-
1
-
-
84861827675
-
Osteoarthritis: A disease of the joint as an organ
-
22392533 10.1002/art.34453 This excellent review summarizes the key features of OA in various tissues affected, and provides an overview of the currently known mechanisms that contribute to the pathological changes in these tissues
-
•• Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64:1697-707. This excellent review summarizes the key features of OA in various tissues affected, and provides an overview of the currently known mechanisms that contribute to the pathological changes in these tissues.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1697-1707
-
-
Loeser, R.F.1
Goldring, S.R.2
Scanzello, C.R.3
Goldring, M.B.4
-
2
-
-
78049527698
-
The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
-
20924410 10.1038/nrrheum.2010.159 1:CAS:528:DC%2BC3cXhtlGkt7nI
-
Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol. 2010;6:625-35.
-
(2010)
Nat Rev Rheumatol
, vol.6
, pp. 625-635
-
-
Sellam, J.1
Berenbaum, F.2
-
3
-
-
80052032038
-
Inflammation in osteoarthritis
-
21788902 10.1097/BOR.0b013e328349c2b1 1:CAS:528:DC%2BC3MXhtVaksbvO
-
Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23:471-8.
-
(2011)
Curr Opin Rheumatol
, vol.23
, pp. 471-478
-
-
Goldring, M.B.1
Otero, M.2
-
5
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
-
20404851 10.1038/ni.1863 1:CAS:528:DC%2BC3cXkvFSjsrc%3D
-
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11:373-84.
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
6
-
-
84861983196
-
The role of synovitis in osteoarthritis pathogenesis
-
22387238 10.1016/j.bone.2012.02.012 1:CAS:528:DC%2BC38XjvVekur0%3D This review provides insights into the pathogenic mechanisms underlying the development synovitis in OA
-
•• Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51:249-57. This review provides insights into the pathogenic mechanisms underlying the development synovitis in OA.
-
(2012)
Bone
, vol.51
, pp. 249-257
-
-
Scanzello, C.R.1
Goldring, S.R.2
-
7
-
-
34447504847
-
Toll-like receptors and chondrocytes: The lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7
-
DOI 10.1002/art.22637
-
Bobacz K, Sunk IG, Hofstaetter JG, Amoyo L, Toma CD, Akira S, et al. Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7. Arthritis Rheum. 2007;56:1880-93. (Pubitemid 47110387)
-
(2007)
Arthritis and Rheumatism
, vol.56
, Issue.6
, pp. 1880-1893
-
-
Bobacz, K.1
Sunk, I.G.2
Hofstaetter, J.G.3
Amoyo, L.4
Toma, C.D.5
Akira, S.6
Weichhart, T.7
Saemann, M.8
Smolen, J.S.9
-
8
-
-
33745879478
-
The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes
-
DOI 10.1002/art.21951
-
Kim HA, Cho ML, Choi HY, Yoon CS, Jhun JY, Oh HJ, et al. The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes. Arthritis Rheum. 2006;54:2152-63. (Pubitemid 44051072)
-
(2006)
Arthritis and Rheumatism
, vol.54
, Issue.7
, pp. 2152-2163
-
-
Kim, H.A.1
Cho, M.-L.2
Choi, H.Y.3
Yoon, C.S.4
Jhun, J.Y.5
Oh, H.J.6
Kim, H.-Y.7
-
9
-
-
77955703092
-
RAGE: A multi-ligand receptor unveiling novel insights in health and disease
-
20459381 10.2174/092986710791331086 1:CAS:528:DC%2BC3cXpsFeitb4%3D
-
Alexiou P, Chatzopoulou M, Pegklidou K, Demopoulos VJ. RAGE: a multi-ligand receptor unveiling novel insights in health and disease. Curr Med Chem. 2010;17:2232-52.
