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Volumn 13, Issue 5, 2013, Pages 682-696

Small molecule fluorescent ligands as central nervous system imaging probes

Author keywords

Fluorescence; Fluorescence spectroscopy; High throughput screening; Imaging agents; Neurochemistry

Indexed keywords

2 AMINO 4 PHOSPHONOMETHYL 3 HEPTENOIC ACID; 2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; ADENOSINE A1 RECEPTOR; ADRENALIN; AMYLOID BETA PROTEIN; BENZODIAZEPINE RECEPTOR; BENZYLAMINE; DOPAMINE; DOPAMINE 3 RECEPTOR; DOPAMINE TRANSPORTER; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORADRENALIN; PHENETHYLAMINE; SEROTONIN; SEROTONIN 1A RECEPTOR; SMALL MOLECULE FLUORESCENT LIGAND; TYRAMINE; UNCLASSIFIED DRUG;

EID: 84877799679     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557511313050005     Document Type: Review
Times cited : (10)

References (107)
  • 2
    • 0030296328 scopus 로고    scopus 로고
    • Fluorescent ligands for the study of receptors
    • McGrath, J.C.; Arribas, S.; Daly, C.J. Fluorescent ligands for the study of receptors. Trends. Pharm., Sci. 1996, 17, 393-399.
    • (1996) Trends. Pharm., Sci , vol.17 , pp. 393-399
    • McGrath, J.C.1    Arribas, S.2    Daly, C.J.3
  • 3
    • 0242637558 scopus 로고    scopus 로고
    • Fluorescent ligands, antibodies, and proteins for the study of receptors
    • Daly, C.J.; McGrath, J.C. Fluorescent ligands, antibodies, and proteins for the study of receptors. Pharm. Therap., 2003, 100, 101-118.
    • (2003) Pharm. Therap , vol.100 , pp. 101-118
    • Daly, C.J.1    McGrath, J.C.2
  • 4
    • 0026701564 scopus 로고
    • AHN 683: A fluorescent ligand for peripheral-type benzodiazepine receptors
    • McCabe, R.T.; Newman, A.H.; Skolnick, P.; AHN 683: a fluorescent ligand for peripheral-type benzodiazepine receptors. J. Pharm. Exp. Terap., 1992, 262(2), 734-740.
    • (1992) J. Pharm. Exp. Terap , vol.262 , Issue.2 , pp. 734-740
    • McCabe, R.T.1    Newman, A.H.2    Skolnick, P.3
  • 5
    • 0024588673 scopus 로고
    • Drug and neurotransmitter receptors. New perspectives with clinical relevance
    • Snyder, S.H.; Drug and neurotransmitter receptors. New perspectives with clinical relevance. J. Am. Med. Assoc., 1989, 261, 3126-3129.
    • (1989) J. Am. Med. Assoc , vol.261 , pp. 3126-3129
    • Snyder, S.H.1
  • 6
    • 0025194762 scopus 로고
    • GABAA receptor subtypes: Autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system
    • Olsen, R.W.; McCabe, R.T.; Wamsley, J.K. GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J. Chem. Neuroanat., 1990, 3, 59-76.
    • (1990) J. Chem. Neuroanat , vol.3 , pp. 59-76
    • Olsen, R.W.1    McCabe, R.T.2    Wamsley, J.K.3
  • 7
    • 33646709877 scopus 로고    scopus 로고
    • Technology insight: Pharmacoproteomics for cancer--promises of patient-tailored medicine using protein microarrays
    • Wulfkuhle, J.D.; Edminston, K.H.; Liotta, L.A.; Petricoin, E.F. Technology insight: pharmacoproteomics for cancer--promises of patient-tailored medicine using protein microarrays. Nat. Clin. Pract. Onc., 2006, 3, 256-268.
    • (2006) Nat. Clin. Pract. Onc , vol.3 , pp. 256-268
    • Wulfkuhle, J.D.1    Edminston, K.H.2    Liotta, L.A.3    Petricoin, E.F.4
  • 8
    • 0021740032 scopus 로고
    • Role of thrombospondin in platelet aggregation
    • Leung, L.L. Role of thrombospondin in platelet aggregation. J. Clin. Invest. 1984, 74(5), 1764-1772.
    • (1984) J. Clin. Invest , vol.74 , Issue.5 , pp. 1764-1772
    • Leung, L.L.1
  • 9
    • 0028631109 scopus 로고
    • Selective fluorescent ligands for pharmacological receptors
    • Baindur, N.; Triggle, D.J. Selective fluorescent ligands for pharmacological receptors. Drug. Dev. Res., 1994, 33, 373-398.
