Point mutation in luminal Loop 7 of scap protein blocks interaction with Loop 1 and abolishes movement to Golgi

Journal of Biological Chemistry

Volumn 288, Issue 20, 2013, Pages 14059-14067

  Zhang, Yinxin ^a   Motamed, Massoud ^a,b   Seemann, Joachim ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL HOMEOSTASIS; CO-IMMUNOPRECIPITATIONS; CO-TRANSFECTIONS; ENDOPLASMIC RETICULUM; POLYTOPIC PROTEINS; STEROL REGULATORY ELEMENT-BINDING PROTEINS; TERMINAL PORTIONS; TRANSMEMBRANE HELICES;

ALCOHOLS; CELL MEMBRANES; CHOLESTEROL;

PROTEINS;

25 HYDROXYCHOLESTEROL; CELL PROTEIN; COAT PROTEIN COMPLEX II; SCAP PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEFECT; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; STRUCTURE ACTIVITY RELATION;

CHOLESTEROL REGULATION; CHOLESTEROL-BINDING PROTEIN; MEMBRANE FUNCTION; MEMBRANE LIPIDS; MEMBRANE PROTEINS; SCAP; STEROL REGULATORY ELEMENT-BINDING PROTEIN (SREBP);

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CHOLESTEROL; CRICETINAE; CULTURE MEDIA; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PLASMIDS; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; STEROL REGULATORY ELEMENT BINDING PROTEINS; STEROLS;

EID: 84877883035     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.469528     Document Type: Article

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