-
(2010)
Curr Med Chem
, vol.17
, pp. 2232-2252
-
-
Alexiou, P.1
Chatzopoulou, M.2
Pegklidou, K.3
Demopoulos, V.J.4
-
10
-
-
23644436200
-
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis
-
DOI 10.1002/art.21199
-
Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, et al. Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum. 2005;52:2376-85. (Pubitemid 41117422)
-
(2005)
Arthritis and Rheumatism
, vol.52
, Issue.8
, pp. 2376-2385
-
-
Loeser, R.F.1
Yammani, R.R.2
Carlson, C.S.3
Chen, H.4
Cole, A.5
Im, H.-J.6
Bursch, L.S.7
Yan, S.D.8
-
11
-
-
34447131097
-
Mechanisms of Disease: A 'DAMP' view of inflammatory arthritis
-
DOI 10.1038/ncprheum0531, PII NCPRHEUM0531
-
Foell D, Wittkowski H, Roth J. Mechanisms of disease: a 'DAMP' view of inflammatory arthritis. Nat Clin Pract Rheumatol. 2007;3:382-90. (Pubitemid 47034539)
-
(2007)
Nature Clinical Practice Rheumatology
, vol.3
, Issue.7
, pp. 382-390
-
-
Foell, D.1
Wittkowski, H.2
Roth, J.3
-
12
-
-
70349307219
-
Analysing the role of endogenous matrix molecules in the development of osteoarthritis
-
19765101 10.1111/j.1365-2613.2009.00676.x 1:CAS:528:DC%2BD1MXhtlGgu7%2FI
-
Sofat N. Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Int J Exp Pathol. 2009;90:463-79.
-
(2009)
Int J Exp Pathol
, vol.90
, pp. 463-479
-
-
Sofat, N.1
-
13
-
-
84863221746
-
The growing array of innate inflammatory ignition switches in osteoarthritis
-
22488656 10.1002/art.34492
-
Liu-Bryan R, Terkeltaub R. The growing array of innate inflammatory ignition switches in osteoarthritis. Arthritis Rheum. 2012;64:2055-8.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2055-2058
-
-
Liu-Bryan, R.1
Terkeltaub, R.2
-
14
-
-
74849136922
-
The role of HMGB1 in the pathogenesis of rheumatic disease
-
20123076 10.1016/j.bbagrm.2009.11.003 1:CAS:528:DC%2BC3cXpslWguw%3D%3D
-
Andersson U, Harris HE. The role of HMGB1 in the pathogenesis of rheumatic disease. Biochim Biophys Acta. 2010;1799:141-8.
-
(2010)
Biochim Biophys Acta
, vol.1799
, pp. 141-148
-
-
Andersson, U.1
Harris, H.E.2
-
15
-
-
84877876118
-
S100 proteins in cartilage: Role in arthritis
-
Yammani RR. S100 proteins in cartilage: role in arthritis. Biochim Biophys Acta. 1822;2012:600-6.
-
(1822)
Biochim Biophys Acta
, vol.2012
, pp. 600-606
-
-
Yammani, R.R.1
-
16
-
-
84861952489
-
Role of S100A12 in the pathogenesis of osteoarthritis
-
22609404 10.1016/j.bbrc.2012.05.036 1:CAS:528:DC%2BC38XotVejsr4%3D
-
Nakashima M, Sakai T, Hiraiwa H, Hamada T, Omachi T, Ono Y, et al. Role of S100A12 in the pathogenesis of osteoarthritis. Biochem Biophys Res Commun. 2012;422:508-14.
-
(2012)
Biochem Biophys Res Commun
, vol.422
, pp. 508-514
-
-
Nakashima, M.1
Sakai, T.2
Hiraiwa, H.3
Hamada, T.4
Omachi, T.5
Ono, Y.6
Inukai, N.7
Ishizuka, S.8
Matsukawa, T.9
Oda, T.10
Takamatsu, A.11
Yamashita, S.12
Ishiguro, N.13
-
17
-
-
84877873254
-
Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation
-
This study reported that levels of TN-C are highly elevated in human knee joints after injury or OA that correlated with markers of cartilage degradation and inflammation. S1063-4584(12
-
• Chockalingam PS, Glasson SS, Lohmander LS. Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation. Osteoarthritis Cartilage. 2012 pii: S1063-4584(12)01011-4. This study reported that levels of TN-C are highly elevated in human knee joints after injury or OA that correlated with markers of cartilage degradation and inflammation.
-
(2012)
Osteoarthritis Cartilage
, pp. 01011-010114
-
-
Chockalingam, P.S.1
Glasson, S.S.2
Lohmander, L.S.3
-
18
-
-
84866388274
-
Tenascin-C fragments are endogenous inducers of cartilage matrix degradation
-
21874326 10.1007/s00296-011-2067-8 1:CAS:528:DC%2BC38Xht1yms73K
-
Sofat N, Robertson SD, Hermansson M, Jones J, Mitchell P, Wait R. Tenascin-C fragments are endogenous inducers of cartilage matrix degradation. Rheumatol Int. 2012;32:2809-17.