    • (1994) Drug. Dev. Res , vol.33 , pp. 373-398
    • Baindur, N.1    Triggle, D.J.2
  • 10
    • 0028029827 scopus 로고
    • Concepts and progress in the development of receptor-specific fluorescent ligand
    • Baindur, N.; Triggle, D.J. Concepts and progress in the development of receptor-specific fluorescent ligand. Med. Res. Rev., 1994, 14, 591-664.
    • (1994) Med. Res. Rev , vol.14 , pp. 591-664
    • Baindur, N.1    Triggle, D.J.2
  • 13
    • 0034655706 scopus 로고    scopus 로고
    • Fluorescein-labeled naloxone binding to mu opioid receptors on live Chinese hamster ovary cells using confocal fluorescent microscopy
    • Madsen, B.W.; Beglan, C.L.; Spivak, C.E. Fluorescein-labeled naloxone binding to mu opioid receptors on live Chinese hamster ovary cells using confocal fluorescent microscopy. J. Neurosci. Methods. 2000, 97, 123-131.
    • (2000) J. Neurosci. Methods , vol.97 , pp. 123-131
    • Madsen, B.W.1    Beglan, C.L.2    Spivak, C.E.3
  • 15
    • 0037030691 scopus 로고    scopus 로고
    • Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors
    • Terrillon, S.; Cheng, L.L.; Stoev, S.; Mouillac, B.; Barberis, C.; Manning, M.; Durroux, T. Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J. Med. Chem. 2002, 45, 2579-2588.
    • (2002) J. Med. Chem , vol.45 , pp. 2579-2588
    • Terrillon, S.1    Cheng, L.L.2    Stoev, S.3    Mouillac, B.4    Barberis, C.5    Manning, M.6    Durroux, T.7
  • 16
    • 0030826420 scopus 로고    scopus 로고
    • Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands
    • Turcatti, G.; Zoffmann, S.; Lowe, J.A.; Drozda, S.E.; Chassaing, G.; Schwartz, T.W.; Chollet, A. Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands. J. Biol. Chem. 1997, 272, 21167-21175.
    • (1997) J. Biol. Chem , vol.272 , pp. 21167-21175
    • Turcatti, G.1    Zoffmann, S.2    Lowe, J.A.3    Drozda, S.E.4    Chassaing, G.5    Schwartz, T.W.6    Chollet, A.7
  • 17
    • 0029838186 scopus 로고    scopus 로고
    • Probing the structure and function of the tachykinin neurokinin-2 receptor through biosynthetic incorporation of fluorescent amino acids at specific sites
    • Turcatti, G.; Nemeth, K.; Edgerton, M.D.; Meseth, U.; Talabot, F.; Peitsch, M.; Knowles, J.; Vogel, H.; Chollet, A. Probing the structure and function of the tachykinin neurokinin-2 receptor through biosynthetic incorporation of fluorescent amino acids at specific sites. J. Biol. Chem. 1996, 271, 19991-19998.
    • (1996) J. Biol. Chem , vol.271 , pp. 19991-19998
    • Turcatti, G.1    Nemeth, K.2    Edgerton, M.D.3    Meseth, U.4    Talabot, F.5    Peitsch, M.6    Knowles, J.7    Vogel, H.8    Chollet, A.9
  • 19
    • 0033549881 scopus 로고    scopus 로고
    • Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: Potential neuroblastoma imaging agents
    • Hadrich, D.; Berthold, F.; Steckhan, E.; Bonisch, H. Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: potential neuroblastoma imaging agents. J. Med. Chem. 1999, 42, 3101-3108.
    • (1999) J. Med. Chem , vol.42 , pp. 3101-3108
    • Hadrich, D.1    Berthold, F.2    Steckhan, E.3    Bonisch, H.4
  • 20
    • 20844456605 scopus 로고    scopus 로고
    • [Aladan3]TIPP: A fluorescent delta-opioid antagonist with high delta-receptor binding affinity and delta selectivity
    • Chen, H.; Chung, N.N.; Lemieux, C.; Zelent, B.; Vanderkooi, J.M.; Gryczynski, I.; Wilkes, B.C.; Schiller, P.W. [Aladan3]TIPP: a fluorescent delta-opioid antagonist with high delta-receptor binding affinity and delta selectivity. Biopolymers. 2005, 80, 325-331.
