Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of alzheimer's disease patients

Journal of the American Chemical Society

Volumn 131, Issue 18, 2009, Pages 6543-6548

  Ojida, Akio ^a,b   Sakamoto, Takashi ^a   Inoue, Masa Aki ^a   Fujishima, Sho Hei ^a   Lippens, Guy ^c   Hamachi, Itaru ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; AMINES; AMINO ACIDS; BINDING ENERGY; BINDING SITES; DISSOCIATION; ELECTRIC CONDUCTIVITY MEASUREMENT; GLYCOPROTEINS; ORGANIC ACIDS; PEPTIDES; PHOSPHORYLATION; PROBES; TITRATION; ZINC; ZINC COMPOUNDS;

ALZHEIMER'S DISEASE; AMYLOID PLAQUES; BRAIN TISSUE; DISSOCIATION CONSTANT; FLUORESCENCE TITRATIONS; HYPERPHOSPHORYLATED; MICROMOLAR RANGE; MOLECULAR PROBES; NEUROFIBRILLARY TANGLES; PHOSPHORYLATED AMINO ACID; PHOSPHORYLATED PEPTIDES; RATIONAL DESIGN; SELECTIVE DETECTION; SELECTIVE FLUORESCENCE; SENSING PROPERTY; TAU PROTEINS; TISSUE SECTIONS; ZN COMPLEX;

FLUORESCENCE;

4,4-DIFLUORO-4-BORA-3A,4A-DIAZA-S-INDACENE; BORON DERIVATIVE; TAU PROTEIN; ZINC;

ALZHEIMER DISEASE; BRAIN; DIAGNOSTIC USE; GENETIC PROCEDURES; HIPPOCAMPUS; HUMAN; METABOLISM; NEUROFIBRILLARY TANGLE; PATHOLOGY; PHOSPHORYLATION;

ALZHEIMER DISEASE; BORON COMPOUNDS; BRAIN; HIPPOCAMPUS; HUMANS; MOLECULAR PROBE TECHNIQUES; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION; TAU PROTEINS; ZINC;

EID: 69949123361     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9008369     Document Type: Article

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