove Xylocarpus granatum. Chem. Pharm. Bull. 2006, 54, 1582-1585.
231. 13C NMR data for two 3β,8β-epoxymexicanolides from the fruit of a Chinese mangrove Xylocarpus granatum. Magn. Res. Chem. 2006, 44, 87-89.
232. Wu, J.J. Two new mexicanolides from the fruit of the Chinese mangrove Xylocarpus granatum. Z. Naturforsch. Sect. B 2005, B60, 1291-1294.
233. Zhou, Y.; Cheng, F.; Wu, J.; Zou, K. Polyhydroxylated phragmalins from the fruit of a Chinese mangrove, Xylocarpus granatum. J. Nat. Prod. 2006, 69, 1083-1085.
234. Zhou, Y.; Wu, J.; Zou, K. Xylogranatinin, a new pyrido[1,2-a]pyrazine alkaloid from the fruit of a Chinese mangrove Xylocarpus granatum. Chem. Nat. Comp. 2007, 43, 426-428.
235. Shen, L.-R.; Guo, D.; Yu, Y.-M.; Yin, B.-W.; Zhao, L.; Shi, Q.-W.; Wang, Y.-L.; Huo, C.-H. Chemical constituents of plants from the genus Xylocarpus. Chem. Biodiv. 2009, 6, 1293-1308.
236. Phatthalung, P.N.; Chusri, S.; Voravuthikunchai, S.P. Thai ethnomedicinal plants as resistant modifying agents for combating Acinetobacter baumannii infections. BMC Complement. Altern. Med. 2012, 12, 56.
237. Alam, M.Q.; Sarder, M.; Awal, M.A.; Sikder, M.M.H.; Daulla, K.A. Antibacterial activity of the crude ethanolic extract of Xylocarpus granatum stem barks. Bangladesh J. Vet. Med. 2006, 4, 69-72.
238. Choudhury, S.; Sree, A.; Mukherjee, S.C.; Pattnaik, P.; Bapuji, M. In vitro antibacterial activity of extracts of selected marine algae and mangroves against fish pathogens. Asian Fish. Sci. 2005, 18, 285-294.
239. Misra, S.; Verma, M.; Mishra, S.; Srivastava, S.; Lakhsmi, V.; Misra-Bhattacharya, S. Gedunin and photogedunin of Xylocarpus granatum possess antifilarial activity against human lymphatic filarial parasite Brugia malayi in experimental rodent host. Parasitol. Res. 2011, 109, 1351-1360.
240. Lakhsmi, V.; Srivastava, S.; Mishran, S.K.; Srivastava, M.N.; Srivastava, K.; Puri, S.K. Antimalarial activity in Xylocarpus granatum (Koen). Nat. Prod. Res. 2012, 26, 1012-1015.
241. Lakhsmi, V.; Singh, N.; Shrivastva, S.; Mishra, S.K.; Dharmani, P.; Mishra, V.; Palit, G. Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats. Phytomedicine 2010, 17, 569-574.
242. Uddin, S.J.; Nahar, L.; Shilpi, J.A.; Shoeb, M.; Borkowski, T.; Gibbons, S.; Middleton, M.; Byres, M.; Sarker, S.D. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother. Res. 2007, 21, 757-761.
243. Uddin, S.J.; Grice, I.D.; Tiralongo, E. Cytotoxic effects of Bangladeshi medicinal plant extracts. Evid. Based Complement. Altern. Med. 2011, 2011, doi:10.1093/ecam/nep111.
244. Uddin, S.J.; Shilpi, J.A.; Alam, S.M.S.; Alamgir, M.; Rahman, M.T.; Sarker, S.D. Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus moluccensis in castor oiland magnesium sulphate-induced diarrhoea models in mice. J. Ethnopharmacol. 2005, 101, 139-143.
245. Piyagaw, Xylocarpus moluccensis. Available online: http://stuartxchange.org/Piyagaw.html (accessed on 15 February 2013).
