Inhibition of chemical carcinogenesis in mice by Ixora coccinea flowers

Pharmaceutical Biology

Volumn 38, Issue 2, 2000, Pages 152-156

  Latha, P G ^a   Panikkar, K R ^a  

^a Tropical Botanic Garden and Research Institute   (India)

Author keywords

7,12 Dimethylbenz(a)anthracene; Chemical carcinogenesis inhibition; Ixora coccinea; Methylcholanthrene

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE; IXORA COCCINEA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; FIBROSARCOMA; MALE; MOUSE; NONHUMAN; PAPILLOMA; SKIN CARCINOGENESIS;

ANIMALIA; COCCOIDEA; CROTON; IXORA COCCINEA;

EID: 0033861163     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/1388-0209(200004)3821-1FT152     Document Type: Article

References (19)

1. Culling CFA, Allison RT, Barr WT (1985): Cellular Pathology Technique, pp. 76-83, London, Butterworths.
2. Dominic YA, Subbaiyan M (1993): Studies on mitochondrial lipid peroxidation in tumour bearing rats treated with ursolic acid and ursolic acetate. Med Sci Res 21: 213-217.
3. Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, Stauber K, Ma W, Georgiardis C (1994): Inhibition of skin tumorigenesis by rosemary and its constituents, carnasol and ursolic acid. Cancer Res 54: 701-704.
4. Ito Y, Yanase S, Tokuda H, Kishishita M, Ohigashi H, Irota M, Koshimizu K (1983): Epstein-Barr virus activation by tung oil and diterpene ester. Cancer Lett 18: 87-90.
5. Latha PG, Panikkar KR (1996): Chemo-protection of Ixora coccinea L. flower extracts towards cyclophosphamide toxicity in normal and tumour bearing mice. Proceedings of the Eighth Kerala Science Congress, Cochin, Kerala, India, pp. 244-248.
6. Latha PC, Panikkar KR (1998): Cytotoxic and antitumour principles from Ixora coccinea flowers. Cancer Lett 130: 197-202.
7. Lee HY, Chung HY, Kim KH, Lee JJ, Kim KW (1994): Induction of differentiation in cultured F9 teratocarcinoma stem cells by triterpene acids. J Cancer Res Clin Oncol 120: 513-515.
8. Liu J (1995): Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 49: 57-62.
9. Murakami A, Ohigashi H, Koshimizu K (1996): Antitumour promotion with food chemicals: a strategy for cancer chemoprevention. Biosci Biotech Biochem 60: 1-5.
10. Nair SC, Panikkar KR (1990): Antitumour principles from Ixora javanica. Cancer Lett 49: 121-124.
11. Nair SC, Panikkar KR (1991): Inhibitory effects of Ixora javanica extract on skin chemical carcinogenesis in mice and its antitumour activity. Cancer Lett 60: 523-526.
12. Panikkar KR, Bhanumathy P, Raghunath PN (1986): Antitumour activity of an ayurvedic oil preparation. Ancient Sci Life 6: 107-110.
13. Patnaik GK, Visen PK, Binduja S, Dayal R, Srimal RC (1993): Ursolic acid, a potent hepatoprotective agent from Eucalyptus tereticornis. Indian J Pharmacol 25: 38-41.
14. Prashar R, Kumar A (1994): Chemoprotection of Liv - 52 on DMBA induced papillomagenesis in skin of mice. Indian J Exp Biol 32: 643-646.
15. Rhew TH, Park SM, Park KY, Chung HY, Ha JC, Lee CK (1992): Effect of ursolic acid on oncogene expression detected by in situ hybridisation in mice. Yakhak Hoechi 36: 529-537.
16. Salomi MJ, Nair SC, Panikkar KR (1991): Inhibitory effects of saffron and Nigella saliva extracts on chemical carcinogenesis in mice. Nutr Cancer 16: 67-70.
17. Slaga TJ (1986): Sencar mouse skin tumorigenesis model versus other strains and stocks of mice. Environ Health Perspect 68: 27-31.
18. Tokuda H, Ohigashi H, Koshmizu K, Ito Y (1986): Inhibitory effects of ursolic and oleanolic acids on skin tumour promotion by 12-0-tetradecanoyl phorbol-13 acetate. Cancer Lett 33: 279-282.
19. Wattenberg LW (1985): Chemoprevention of cancer. Cancer Res 41: 1-5.