Current situation on analysis of marine toxins

Reviews in Analytical Chemistry

Volumn 32, Issue 1, 2013, Pages 15-34

  Botana, Ana M ^a   Otero, Paz ^a   Rodriguez, Paula ^a   Alfonso, Amparo ^a   Botana, Luis M ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Analytical standards; Chromatography; Marine toxins; Mass spectrometry

Indexed keywords

EID: 84877947301     PISSN: 07930135     EISSN: None     Source Type: Journal    
DOI: 10.1515/revac-2012-0020     Document Type: Article

References (170)

1. Alfonso, A.; Vieytes, M. R.; Yasumoto, T.; Botana, L. M. Arapid microplate fluorescence method to detect yessotoxins based on their capacity to activate phosphodiesterases. Anal. Biochem. 2004, 326, 93 - 99. (Pubitemid 38177487)
2. Alfonso, C.; Rehmann, N.; Hess, P.; Alfonso, A.; Wandscheer, C. B.; Abuin, M.; Vale, C.; Otero, P.; Vieytes, M. R.; Botana, L. M. Evaluation of various pH and temperature conditions on the stability of Azaspiracids and their importance in preparative isolation and toxicological studies. Anal. Chem. 2008, 80, 9672 - 9680.
3. Association of Official Analytical Chemists. Official Methods of Analysis of the Association of Official Analytical Chemists Method 2005.06; First Action. MD, USA: AOAC, 2005.
4. Bates, H. A.; Rapoport, H. Chemical assay for saxitoxin, the paralytic shellfish poison. J. Agr. Food Chem. 1975, 23, 237 - 239.
5. Bates, S. S.; Bird, C. J.; De Freitas, A. S. W.; Foxall, R. A.; Gilgan, M.; Hanic, L. A.; Johnson, G. R.; McCulloch, A. W.; Odense, P.; Pocklington, R.; Quilliam, M. A.; Sim, P. G.; Smith, J. C.; Subba Rao, D. V.; Todd, E. C. D.; Walter, J. A.; Wright, J. L. C. Pennate Diatom Nitzschia pungens as the Primary Source of Domoic Acid, a Toxin in Shellfish from Eastern Prince Edward Island, Canada. Can. J. Fish Aquat. Sci. 1989, 46, 1203 - 1215.
6. Beani, L.; Bianchi, C.; Guerrini, F.; Marani, L.; Pistocchi, R.; Tomasini, M. C.; Ceredi, A.; Milandri, A.; Poletti, R.; Boni, L. High sensitivity bioassay of paralytic (PSP) and amnesic (ASP) algal toxins based on the fluorimetric detection of [Ca 2 + ] i in rat cortical primary cultures. Toxicon. 2000, 38, 1283 - 1297. (Pubitemid 30151144)
7. Bentur, Y.; Spanier, E. Ciguatoxin-like substances in edible fish on the eastern Mediterranean. Clin. Toxicol. (Phila ) 2007, 45, 695 - 700. (Pubitemid 47394412)
8. Bentur, Y.; Ashkar, J.; Lurie, Y.; Levy, Y.; Azzam, Z. S.; Litmanovich, M.; Golik, M.; Gurevych, B.; Golani, D.; Eisenman, A. Lessepsian migration and tetrodotoxin poisoning due to Lagocephalus sceleratus in the eastern Mediterranean. Toxicon 2008, 52, 964- 968.
9. Blay, P.; Hui, J. P.; Chang, J.; Melanson, J. E. Screening for multiple classes of marine biotoxins by liquid chromatography - highresolution mass spectrometry. Anal. Bioanal. Chem. 2011, 400, 577 - 585.
10. Botana, L. M.; Alfonso, A.; Botana, A.; Vieytes, M. R.; Vale, C.; Vilarino, N.; Louzao, M. C. Functional assays for marine toxins as an alternative, high-throughput-screening solution to animal tests. Trends Anal. Chem. 2009, 28, 603 - 611.
11. Botana, L. M.; Vilari n o, N.; Elliott, C. T.; Campbell, K.; Alfonso, A.; Vale, C.; Louzao, M. C.; Botana, A. M. The problem of toxicity equivalent factors in developing alternative methods to animal bioassays for marine-toxin detection. Trends Anal. Chem. 2010, 29, 1316 - 1325.
12. Botana, L. M.; Vieytes, M. R.; Botana, A. M.; Vale, C.; Vilarino, N. In: Cabado, A.G; Vieites, J. M., eds. New Trends in Marine and Freshwater Toxins. New York: Nova Science, Inc., 2012, p. 203.
13. Buckley, L. J.; Oshima, Y.; Shimizu, Y. Construction of a paralytic shellfish toxin analyzer and its application. Anal. Biochem. 1978, 85, 157 - 164. (Pubitemid 8301315)
14. Caillaud, A.; de la Iglesia, P.; Darius, H. T.; Pauillac, S.; Aligizaki, K.; Fraga, S.; Chinain, M.; Diogene, J. Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe. Mar. Drugs 2010, 8, 1838 - 1907.
15. Campbell, K.; Stewart, L. D.; Doucette, G. J.; Fodey, T. L.; Haughey, S. A.; Vilarino, N.; Kawatsu, K.; Elliott, C. T. Assessment of specific binding proteins suitable for the detection of paralytic shellfish poisons using optical biosensor technology. Anal. Chem. 2007, 79, 5906 - 5914. (Pubitemid 47229843)
16. Campbell, K.; Haughey, S. A.; van den Top, H.; van Egmond, H.; Vilarino, N.; Botana, L. M.; Elliott, C. T. Single laboratory validation of a surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins. Anal. Chem. 2010, 82, 2977 - 2988.
17. Campbell, A.; Vilari n o, N.; Botana, L. M.; Elliott, C. T. A European perspective on progress in moving away from the mouse bioassay for marine-toxin analysis. Trends Anal. Chem. 2011, 30, 239 - 253.
