메뉴 건너뛰기




Volumn 345, Issue 3, 2013, Pages 404-418

Parathyroid hormone (PTH) and PTH-related peptide domains contributing to activation of different PTH receptor-mediated signaling pathwayss

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PEPTIDE[1-34]; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE[1-34]; UNCLASSIFIED DRUG;

EID: 84878059956     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.199752     Document Type: Article
Times cited : (54)

References (50)
  • 1
    • 0026598246 scopus 로고
    • Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium
    • Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, and Potts JT, Jr, et al. (1992) Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2732-2736
    • Abou-Samra, A.B.1    Jüppner, H.2    Force, T.3    Freeman, M.W.4    Kong, X.F.5    Schipani, E.6    Urena, P.7    Richards, J.8    Bonventre, J.V.9    Potts Jr., J.T.10
  • 2
    • 84867290208 scopus 로고    scopus 로고
    • Measurements of b-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation
    • Bassoni DL, Raab WJ, Achacoso PL, Loh CY, and Wehrman TS (2012) Measurements of b-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation. Methods Mol Biol 897:181-203.
    • (2012) Methods Mol Biol , vol.897 , pp. 181-203
    • Bassoni, D.L.1    Raab, W.J.2    Achacoso, P.L.3    Loh, C.Y.4    Wehrman, T.S.5
  • 3
    • 0037064132 scopus 로고    scopus 로고
    • Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations
    • Bisello A, Chorev M, Rosenblatt M, Monticelli L, Mierke DF, and Ferrari SL (2002) Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations. J Biol Chem 277:38524-38530.
    • (2002) J Biol Chem , vol.277 , pp. 38524-38530
    • Bisello, A.1    Chorev, M.2    Rosenblatt, M.3    Monticelli, L.4    Mierke, D.F.5    Ferrari, S.L.6
  • 5
    • 78449304780 scopus 로고    scopus 로고
    • Synthesis and structural studies of new analogues of PTH(1-11) containing Ca-tetra-substituted amino acids in position 8
    • Caporale A, Sturlese M, Schievano E, Mammi S, and Peggion E (2010) Synthesis and structural studies of new analogues of PTH(1-11) containing Ca-tetra-substituted amino acids in position 8. Amino Acids 39:1369-1379.
    • (2010) Amino Acids , vol.39 , pp. 1369-1379
    • Caporale, A.1    Sturlese, M.2    Schievano, E.3    Mammi, S.4    Peggion, E.5
  • 6
    • 27644521278 scopus 로고    scopus 로고
    • Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism
    • Castro M, Nikolaev VO, Palm D, Lohse MJ, and Vilardaga JP (2005) Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proc Natl Acad Sci USA 102:16084-16089.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16084-16089
    • Castro, M.1    Nikolaev, V.O.2    Palm, D.3    Lohse, M.J.4    Vilardaga, J.P.5
  • 9
    • 0001163236 scopus 로고    scopus 로고
    • (Bilezikian JP, Raisz LG, and Rodan GA, eds, ed), Academic Press, Inc., San Diego, CA
    • Fitzpatrick LA and Bilezikian JP (1996) Principles of Bone Biology (Bilezikian JP, Raisz LG, and Rodan GA, eds, ed) pp 339-346, Academic Press, Inc., San Diego, CA.
    • (1996) Principles of Bone Biology , pp. 339-346
    • Fitzpatrick, L.A.1    Bilezikian, J.P.2
  • 10
    • 0035405802 scopus 로고    scopus 로고
    • Molecular properties of the PTH/PTHrP receptor
    • Gardella TJ and Jüppner H (2001) Molecular properties of the PTH/PTHrP receptor. Trends Endocrinol Metab 12:210-217.
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 210-217
    • Gardella, T.J.1    Jüppner, H.2
  • 11
    • 13444274543 scopus 로고    scopus 로고
    • Parathyroid hormone and parathyroid hormone-related peptide, and their receptors
    • Gensure RC, Gardella TJ, and Jüppner H (2005) Parathyroid hormone and parathyroid hormone-related peptide, and their receptors. Biochem Biophys Res Commun 328:666-678.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 666-678
    • Gensure, R.C.1    Gardella, T.J.2    Jüppner, H.3
  • 13
    • 73949084919 scopus 로고    scopus 로고
    • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation
    • Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, and Lutrell LM (2009) A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci Transl Med 1:1-20.
