Tenascin-C fragments are endogenous inducers of cartilage matrix degradation

Rheumatology International

Volumn 32, Issue 9, 2012, Pages 2809-2817

  Sofat, Nidhi ^a   Robertson, Saralili Dipa ^a   Hermansson, Monika ^a   Jones, Jonathan ^b   Mitchell, Philip ^c   Wait, Robin ^d  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b FRIMLEY PARK HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^c ST GEORGE S HOSPITAL   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Aggrecanases; Damageassociated molecular patterns; Extracellular matrix; Matrix metalloproteinases; Tenascin C

Indexed keywords

AGGRECANASE; GLYCOSAMINOGLYCAN; MATRIX METALLOPROTEINASE; TENASCIN;

ARTICLE; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CARTILAGE MATRIX DEGRADATION; CONTROLLED STUDY; ENZYME ACTIVITY; EX VIVO STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JOINT PROSTHESIS; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; ENDOPEPTIDASES; GLYCOSAMINOGLYCANS; HUMANS; MATRIX METALLOPROTEINASES; MODELS, ANIMAL; OSTEOARTHRITIS; PEPTIDE FRAGMENTS; SWINE; TENASCIN; UP-REGULATION;

EID: 84866388274     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-011-2067-8     Document Type: Article

References (47)