18. C.E. (CEN). European Committee for Standardization (CEN), 2003.
19. Chan, I. O.; Tsang, V. W.; Chu, K. K.; Leung, S. K.; Lam, M. H.; Lau, T. C.; Lam, P. K.; Wu, R. S. Solid-phase extraction-fluorimetric high performance liquid chromatographic determination of domoic acid in natural seawater mediated by an amorphous titania sorbent. Anal. Chim. Acta 2007, 583, 111 - 117. (Pubitemid 46037631)
20. Chen, X. W.; Liu, H. X.; Jin, Y. B.; Li, S. F.; Bi, X.; Chung, S.; Zhang, S. S.; Jiang, Y. Y. Separation, identification and quantification of tetrodotoxin and its analogs by LC-MS without calibration of individual analogs. Toxicon. 2011, 57, 938- 943.
21. Cho, H. E.; Ahn, S. Y.; Son, I. S.; In, S.; Hong, R. S.; Kim, D. W.; Woo, S. H.; Moon, D. C.; Kim, S. Determination and validation of tetrodotoxin in human whole blood using hydrophilic interaction liquid chromatography - tandem mass spectroscopy and its application. Forensic Sci. Int. 2012, 217, 76 - 80.
22. Chulanetra, M.; Sookrung, N.; Srimanote, P.; ndrawattana, N.; Thanongsaksrikul, J.; Sakolvaree, Y.; Chongsa-Nguan, M.; Kurazono, H.; Chaicumpa, W. Toxic marine puffer fish in thailand seas and tetrodotoxin they contained. Toxins. (Basel) 2011, 3, 1249 - 1262.
23. Ciminiello, P.; Dell'aversano, C.; Fattorusso, E.; Forino, M.; Magno, G. S.; Tartaglione, L.; Quilliam, M. A.; Tubaro, A.; Poletti, R. Hydrophilic interaction liquid chromatography/mass spectrometry for determination of domoic acid in Adriatic shellfish. Rapid Commun. Mass. Spectrom. 2005, 19, 2030 - 2038. (Pubitemid 41026427)
24. Ciminiello, P.; Dell'aversano, C.; Dello Iacovo, E.; Fattorusso, E.; Forino, M.; Grauso, L.; Tartaglione, L.; Guerrini, F.; Pistocchi, R. Complex palytoxin-like profile of Ostreopsis ovata. Identification of four new ovatoxins by high-resolution liquid chromatography/mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24, 2735 - 2744.
25. Cohen, N. J.; Deeds, J. R.; Wong, E. S.; Hanner, R. H.; Yancy, H. F.; White, K. D.; Thompson, T. M.; Wahl, M.; Pham, T. D.; Guichard, F. M.; Huh, I.; Austin, C.; Dizikes, G.; Gerber, S. I. J. Food Prot. 2009, 72, 810.
26. Commission Regulation. Off. J. Eur. Commun. 2011, L6, 3.
27. de la Iglesia, P.; Gimenez, G.; Diogene, J. Determination of dissolved domoic acid in seawater with reversed-phase extraction disks and rapid resolution liquid chromatography tandem mass spectrometry with head-column trapping. J. Chromatogr. A 2008, 1215, 116 - 124.
28. Dechraoui, M. Y.; Tiedeken, J. A.; Persad, R.; Wang, Z.; Granade, H. R.; Dickey, R. W.; Ramsdell, J. S. Use of two detection methods to discriminate ciguatoxins from brevetoxins: Application to great barracuda from Florida Keys. Toxicon. 2005, 46, 261 - 270. (Pubitemid 41033157)
29. Dell'aversano, C.; Hess, P.; Quilliam, M. A. Hydrophilic interaction liquid chromatography - mass spectrometry for the analysis of paralytic shellfish poisoning (PSP) toxins. J. Chromatogr. A 2005, 1081, 190 - 201. (Pubitemid 40848402)
30. Diener, M.; Erler, K.; Christian, B.; Luckas, B. Application of a new zwitterionic hydrophilic interaction chromatography column for determination of paralytic shellfish poisoning toxins. J. Sep. Sci. 2007, 30, 1821 - 1826. (Pubitemid 47243964)
31. Doucette, G.; Mikulski, C.; Jones, K.; King, K.; Marin, R.; Jensen, S.; Roman, B.; Elliott, C.; Scholin, C. Remote, subsurface detection of the algal toxin domoic acid onboard the environmental sample processor: assay development and field trials. Harmful Algae 2009, 8, 880 - 888.
32. European Commission. Off. J. Eur. Union 2004a, L226, 22.
33. European Commission. Off. J. Eur Union L 2004b, 226, 83.
34. European Commission. Off. J. Eur. Union 2005, L338, 27.
35. European Commission. Off. J. Eur. Union 2006, L320, 13.
36. European Commission. Off. J. Eur. Union 2007, L281, 12.
37. European Commission Panel. EFSA J. 2009a, 1181, 1.
38. European Commission Panel. EFSA J. 2009b, 1306, 1.
39. Fonfria, E. S.; Vilarino, N.; Campbell, K.; Elliott, C.; Haughey, S. A.; Ben-Gigirey, B.; Vieites, J. M.; Kawatsu, K.; Botana, L. M. Paralytic shellfish poisoning detection by surface plasmon resonance-based biosensors in shellfish matrixes. Anal. Chem. 2007, 79, 6303 - 6311. (Pubitemid 47282344)
40. Furey, A.; Lehane, M.; Gillman, M.; Fernandez-Puente, P.; James, K. J. Determination of domoic acid in shellfish by liquid chromatography with electrospray ionization and multiple tandem mass spectrometry. J. Chromatogr. A 2001, 938, 167-174. (Pubitemid 33145462)
41. Fux, E.; McMillan, D.; Bire, R.; Hess, P. Development of an ultraperformance liquid chromatography - mass spectrometry method for the detection of lipophilic marine toxins. J. Chromatogr. A 2007, 1157, 273 - 280. (Pubitemid 46970854)
42. Gago-Martinez, A.; Pineiro, N.; Aguete, E. C.; Vaquero, E.; Nogueiras, M.; Leao, J. M.; Rodriguez-Vazquez, J. A.; Dabek- Zlotorzynska, E. Further improvements in the application of high-performance liquid chromatography, capillary electrophoresis and capillary electrochromatography to the analysis of algal toxins in the aquatic environment. J. Chromatogr. A 2003, 992, 159 - 168. (Pubitemid 36349639)
43. Galil, B. S.; Zenetos, A. In: Leppa, E.; Koski, S.; Gollasch, S.; Olenin, eds. Invasive Aquatic Species of Europe: Distribution, Impacts and Management. Dordrecht, The Netherlands: Kluwer Academic, 2002, p. 325.
