A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A

Journal of Biological Chemistry

Volumn 283, Issue 5, 2008, Pages 2871-2882

  Mallorquí Fernández, Noemí ^a   Manandhar, Surya P ^b   Mallorquí Fernández, Goretti ^a   Usón, Isabel ^a   Wawrzonek, Katarzyna ^c   Kantyka, Tomasz ^c   Solà, Maria ^a   Thøgersen, Ida B ^d   Enghild, Jan J ^d   Potempa, Jan ^b,c   Gomis Rüth, F Xavier ^a  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^b University of Georgia ^*  (United States)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ACTIVE CONFORMATIONS; CATALYTIC CYSTEINE RESIDUES; CATALYTIC CYSTEINES; COMPETENT CONFORMATIONS; CYSTEINE PROTEASES; HOST DEFENSES; INTERMEDIA; PROTEOLYTIC ENZYMES; SUB DOMAINS; TISSUE DESTRUCTIONS; VIRULENCE FACTORS;

AMINO ACIDS;

ALANINE; CYSTEINE PROTEINASE; ENZYME PRECURSOR; HISTIDINE; INTERPAIN A; TRYPTOPHAN; UNCLASSIFIED DRUG; BACTERIAL DNA; PRIMER DNA; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; NONHUMAN; PREVOTELLA INTERMEDIA; PRIORITY JOURNAL; PROTEIN DOMAIN; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTRICITY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA;

AMINO ACID SEQUENCE; BASE SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; DNA PRIMERS; DNA, BACTERIAL; ELECTROSTATICS; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PREVOTELLA INTERMEDIA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 41449101928     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708481200     Document Type: Article

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