    • (2005) Biopolymers , vol.80 , pp. 325-331
    • Chen, H.1    Chung, N.N.2    Lemieux, C.3    Zelent, B.4    Vanderkooi, J.M.5    Gryczynski, I.6    Wilkes, B.C.7    Schiller, P.W.8
  • 26
    • 0029057619 scopus 로고
    • Photobleaching kinetics of fluorescein in quantitative fluorescence microscopy
    • Song, I.; Hennink, E.J.; Young, I.T.; Tanke, H.J. Photobleaching kinetics of fluorescein in quantitative fluorescence microscopy. Biophys. J. 1995, 68, 2588-2600.
    • (1995) Biophys. J , vol.68 , pp. 2588-2600
    • Song, I.1    Hennink, E.J.2    Young, I.T.3    Tanke, H.J.4
  • 27
    • 0030029881 scopus 로고    scopus 로고
    • Influence of the triplet excited state on the photobleaching kinetics of fluorescein in microscopy
    • Song, I.; Varma, J.W.; Verhoeven, J.W.; Tanke, H.J. Influence of the triplet excited state on the photobleaching kinetics of fluorescein in microscopy. Biophys. J. 1996, 70, 2959-2968.
    • (1996) Biophys. J , vol.70 , pp. 2959-2968
    • Song, I.1    Varma, J.W.2    Verhoeven, J.W.3    Tanke, H.J.4
  • 28
    • 0004172941 scopus 로고    scopus 로고
    • 2nd ed.; BIOS Scientific Publishers: Oxford, UK
    • Herman, B. Fluorescence Microscopy; 2nd ed.; BIOS Scientific Publishers: Oxford, UK, 1998.
    • (1998) Fluorescence Microscopy
    • Herman, B.1
  • 31
    • 0037085321 scopus 로고    scopus 로고
    • Optical Sectioning-Slices of Life
    • Paddock S.; Optical Sectioning-Slices of Life. Science., 2002, 295, 1319-1321.
    • (2002) Science , vol.295 , pp. 1319-1321
    • Paddock, S.1
  • 32
    • 0142125229 scopus 로고    scopus 로고
    • Potential for broad applications of flow cytometry and fluorescence techniques in microbiological and somatic cell analyses of milk
    • Gunsekera, T.S.; Veal, D.A.; Attfield, P.V. Potential for broad applications of flow cytometry and fluorescence techniques in microbiological and somatic cell analyses of milk. International Journal of Food Microbiology., 2003, 85, 269-279.
    • (2003) International Journal of Food Microbiology , vol.85 , pp. 269-279
    • Gunsekera, T.S.1    Veal, D.A.2    Attfield, P.V.3
  • 34
    • 0028494792 scopus 로고
    • Improved axial resolution in confocal fluorescence microscopy using annular pupils
    • Gu, M.T.; Tannous, T.; Sheppard, C.J.R. Improved axial resolution in confocal fluorescence microscopy using annular pupils. Optics Communications., 1994, 110, 533-539.
    • (1994) Optics Communications , vol.110 , pp. 533-539
    • Gu, M.T.1    Tannous, T.2    Sheppard, C.J.R.3
  • 36
    • 22844447651 scopus 로고    scopus 로고
    • Chemical modification of the naphthoyl 3-position of JWH-015: In search of a fluorescent probe to the cannabinoid CB2 receptor
    • Yates, A.S.; Doughty, S.W.; Kendall, D.A.; Kellam, B. Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor. Bioorg. Med. Chem. 2005, 15, 3758-3762.
    • (2005) Bioorg. Med. Chem , vol.15 , pp. 3758-3762
    • Yates, A.S.1    Doughty, S.W.2    Kendall, D.A.3    Kellam, B.4
  • 38
    • 28144452935 scopus 로고    scopus 로고
    • Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogs as high-affinity fluorescent probes for the dopamine transporter
    • Cha, J.H.; Zou, M.; Adkins, E.M.; Rasmussen, S.G.F.; Loland, C.J.; Schoenenberger, B.; Gether, U.; Newman, A.H. Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogs as high-affinity fluorescent probes for the dopamine transporter. J. Med. Chem. 2005, 48, 7513-7516.
    • (2005) J. Med. Chem , vol.48 , pp. 7513-7516
    • Cha, J.H.1    Zou, M.2    Adkins, E.M.3    Rasmussen, S.G.F.4    Loland, C.J.5    Schoenenberger, B.6    Gether, U.7    Newman, A.H.8
  • 39
    • 33847362848 scopus 로고    scopus 로고
    • New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells
    • Middleton, R.J.; Briddon, S.J.; Cordeaux, Y.; Yates, A.S.; Dale, C.L.; George, M.W.; Baker, J.G.; Hill, S.J.; Kellam, B. New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells. J. Med. Chem. 2007, 50, 782-793.