44. Garet, E.; Gonzalez-Fernandez, A.; Lago, J.; Vieites, J. M.; Cabado, A. G. Comparative evaluation of Enzyme-Linked Immunoassay and reference methods for the detection of shellfish hydrophilic toxins in several presentations of seafood. Toxicon 2010, 58, 1410-1415.
45. Gerssen, A.; McElhinney, M. A.; Mulder, P. P.; Bire, R.; Hess, P.; de Boer, J. Solid phase extraction for removal of matrix effects in lipophilic marine toxin analysis by liquid chromatographytandem mass spectrometry. Anal. Bioanal. Chem. 2009, 394, 1213 - 1226.
46. Gerssen, A.; Mulder, P. P.; de Boer, J. Screening of lipophilic marine toxins in shellfish and algae: development of a library using liquid chromatography coupled to orbitrap mass spectrometry. Anal. Chim. Acta. 2011, 685, 176 - 185.
47. Gessner, B. D.; McLaughlin, J. B. In: Botana, L. M. ed. Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection. Boca Raton, FL: CRC Press (Taylor and Francis Group), 2008, p. 77.
48. Golani, D. Distribution of Lessepsian migrant fish in the Mediterranean. Ital. J. Zool. 1998, 65, 95 - 99. (Pubitemid 29319522)
49. Gonzalez, J. C.; Leira, F.; Fontal, O. I.; Vieytes, M. R.; Arevalo, F. F.; Vieites, J. M.; Berm u dez-Puente, M.; Muniz, S.; Salgado, C.; Yasumoto, T.; Botana, L. M. Inter-laboratory validation of the fluorescent protein phosphatase inhibition assay to determine diarrhetic shellfish toxins: intercomparison with liquid chromatography and mouse bioassay. Anal. Chim. Acta. 2002, 466, 233 - 246.
50. Hamasaki, K.; Kogure, K.; Ohwada, K. A biological method for the quantitative measurement of tetrodotoxin (TTX): Tissue culture bioassay in combination with a water-soluble tetrazolium salt. Toxicon. 1996, 34, 490 - 495. (Pubitemid 26130128)
51. Hamilton, B.; Hurbungs, M.; Jones, A.; Lewis, R. J. Multiple ciguatoxins present in Indian Ocean reef fish. Toxicon. 2002a, 40, 1347 - 1353. (Pubitemid 35239906)
52. Hamilton, B.; Hurbungs, M.; Vernoux, J. P.; Jones, A.; Lewis, R. J. Isolation and characterisation of Indian Ocean ciguatoxin. Toxicon. 2002b, 40, 685 - 693. (Pubitemid 34439231)
53. Hamilton, B., Whittle, N., Shaw, G., Eaglesham, G., Moore, M. R., Lewis, R. J. Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon. 2010, 56, 668-673.
54. He, Y.; Fekete, A.; Chen, G.; Harir, M.; Zhang, L.; Tong, P.; Schmitt- Kopplin, P. Analytical approaches for an important shellfish poisoning agent: domoic acid. J. Agric. Food Chem. 2010, 58, 11525 - 11533.
55. Hess, P.; Gallacher, S.; Bates, L. A.; Brown, N.; Quilliam, M. A. Determination and confirmation of the amnesic shellfish poisoning toxin, domoic acid, in shellfish from Scotland by liquid chromatography and mass spectrometry. J. AOAC Int. 2001, 84, 1657-1667. (Pubitemid 33610607)
56. Hess, P.; Grune, B.; Anderson, D. B.; Aune, T.; Botana, L. M.; Caricato, P.; van Egmond, H. P.; Halder, M.; Hall, S.; Lawrence, J. F.; Moffat, C.; Poletti, R.; Richmond, J.; Rossini, G. P.; Seamer, C.; Vilageliu, J. S. Altern. Lab. Anim. 2006, 34, 193.
57. Horner, R. A.; Kusske, M. B.; Moynihan, B. P.; Skinner, R. N.; Wekell, J. C. Retention of domoic acid by Pacific razor clams, Siliqua patula (Dixon, 1798): preliminary study J. Shellfish Res. 1993, 12, 451.
58. Huang, X.; Hsu, K. H.; Chu, F. S. Direct competitive enzyme-linked immunosorbent assay for saxitoxin and neosaxitoxin. J. Agric. Food Chem. 1996, 44, 1029 - 1035. (Pubitemid 126466949)
59. International, A. In: Horowitz, ed. Official Methods of Analysis of the AOAC. Gaithersburg, Maryland: AOAC, 2000.
60. James, K. J.; Gillman, M.; Lehane, M.; Gago-Martinez, A. New fluorimetric method of liquid chromatography for the determination of the neurotoxin domoic acid in seafood and marine phytoplankton. J. Chromatogr. A. 2000, 871, 1 - 6. (Pubitemid 30103728)
61. Jang, J. H.; Lee, J. S.; Yotsu-Yamashita, M. LC/MS analysis of tetrodotoxin and its deoxy analogs in the marine puffer fish Fugu niphobles from the southern coast of Korea, and in the brackishwater puffer fishes Tetraodon nigroviridis and Tetraodon biocellatus from Southeast Asia. Mar. Drugs 2010, 8, 1049 - 1058.
