Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay

Expert Opinion on Drug Discovery

Volumn 6, Issue 10, 2011, Pages 981-994

  Trinquet, Eric ^a   Bouhelal, Rochdi ^b   Dietz, Michel ^c  

^a RandD ^*  (France)

^b NOVARTIS PHARMA AG   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Functional assays; G protein coupled receptors; HTRF; Inositol phosphate; IP1

Indexed keywords

1,5 BIS(4 ALLYLDIMETHYLAMMONIUMPHENYL)PENTAN 3 ONE DIBROMIDE; 2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 8,9 DICHLORO 2,3,4,4A TETRAHYDRO 1H PYRAZINO[1,2 A]QUINOXALIN 5(6H) ONE; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; AMINOBENZTROPINE; ATROPINE; BENZATROPINE; BENZATROPINE MESILATE; CARBACHOL; DICYCLOVERINE; ENDOTHELIN 2; G PROTEIN COUPLED RECEPTOR; GQ COUPLED RECEPTOR; HYOSCYAMINE; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL PHOSPHATE; IPRATROPIUM BROMIDE; ORPHENADRINE; OXYBUTYNIN; OXYTOCIN; PANCURONIUM BROMIDE; PIRENZEPINE; PROPANTHELINE BROMIDE; QUISQUALIC ACID; SEROTONIN; TRIHEXYPHENIDYL; TROPICAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASOPRESSIN;

CALCIUM TRANSPORT; DRUG INDUSTRY; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 80053287704     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2011.608658     Document Type: Review

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