-
(2012)
Rheumatol Int.
, vol.32
, pp. 2809-2817
-
-
Sofat, N.1
Robertson, S.D.2
Hermansson, M.3
Jones, J.4
Mitchell, P.5
Wait, R.6
-
19
-
-
79960555062
-
Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage
-
21762512 10.1186/1471-2474-12-164 1:CAS:528:DC%2BC3MXhtVGht7rF
-
Patel L, Sun W, Glasson SS, Morris EA, Flannery CR, Chockalingam PS. Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage. BMC Musculoskelet Disord. 2011;12:164.
-
(2011)
BMC Musculoskelet Disord
, vol.12
, pp. 164
-
-
Patel, L.1
Sun, W.2
Glasson, S.S.3
Morris, E.A.4
Flannery, C.R.5
Chockalingam, P.S.6
-
20
-
-
77954233637
-
Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice
-
20506365
-
Liu-Bryan R, Terkeltaub R. Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice. Arthritis Rheum. 2010;62:2004-12.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2004-2012
-
-
Liu-Bryan, R.1
Terkeltaub, R.2
-
21
-
-
11144357921
-
Accumulation of Advanced Glycation End Products as a Molecular Mechanism for Aging as a Risk Factor in Osteoarthritis
-
DOI 10.1002/art.20170
-
DeGroot J, Verzijl N, Wenting-van Wijk MJ, Jacobs KM, Van El B, Van Roermund PM, et al. Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis. Arthritis Rheum. 2004;50:1207-15. (Pubitemid 38480831)
-
(2004)
Arthritis and Rheumatism
, vol.50
, Issue.4
, pp. 1207-1215
-
-
DeGroot, J.1
Verzijl, N.2
Wenting-Van Wijk, M.J.G.3
Jacobs, K.M.G.4
Van El, B.5
Van Roermund, P.M.6
Bank, R.A.7
Bijlsma, J.W.J.8
TeKoppele, J.M.9
Lafeber, F.P.J.G.10
-
22
-
-
84855429655
-
Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4
-
22225630 10.1186/ar3555 1:CAS:528:DC%2BC38Xjs1egsr8%3D
-
Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, Lahey LJ, et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther. 2012;14:R7.
-
(2012)
Arthritis Res Ther
, vol.14
, pp. 7
-
-
Sohn, D.H.1
Sokolove, J.2
Sharpe, O.3
Erhart, J.C.4
Chandra, P.E.5
Lahey, L.J.6
Lindstrom, T.M.7
Hwang, I.8
Boyer, K.A.9
Andriacchi, T.P.10
Robinson, W.H.11
-
23
-
-
84858962775
-
Alarmin S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4
-
22127564 10.1002/art.33495 1:CAS:528:DC%2BC38XmtFWgs7s%3D
-
Schelbergen RF, Blom AB, van den Bosch MH, Sloetjes A, Abdollahi-Roodsaz S, Schreurs BW, et al. Alarmin S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4. Arthritis Rheum. 2012;64:1477-87.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1477-1487
-
-
Schelbergen, R.F.1
Blom, A.B.2
Van Den Bosch, M.H.3
Sloetjes, A.4
Abdollahi-Roodsaz, S.5
Schreurs, B.W.6
Mort, J.S.7
Vogl, T.8
Roth, J.9
Van Den Berg, W.B.10
Van Lent, P.L.11
-
24
-
-
77649277920
-
S100A8 and S100A9 in experimental osteoarthritis
-
20105291 10.1186/ar2917
-
Zreiqat H, Belluoccio D, Smith MM, Wilson R, Rowley LA, Jones K, et al. S100A8 and S100A9 in experimental osteoarthritis. Arthritis Res Ther. 2010;12(1):R16.
-
(2010)
Arthritis Res Ther
, vol.12
, Issue.1
, pp. 16
-
-
Zreiqat, H.1
Belluoccio, D.2
Smith, M.M.3
Wilson, R.4
Rowley, L.A.5
Jones, K.6
Ramaswamy, Y.7
Vogl, T.8
Roth, J.9
Bateman, J.F.10
Little, C.B.11
-
25
-
-
67650502739
-
Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
-
19561617 10.1038/nm.1987 1:CAS:528:DC%2BD1MXnslKqt70%3D
-
Midwood K, Sacre S, Piccinini AM, Inglis J, Trebaul A, Chan E, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med. 2009;15:774-80.