62. Jen, H. C.; Lin, S. J.; Lin, S. Y.; Huang, Y. W.; Liao, I. C.; Arakawa, O.; Hwang, D. F. Occurrence of tetrodotoxin and paralytic shellfish poisons in a gastropod implicated in food poisoning in southern Taiwan. Food Addit. Contam. 2007, 24, 902 - 909. (Pubitemid 47050299)
63. Jen, H. C.; Lin, S. J.; Tsai, Y. H.; Chen, C. H.; Lin, Z. C.; Hwang, D. F. Tetrodotoxin poisoning evidenced by solid-phase extraction combining with liquid chromatography\xe2\u20ac\u201ctandem mass spectrometry. J. Chromatogr. B 2008, 871, 95 - 100.
64. Katikou, P.; Georgantelis, D.; Sinouris, N.; Petsi, A.; Fotaras, T. First report on toxicity assessment of the Lessepsian migrant pufferfish Lagocephalus sceleratus (Gmelin, 1789) from European waters (Aegean Sea, Greece). Toxicon. 2009, 54, 50 - 55.
65. Kawabata, T. Food Hygiene Examination Manual. Tokyo: Japan Food Hygiene Association, 1978, p. 232.
66. Kawatsu, K.; Shibata, T.; Hamano, Y. Application of immunoaffinity chromatography for detection of tetrodotoxin from urine samples of poisoned patients. Toxicon. 1999, 37, 325 - 333. (Pubitemid 29042167)
67. Kilcoyne, J.; Fux, E. Strategies for the elimination of matrix effects in the liquid chromatography tandem mass spectrometry analysis of the lipophilic toxins okadaic acid and azaspiracid-1 in molluscan shellfish. J.Chromatogr. A. 2010, 1217, 7123-7130.
68. Kleivdal, H.; Kristiansen, S. I.; Nilsen, M. V.; Goksoyr, A.; Briggs, L.; Holland, P.; McNabb, P. Determination of domoic acid toxins in shellfish by biosense ASP ELISA - a direct competitive enzymelinked immunosorbent assay: collaborative study. J. AOAC Int. 2007, 90, 1011.
69. Kodamatani, H.; Saito, K.; Niina, N.; Yamazaki, S.; Muromatsu, A.; Sakurada, I. Sensitive determination of domoic acid using high-performance liquid chromatography with electrogenerated Tris(2, 2 ′ -bipyridine)ruthenium(III) chemiluminescence detection. Anal. Sci. 2004, 20, 1065 - 1068.
70. Kono, M.; Matsui, T.; Furukawa, K.; Takase, T.; Yamamori, K.; Kaneda, H.; Aoki, D.; Jang, J. H.; Yotsu-Yamashita, M. Examination of transformation among tetrodotoxin and its analogs in the living cultured juvenile puffer fish, kusafugu, Fugu niphobles by intramuscular administration. Toxicon. 2008, 52, 714 - 720.
71. Kreuzer, M. P.; Pravda, M.; O'Sullivan, C. K.; Guilbault, G. G. Novel electrochemical immunosensors for seafood toxin analysis. Toxicon. 2002, 40, 1267 - 1274. (Pubitemid 35239896)
72. Kudo, Y.; Yasumoto, T.; Konoki, K.; Cho, Y.; Yotsu-Yamashita, M. Isolation and structural determination of the first 8- epi- type tetrodotoxin analogs from the newt, cynops ensicauda popei, and comparison of tetrodotoxin analogs profiles of this newt and the puffer fish, Fugu poecilonotus. Mar. Drugs 2012, 10, 655 - 667.
73. Lawrence, J. F.; Menard, C. Liquid chromatographic determination of paralytic shellfish poisons in shellfish after prechromatographic oxidation. J. AOAC Int. 1991, 74, 1006-1012.
74. Lawrence, J. F.; Charbonneau, C. F.; Menard, C.; Quilliam, M. A.; Sim, P. G. Liquid chromatographic determination of domoic acid in shellfish products using the paralytic shellfish poison extraction procedure of the association of official analytical chemists. J. Chromatogr. 1989, 462, 349 - 356. (Pubitemid 19047379)
75. Lawrence, J. F.; Cleroux, C.; Truelove, J. F. Comparison of highperformance liquid chromatography with radioimmunoassay for the determination of domoic acid in biological samples. J. Chromatogr. A 1994, 662, 173 - 177. (Pubitemid 24065385)
76. Lawrence, J. F.; Menard, C.; Cleroux, C. Evaluation of prechromatographic oxidation for liquid chromatographic determination of paralytic shellfish poisons in shellfish. J. AOAC Int. 1995, 78, 514.
77. Le Berre, M.; Kane, M. Biosensor-based assay for domoic acid: comparison of performance using polyclonal, monoclonal, and recombinant antibodies. Anal. Lett. 2006, 39, 1587 - 1598. (Pubitemid 43879692)
78. Lefebvre, K. A.; Robertson, A.; Frame, E. R.; Colegrove, K. M.; Nance, S.; Baugh, K. A.; Wiedenhoft, H.; Gulland, F. M. D. Clinical signs and histopathology associated with domoic acid poisoning in northern fur seals (callorhinus ursinus) and comparison of toxin detection methods. Harmful Algae 2010, 9, 374.
79. Lehman, E. M.; Brodie, E. D. Jr.; Brodie, E. D. III. No evidence for an endosymbiotic bacterial origin of tetrodotoxin in the newt Taricha granulosa. Toxicon. 2004, 44, 243 - 249.
80. Leira, F.; Alvarez, C.; Cabado, A. G.; Vieites, J. M.; Vieytes, M. R.; Botana, L. M. Development of a F actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins. Anal. Biochem. 2003, 317, 129 - 135. (Pubitemid 36577621)
81. Leung, K. S.-Y.; Fong, B. M.-W.; Tsoi, Y.-K. Analytical challenges: determination of tetrodotoxin in human urine and plasma by LC-MS/MS. Mar. Drugs 2011, 9, 2291 - 2303.
