The growing array of innate inflammatory ignition switches in osteoarthritis

Arthritis and Rheumatism

Volumn 64, Issue 7, 2012, Pages 2055-2058

  Liu Bryan, Ru ^a   Terkeltaub, Robert ^a  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN;

ARTICULAR CARTILAGE; DISEASE COURSE; EDITORIAL; HUMAN; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; RHEUMATIC DISEASE;

ANTIGENS, CD14; FEMALE; HUMANS; MALE; OSTEOARTHRITIS, KNEE; SYNOVIAL FLUID; SYNOVIAL MEMBRANE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84863221746     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34492     Document Type: Editorial

References (14)

1. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 2010;6:625-35.
2. Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol 2011;23:471-8.
3. Nair A, Kanda V, Bush-Joseph C, Verma N, Chubinskaya S, Mikecz K, et al. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to Tolllike receptor 4 and Toll-like receptor 2 ligands via soluble CD14. Arthritis Rheum 2012;64:2268-77.
4. Scanzello CR, McKeon B, Swaim BH, DiCarlo E, Asomugha EU, Kanda V, et al. Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum 2011;63:391-400.
5. Finberg RW, Kurt-Jones EA. CD14: chaperone or matchmaker? Immunity 2006;24:127-9. (Pubitemid 43214581)
6. Midwood K, Sacre S, Piccinini AM, Inglis J, Trebaul A, Chan E, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med 2009;15:774-80.
7. Okamura N, Hasegawa M, Nakoshi Y, Iino T, Sudo A, Imanaka-Yoshida K, et al. Deficiency of tenascin-C delays articular cartilage repair in mice. Osteoarthritis Cartilage 2010;18:839-48.
8. Van Lent PL, Blom AB, Schelbergen RF, Sloetjes A, Lafeber FP, Lems WF, et al. Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis. Arthritis Rheum 2012;64:1466-76.
9. Schelbergen RF, Blom AB, van den Bosch MH, Sloetjes A, Abdollahi-Roodsaz S, Schreurs BW, et al. Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4. Arthritis Rheum 2012;64:1477-87.
10. Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, Vignery A, et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite- associated arthropathy. Proc Natl Acad Sci U S A 2011;108:14867-72.
11. Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, et al. Identification of a central role for complement in osteoarthritis. Nat Med 2011;17:1674-9.
12. Vos PA, Degroot J, Barten-van Rijbroek AD, Zuurmond AM, Bijlsma JW, Mastbergen SC, et al. Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage. J Orthop Res 2012. E-pub ahead of print.
13. Blom AB, van Lent PL, Abdollahi-Roodsaz S, van der Kraan P, van den Berg W. Elusive role for Toll like receptor 2 in joint pathology during experimental osteoarthritis [abstract]. Osteoarthritis Cartilage 2011;19 Suppl 1:25.
14. Piccinini AM, Midwood KS. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm 2010;2010:672395.