-
(2009)
Nat Med
, vol.15
, pp. 774-780
-
-
Midwood, K.1
Sacre, S.2
Piccinini, A.M.3
Inglis, J.4
Trebaul, A.5
Chan, E.6
Drexler, S.7
Sofat, N.8
Kashiwagi, M.9
Orend, G.10
Brennan, F.11
Foxwell, B.12
-
26
-
-
41049117932
-
Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)
-
18264787 10.1007/s10456-008-9093-5 1:CAS:528:DC%2BD1cXjsFWksb0%3D
-
van Beijnum JR, Buurman WA, Griffioen AW. Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1). Angiogenesis. 2008;11:91-9.
-
(2008)
Angiogenesis
, vol.11
, pp. 91-99
-
-
Van Beijnum, J.R.1
Buurman, W.A.2
Griffioen, A.W.3
-
27
-
-
84871501209
-
The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
-
23200851 10.1016/j.cellsig.2012.11.022
-
Rojas A, Delgado-Lopez F, Gonzalez I, Perez-Castro R, Romero J, Rojas I. The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor. Cell Signal. 2012;25:609-14.
-
(2012)
Cell Signal
, vol.25
, pp. 609-614
-
-
Rojas, A.1
Delgado-Lopez, F.2
Gonzalez, I.3
Perez-Castro, R.4
Romero, J.5
Rojas, I.6
-
28
-
-
77952881653
-
Deficiency of tenascin-C delays articular cartilage repair in mice
-
19747998 10.1016/j.joca.2009.08.013 1:STN:280:DC%2BC3czjvFamtA%3D%3D This paper reports worsened cartilage degeneration and delayed cartilage repair in tenascin-C knockout mice in the aging-related spontaneous OA and mechanical injury-induced OA mouse models
-
• Okamura N, Hasegawa M, Nakoshi Y, Iino T, Sudo A, Imanaka-Yoshida K, et al. Deficiency of tenascin-C delays articular cartilage repair in mice. Osteoarthritis Cartilage. 2010;18:839-48. This paper reports worsened cartilage degeneration and delayed cartilage repair in tenascin-C knockout mice in the aging-related spontaneous OA and mechanical injury-induced OA mouse models.
-
(2010)
Osteoarthritis Cartilage
, vol.18
, pp. 839-848
-
-
Okamura, N.1
Hasegawa, M.2
Nakoshi, Y.3
Iino, T.4
Sudo, A.5
Imanaka-Yoshida, K.6
Yoshida, T.7
Uchida, A.8
-
29
-
-
84863211031
-
Elusive role for toll like receptor 2 in joint pathology during experimental osteoarthritis
-
This study shows that TLR2 deficiency increased the extent of OA in the collagenase-induced model of mouse knee OA (which is associated with significant synovitis), but did not decrease experimental OA in the DMM model
-
•• Blom AB, van Lent PL, Abdollahi-Roodsaz S, van der Kraan P, van den Berg W. Elusive role for toll like receptor 2 in joint pathology during experimental osteoarthritis. Osteoarthritis and Cartilage. 2011;19 Suppl 1:25. This study shows that TLR2 deficiency increased the extent of OA in the collagenase-induced model of mouse knee OA (which is associated with significant synovitis), but did not decrease experimental OA in the DMM model.
-
(2011)
Osteoarthritis and Cartilage
, vol.19
, Issue.SUPPL. 1
, pp. 25
-
-
Blom, A.B.1
Van Lent, P.L.2
Abdollahi-Roodsaz, S.3
Van Der Kraan, P.4
Van Den Berg, W.5
-
30
-
-
84858962777
-
Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
-
22143922 10.1002/art.34315 This study reports that S100A8 and S100A9 play a significant role in synovial activation and joint destruction in the collagenase-induced OA model
-
•• van Lent PL, Blom AB, Schelbergen RF, Sloetjes A, Lafeber FP, Lems WF, et al. Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis. Arthritis Rheum. 2012;64(5):1466-76. This study reports that S100A8 and S100A9 play a significant role in synovial activation and joint destruction in the collagenase-induced OA model.