82. Lewis, R. J.; Jones, A. Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography/mass spectrometry. Toxicon. 1997, 35, 159 - 168. (Pubitemid 27102281)
83. Lewis, R. J.; Vernoux, B. I. M. Structure of Caribbean ciguatoxin lsolated from Caranx latus. J. Am. Chem. Soc. 1998, 120, 5914 - 5920. (Pubitemid 28306975)
84. Lewis, R. J.; Yang, A.; Jones, A. Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh. Toxicon. 2009, 54, 62 - 66.
85. Lin, S. J.; Hwang, D. F. Possible source of tetrodotoxin in the starfish Astropecten scoparius. Toxicon. 2001, 39, 573 - 579.
86. Litaker, R. W.; Vandersea, M. W.; Faust, M. A.; Kibler, S. R.; Nau, A. W.; Holland, W. C.; Chinain, M.; Holmes, M. J.; Tester, P. A. Toxicon. 2010, 56, 711 - 730.
87. Llamas, N. M.; Stewart, L.; Fodey, T.; Higgins, H. C.; Velasco, M. L.; Botana, L. M.; Elliott, C. T. Development of a novel immunobiosensor method for the rapid detection of okadaic acid contamination in shellfish extracts. Anal. Bioanal. Chem. 2007, 389, 581 - 587. (Pubitemid 47319583)
88. Louzao, M. C.; Vieytes, M. R.; Baptista de Sousa, J. M.; Leira, F.; Botana, L. M. A fluorimetric method based on changes in membrane potential for screening paralytic shellfish toxins in mussels. Anal. Biochem. 2001, 289, 246 - 250. (Pubitemid 32173672)
89. Lundholm, N.; Skov, J.; Pocklington, R.; Moestrup, O. Domoic acid, the toxic amino acid responsible for amnesic shellfish poisoning, now in Pseudonitzschia seriata (Bacillariophyceae) in Europe. Phycologia 1994, 33, 475 - 478.
90. Mafra, L. L. Jr.; Leger, C.; Bates, S. S.; Quilliam, M. A. Analysis of trace levels of domoic acid in seawater and plankton by liquid chromatography without derivatization, using UV or mass spectrometry detection. J. Chromatogr. A. 2009, 1216, 6003 - 6011.
91. Man, C. N.; Noor, N. M.; Harn, G. L.; Lajis, R.; Mohamad, S. Screening of tetrodotoxin in puffers using gas chromatography - mass spectrometry. J. Chromatogr. A 2010, 1217, 7455 - 7459.
92. McNabb, P. In: Botana, L. M., ed. Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection. Boca Raton, FL: CRC Press (Taylor and Francis Group), 2008, p. 209.
93. McNabb, P.; Selwood, A. I.; Holland, P. T.; Aasen, J.; Aune, T.; Eaglesham, G.; Hess, P.; Igarishi, M.; Quilliam, M.; Slattery, D.; Van de Riet, J.; Van Egmond, H.; Van den Top, H.; Yasumoto, T. J. AOAC Int. 2005, 88, 761.
94. Messner, D. J.; Catterall, W. A. The sodium channel from rat brain. Role of the beta 1 and beta 2 subunits in saxitoxin binding. J. Biol. Chem. 1986, 261, 211.
95. Micheli, L.; Radoi, A.; Guarrina, R.; Massaud, R.; Bala, C.; Moscone, D.; Palleschi, G. Disposable immunosensor for the determination of domoic acid in shellfish. Biosens. Bioelectron. 2004, 20, 190 - 196. (Pubitemid 39077621)
96. M i guez, A.; Fernandez, M. L.; Fraga, S. First detection of domoic acid in Galicia (NW of Spain). In: Yasumoto, T.; Oshima, Y.; Fukuyo, Y., eds. Harmful and Toxic Algal Blooms: Intergovernmental Oceanographic Commission of UNESCO. Paris, France: UNESCO, 1996, p. 143.
97. Miyazawa, K.; Noguchi, T. J. Toxicol. Toxin. Rev. 2001, 20, 11.
98. Mosher, H.S.; Fuhrman, G.J.; Fuhrman, F.A.; Fischer, H.G. Tarichatoxintetrodotoxin: a potent neurotoxin. Science 1965, 144, 1100- 1110.
99. Narita, H.; Martsubara, S.; Miwa, N.; Akahane, S.; Murakami, M.; Goto, T.; Nara, M.; Noguchi, T.; Saito, T.; Shida, Y.; Hashimoto, K. Occurrence of Tetrodotoxin in a Trumpet Shell, " Boshubora " Charonia sauliae. Bull. Japan Soc. Sci. Fish. 1987, 47, 935- 941.
100. Neagu, D.; Micheli, L.; Palleschi, G. Study of a toxin - alkaline phosphatase conjugate for the development of an immunosensor for tetrodotoxin determination. Anal. Bioanal. Chem. 2006, 385, 1068 - 1074. (Pubitemid 43992163)
101. Negri, A.; Stirling, D.; Quilliam, M.; Blackburn, S.; Bolch, C.; Burton, I.; Eaglesham, G.; Thomas, K.; Walter, J.; Willis, R. Three novel hydroxybenzoate saxitoxin analogues isolated from the dinoflagellate Gymnodinium catenatum. Chem. Res. Toxicol. 2003, 16, 1029 - 1033. (Pubitemid 37047921)
102. Noguchi, T.; Ebesu, J. S. M. Puffer poisoning: epidemiology and treatment. J. Toxicol. Toxin Rev. 2001, 20, 1-10. (Pubitemid 32294900)
103. Noguchi, T.; Arakawa, O. Tetrodotoxin - distribution and accumulation in aquatic organisms, and cases of human intoxication. Mar. Drugs 2008, 6, 220 - 242. (Pubitemid 351919081)
104. O'Leary, M. A.; Schneider, J. J.; Isbister, G. K. Use of high performance liquid chromatography to measure tetrodotoxin in serum and urine of poisoned patients. Toxicon. 2004, 44, 549- 553. (Pubitemid 39278378)
105. Onodera, H.; Satake, M.; Oshima, Y.; Yasumoto, T.; Carmichael, W. W. New saxitoxin analogues from the freshwater filamentous cyanobacterium Lyngbya wolle Nat. Toxins 1997, 5, 146- 151. (Pubitemid 27514121)
106. Oshima, Y. Postcolumn derivatization liquid chromatographic method for paralytic shellfish toxins. J. AOAC Int. 1995, 78, 528.