    • (2009) Sci Transl Med , vol.1 , pp. 1-20
    • Gesty-Palmer, D.1    Flannery, P.2    Yuan, L.3    Corsino, L.4    Spurney, R.5    Lefkowitz, R.J.6    Lutrell, L.M.7
  • 14
    • 77954923592 scopus 로고    scopus 로고
    • Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Endocrinology 15
    • Guo J, Liu M, Yang D, Bouxsein ML, Thomas CC, Schipani E, Bringhurst FR, and Kronenberg HM (2010) Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Endocrinology 15. Endocrinology 151:3502-3513.
    • (2010) Endocrinology , vol.151 , pp. 3502-3513
    • Guo, J.1    Liu, M.2    Yang, D.3    Bouxsein, M.L.4    Thomas, C.C.5    Schipani, E.6    Bringhurst, F.R.7    Kronenberg, H.M.8
  • 15
    • 0029855956 scopus 로고    scopus 로고
    • Truncation of the amino terminus of PTH alters its anabolic activity on bone in vivo
    • Hilliker S, Wergedal JE, Gruber HE, Bettica P, and Baylink DJ (1996) Truncation of the amino terminus of PTH alters its anabolic activity on bone in vivo. Bone 19: 469-477.
    • (1996) Bone , vol.19 , pp. 469-477
    • Hilliker, S.1    Wergedal, J.E.2    Gruber, H.E.3    Bettica, P.4    Baylink, D.J.5
  • 16
    • 0026584625 scopus 로고
    • Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone
    • Hock JM and Gera I (1992) Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone. J Bone Miner Res 7:65-72.
    • (1992) J Bone Miner Res , vol.7 , pp. 65-72
    • Hock, J.M.1    Gera, I.2
  • 17
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • Jilka RL (2007) Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40:1434-1446.
    • (2007) Bone , vol.40 , pp. 1434-1446
    • Jilka, R.L.1
  • 18
  • 19
    • 36348946976 scopus 로고    scopus 로고
    • Functional selectivity through protean and biased agonism: Who steers the ship?
    • Kenakin T (2007) Functional selectivity through protean and biased agonism: Who steers the ship? Mol Pharmacol 72:1393-1401.
    • (2007) Mol Pharmacol , vol.72 , pp. 1393-1401
    • Kenakin, T.1
  • 20
    • 78751498756 scopus 로고    scopus 로고
    • Functional selectivity and biased receptor signaling
    • Kenakin T (2011) Functional selectivity and biased receptor signaling. J Pharmacol Exp Ther 336:296-302.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 296-302
    • Kenakin, T.1
  • 21
    • 0034878897 scopus 로고    scopus 로고
    • Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation
    • Ma YL, Cain RL, Halladay DL, Yang X, Zeng Q, Miles RR, Chandrasekhar S, Martin TJ, and Onyia JE (2001) Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 142:4047-4054.
    • (2001) Endocrinology , vol.142 , pp. 4047-4054
    • Ma, Y.L.1    Cain, R.L.2    Halladay, D.L.3    Yang, X.4    Zeng, Q.5    Miles, R.R.6    Chandrasekhar, S.7    Martin, T.J.8    Onyia, J.E.9
  • 23
    • 13944269143 scopus 로고    scopus 로고
    • In vitro and in vivo activities of C-terminally truncated PTH peptides reveal a disconnect between cAMP signaling and functional activity
    • Murrills RJ, Matteo JJ, Samuel RL, Andrews JL, Bhat BM, Coleburn VE, Kharode YP, and Bex FJ (2004) In vitro and in vivo activities of C-terminally truncated PTH peptides reveal a disconnect between cAMP signaling and functional activity. Bone 35:1263-1272.
    • (2004) Bone , vol.35 , pp. 1263-1272
    • Murrills, R.J.1    Matteo, J.J.2    Samuel, R.L.3    Andrews, J.L.4    Bhat, B.M.5    Coleburn, V.E.6    Kharode, Y.P.7    Bex, F.J.8
  • 25
    • 79960902373 scopus 로고    scopus 로고
    • Understanding the effect of different assay formats on agonist parameters: A study using the m-opioid receptor
    • Nickolls SA, Waterfield A, Williams RE, and Kinloch RA (2011) Understanding the effect of different assay formats on agonist parameters: A study using the m-opioid receptor. J Biomol Screen 16:706-716.