246. Sarker, S.D.; Uddin, S.J.; Shilpi, J.A.; Rouf, R.; Ferdous, M.E.M.; Nahar, L. Neuropharmacological properties of Xylocarpus moluccensis. Fitoterapia 2007, 78, 107-111.
247. Connolly, J.D.; MacLellan, M.; Okorie, D.A.; Taylor, D.A.H. Limonoids from Xylocarpus moluccensis (Lam.) M. Roem. J. Chem. Soc. Perkin Trans. 1 1976, 19, 1993-1996.
248. Mulholland, D.A.; Taylor, D.A.H. Limonoids from Australian members of the Meliaceae. Phytochemistry 1992, 31, 4163-4166.
249. Taylor, D.A.H. Limonoid extractives from Xylocarpus moluccensis. Phytochemistry 1983, 22, 1297-1299.
250. Bercich, M.G.; Cambie, R.C.; Lal, A.R.; Sidwell, D. Chemistry of Fijian plants. XIV. An unsaturated aryl keto acid from Xylocarpus moluccensis. Austr. J. Chem. 1998, 51, 795-797.
251. Roy, A.D.; Kumar, R.; Gupta, P.; Khaliq, T.; Narender, T.; Aggarwal, V.; Roy, R. Xyloccensin X and Y, two new limonoids from Xylocarpus moluccensis: NMR investigation in mixture. Magn. Res. Chem. 2006, 44, 1054-1057.
252. Kubo, I.; Miura, I.; Nakanishi, K. Structure of xylomollin, a secoiridoid hemiacetal acetal. J. Am. Chem. Soc. 1976, 98, 6704-6705.
253. Li, M.-Y.; Yang, S.-X.; Pan, J.-Y.; Xiao, Q.; Satyanandamurty, T.; Wu, J. Moluccensins A-G, phragmalins with a conjugated C-30 carbonyl group from a Krishna mangrove, Xylocarpus moluccensis. J. Nat. Prod. 2009, 72, 1657-1662.
254. Li, J.; Li, M.-Y.; Feng, G.; Xiao, Q.; Sinkkonen, J.; Satyanandamurty, T.; Wu, J. Limonoids from the seeds of a Godavari mangrove, Xylocarpus moluccensis. Phytochemistry 2010, 71, 1917-1924.
255. Li, J.; Li, M.-Y.; Satyanandamurty, T.; Wu, J. Godavarin K: A new limonoid with an oxygen bridge between C(1) and C(29) from the Godavari mangrove Xylocarpus moluccensis. Helv. Chim. Acta 2011, 94, 1651-1656.
256. Li, M.-Y.; Zhang, J.; Feng, G.; Satyanandamurty, T.; Wu, J. Khayasin and 2′S-methylbutanoylproceranolide: Promising candidate insecticides from the control of the coconut leaf beetle, Brontispa longissima. J. Pestic. Sci. 2011, 36, 22-26.
257. Li, J.; Li, M.-Y.; Feng, G.; Zhang, J.; Karonen, M.; Sinkkonen, J.; Satyanandamurty, T.; Wu, J. Moluccensins R-Y, limonoids from the seeds of a mangrove, Xylocarpus moluccensis. J. Nat. Prod. 2012, 75, 1277-1283.
258. Pudhom, K.; Sommit, D.; Nuclear, P.; Ngamrojanavanich, N.; Petsom, A. Moluccensins H-J, 30-ketophragmalin limonoids from Xylocarpus moluccensis. J. Nat. Prod. 2010, 73, 263-266.
259. Ravangpai, W.; Sommit, D.; Teerawatananond, T.; Sinpranee, N.; Palaga, T.; Pengpreecha, S.; Muangsin, N.; Pudhom, K. Limonoids from seeds of Thai Xylocarpus moluccensis. Bioorg. Med. Chem. Lett. 2011, 21, 4485-4489.
260. Wu, J.; Yang, S.-X.; Li, M.-Y.; Feng, G.; Pan, J.-Y.; Xiao, Q.; Sinkkonen, J.; Satyanandamurty, T. Limonoids and tirucallane derivatives from the seeds of a Krishna mangrove, Xylocarpus moluccensis. J. Nat. Prod. 2010, 73, 644-649.