107. Oshima, Y.; Fallon, W. E.; Shimizu, Y.; Noguchi, T.; Hashimoto, Y. Toxins of the Gonyaulax sp. and Infested Bivalves in Owase Bay. Bull. Jpn. Soc. Sci. Fish 1976, 42, 851 - 856.
108. Oshima, Y.; Machida, M.; Sasaki, K.; Tamaoki, Y.; Yasumoto, T. Liquid chromatographic-fluorometric analysis of paralytic shellfish toxins. Agric. Biol. Chem. 1984, 48, 1707 - 1711. (Pubitemid 14028000)
109. Oshima, Y.; Hasegawa, M.; Yasumoto, T.; Hallegraeff, G.; Blackburn, S. Dinoflagellate Gymnodinium catenatum as the source of paralytic shellfish toxins in Tasmanian shellfish. Toxicon 1987, 25, 1105 - 1111. (Pubitemid 18041679)
110. Otero, P.; Perez, S.; Alfonso, A.; Vale, C.; Rodriguez, P.; Gouveia, N. N.; Gouveia, N.; Delgado, J.; Vale, P.; Hirama, M.; Ishihara, Y.; Molg o, J.; Botana, L. M. First toxin profile of ciguateric fish in Madeira arquipelago (Europe). Anal. Chem. 2010, 82, 6032- 6039.
111. Otero, P.; Alfonso, A.; Alfonso, C.; Rodriguez, P.; Vieytes, M. R.; Botana, L. M. Effect of uncontrolled factors in a validated liquid chromatography - tandem mass spectrometry method question its use as a reference method for marine toxins: major causes for concern. Anal. Chem. 2011a, 83, 5903 - 5911.
112. Otero, P.; Alfonso, A.; Alfonso, C.; Araoz, R.; Molg o, J.; Vieytes, M. R.; Botana, L. M. First direct fluorescence polarization assay for the detection and quantification of spirolides in mussel samples. Anal. Chim. Acta 2011b, 701, 200 - 208.
113. Pardo, O.; Yusa, V.; Leon, N.; Pastor, A. Development of a pressurised liquid extraction and liquid chromatography with electrospray ionization-tandem mass spectrometry method for the determination of domoic acid in shellfish. J. Chromatogr. A 2007, 1154, 287 - 294. (Pubitemid 46850741)
114. Perez-Arellano, J. L.; Luzardo, O. P.; Perez Brito, A.; Hernandez Cabrera, M.; Zumbado, M.; Carranza, C.; Angel-Moreno, A.; Dickey, R. W.; Boada, L. D. Ciguatera fish poisoning, Canary Islands. Emerg. Infect. Dis. 2005, 11, 1981.
115. Pleasance, S.; Xie, M.; LeBlanc, Y.; Quilliam, M. A. Analysis of domoic acid and related compounds by mass spectrometry and gas chromatography/mass spectrometry as N -trifluoroacetyl- O -silyl derivatives. Biomed. Environ. Mass. Spectrom. 1990, 19, 420 - 427. (Pubitemid 20335929)
116. Pocklington, R.; Milley, J. E.; Bates, S. S.; Bird, C. J.; De Freitas, A. S. W.; Quilliam, M. A. Trace determination of domoic acid in sea water and phytoplankton by high-performance liquid chromatography of the fluorenylmethoxycarbonyl (FMOC) derivative. Int. J. Environ. Anal. Chem. 1990, 38, 351 - 368.
117. Pottier, I.; Vernoux, J. P.; Jones, A.; Lewis, R. J. Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies. Food Addit. Contam. 2002a, 19, 1034 - 1042. (Pubitemid 35331477)
118. Pottier, I.; Vernoux, J. P.; Jones, A.; Lewis, R. J. Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack ( Caranx latus ) by high-performance liquid chromatography/mass spectrometry. Toxicon. 2002b, 40, 929 - 939. (Pubitemid 34663686)
119. Powell, C. L.; Ferdin, M. E.; Busman, M.; Kvitek, R. G.; Doucette, G. J. Development of a protocol for determination of domoic acid in the sand crab ( Emerita analoga ): a possible new indicator species. Toxicon. 2002, 40, 485 - 492. (Pubitemid 34124047)
120. Quilliam, M. A. The role of chromatography in the hunt for red tide toxins. J. Chromatogr. A 2003, 1000, 527 - 548. (Pubitemid 36638473)
121. Quilliam, M. A.; Thomas, K.; Wright, J. L. Analysis of domoic acid in shellfish by thin-layer chromatography. Nat. Toxins 1998, 6, 147 - 152. (Pubitemid 29121551)
122. Raybould, T.; Bignami, G. S.; Inouye, L. K.; Simpson, S. B.; Byrnes, J. B.; Grothaus, P. G.; Vann, D. C. Amonoclonal antibody-based immunoassay for detecting tetrodotoxin in biological samples. J. Clin. Lab. Anal. 1992, 6, 65 - 72.
123. Rhodes, L. L.; Smith, K. F.; Munday, R.; Selwood, A. I.; McNabb, P. S.; Holland, P. T.; Bottein, M. Y. Toxic dinoflagellates ( Dinophyceae) from Rarotonga, Cook Islands. Toxicon. 2010, 56, 751- 758.
124. Rodriguez, P.; Alfonso, A.; Vale, C.; Alfonso, C.; Vale, P.; Tellez, A.; Botana, L. M. First toxicity report of tetrodotoxin and 5, 6, 11-trideoxyTTX in the trumpet shell Charonia lampas lampas in Europe. Anal. Chem. 2008, 80, 5622 - 5629.
125. Rodriguez, P.; Alfonso, A.; Botana, A. M.; Vieytes, M. R.; Botana, L. M. Comparative analysis of pre- and post-column oxidation methods for detection of paralytic shellfish toxins. Toxicon. 2010, 56, 448- 457.