    • (2011) J Biomol Screen , vol.16 , pp. 706-716
    • Nickolls, S.A.1    Waterfield, A.2    Williams, R.E.3    Kinloch, R.A.4
  • 27
    • 55949089800 scopus 로고    scopus 로고
    • Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation
    • Okazaki M, Ferrandon S, Vilardaga JP, Bouxsein ML, Potts JT, Jr, and Gardella TJ (2008) Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proc Natl Acad Sci USA 105:16525-16530.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16525-16530
    • Okazaki, M.1    Ferrandon, S.2    Vilardaga, J.P.3    Bouxsein, M.L.4    Potts Jr., J.T.5    Gardella, T.J.6
  • 28
    • 34147207553 scopus 로고    scopus 로고
    • Beta galactosidase complementation: A cell-based luminescent assay platform for drug discovery
    • Olson KR and Eglen RM (2007) Beta galactosidase complementation: A cell-based luminescent assay platform for drug discovery. Assay Drug Dev Technol 5:137-144.
    • (2007) Assay Drug Dev Technol , vol.5 , pp. 137-144
    • Olson, K.R.1    Eglen, R.M.2
  • 30
    • 42449160533 scopus 로고    scopus 로고
    • Molecular recognition of parathyroid hormone by its G protein-coupled receptor
    • Pioszak AA and Xu HE (2008) Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proc Natl Acad Sci USA 105:5034-5039.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5034-5039
    • Pioszak, A.A.1    Xu, H.E.2
  • 31
    • 70350504319 scopus 로고    scopus 로고
    • Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides
    • Pioszak AA, Parker NR, Gardella TJ, and Xu HE (2009) Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem 284:28382-28391.
    • (2009) J Biol Chem , vol.284 , pp. 28382-28391
    • Pioszak, A.A.1    Parker, N.R.2    Gardella, T.J.3    Xu, H.E.4
  • 33
    • 84855901533 scopus 로고    scopus 로고
    • Molecular mechanism of b-arrestin-biased agonism at seven-transmembrane receptors
    • Reiter E, Ahn S, Shukla AK, and Lefkowitz RJ (2012) Molecular mechanism of b-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol 52:179-197.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 179-197
    • Reiter, E.1    Ahn, S.2    Shukla, A.K.3    Lefkowitz, R.J.4
  • 34
    • 33646254393 scopus 로고    scopus 로고
    • In vitro and in vivo effect of parathyroid hormone analogue (1-14 containing-amino-iso-butyric acid residue (Aib)13
    • Rhee Y, Lee W, Lee EJ, Ma S, Park SY, and Lim SK (2006) In vitro and in vivo effect of parathyroid hormone analogue (1-14) containing-amino-iso-butyric acid residue (Aib)1,3. Yonsei Med J 47:214-222.
    • (2006) Yonsei Med J , vol.47 , pp. 214-222
    • Rhee, Y.1    Lee, W.2    Lee, E.J.3    Ma, S.4    Park, S.Y.5    Lim, S.K.6
  • 36
    • 0035966121 scopus 로고    scopus 로고
    • Parathyroid hormone (PTH)-(1-14) and-(1-11) analogs conformationally constrained by alpha-aminoisobutyric acid mediate full agonist responses via the juxtamembrane region of the PTH-1 receptor
    • Shimizu N, Guo J, and Gardella TJ (2001) Parathyroid hormone (PTH)-(1-14) and-(1-11) analogs conformationally constrained by alpha-aminoisobutyric acid mediate full agonist responses via the juxtamembrane region of the PTH-1 receptor. J Biol Chem 276:49003-49012.
    • (2001) J Biol Chem , vol.276 , pp. 49003-49012
    • Shimizu, N.1    Guo, J.2    Gardella, T.J.3
  • 37
    • 12544259198 scopus 로고    scopus 로고
    • Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3
    • Shimizu N, Dean T, Khatri A, and Gardella TJ (2004) Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3. J Bone Miner Res 19:2078-2086.
    • (2004) J Bone Miner Res , vol.19 , pp. 2078-2086
    • Shimizu, N.1    Dean, T.2    Khatri, A.3    Gardella, T.J.4
  • 38
    • 2542484525 scopus 로고    scopus 로고
    • Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: Conditional efficacy of PTH peptide fragments
    • Sneddon WB, Magyar CE, Willick GE, Syme CA, Galbiati F, Bisello A, and Friedman PA (2004) Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: Conditional efficacy of PTH peptide fragments. Endocrinology 145:2815-2823.
    • (2004) Endocrinology , vol.145 , pp. 2815-2823
    • Sneddon, W.B.1    Magyar, C.E.2    Willick, G.E.3    Syme, C.A.4    Galbiati, F.5    Bisello, A.6    Friedman, P.A.7
  • 39
    • 15744405759 scopus 로고    scopus 로고
    • Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling
    • Syme CA, Friedman PA, and Bisello A (2005) Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling. J Biol Chem 280:11281-11288.