-
(2012)
Arthritis Rheum
, vol.64
, Issue.5
, pp. 1466-1476
-
-
Van Lent, P.L.1
Blom, A.B.2
Schelbergen, R.F.3
Sloetjes, A.4
Lafeber, F.P.5
Lems, W.F.6
Cats, H.7
Vogl, T.8
Roth, J.9
Van Den Berg, W.B.10
-
31
-
-
65249136616
-
The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli
-
19342682 10.4049/jimmunol.0803603 1:CAS:528:DC%2BD1MXjvFOis7g%3D
-
Cecil DL, Appleton CT, Polewski MD, Mort JS, Schmidt AM, Bendele A, et al. The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli. J Immunol. 2009;182:5024-31.
-
(2009)
J Immunol
, vol.182
, pp. 5024-5031
-
-
Cecil, D.L.1
Appleton, C.T.2
Polewski, M.D.3
Mort, J.S.4
Schmidt, A.M.5
Bendele, A.6
Beier, F.7
Terkeltaub, R.8
-
32
-
-
59149096239
-
Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: A decrease in mitochondrial superoxide dismutase points to a redox imbalance
-
18784066 10.1074/mcp.M800292-MCP200 1:CAS:528:DC%2BD1MXpsFCjsg%3D%3D
-
Ruiz-Romero C, Calamia V, Mateos J, Carreira V, Martinez-Gomariz M, Fernandez M, et al. Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance. Mol Cell Proteomics. 2009;8(1):172-89.
-
(2009)
Mol Cell Proteomics
, vol.8
, Issue.1
, pp. 172-189
-
-
Ruiz-Romero, C.1
Calamia, V.2
Mateos, J.3
Carreira, V.4
Martinez-Gomariz, M.5
Fernandez, M.6
Blanco, F.J.7
-
33
-
-
77955436218
-
Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
-
20511611 10.1136/ard.2009.119966 1:CAS:528:DC%2BC3cXhtVyktL7O
-
Scott JL, Gabrielides C, Davidson RK, Swingler TE, Clark IM, Wallis GA, et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Ann Rheum Dis. 2010;69:1502-10.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 1502-1510
-
-
Scott, J.L.1
Gabrielides, C.2
Davidson, R.K.3
Swingler, T.E.4
Clark, I.M.5
Wallis, G.A.6
Boot-Handford, R.P.7
Kirkwood, T.B.8
Taylor, R.W.9
Young, D.A.10
-
34
-
-
84873850757
-
Mitochondrial dysfunction in osteoarthritis is associated with a down-regulation of superoxide dismutase 2
-
Nov 8. doi: 10.1002/art.37782
-
Gavriilidis C, Miwa S, von Zglinicki T, Taylor RW, Young DA. Mitochondrial dysfunction in osteoarthritis is associated with a down-regulation of superoxide dismutase 2. Arthritis Rheum. 2012 Nov 8. doi: 10.1002/art.37782.
-
(2012)
Arthritis Rheum
-
-
Gavriilidis, C.1
Miwa, S.2
Von Zglinicki, T.3
Taylor, R.W.4
Young, D.A.5
-
35
-
-
32244432671
-
CD14: Chaperone or matchmaker?
-
DOI 10.1016/j.immuni.2006.01.010, PII S1074761306001099
-
Finberg RW, Kurt-Jones EA. CD14: chaperone or matchmaker? Immunity. 2006;24:127-9. (Pubitemid 43214581)
-
(2006)
Immunity
, vol.24
, Issue.2
, pp. 127-129
-
-
Finberg, R.W.1
Kurt-Jones, E.A.2
-
36
-
-
84863206376
-
Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR4 and TLR2 ligands via soluble CD14
-
22492243 10.1002/art.34495 1:CAS:528:DC%2BC38XptFCgu74%3D This study reports that soluble CD14 is increased in synovial fluid in both early and advanced stages of human knee OA, and that the synovial fluid of early OA patients can modulate cultured synovial lining cell inflammatory responses to exogenous microbial TLR2 and TLR4 ligands
-
• Nair A, Kanda V, Bush-Joseph C, Verma N, Chubinskaya S, Mikezcz K, et al. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR4 and TLR2 ligands via soluble CD14. Arthritis Rheum. 2012;64:2268-77. This study reports that soluble CD14 is increased in synovial fluid in both early and advanced stages of human knee OA, and that the synovial fluid of early OA patients can modulate cultured synovial lining cell inflammatory responses to exogenous microbial TLR2 and TLR4 ligands.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2268-2277
-
-
Nair, A.1
Kanda, V.2
Bush-Joseph, C.3
Verma, N.4
Chubinskaya, S.5
Mikezcz, K.6
Glant, T.7
Malfait, A.M.8
Crow, M.K.9
Spear, G.T.10
Finnrgan, A.11
Scanzello, C.R.12
-
37
-
-
80052162537
-
Complement in health and disease
-
21704094 10.1016/j.addr.2011.06.005 1:CAS:528:DC%2BC3MXhtFaksLjK
-
Carroll MV, Sim RB. Complement in health and disease. Adv Drug Deliv Rev. 2011;63:965-75.
