Antidiabetic activity of cycloart-23-ene-3β, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice

European Journal of Pharmacology

Volumn 632, Issue 1-3, 2010, Pages 103-109

  Badole, Sachin L ^a   Bodhankar, Subhash L ^a  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

25 diol (B2); Antidiabetic; Antioxidant; Cycloart 23 ene 3 ; Pongamia pinnata

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; CYCLOART 23 ENE 3BETA,25 DIOL; GLIBENCLAMIDE; GLOBULIN; GLUCOSE; GLUTATHIONE; GLYCOSYLATED HEMOGLOBIN; INSULIN; LACTATE DEHYDROGENASE; MALONALDEHYDE; NATURAL PRODUCT; NICOTINAMIDE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; URIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ISOLATION; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; HISTOPATHOLOGY; INSULIN BLOOD LEVEL; INSULIN RELEASE; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PANCREAS NECROSIS; PONGAMIA; PONGAMIA PINNATA; PRIORITY JOURNAL; REPEATED DRUG DOSE; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; GLYBURIDE; HYPOGLYCEMIC AGENTS; MICE; MILLETTIA; MODELS, CHEMICAL; NIACINAMIDE; STREPTOZOCIN; TRITERPENES;

EID: 77549083993     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.01.019     Document Type: Article

References (40)