    • (2005) J Biol Chem , vol.280 , pp. 11281-11288
    • Syme, C.A.1    Friedman, P.A.2    Bisello, A.3
  • 40
    • 0032918004 scopus 로고    scopus 로고
    • Dual signaling and ligand selectivity of the human PTH/PTHrP receptor
    • Takasu H, Guo J, and Bringhurst FR (1999) Dual signaling and ligand selectivity of the human PTH/PTHrP receptor. J Bone Miner Res 14:11-20.
    • (1999) J Bone Miner Res , vol.14 , pp. 11-20
    • Takasu, H.1    Guo, J.2    Bringhurst, F.R.3
  • 41
    • 0020064261 scopus 로고
    • Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: Differential effects of intermittent and continuous administration
    • Tam CS, Heersche JN, Murray TM, and Parsons JA (1982) Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: Differential effects of intermittent and continuous administration. Endocrinology 110: 506-512.
    • (1982) Endocrinology , vol.110 , pp. 506-512
    • Tam, C.S.1    Heersche, J.N.2    Murray, T.M.3    Parsons, J.A.4
  • 42
    • 84856269291 scopus 로고    scopus 로고
    • From parathyroid hormone to cytosolic Ca21 signals
    • Taylor CW and Tovey SC (2012) From parathyroid hormone to cytosolic Ca21 signals. Biochem Soc Trans 40:147-152.
    • (2012) Biochem Soc Trans , vol.40 , pp. 147-152
    • Taylor, C.W.1    Tovey, S.C.2
  • 43
    • 80053287704 scopus 로고    scopus 로고
    • Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay
    • Trinquet E, Bouhelal R, and Dietz M (2011) Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay. Expert Opin Drug Discov 6:981-994.
    • (2011) Expert Opin Drug Discov , vol.6 , pp. 981-994
    • Trinquet, E.1    Bouhelal, R.2    Dietz, M.3
  • 46
    • 78650968168 scopus 로고    scopus 로고
    • Molecular basis of parathyroid hormone receptor signaling and trafficking: A family B GPCR paradigm
    • Vilardaga JP, Romero G, Friedman PA, and Gardella TJ (2011) Molecular basis of parathyroid hormone receptor signaling and trafficking: A family B GPCR paradigm. Cell Mol Life Sci 68:1-13.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1-13
    • Vilardaga, J.P.1    Romero, G.2    Friedman, P.A.3    Gardella, T.J.4
  • 47
    • 78649803293 scopus 로고    scopus 로고
    • Osteoclastogenic activity and RANKL expression are inhibited in osteoblastic cells expressing constitutively active Ga(12) or constitutively active RhoA
    • Wang J and Stern PH (2010) Osteoclastogenic activity and RANKL expression are inhibited in osteoblastic cells expressing constitutively active Ga(12) or constitutively active RhoA. J Cell Biochem 111:1531-1536.
    • (2010) J Cell Biochem , vol.111 , pp. 1531-1536
    • Wang, J.1    Stern, P.H.2
  • 48
    • 0030031878 scopus 로고    scopus 로고
    • Stimulation of the growth of femoral trabecular bone in ovariectomized rats by the novel parathyroid hormone fragment, hPTH-(1-31) NH2 (Ostabolin
    • Whitfield JF, Morley P, Willick GE, Ross V, Barbier JR, Isaacs RJ, and Ohannessian-Barry L (1996) Stimulation of the growth of femoral trabecular bone in ovariectomized rats by the novel parathyroid hormone fragment, hPTH-(1-31)NH2 (Ostabolin). Calcif Tissue Int 58:81-87.
    • (1996) Calcif Tissue Int , vol.58 , pp. 81-87
    • Whitfield, J.F.1    Morley, P.2    Willick, G.E.3    Ross, V.4    Barbier, J.R.5    Isaacs, R.J.6    Ohannessian-Barry, L.7
  • 49
    • 34249075203 scopus 로고    scopus 로고
    • Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone
    • Yang D, Singh R, Divieti P, Guo J, Bouxsein ML, and Bringhurst FR (2007) Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone. Bone 40: 1453-1461.
    • (2007) Bone , vol.40 , pp. 1453-1461
    • Yang, D.1    Singh, R.2    Divieti, P.3    Guo, J.4    Bouxsein, M.L.5    Bringhurst, F.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.