-
(2011)
Adv Drug Deliv Rev
, vol.63
, pp. 965-975
-
-
Carroll, M.V.1
Sim, R.B.2
-
38
-
-
80051672429
-
Role of the complement system in rheumatoid arthritis and psoriatic arthritis: Relationship with anti-TNF inhibitors
-
21549221 10.1016/j.autrev.2011.04.012 1:CAS:528:DC%2BC3MXhtVels7rN
-
Ballanti E, Perricone C, di Muzio G, Kroegler B, Chimenti MS, Graceffa D, et al. Role of the complement system in rheumatoid arthritis and psoriatic arthritis: relationship with anti-TNF inhibitors. Autoimmun Rev. 2011;10:617-23.
-
(2011)
Autoimmun Rev
, vol.10
, pp. 617-623
-
-
Ballanti, E.1
Perricone, C.2
Di Muzio, G.3
Kroegler, B.4
Chimenti, M.S.5
Graceffa, D.6
Perricone, R.7
-
39
-
-
0030478689
-
Complement in acute and chronic arthritides: Assessment of C3c, C9, and protectin (CD59) in synovial membrane
-
Konttinen YT, Ceponis A, Meri S, Vuorikoski A, Kortekangas P, Sorsa T, et al. Complement in acute and chronic arthritides: assessment of C3c, C9, and protectin (CD59) in synovial membrane. Ann Rheum Dis. 1996;55:888-94. (Pubitemid 26426682)
-
(1996)
Annals of the Rheumatic Diseases
, vol.55
, Issue.12
, pp. 888-894
-
-
Konttinen, Y.T.1
Ceponis, A.2
Meri, S.3
Vuorikoski, A.4
Kortekangas, P.5
Sorsa, T.6
Sukura, A.7
Santavirta, S.8
-
40
-
-
34247847988
-
High abundance synovial fluid proteome: Distinct profiles in health and osteoarthritis
-
DOI 10.1186/ar2172
-
Gobezie R, Kho A, Krastins B, Sarracino DA, Thornhill TS, Chase M, et al. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther. 2007;9:R36. (Pubitemid 46692394)
-
(2007)
Arthritis Research and Therapy
, vol.9
-
-
Gobezie, R.1
Kho, A.2
Krastins, B.3
Sarracino, D.A.4
Thornhill, T.S.5
Chase, M.6
Millett, P.J.7
Lee, D.M.8
-
41
-
-
84856100338
-
Identification of a central role for complement in osteoarthritis
-
22057346 10.1038/nm.2543 1:CAS:528:DC%2BC3MXhsVagtbvI This study highlights a key role of activation of complement cascade, particularly membrane attack complex assembly, in the pathogenesis of OA
-
•• Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, et al. Identification of a central role for complement in osteoarthritis. Nat Med. 2011;17:1674-9. This study highlights a key role of activation of complement cascade, particularly membrane attack complex assembly, in the pathogenesis of OA.
-
(2011)
Nat Med
, vol.17
, pp. 1674-1679
-
-
Wang, Q.1
Rozelle, A.L.2
Lepus, C.M.3
Scanzello, C.R.4
Song, J.J.5
Larsen, D.M.6
Crish, J.F.7
Bebek, G.8
Ritter, S.Y.9
Lindstrom, T.M.10
Hwang, I.11
Wong, H.H.12
Punzi, L.13
Encarnacion, A.14
Shamloo, M.15
Goodman, S.B.16
Wyss-Coray, T.17
Goldring, S.R.18
Banda, N.K.19
Thurman, J.M.20
Gobezie, R.21
Crow, M.K.22
Holers, V.M.23
Lee, D.M.24
Robinson, W.H.25
more..