1. Altman RD (1991) Classification of disease: osteoarthritis. Semin Arthritis Rheum 20:40-47
2. Nuki G (1999) Osteoarthritis: a problem of joint failure. Z Rheumatol 58:142-147 (Pubitemid 29315446)
3. Mankin HJ, Lippiello L (1971) Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. J Bone Joint Surg Am 52:424-434
4. Goldring SR, Goldring MB (2004) The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res 427:S27-S36 (Pubitemid 39362798)
5. Nagase H, Kashiwagi M (2003) Aggrecanases and cartilage matrix degradation. Arthritis Res Ther 5:94-103 (Pubitemid 36849755)
6. Kurz B, Jin M, Patwari P, Cheng DM, Lark MW, Grodzinsky AJ (2001) Biosynthetic response and mechanical properties of articular cartilage after injurious compression. J Orthop Res 19:1140-1146 (Pubitemid 34000374)
7. Hunter DJ (2011) Pharmacologic therapy for osteoarthritis-the era of disease modification. Nat Rev Rheumatol 7(1):13-22
8. Okada Y (2001) Proteinases and matrix degradation. In: Ruddy S, Harris ED, Sledge C (eds) Kelley's textbook of rheumatology. Saunders, Philadelphia, pp 55-73
9. Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ (2005) ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434:648-652 (Pubitemid 40488557)
10. Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer I, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS (1997) Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J Clin Invest 100:93-106 (Pubitemid 27311247)
11. Dodge GR, Poole AR (1989) Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1. J Clin Invest 83:647-661 (Pubitemid 19061189)
12. Aigner T, Zien A, Gehrsitz A, Gebhard PM, Mckenna L (2001) Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNAarray technology. Arthritis Rheum 44:2777-2789 (Pubitemid 34016197)
13. Lee JH, Fitzgerald JB, Dimicco MA, Grodzinsky AJ (2005) Mechanical injury of cartilage explants causes specific timedependent changes in chondrocyte gene expression. Arthritis Rheum 52:2386-2395 (Pubitemid 41117423)
14. Loening AM, James IE, Levenston ME, Badger AM, Frank EH, Kurz B, Nuttall ME, Hung HH, Blake SM, Grodzinsky AJ, Lark MW (2000) Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Arch Biochem Biophys 381:205-212 (Pubitemid 32260306)
15. Fichter M, Korner U, Schomburg J, Jennings L, Cole AA, Mollenhauer J (2006) Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes. J Orthop Res 24(1):63-70 (Pubitemid 43772609)
16. Heathfield TF, Onnerfjord P, Dahlberg L, Heinegard D (2004) Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13. J Biol Chem 279(8):6286-6295 (Pubitemid 38248761)
17. Homandberg GA, Meyers R, Xie DL (1992) Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture. J Biol Chem 267:3597-3604
18. Knudson W, Casey B, Nishida Y, Eger W, Kuettner KE, Knudson CB (2000) Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis. Arthritis Rheum 43:1165-1174 (Pubitemid 30368196)
19. Jones PL, Jones FS (2000) Tenascin-C in development and disease: gene regulation and cell function. Matrix Biol 19:581-596
20. Salter DM (1993) Tenascin is increased in cartilage and synovium from arthritic knees. Br J Rheumatol 32:780-786 (Pubitemid 23267593)
21. Chevalier X, Groult N, Larget Piet B, Zardi L, Hornebeck W (1994) Tenascin distribution in articular cartilage from normal subjects and from patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum 37(7):1013-1022 (Pubitemid 24222092)
22. Cutolo M, Picasso M, Ponassi M, Sun MZ, Balza E (1992) Tenascin and fibronectin distribution in human normal and pathologic synovium. J Rheumatol 19:1439-1447
23. McCachren SS, Lightner VA (1992) Expression of human tenascin in synovitis and its regulation by interleukin-1. Arthritis Rheumatism 35:1185-1196
24. Hasegawa M, Nakoshi Y, Muraki M, Sudo A, Kinoshita N, Yoshida T, Uchida A (2007) Expression of large tenascin-c splice variants in synovial fluid of patients with rheumatoid arthritis. J Orthop Res 25:563-568 (Pubitemid 46730509)
25. Midwood K, Sacre S, Piccinini AM, Inglis J, Trebaul A, Chan E, Drexler S, Sofat N, Kashiwagi M, Orend G, Brennan F, Foxwell B (2009) Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med 15(7):774-781
26. Okamura N, Hasegawa M, Nakoshi Y, Iino T, Sudo A, Imanaka-Yoshida K, Yoshida T, Uchida A (2010) Deficiency of tenascin-C delays articular cartilage repair in mice. Osteoarthr Cartilage 18(6):839-848
27. Wykcoff D, Rodbard A, Chrambach A (1977) Polyacrylamide gel electrophoresis in sodium dodecyl sulfate-containing buffers using multiphasic buffer systems: properties of the stack, valid Rf-measurement, and optimized procedure. Anal Biochem 78:459-482 (Pubitemid 8077888)
28. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
29. Meyer TS, Lambert BL (1965) Use of Coomassie brilliant blue R250 for the electrophoresis of microgram quantities of parotid saliva proteins on acrylamide-gel strips. Biochim Biophys Acta 107:144-145
30. Shevchenko A, Wilm M, Vorm O, Mann M (1980) Mass spectrometric sequencing of proteins silver stained polyacrylamide gels. Anal Chem 68:850-858
31. Gendron C, Kashiwagi M, Hughes C, Caterson B, Nagase H (2003) TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors. FEBS Lett 555:431-436 (Pubitemid 37532588)
32. Farndale RW, Buttle DJ, Barrett AJ (1986) Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 883:173-177 (Pubitemid 16027978)
33. Sofat N (2009) Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Int J Exp Pathol 90:463-479
34. Nakoshi Y, Hasegawa M, Akeda K, Iino T, Sudo A, Yoshida T, Uchida A (2010) Distribution and role of tenascin-C in human osteoarthritic cartilage. J Orthop Sci 15(5):666-673
35. Zhen EY, Brittain IJ, Laska DA, Mitchell PG, Sumer EU, Karsdal MA, Duffen KL (2008) Characterization of metalloproteinase cleavage products of human articular cartilage. Arthritis Rheum 58(8):2420-2431
36. Latijnhouwers MAHE, Bergers M, Veenhuis RT, Beekman B, Ankersmit-Ter Horst MFP, Schalkwijk J (1998) Tenascin-C degradation in chronic wounds is dependent on serine proteinase activity. Arch Dermatol Res 290:490-496 (Pubitemid 28468392)
37. Wallner K, Li C, Shah PK, Wu K-J, Schwartz SM, Sharifi BG (2004) EGF-like domain of tenascin-C is proapoptotic for cultured smooth muscle cells. Arterioscler Thromb Vasc Biol 24:1416-1421 (Pubitemid 39050434)
38. Prieto AL, Andersson-Fissone C, Crossin KL (1992) Characterization of multiple adhesive and counteradhesive domains in the extracellular matrix protein cytotactin. J Cell Biol 111:685-698
39. Spring J, Beck K, Chiquet-Ehrisman R (1989) Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments. Cell 59:325-334 (Pubitemid 19264377)
40. Siri A, Knauper V, Veirana N, Caocci F, Murphy G, Zardi L (1995) Different susceptibility of small and large human tenascin-C isoforms to degradation by matrix metalloproteinases. J Biol Chem 270:8650-8654
41. Spring J, Beck K, Chiquet-Ehrisman R (1989) Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments. Cell 59:325-334 (Pubitemid 19264377)
42. Weber P, Zimmerman DR, Winterhalter KH, Vaughan L (1995) Tenascin-C binds heparin by its fibronectin type III domain five. J Biol Chem 270:4619-4623
43. Day JM, Olin AI, Murdoch AD, Canfield A, Sasaki T, Timpl R, Hardingham TE, Aspberg A (2004) Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins. J Biol Chem 279:12511-12518 (Pubitemid 38445821)
44. Echtermeyer F, Betrand J, Dreier R et al (2009) Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med 15(9):1072-1076
45. Salter DM, Hughes DE, Simpson R, Gardner DL (1992) Integrin expression by human articular chondrocytes. Br J Rheumatol 31:231-234
46. Zhang Q, Hui W, Litherland GJ et al (2008) Differential Toll-like receptor-dependent collagenase expression in chondrocytes. Ann Rheum Dis 67(11):1633-1641
47. Hashimoto G, Shimoda M, Okada Y (2004) ADAMTS4 (aggrecanase-1) interaction with the COOH-terminal domain of fibronectin inhibits proteolysis of aggrecan. J Biol Chem 279:32483-32491 (Pubitemid 39014703)