Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases

Journal of Biological Chemistry

Volumn 288, Issue 20, 2013, Pages 14287-14296

  De Diego, Iñaki ^a   Veillard, Florian T ^b   Guevara, Tibisay ^a   Potempa, Barbara ^b   Sztukowska, Maryta ^b   Potempa, Jan ^b,c   Gomis Rüth, F Xavier ^a  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^b UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^c JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC CYSTEINES; CATALYTIC DOMAINS; CYSTEINE PEPTIDASE; INHIBITORY MECHANISM; PERIODONTAL DISEASE; REGULATORY MECHANISM; STRUCTURAL DETERMINANTS; SUBSTRATE SPECIFICITY;

ENZYMES; HYDROGEN BONDS; PROTEINS;

AMINO ACIDS;

ARGININE; CYSTEINE; ENZYME PRECURSOR; GINGIPAIN RGPB; GLUTAMINE; HISTIDINE; LECTIN; SUGAR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL SECRETION SYSTEM; BACTERIAL STRAIN; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; REGULATORY MECHANISM; STRUCTURE ANALYSIS; ZYMOGENICITY;

CYSTEINE PROTEASE; INHIBITION; LATENCY; PEPTIDASES; PRO-PEPTIDASE; PROTEASE INHIBITOR; PROTEIN CRYSTALLIZATION; X-RAY CRYSTALLOGRAPHY;

ADHESINS, BACTERIAL; ARGININE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; CYSTEINE ENDOPEPTIDASES; ENZYME PRECURSORS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PORPHYROMONAS GINGIVALIS; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; VIRULENCE FACTORS;

EID: 84877912442     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.444927     Document Type: Article

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