-
42
-
-
78650070714
-
Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis
-
20737467 10.1002/art.27720 1:CAS:528:DC%2BC3cXhs1antrvM
-
Happonen KE, Saxne T, Aspberg A, Morgelin M, Heinegard D, Blom AM. Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum. 2010;62:3574-83.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 3574-3583
-
-
Happonen, K.E.1
Saxne, T.2
Aspberg, A.3
Morgelin, M.4
Heinegard, D.5
Blom, A.M.6
-
43
-
-
25444482114
-
The extracellular matrix and inflammation: Fibromodulin activates the classical pathway of complement by directly binding C1q
-
DOI 10.1074/jbc.M504828200
-
Sjoberg A, Onnerfjord P, Morgelin M, Heinegard D, Blom AM. The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J Biol Chem. 2005;280:32301-8. (Pubitemid 41361839)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.37
, pp. 32301-32308
-
-
Sjoberg, A.1
Onnerfjord, P.2
Morgelin, M.3
Heinegard, D.4
Blom, A.M.5
-
44
-
-
84858762160
-
Crosstalk between complement and toll-like receptors
-
22109714 10.1177/0192623311428478 1:CAS:528:DC%2BC38XlvVyisbw%3D
-
Song WC. Crosstalk between complement and toll-like receptors. Toxicol Pathol. 2012;40:174-82.
-
(2012)
Toxicol Pathol
, vol.40
, pp. 174-182
-
-
Song, W.C.1
-
45
-
-
77950187449
-
Crosstalk pathways between Toll-like receptors and the complement system
-
20153254 10.1016/j.it.2010.01.002 1:CAS:528:DC%2BC3cXksVegtro%3D
-
Hajishengallis G, Lambris JD. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol. 2010;31:154-63.
-
(2010)
Trends Immunol
, vol.31
, pp. 154-163
-
-
Hajishengallis, G.1
Lambris, J.D.2
-
46
-
-
34347400796
-
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo
-
DOI 10.1182/blood-2006-12-063636
-
Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris JD, et al. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood. 2007;110:228-36. (Pubitemid 47026839)
-
(2007)
Blood
, vol.110
, Issue.1
, pp. 228-236
-
-
Zhang, X.1
Kimura, Y.2
Fang, C.3
Zhou, L.4
Sfyroera, G.5
Lambris, J.D.6
Wetsel, R.A.7
Miwa, T.8
Song, W.-C.9
-
47
-
-
70349469876
-
Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature
-
19717455 10.1073/pnas.0903613106
-
Lappegard KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, Lindstad J, et al. Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature. Proc Natl Acad Sci USA. 2009;106:15861-6.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 15861-15866
-
-
Lappegard, K.T.1
Christiansen, D.2
Pharo, A.3
Thorgersen, E.B.4
Hellerud, B.C.5
Lindstad, J.6
Nielsen, E.W.7
Bergseth, G.8
Fadnes, D.9
Abrahamsen, T.G.10
Hoiby, E.A.11
Schejbel, L.12
Garred, P.13
Lambris, J.D.14
Harboe, M.15
Mollnes, T.E.16
-
48
-
-
78650332477
-
Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils
-
21183027 10.3168/jds.2010-3358 1:CAS:528:DC%2BC3MXjslCntrs%3D
-
Stevens MG, Van Poucke M, Peelman LJ, Rainard P, De Spiegeleer B, Rogiers C, et al. Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils. J Dairy Sci. 2011;94:152-64.
-
(2011)
J Dairy Sci
, vol.94
, pp. 152-164
-
-
Stevens, M.G.1
Van Poucke, M.2
Peelman, L.J.3
Rainard, P.4
De Spiegeleer, B.5
Rogiers, C.6
Van De Walle, G.R.7
Duchateau, L.8
Burvenich, C.9
-
49
-
-
52949118458
-
Harmful molecular mechanisms in sepsis
-
18802444 10.1038/nri2402 1:CAS:528:DC%2BD1cXhtFKkur%2FM
-
Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol. 2008;8:776-87.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 776-787
-
-
Rittirsch, D.1
Flierl, M.A.2
Ward, P.A.3
-
50
-
-
78650983649
-
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
-
21119608 10.1038/nrrheum.2010.196 1:CAS:528:DC%2BC3MXht1Ghsg%3D%3D
-
Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33-42.