126. Rodriguez, P.; Alfonso, A.; Otero, P.; Katikou, P.; Georgantelis, D.; Botana, L. M. Liquid chromatography - mass spectrometry method to detect tetrodotoxin and its analogues in the puffer fish Lagocephalus sceleratus (Gmelin, 1789) from European waters. Food Chem. 2012, 132, 1103 - 1111.
127. Rodriguez-Velasco, M. L. Toxin monitoring programs and regulatory review. In: Botana, L. M., ed. Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection. Boca Raton, FL: CRC Press (Taylor and Francis Group), 2008, p. 919.
128. Roeder, K.; Erler, K.; Kibler, S.; Tester, P.; Van The, H.; Nguyen-Ngoc, L.; Gerdts, G.; Luckas, B. Characteristic profiles of Ciguatera toxins in different strains of Gambierdiscus spp. Toxicon. 2010, 56, 731 - 738.
129. Rubiolo, J. A.; Lopez-Alonso, H.; Alfonso, A.; Vega, F. V.; Vieytes, M. R.; Botana, L. M. Characterization and activity determination of the human protein phosphatase 2a catalytic subunit a expressed in insect larvae. Appl. Biochem. Biotechnol. 2012, 167, 918- 928.
130. Rundberget, T.; Aasen, J. A.; Selwood, A. I.; Miles, C. O. Pinnatoxins and spirolides in Norwegian blue mussels and seawater. Toxicon. 2011, 58, 700 - 711.
131. Satake, M.; Ishibashi, Y.; Legrand, A. M.; Yasumoto, T. Biosci. Biotechnol. Biochem. 1997, 60, 2103 - 2105.
132. Shoji, Y.; Yotsu-Yamashita, M.; Miyazawa, T.; Yasumoto, T. Electrospray ionization mass spectrometry of tetrodotoxin and its analogs: liquid chromatography/mass spectrometry, tandem mass spectrometry, and liquid chromatography/tandem mass spectrometry. Anal. Biochem. 2001, 290, 10.
133. Silva, M.; Azevedo, J.; Rodriguez, P.; Alfonso, A.; Botana, L. M.; Vasconcelos, V. New gastropod vectors and tetrodotoxin potential expansion in temperate waters of the Atlantic Ocean. Mar. Drugs 2012, 10, 712 - 726.
134. Sommer, H.; Meyer, K. F. Paralytic shellfish poisoning. Arch. Path. 1937, 24, 560.
135. Stevens, R. C.; Soelberg, S. D.; Eberhart, B.-T. L.; Spencer, S.; Wekell, J. C.; Chinowsky, T. M.; Trainer, V. L.; Furlong, C. E. Detection of the toxin domoic acid from clam extracts using a portable surface plasmon resonance biosensor. Harmful Algae 2007, 6, 166 - 174. (Pubitemid 46136083)
136. Stewart, L.; Elliott, C.; Walker, A.; Curran, R.; Connolly, L. Development of a monoclonal antibody binding okadaic acid and dinophysistoxins-1, -2 in proportion to their toxicity equivalence factors. Toxicon. 2009a, 54, 491 - 498.
137. Stewart, L. D.; Hess, P.; Connolly, L.; Elliott, C. T. Development and single-laboratory validation of a pseudofunctional biosensor immunoassay for the detection of the okadaic acid group of toxins. Anal. Chem. 2009b, 81, 10208 - 10214.
138. Stobo, L. A.; Lacaze, J. P.; Scott, A. C.; Gallacher, S.; Smith, E. A.; Quilliam, M. A. J. AOAC Int. 2005, 88, 1371.
139. Suzuki, T.; Quilliam, M. A. LC-MS/MS analysis of diarrhetic shellfish poisoning (DSP) toxins, okadaic acid and dinophysistoxin analogues, and other lipophilic toxins. Anal. Sci. 2011, 27, 571.
140. Traynor, I. M.; Plumpton, L.; Fodey, T. L.; Higgins, C.; Elliott, C. T. J. AOAC Int. 2006, 89, 868.
141. Tsai, Y. H.; Hwang, D. F.; Cheng, C. A.; Hwang, C. C.; Deng, J. F. Determination of tetrodotoxin in human urine and blood using C18 cartridge column, ultrafiltration and LC-MS. J. Chromatogr. B 2006, 832, 75 - 80. (Pubitemid 43213012)
142. Turner, A. D.; Norton, D. M.; Hatfield, R. G.; Morris, S.; Reese, A. R.; Algoet, M.; Lees, D. N. Refinement and extension of AOAC method 2005.06 to include additional toxins in mussels: single-laboratory validation. J. AOAC Int. 2009, 92, 190.
143. Ujevic, I.; Nincevic-Gladan, Z.; Roje, R.; Skejic, S.; Arapov, J.; Marasovic, I. Domoic acid - a new toxin in the croatian adriatic shellfish toxin profile. Molecules 2010, 15, 6835 - 6849.
144. Vale, C.; Alfonso, A.; Vieytes, M. R.; Romaris, X. M.; Arevalo, F.; Botana, A. M.; Botana, L. M. In vitro and in vivo evaluation of paralytic shellfish poisoning toxin potency and the influence of the pH of extraction. Anal. Chem. 2008a, 80, 1770 - 1776. (Pubitemid 351429584)
145. Vale, P. Complex profiles of hydrophobic paralytic shellfish poisoning compounds in Gymnodinium catenatum identified by liquid chromatography with fluorescence detection and mass spectrometry. J. Chromatogr. A 2008b, 1195, 85 - 93.
146. Vale, P.; Sampayo, M. A. M. Domoic acid in Portuguese shellfish and fish. Toxicon. 2001, 39, 893-904. (Pubitemid 32012957)
147. Vale, P.; Rangel, I.; Silva, B.; Coelho, P.; Vilar, A. Atypical profiles of paralytic shellfish poisoning toxins in shellfish from Luanda and Mussulo bays, Angola. Toxicon. 2009, 53, 176 - 183.