    • (2007) J. Med. Chem , vol.50 , pp. 782-793
    • Middleton, R.J.1    Briddon, S.J.2    Cordeaux, Y.3    Yates, A.S.4    Dale, C.L.5    George, M.W.6    Baker, J.G.7    Hill, S.J.8    Kellam, B.9
  • 40
    • 0038454684 scopus 로고    scopus 로고
    • Synthesis and characterization of the first fluorescent antagonists for human 5-HT4 receptors
    • Berque-Bestel, I.; Soulier, J.L.; Giner, M.; Rivail, L.; Langlois, M.; Sicsic, S. Synthesis and characterization of the first fluorescent antagonists for human 5-HT4 receptors. J. Med. Chem. 2003, 46, 2606-2620.
    • (2003) J. Med. Chem , vol.46 , pp. 2606-2620
    • Berque-Bestel, I.1    Soulier, J.L.2    Giner, M.3    Rivail, L.4    Langlois, M.5    Sicsic, S.6
  • 41
    • 84860390424 scopus 로고    scopus 로고
    • Synthesis, evaluation and application of polycyclic fluorescent analogs as N-methyl-D-aspartate receptor and voltage gated calcium channel ligands
    • Joubert, J.; Van Dyk, S.; Green, I.R.; Malan, S.F. Synthesis, evaluation and application of polycyclic fluorescent analogs as N-methyl-D-aspartate receptor and voltage gated calcium channel ligands. Eur. J. Med. Chem. 2011, 46, 5010-5020.
    • (2011) Eur. J. Med. Chem , vol.46 , pp. 5010-5020
    • Joubert, J.1    Van Dyk, S.2    Green, I.R.3    Malan, S.F.4
  • 44
    • 34848830427 scopus 로고    scopus 로고
    • Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging
    • Tam, J.M.; Upadhyay, R.; Pittet, M.J.; Weissleder, R.; Mahmood, U. Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging. Mol. Imaging. 2007, 6(4), 269-276.
    • (2007) Mol. Imaging , vol.6 , Issue.4 , pp. 269-276
    • Tam, J.M.1    Upadhyay, R.2    Pittet, M.J.3    Weissleder, R.4    Mahmood, U.5
  • 45
    • 0642340255 scopus 로고    scopus 로고
    • Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives
    • Wang, Y.; Mathis, C.A.; Huang, G.F.; Debnath, M.L.; Holt, D.P.; Shao, L.; Klunk, W.E. Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives. J. Mol. Neurosci. 2003, 20(3), 255-260.
    • (2003) J. Mol. Neurosci , vol.20 , Issue.3 , pp. 255-260
    • Wang, Y.1    Mathis, C.A.2    Huang, G.F.3    Debnath, M.L.4    Holt, D.P.5    Shao, L.6    Klunk, W.E.7
  • 47
    • 0023891240 scopus 로고
    • Irreversible binding of the fluorescent beta-adrenoceptor probes alprenolol-NBD and pindolol-NBD to specific and non-specific binding sites
    • Rademaker, B.; Kramer, K.; Bast, A.; Timmerman, H. Irreversible binding of the fluorescent beta-adrenoceptor probes alprenolol-NBD and pindolol-NBD to specific and non-specific binding sites. Res. Commun. Chem. Pathol. Pharmacol. 1988, 60, 147-159.
    • (1988) Res. Commun. Chem. Pathol. Pharmacol , vol.60 , pp. 147-159
    • Rademaker, B.1    Kramer, K.2    Bast, A.3    Timmerman, H.4
  • 48
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyrimidines
    • Ralevic, V.R.; Burnstock, G. Receptors for purines and pyrimidines. Pharmacol. Rev., 1998, 50, 413-492.
    • (1998) Pharmacol. Rev , vol.50 , pp. 413-492
    • Ralevic, V.R.1    Burnstock, G.2
  • 50
    • 0037167775 scopus 로고    scopus 로고
    • 4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor. Il
    • Macchia, M.; Bertini, S.; Di Bussolo, V.; Manera, C.; Martini, C.; Minutolo, F.; Mori, C.; Saccomanni, G.; Tuscano, D.; Ferrarini, P.L.; 4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor. Il. Farmaco. 2002, 57(10), 783-786.