261. Zhang, J.; Yang, S.-X.; Yang, X.-B.; Li, M.-Y.; Feng, G.; Pan, J.-Y.; Satyanandamurty, T.; Wu, J. Mexicanolides from the seeds of a Krishna mangrove, Xylocarpus moluccensis. Chem. Pharm. Bull. 2010, 58, 552-555.
262. Gunawan, S.; Darmawan, R.; Nanda, M.; Setiawan, A.D.; Fansuri, H. Proximate composition of Xylocarpus moluccensis seeds and their oils. Ind. Crops Prod. 2013, 41, 107-112.
263. Li, M.; Wu, J. Khayasin from Xylocarpus moluccensis for Control of Brontispa longissima larvae. Chinese Patent N 101849541 A, 2010.
264. Li, M.; Wu, J. Application of Xylolimonoid A from Xylocarpus moluccensis as Insecticide for Brontispa longissima. Chinese Patent CN 101849542 A, 2010.
265. Wisutsitthiwong, C.; Buranaruk, C.; Pudhom, K.; Palaga, T. The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-κB and MAPK pathways. Biochem. Biophys. Res. Comm. 2011, 415, 361-366.
266. Adzu, B.; Amos, S.; Amizan, M.B.; Gamaniel, K. Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats. Acta Trop. 2003, 87, 245-250.
267. Agbor, G.A.; Léopold, T.; Jeanne, N.Y. The antidiarrhoeal activity of Alchornea cordifolia leaf extract. Phytother. Res. 2004, 18, 873-876.
268. Atta, A.H.; Mouneir, S.M. Antidiarrhoeal activity of some Egyptian medicinal plant extracts. J. Ethnopharmacol. 2004, 92, 303-309.
269. Gabriel, S.E.; Davenport, S.E.; Steagall, R.J.; Vimal, V.; Carlson, T.; Rozhon, E.J. A novel plant-derived inhibitor of cAMP-mediated fluid and chloride secretion. Am. J. Physiol. Gastrointest. Liver Physiol. 1999, 276, G58-G63.
270. Schuier, M.; Sies, H.; Illek, B.; Fischer, H. Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia. J. Nutr. 2005, 135, 2320-2325.
271. Toda, S.; Shirataki, Y. Inhibitory effects of sophoraflavanones B and H in Sophora moorcroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate in vitro. Biol. Trace Element Res. 2000, 78, 157-162.
272. Kaur, T.; Singh, S.; Dhawan, V.; Ganguly, N.K. Shigella dysenteriae type 1 toxin induced lipid peroxidation in enterocytes isolated from rabbit ileum. Mol. Cell. Biochem. 1998, 178, 169-179.
273. Rawal, S.; Majumdar, S.; Dhawan, V.; Vohra, H. Entamoeba histolytica Gal/GalNAc lectin depletes antioxidant defences of target epithelial cells. Parasitology 2004, 128, 617-624.
274. Nieto, N.; López-Pedrosa, J.M.; Mesa, M.D.; Torres, M.I.; Fernández, M.I.; Ríos, A.; Suárez, M.D.; Gil, A. Chronic diarrhea impairs intestinal antioxidant defense system in rats at weaning. Dig. Dis. Sci. 2000, 45, 2044-2050.
275. Naito, Y.; Takagi, T.; Yoshikawa, T. Neutrophil-dependent oxidative stress in ulcerative colitis. J. Clin. Biochem. Nutr. 2007, 41, 18-26.
276. Tomassoni, A.J.; Simone, K. Herbal medicines for children: An illusion of safety? Curr. Opin. Pediatr. 2001, 13, 162-169.
277. Farnsworth, N.R. Ethnopharmacology and Drug Development. In Ethnobotany and the Search for New Drugs; Chadwick, D.J., Marsh, J., Eds.; Wiley: Chichester, UK, 1994; pp. 42-76.