148. van den Top, H. J.; Gerssen, A.; McCarron, P.; van Egmond, H. P. Quantitative determination of marine lipophilic toxins in mussels, oysters and cockles using liquid chromatographymass spectrometry: inter-laboratory validation study. Food Addit. Contam. 2011a, 28, 1745-1757.
149. van den Top, H. J.; Elliott, C. T.; Haughey, S. A.; Vilarino, N.; van Egmond, H. P.; Botana, L. M.; Campbell, K. Surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins: a pilot interlaboratory study. Anal. Chem. 2011b, 83, 4206 - 4213.
150. Van Dolah, F. M. Diversity of marine and freshwater algal toxins. In: Botana, L. M., ed. Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection. New York: Marcel Dekker, 2000, p. 19.
151. Vieites, J. M.; Cabado, A. G. Incidence of marine toxins on industrial activity. In: Botana, L. M., ed. Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection. Boca Raton, FL: CRC Press (Taylor and Francis Group), 2008, p. 899.
152. Vieytes, M. R.; Cabado, A. G.; Alfonso, A.; Louzao, M. C.; Botana, A. M.; Botana, L. M. Solid-phase radioreceptor assay for paralytic shellfish toxins. Anal. Biochem. 1993, 211, 87 - 93. (Pubitemid 23189334)
153. Vieytes, M. R.; Fontal, O. I.; Leira, F.; Baptista de Sousa, J. M.; Botana, L. M. A fluorescent microplate assay for diarrheic shellfish toxins. Anal. Biochem. 1997, 248, 258 - 264. (Pubitemid 27233162)
154. Vilarino, N.; Fonfria, E. S.; Molgo, J.; Araoz, R.; Botana, L. M. Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization. Anal. Chem. 2009, 81, 2708- 2714.
155. Villar-Gonzalez, A.; Rodriguez-Velasco, M. L.; Ben-Gigirey, B.; Botana, L. M. Lipophilic toxin profile in Galicia (Spain): 2005 toxic episode. Toxicon. 2007, 49, 1129.
156. Villar-Gonzalez, A.; Rodriguez-Velasco, M. L.; Ben-Gigirey, B.; Yasumoto, T.; Botana, L. M. Assessment of the hydrolysis process for the determination of okadaic acid-group toxin ester: Presence of okadaic acid 7- O -acyl-ester derivates in Spanish shellfish. Toxicon. 2008, 51, 765 - 773.
157. Wang, Z.; King, K. L.; Ramsdell, J. S.; Doucette, G. J. Determination of domoic acid in seawater and phytoplankton by liquid chromatography - tandem mass spectrometry. J. Chromatogr. A 2007, 1163, 169 - 176. (Pubitemid 47247712)
158. Wang, X. J.; Yu, R. C.; Luo, X.; Zhou, M. J.; Lin, X. T. Toxin-screening and identification of bacteria isolated from highly toxic marine gastropod Nassarius semiplicatus. Toxicon. 2008, 52, 55 - 61.
159. Wiese, M.; D'Agostino, P. M.; Mihali, T. K.; Moffitt, M. C.; Neilan, B. A. Neurotoxic alkaloids: saxitoxin and its analogs. Mar. Drugs 2010, 8, 2185- 2211.
160. Wright, J. L. C.; Falk, M.; McInnes, A. G.; Walter, J. A. Identification of isodomoic acid D and two new geometrical isomers of domoic acid in toxic mussels. Can. J. Chem. 1990, 68, 22 - 25. (Pubitemid 20136211)
161. Yakes, B. J.; Deeds, J.; White, K.; DeGrasse, S. L. Evaluation of surface plasmon resonance biosensors for detection of tetrodotoxin in food matrices and comparison to analytical methods. J. Agric. Food Chem. 2011, 59, 839 - 846.
162. Yasumoto, Y. The Manual for the Methods of Food Sanitation Tests. Japan Food Hygienic Association: Tokyo, Japan, 1991, p. 296.
163. Yasumoto, T.; Fukui, M.; Sasaki, K.; Sugiyama, K. Determinations of marine toxins in foods. J. AOAC Int. 1995, 78, 574-582.
164. Yogi, K.; Oshiro, N.; Inafuku, Y.; Hirama, M.; Yasumoto, T. Detailed LC-MS/MS analysis of ciguatoxins revealing distinct regional and species characteristics in fish and causative alga from the Pacific. Anal. Chem. 2011, 83, 8886 - 8891.
165. Yu, C. H.; Yu, C. F.; Tam, S.; Yu, P. H. Rapid screening of tetrodotoxin in urine and plasma of patients with puffer fish poisoning by HPLC with creatinine correction. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 2010, 27, 89-96.
166. Yu, F.-Y.; Liu, B.-H.; Wu, T.-S.; Chi, T.-F.; Su, M.-C. Development of a sensitive enzyme-linked immunosorbent assay for the determination of domoic acid in shellfish. J. Agric. Food Chem. 2004, 52, 5334 - 5339.
167. Zaki, M. A.; Mossa, A. E. W. Red Sea puffer fish poisoning: Emergency diagnosis and management of human intoxication. Egypt. J. Aquat. Res. 2005, 31, 370-378.
168. Zaman, L.; Arakawa, O.; Shimosu, A.; Onoue, Y.; Nishio, S.; Shida, Y.; Noguchi, T. Two new isomers of domoic acid from a red alga, Chondria armata. Toxicon. 1997, 35, 205- 212. (Pubitemid 27102286)
169. Zhao, J. Y.; Thibault, P.; Quilliam, M. A. Analysis of domoic acid isomers in seafood by capillary electrophoresis. Electrophoresis 1997, 18, 268 - 276. (Pubitemid 27089592)
170. Zhou, Y.; Li, Y.-S.; Pan, F.-G.; Liu, Z.-S.; Wang, Z. The development and optimization of ELISA for the determination of tetrodotoxin. J. Med. Coll. of PLA 2007, 22, 347 - 351.