    • (2002) Farmaco , vol.57 , Issue.10 , pp. 783-786
    • MacChia, M.1    Bertini, S.2    Di Bussolo, V.3    Manera, C.4    Martini, C.5    Minutolo, F.6    Mori, C.7    Saccomanni, G.8    Tuscano, D.9    Ferrarini, P.L.10
  • 51
    • 0037472231 scopus 로고    scopus 로고
    • 5-HT4 receptor ligands: Applications and new prospects
    • Langlois, M.; Fischmeister, R. 5-HT4 receptor ligands: applications and new prospects. J. Med. Chem. 2003, 46, 1-26.
    • (2003) J. Med. Chem , vol.46 , pp. 1-26
    • Langlois, M.1    Fischmeister, R.2
  • 52
    • 0035977026 scopus 로고    scopus 로고
    • The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein
    • Robert, S.J.; Zugara, J.L.; Fischmeister, R.; Gardier, A.M.; Lezoualc'h, F. The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein. J. Biol. Chem. 2001, 276, 44881-44888.
    • (2001) J. Biol. Chem , vol.276 , pp. 44881-44888
    • Robert, S.J.1    Zugara, J.L.2    Fischmeister, R.3    Gardier, A.M.4    Lezoualc'h, F.5
  • 54
    • 0036830627 scopus 로고    scopus 로고
    • NMDA receptor pathways as drug targets
    • Kemp, J.A.; McKernan, R.M. NMDA receptor pathways as drug targets. Nat. Neurosci. 2002, 5, 1039-1042.
    • (2002) Nat. Neurosci , vol.5 , pp. 1039-1042
    • Kemp, J.A.1    McKernan, R.M.2
  • 55
    • 0035955638 scopus 로고    scopus 로고
    • Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death
    • Cano-Abad, M.F.; Villarroya, M.; García, A.G.; Gabilan, N.H.; Manuela, G., López, M.G. Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death. J. Biol. Chem. 2001, 276, 39695-39704.
    • (2001) J. Biol. Chem , vol.276 , pp. 39695-39704
    • Cano-Abad, M.F.1    Villarroya, M.2    García, A.G.3    Gabilan, N.H.4    Manuela, G.5    López, M.G.6
  • 56
    • 0025185948 scopus 로고
    • Characterization of [3H]alprazolam binding to central benzodiazepine receptors
    • McCabe, R.T.; Mahan, D.R.; Smith, R.B.; Wamsley, J.K. Characterization of [3H]alprazolam binding to central benzodiazepine receptors. Pharmacol. Biochem. Behav. 1990, 37, 365-370.
    • (1990) Pharmacol. Biochem. Behav , vol.37 , pp. 365-370
    • McCabe, R.T.1    Mahan, D.R.2    Smith, R.B.3    Wamsley, J.K.4
  • 57
    • 1542404521 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane derivatives as potential therapeutic agents in Parkinson's disease
    • Geldenhuys, W.J.; Malan, S.F.; Murugensan, T.; Van Der Schyf, C.J. Synthesis and biological evaluation of pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane derivatives as potential therapeutic agents in Parkinson's disease. Bioorg. Med. Chem. 2004, 12, 1799-1806.
    • (2004) Bioorg. Med. Chem , vol.12 , pp. 1799-1806
    • Geldenhuys, W.J.1    Malan, S.F.2    Murugensan, T.3    van der Schyf, C.J.4
  • 60
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • Moncada, S.; Palmer, R.M.; Higgs, E.A. Pharmacol. Rev. Nitric oxide: physiology, pathophysiology, and pharmacology. 1991, 43(2), 109-142.
    • (1991) Pharmacol. Rev , vol.43 , Issue.2 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 61
    • 33751402320 scopus 로고    scopus 로고
    • Fluorescent nitric oxide detection by copper complexes bearing anthracenyl and dansyl fluorophore ligands
    • Lim, M.H.; Lippard, S.J. Fluorescent nitric oxide detection by copper complexes bearing anthracenyl and dansyl fluorophore ligands. Inorg. Chem. 2006, 45, 8980-8989.
    • (2006) Inorg. Chem , vol.45 , pp. 8980-8989
    • Lim, M.H.1    Lippard, S.J.2
  • 63
    • 0036545820 scopus 로고    scopus 로고
    • Bioimaging of nitric oxide
    • Nagano, T.; Yoshimura, T. Bioimaging of nitric oxide. Chem. Rev. 2002, 102, 1235-1270.
    • (2002) Chem. Rev , vol.102 , pp. 1235-1270
    • Nagano, T.1    Yoshimura, T.2
  • 64
    • 52949098313 scopus 로고    scopus 로고
    • Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition
    • Joubert, J.; van Dyk, S.; Malan, S.F. Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition. Bioorg. Med. Chem. 2008, 16, 8952-8958.
