Parathyroid Hormone (PTH)-(1-14) and -(1-11) Analogs Conformationally Constrained by α-Aminoisobutyric Acid Mediate Full Agonist Responses via the Juxtamembrane Region of the PTH-1 Receptor

Journal of Biological Chemistry

Volumn 276, Issue 52, 2001, Pages 49003-49012

  Shimizu, Naoto ^a   Guo, Jun ^a   Gardella, Thomas J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOASSAY; CELLS; SUBSTITUTION REACTIONS;

BINDING AFFINITY;

HORMONES;

2 AMINO 2 METHYLPROPIONIC ACID; CYCLIC AMP; HORMONE STIMULATING AGENT; INOSITOL PHOSPHATE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RECEPTOR 1; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE[1-11]; PARATHYROID HORMONE[1-14]; PARATHYROID HORMONE[1-21]; PARATHYROID HORMONE[1-34]; PHOSPHOLIPASE C; TRITIUM; UNCLASSIFIED DRUG; 2-AMINOISOBUTYRIC ACID; PARATHYROID HORMONE; PEPTIDE FRAGMENT;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING COMPETITION; BINDING SITE; DRUG POTENCY; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; KIDNEY CELL; NONHUMAN; PARATHYROID GLAND; PEPTIDE ANALYSIS; PRIORITY JOURNAL; ANIMAL; BONE; BONE MINERALIZATION; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CELL STRAIN COS1; CHEMISTRY; CIRCULAR DICHROISM; CYTOLOGY; DRUG EFFECT; EMBRYO; GENETICS; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; SWINE;

ANIMALIA;

AMINOISOBUTYRIC ACIDS; ANIMAL; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL LINE; CHONDROCYTES; CIRCULAR DICHROISM; COS CELLS; CYCLIC AMP; EMBRYO; HUMAN; MICE; PARATHYROID HORMONES; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, PARATHYROID HORMONE; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, P.H.S.; SWINE; TUMOR CELLS, CULTURED;

EID: 0035966121     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106827200     Document Type: Article

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