-
(2011)
Nat Rev Rheumatol
, vol.7
, pp. 33-42
-
-
Kapoor, M.1
Martel-Pelletier, J.2
Lajeunesse, D.3
Pelletier, J.P.4
Fahmi, H.5
-
51
-
-
26444600233
-
Expression and regulation of Toll-like receptor 2 by IL-1β and fibronectin fragments in human articular chondrocytes
-
DOI 10.1016/j.joca.2005.04.017, PII S1063458405001159
-
Su SL, Tsai CD, Lee CH, Salter DM, Lee HS. Expression and regulation of Toll-like receptor 2 by IL-1beta and fibronectin fragments in human articular chondrocytes. Osteoarthritis Cartilage. 2005;13:879-86. (Pubitemid 41430793)
-
(2005)
Osteoarthritis and Cartilage
, vol.13
, Issue.10
, pp. 879-886
-
-
Su, S.-L.1
Tsai, C.-D.2
Lee, C.-H.3
Salter, D.M.4
Lee, H.-S.5
-
52
-
-
0030016478
-
Synthesis of classical pathway complement components by chondrocytes
-
Bradley K, North J, Saunders D, Schwaeble W, Jeziorska M, Woolley DE, et al. Synthesis of classical pathway complement components by chondrocytes. Immunology. 1996;88:648-56. (Pubitemid 26255139)
-
(1996)
Immunology
, vol.88
, Issue.4
, pp. 648-656
-
-
Bradley, K.1
North, J.2
Saunders, D.3
Schwaeble, W.4
Jeziorska, M.5
Woolley, D.E.6
Whaley, K.7
-
53
-
-
80052626087
-
The NLRP3 inflammasome in health and disease: The good, the bad and the ugly
-
21762124 10.1111/j.1365-2249.2011.04440.x 1:CAS:528:DC%2BC3MXhtlSks7nK
-
Menu P, Vince JE. The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol. 2011;166:1-15.
-
(2011)
Clin Exp Immunol
, vol.166
, pp. 1-15
-
-
Menu, P.1
Vince, J.E.2
-
54
-
-
80052581043
-
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
-
21856950 10.1073/pnas.1111101108 1:CAS:528:DC%2BC3MXhtFyktLfE This study shows that the NLRP3 inflammasome mediates synovitis and joint destruction in the pathogenesis of OA associated with deposition of hydroxyapatite
-
• Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, Vignery A, et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc Natl Acad Sci USA. 2011;108:14867-72. This study shows that the NLRP3 inflammasome mediates synovitis and joint destruction in the pathogenesis of OA associated with deposition of hydroxyapatite.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14867-14872
-
-
Jin, C.1
Frayssinet, P.2
Pelker, R.3
Cwirka, D.4
Hu, B.5
Vignery, A.6
Eisenbarth, S.C.7
Flavell, R.A.8
-
55
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
DOI 10.1038/nature04516, PII N04516
-
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440:237-41. (Pubitemid 43372104)
-
(2006)
Nature
, vol.440
, Issue.7081
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
56
-
-
0036255913
-
Characterization of infiltrating T cells and Th1/Th2-type cytokines in the synovium of patients with osteoarthritis
-
DOI 10.1053/joca.2001.0509
-
Ishii H, Tanaka H, Katoh K, Nakamura H, Nagashima M, Yoshino S. Characterization of infiltrating T cells and Th1/Th2-type cytokines in the synovium of patients with osteoarthritis. Osteoarthritis Cartilage. 2002A;10:277-81. (Pubitemid 34467631)
-
(2002)
Osteoarthritis and Cartilage
, vol.10
, Issue.4
, pp. 277-281
-
-
Ishii, H.1
Tanaka, H.2
Katoh, K.3
Nakamura, H.4
Nagashima, M.5
Yoshino, S.6
-
57
-
-
84861803984
-
Destructive role of myeloid differentiation factor 88 and protective role of TIR-containing adaptor inducing interferon β in IL-17-dependent arthritis
-
22147588 10.1002/art.34328 1:CAS:528:DC%2BC38XnsFOltLw%3D
-
Abdollahi-Roodsaz S, van de Loo FA, Koenders MI, Helsen MM, Walgreen B, van den Bersselaar LA, et al. Destructive role of myeloid differentiation factor 88 and protective role of TIR-containing adaptor inducing interferon β in IL-17-dependent arthritis. Arthritis Rheum. 2012;64:1838-47.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1838-1847
-
-
Abdollahi-Roodsaz, S.1
Van De Loo, F.A.2
Koenders, M.I.3
Helsen, M.M.4
Walgreen, B.5
Van Den Bersselaar, L.A.6
Arntz, O.J.7
Takahashi, N.8
Joosten, L.A.9
Van Den Berg, W.B.10
|