    • (2008) Bioorg. Med. Chem , vol.16 , pp. 8952-8958
    • Joubert, J.1    van Dyk, S.2    Malan, S.F.3
  • 65
    • 0034193705 scopus 로고    scopus 로고
    • Transient changes in the synthesis of nitric oxide result in long-term as well as short-term changes in acetic acid-induced writhing in mice
    • Larson, A.A.; Kovacs, K.J.; Cooper, J.C.; Kitto, K.F. Transient changes in the synthesis of nitric oxide result in long-term as well as short-term changes in acetic acid-induced writhing in mice. Pain. 2000, 86, 103-111.
    • (2000) Pain , vol.86 , pp. 103-111
    • Larson, A.A.1    Kovacs, K.J.2    Cooper, J.C.3    Kitto, K.F.4
  • 66
    • 0030040255 scopus 로고    scopus 로고
    • Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
    • Southan, G.J.; Szabó, C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem. Pharmacol., 1996, 51(4), 383-394.
    • (1996) Biochem. Pharmacol , vol.51 , Issue.4 , pp. 383-394
    • Southan, G.J.1    Szabó, C.2
  • 67
    • 33745745762 scopus 로고    scopus 로고
    • Development of ligands for the peripheral benzodiazepine receptor
    • James, M.L.; Selleri, S.; Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Curr. Med. Chem. 2006, 13, 1991-2001.
    • (2006) Curr. Med. Chem , vol.13 , pp. 1991-2001
    • James, M.L.1    Selleri, S.2    Kassiou, M.3
  • 69
    • 33644498858 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders
    • Papadopoulos, V.; Lecanu, L.; Brown, R.C.; Han, Z.; Yao, Z.X. Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders. Neurosci. 2006, 138, 749-756.
    • (2006) Neurosci , vol.138 , pp. 749-756
    • Papadopoulos, V.1    Lecanu, L.2    Brown, R.C.3    Han, Z.4    Yao, Z.X.5
  • 70
    • 0030739178 scopus 로고    scopus 로고
    • Synthesis and biology of a 7-nitro-2,1,3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: A fluorescent probe for the peripheral-type benzodiazepine receptor
    • Kozikowski, A.P.; Kotoula, M.; Ma, D.; Boujrad, N.; Tuckmantel, W.; Papadopoulos, V. Synthesis and biology of a 7-nitro-2,1,3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptor. J. Med. Chem. 1997, 40(16), 2435-2439.
    • (1997) J. Med. Chem , vol.40 , Issue.16 , pp. 2435-2439
    • Kozikowski, A.P.1    Kotoula, M.2    Ma, D.3    Boujrad, N.4    Tuckmantel, W.5    Papadopoulos, V.6
  • 73
    • 0034741123 scopus 로고    scopus 로고
    • Dopamine D3 receptor as a therapeutic target for antipsychotic and antiparkinsonian drugs
    • Joyce, J.N. Dopamine D3 receptor as a therapeutic target for antipsychotic and antiparkinsonian drugs. Pharmacol. Ther. 2001, 90, 231-259.
    • (2001) Pharmacol. Ther , vol.90 , pp. 231-259
    • Joyce, J.N.1
  • 74
    • 33846900714 scopus 로고    scopus 로고
    • Dopamine D3 receptor agonists for protection and repair in Parkinson's disease
    • Joyce, J.N.; Millan, M.J. Dopamine D3 receptor agonists for protection and repair in Parkinson's disease. Curr Opin Pharmacol, 2007, 7, 100-105.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 100-105
    • Joyce, J.N.1    Millan, M.J.2
  • 75
    • 34948864356 scopus 로고    scopus 로고
    • 4-[omega-[4-arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine derivatives: Fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualisation
    • Leopoldo, M.; Lacivita, E.; Passafiume, E.; Contino, M.; Colabufo, N.A.; Berardi, F.; Perrone, R. 4-[omega-[4-arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualisation. J. Med. Chem. 2007, 50(20), 5043-5047.
    • (2007) J. Med. Chem , vol.50 , Issue.20 , pp. 5043-5047
    • Leopoldo, M.1    Lacivita, E.2    Passafiume, E.3    Contino, M.4    Colabufo, N.A.5    Berardi, F.6    Perrone, R.7
  • 76
    • 0035895969 scopus 로고    scopus 로고
    • Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analog as a molecular reporter
    • Rasmussen, S.G.F.; Carroll, F.I.; Maresch, M.J.; Jensen, A.D.; Tate, C.G.; Gether, U. Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analog as a molecular reporter. J. Biol. Chem. 2001, 276, 4717-4723.