1. Alberti K.G.M., and Press C.M. In: Keen H., and Javve J. (Eds). The biochemistry and the complication of diabetes (1982), Edward Arnold publishers 231-270
2. Almdal T.P., and Vilstrup H. Strict insulin treatment normalizes the organic nitrogen contents and the capacity of urea-N synthesis in experimental diabetes in rats. Diabetologia 3 (1988) 114-118
3. Apparao C., Kameswararao B., and Kesavulu M.M. Evaluation of Antidiabetic effect of Momordica cymbalaria fruit in alloxan-diabetic rats. Fitoterapia 74 (2003) 7-13
4. Asayama K., Nakane T., Uchida N., Hayashihe H., Dobashi K., and Nakazawa S. Serum antioxidant status in streptozotocin-induced diabetic rat. Horm. Metab. Res. 26 (1994) 313-315
5. Badole S.L., and Bodhankar S.L. Investigation of antihyperglycaemic activity of alcoholic extract of stem bark of Pongamia pinnata on serum glucose in diabetic mice. Pharma. Biol. 46 (2008) 900-905
6. Badole S.L., and Bodhankar S.L. Investigation of antihyperglycaemic activity of aqueous and petroleum ether extract of stem bark of Pongamia pinnata on serum glucose in diabetic mice. J. Ethnopharmacol. 123 (2009) 115-120
7. Badole S.L., and Bodhankar S.L. Concomitant administration of petroleum ether extract of stem bark of Pongamia pinnata (L.) Pierre with synthetic oral hypoglycaemic drugs in alloxan induced diabetic mice. Eur. J. Integrat. Med. 1 (2009) 73-79
8. Badole S.L., and Bodhankar S.L. Antihyperglycaemic activity of cycloart-23-ene-3β, 25-diol isolated from stem bark of Pongamia pinnata in alloxan induced diabetic mice. Res. J. Phytochem. 18-24 (2009) 10.3923/rjphyto.2009.18.24
9. Betty A.M., Wendy S., John C.L., Amy L.G., Ira D.G., and Joseph L.E. Protection Against oxidative stress induced insulin resistance in rat L6 muscle cells by micromolar concentrations of α-lipoic acid. Diabetes 50 (2001) 401-410
10. Davis S.N., and Granner D.K. Insulin, oral hypoglycemic agents and the pharmacology of endocrine pancreas. In: Gilman A.G., Goodman L.S., Hardman J.G., and Limbard L.E. (Eds). The Pharmacological Basis of Therapeutics. 10th edition (2001), McGraw Hill companies, New York 1701-1703
11. Fleig P., Marliss E., Ohman J., and Cahill J.F. Plasma amino acid levels in diabetic keto acidosis. Diabetes 19 (1970) 727-729
12. Gomori G.L. Gomori's aldehyde fuschin stain (special stain for β cells). Am. J. Clin. Pathol. 20 (1950) 665-666
13. Halliwell B., and Gutteridge J.M.C. Free radicals in biology and medicine (1985), Oxford, Clarendon Press 1-27
14. Junad A., Lambert A.E., Orci L., Pictet R., Gonet A.E., and Ronald A.E. Studies of diabetogenic action of streptozotocin. Proc. Soc. Exp. Biol. Med. 126 (1967) 201-205
15. Kesari A.N., Kesari S., Singh S.K., Gupta R.K., and Watal G. Studies on the glycemic and lipidemic effect of Murrya koenigii in experimental animals. J. Ethnopharmacol. 112 (2007) 305-311
16. Kumar V., Abbas A.K., and Fausto N. Cellular adaptations, cell injury and cell death. Robbins and Cotran pathologic basis of disease. 7th edition (2005), Elsevier Saunders publisher, Pennsylvania 5-6
17. Kumar G., Sharmila B.G., Murugesan A.G., and Rajasekara P.M. Hypoglycaemic effect of Helicteres isora bark extract in rats. J. Ethnopharmacol. 107 (2006) 304-307
18. Kumari C.S., Govindasamy S., and Sukumar E. Lipid lowering activity of Eclipta prostrata in experimental hyperlipidemia. J. Ethnopharmacol. 105 (2006) 332-335
19. Krentz A.J. Lipoprotien abnormalities and their consequences for patients with type 2 diabetes. Diab. Obes. Metab. 5 (2003) S19-S27
20. Krishnamurthi A. The Wealth of India-Raw Materials, vol-VIII: Ph-Re. Publication and information directorate, Council of Scientific and Industrial Research, New Delhi, India. 1998 (1998) 206-211
21. Lowry O.H., Rosenbrough N.J., Farr A.C., and Randell R.J. Protein measurement with folin-phenol reagent. J. Biol. Chem. 193 (1951) 265-275
22. Mansour H.A., Newairy A.S., Yousef M.I., and Sheiweits S.A. Biochemical study on the effects of some Egyptian herbs in alloxan-induced diabetic rats. Toxicology 170 (2002) 221-228
23. McCord J.M., Keele B.B., and Fridovich I. An enzyme based theory of obligate anaerobiosis, the physiological functions of superoxide dismutase. Proc. Nat. Acad. Sci. U.S.A. 68 (1976) 1024-1027
24. Misera H.P., and Fridovich I. The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for SOD. J. Bio.l Chem. 247 (1972) 3170-3175
25. Morel D.W., and Chisolm G.M. Antidoxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity. J. Lipid Res. 30 (1989) 1827-1834
26. Mori D.M., Baviera A.M., Ramalho L.T.D.O., Vendramini R.C., Brunetti I.L., and Pepato M.T. Temporal response pattern of biochemical analytes in experimental diabetes. Biotechnol. Appl. Biochem. 38 (2003) 183-191
27. Moron M.S., Depierre J.W., and Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochem. Biophys. Act. 582 (1979) 67-78
28. Nicotera P., and Orrenius S. Role of thiols in protection against biological reactive intermediates. Adv. Exp. Med. Biol. 97 (1986) 41-49
29. Saxena R., Madhu V., Shukla R., Prabhu K.M., and Gambhir J.K. Postprandial hypertriglyceridemia and oxidative stress in patients of type 2 diabetes mellitus with macrovascular complications. Clin. Chim. Acta 359 (2005) 101-108
30. Searle A.J., and Wilson R. Glutathione peroxide effect of superoxide, hydroxyl and bromine free radicals on enzyme activity. Int. J. Rad. Biol. 37 (1980) 213-217
31. Sharma S.B., Nasir A., Prabhu K.M., and Murthy P.S. Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. J. Ethnopharmacol. 104 (2006) 367-373
32. Sheela C.G., and Augusti K.T. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol. 30 (1992) 523-526
33. Shirwaikar A., Rajendran K., Kumar C.D., and Bodla. Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats. J. Ethnopharmacol. 91 (2004) 171-175
34. Slater T.F., and Sawyer B.C. The stimulatory effects of carbon tetrachloride and other halogenoalkanes or peroxidative reactions in rat liver fractions in vitro. Biochem. J. 123 (1971) 805-814
35. Strandell E., Eizirik D.L., Korsgren O., and Sandler S. Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations. Mol. Cell Endocrinol. 59 (1988) 83-91
36. Swanston-Flat S.K., Day C., Bailey C.J., and Flatt P.R. Traditional plant treatments for diabetes: studies in normal and streptozotocin diabetic mice. Diabetol. 33 (1990) 462-464
37. Tay Y.C., Wang Y., Kkairaitis I., Rangan G.K., Zang C., and Harris D. Can murine diabetic nephropathy be separated from superimposed acute renal failure?. Kidney Int. 290 (2005) F-214-F-222
38. Tindar P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem. 6 (1969) 24-30
39. Triplitt C.L., Reasner C.A., and Isley W.L. Diabetes mellitus. In: Dipiro J.T., Talbert R.L., Yee G.C., Matzke G.R., Wells B.G., and Posey L.M. (Eds). Pharmacotherapy-a pathophysilogic approach. 6th edition (2005), McGraw-Hill, Medical publishing division, New York 1333-1390
40. Valentovic M.A., Alejandro N., Betts C.A., Brown P.I., and Ramos K. Streptozotocin (STZ) diabetes enhances benzo (alpha) pyrene induced renal injury in Sprague Dawley rats. Toxicol. Lett. 164 (2006) 214-220