    • (2001) J. Biol. Chem , vol.276 , pp. 4717-4723
    • Rasmussen, S.G.F.1    Carroll, F.I.2    Maresch, M.J.3    Jensen, A.D.4    Tate, C.G.5    Gether, U.6
  • 77
    • 0017659528 scopus 로고
    • Spectroscopic and immunochemical studies with nitrobenzoxadiazolealanine, a fluorescent dinitrophenyl analog
    • Lancet, D.; Pecht, I. Spectroscopic and immunochemical studies with nitrobenzoxadiazolealanine, a fluorescent dinitrophenyl analog. Biochem. 1977, 16, 5150-5157.
    • (1977) Biochem , vol.16 , pp. 5150-5157
    • Lancet, D.1    Pecht, I.2
  • 79
    • 28144452935 scopus 로고    scopus 로고
    • Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogs as high-affinity fluorescent probes for the dopamine transporter
    • Cha, J.H.; Zou, M.; Adkins, E.M.; Rasmussen, S.G.F.; Schoenenberger, C.J.L.B. Gether, U.; Newman, A.H. Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogs as high-affinity fluorescent probes for the dopamine transporter. J. Med. Chem. 2005, 48, 7513-7516.
    • (2005) J. Med. Chem , vol.48 , pp. 7513-7516
    • Cha, J.H.1    Zou, M.2    Adkins, E.M.3    Rasmussen, S.G.F.4    Schoenenberger, C.J.L.B.5    Gether, U.6    Newman, A.H.7
  • 81
    • 17144365477 scopus 로고    scopus 로고
    • The role of sigma receptors in depression
    • Bermack, J.E.; Debonnel, G. The role of sigma receptors in depression. J. Pharmacol. Sci. 2005, 97, 317-336.
    • (2005) J. Pharmacol. Sci , vol.97 , pp. 317-336
    • Bermack, J.E.1    Debonnel, G.2
  • 82
    • 77954244972 scopus 로고    scopus 로고
    • Sigma receptors: Potential targets for a new class of antidepressant drug
    • Fishback, J.A.; Robson, M.J.; Xu, Y.T.; Matsumoto, R.R. Sigma receptors: potential targets for a new class of antidepressant drug. Pharmacol. Ther. 2010, 127, 271-282.
    • (2010) Pharmacol. Ther , vol.127 , pp. 271-282
    • Fishback, J.A.1    Robson, M.J.2    Xu, Y.T.3    Matsumoto, R.R.4
  • 83
    • 34548663639 scopus 로고    scopus 로고
    • Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice
    • Wang, J.; Mack, A.L.; Coop, A.; Matsumoto, R.R. Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice. Eur. Neuropsychopharmacol. 2007, 17, 708-716.
    • (2007) Eur. Neuropsychopharmacol , vol.17 , pp. 708-716
    • Wang, J.1    Mack, A.L.2    Coop, A.3    Matsumoto, R.R.4
  • 84
    • 23944504501 scopus 로고    scopus 로고
    • Involvement of sigma receptors in the acute actions of methamphetamine: Receptor binding and behavioral studies
    • Nguyen, E.C.; McCracken, K.A.; Liu, Y.; Pouw, B.; Matsumoto, R.R. Involvement of sigma receptors in the acute actions of methamphetamine: receptor binding and behavioral studies. Neuropharmacology. 2005, 49, 638-645.
    • (2005) Neuropharmacology , vol.49 , pp. 638-645
    • Nguyen, E.C.1    McCracken, K.A.2    Liu, Y.3    Pouw, B.4    Matsumoto, R.R.5
  • 85
    • 0038054062 scopus 로고    scopus 로고
    • Sigma receptors: Potential medications development target for anti-cocaine agents
    • Matsumoto, R.R.; Liu, Y.; Lerner, M.; Howard, E.W.; Brackett, D.J. Sigma receptors: potential medications development target for anti-cocaine agents. Eur. J. Pharmacol. 2003, 469, 1-12.
    • (2003) Eur. J. Pharmacol , vol.469 , pp. 1-12
    • Matsumoto, R.R.1    Liu, Y.2    Lerner, M.3    Howard, E.W.4    Brackett, D.J.5
  • 86
    • 33846162759 scopus 로고    scopus 로고
    • Imaging sigma receptors: Applications in drug development
    • Collier, T.L.; Waterhouse, R.N.; Kassiou, M. Imaging sigma receptors: applications in drug development. Curr. Pharm. 2007, 13, 51-72.
    • (2007) Curr. Pharm , vol.13 , pp. 51-72
    • Collier, T.L.1    Waterhouse, R.N.2    Kassiou, M.3
  • 87
    • 18144377108 scopus 로고    scopus 로고
    • Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors
    • Kassiou, M.; Dannals, R.F.; Liu, X.; Wong, D.F.; Ravert, H.T.; Scheffel, U.A. Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors. Bioorg. Med. Chem. 2005, 13, 3623-3626.
    • (2005) Bioorg. Med. Chem , vol.13 , pp. 3623-3626
    • Kassiou, M.1    Dannals, R.F.2    Liu, X.3    Wong, D.F.4    Ravert, H.T.5    Scheffel, U.A.6
  • 89
    • 33748102817 scopus 로고    scopus 로고
    • Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl carbamate analogs as sigma2 receptor ligands
    • Vangveravong, S.; Xu, J.; Zeng, C.; Mach R.H. Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl carbamate analogs as sigma2 receptor ligands. Bioorg. Med. Chem. 2006, 14, 6988-6997.
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 6988-6997
    • Vangveravong, S.1    Xu, J.2    Zeng, C.3    Mach, R.H.4
  • 90
    • 0031255112 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease
    • Hyman, B.T.; Trojanowski, J.Q. Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J. Neuropathol. Exp. Neurol. 1997, 56(10), 1095-1097.
    • (1997) J. Neuropathol. Exp. Neurol , vol.56 , Issue.10 , pp. 1095-1097
    • Hyman, B.T.1    Trojanowski, J.Q.2
  • 91
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • Goedert, M.; Spillantini, M.G. A century of Alzheimer's disease. Science. 2001, 314, 777-781.
    • (2001) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 93
    • 69949123361 scopus 로고    scopus 로고
    • Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer's disease patients
    • Ojida, A.; Sakamoto, T.; Inoue, M.; Fujishima, S.; Lippens, G.; Hamachi I. Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer's disease patients. J. Am. Chem. Soc. 2009, 131(18), 6543-6548.
    • (2009) J. Am. Chem. Soc , vol.131 , Issue.18 , pp. 6543-6548
    • Ojida, A.1    Sakamoto, T.2    Inoue, M.3    Fujishima, S.4    Lippens, G.5    Hamachi, I.6
  • 97
    • 0142075238 scopus 로고    scopus 로고
    • 11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease
    • Ono, M.; Wilson, A.; Nobrega, J.; Westaway, D.; Verhoeff, P.; Zhuang, Z.P.; Kung, M.P.; Kung, H.F. 11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease. Nucl. Med. Biol. 2003, 30(6), 565-571.
    • (2003) Nucl. Med. Biol , vol.30 , Issue.6 , pp. 565-571
    • Ono, M.1    Wilson, A.2    Nobrega, J.3    Westaway, D.4    Verhoeff, P.5    Zhuang, Z.P.6    Kung, M.P.7    Kung, H.F.8
  • 102
    • 44349166288 scopus 로고    scopus 로고
    • MBC94, a conjugable ligand for cannabinoid CB 2 receptor imaging
    • Bai, M.; Sexton, M.; Stella, N.; Bornhop, D.J. MBC94, a conjugable ligand for cannabinoid CB 2 receptor imaging. Bioconjug. Chem. 2008, 19, 988-992.
    • (2008) Bioconjug. Chem , vol.19 , pp. 988-992
    • Bai, M.1    Sexton, M.2    Stella, N.3    Bornhop, D.J.4
  • 103
    • 0033549881 scopus 로고    scopus 로고
    • Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: Potential neuroblastoma imaging agents
    • Hadrich, D.; Berthold, F.; Steckhan, E.; Bonisch, H. Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: potential neuroblastoma imaging agents. J. Med. Chem. 1999, 42, 3101-3108.
    • (1999) J. Med. Chem , vol.42 , pp. 3101-3108
    • Hadrich, D.1    Berthold, F.2    Steckhan, E.3    Bonisch, H.4
  • 105
    • 33847776789 scopus 로고    scopus 로고
    • Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601)
    • Mamelak, A.N.; Jacoby, D.B. Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601). Exp. Opin. Drug. Deliv. 2007, 4(2), 175-186.
    • (2007) Exp. Opin. Drug. Deliv , vol.4 , Issue.2 , pp. 175-186
    • Mamelak, A.N.1    Jacoby, D.B.2


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