Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: Role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis

American Journal of Pathology

Volumn 180, Issue 3, 2012, Pages 998-1007

  Zhong, Wei ^a   Zhao, Yantao ^b   Tang, Yunan ^c   Wei, Xiaoli ^d   Shi, Xue ^d   Sun, Wenlong ^d   Sun, Xiuhua ^a   Yin, Xinmin ^d   Sun, Xinguo ^a   Kim, Seongho ^d   McClain, Craig J ^c,d,e   Zhang, Xiang ^d   Zhou, Zhanxiang ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b AGRICULTURAL UNIVERSITY OF HEBEI   (China)

^c University of Louisville School of Medicine   (United States)

^d UNIVERSITY OF LOUISVILLE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; DEUTERIUM; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID TRANSPORT; FATTY LIVER; HOMEOSTASIS; INSULIN RESISTANCE; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LIPID METABOLISM; LIPODYSTROPHY; LIPOLYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; UPREGULATION;

ADIPOSE TISSUE; ANIMALS; CHRONIC DISEASE; DEUTERIUM OXIDE; DOWN-REGULATION; ETHANOL; FATTY ACIDS; FATTY LIVER, ALCOHOLIC; HOMEOSTASIS; INSULIN RESISTANCE; LIPID METABOLISM; LIPOLYSIS; LIVER; MALE; MICE; MICE, INBRED C57BL; ORGAN SIZE; PTEN PHOSPHOHYDROLASE; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRIGLYCERIDES; UP-REGULATION;

EID: 84863122866     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.11.017     Document Type: Article

References (36)

1. P. Hall Pathological spectrum of alcoholic liver disease P. Hall, Alcoholic Liver Disease 2nd ed. 1995 Edward Arnold London 41 88
2. M.R. Lakshman Some novel insights into the pathogenesis of alcoholic steatosis Alcohol 34 2004 45 48
3. V. Purohit, D. Russo, P.M. Coates Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium Alcohol 34 2004 3 8
4. M. You, D.W. Crabb Recent advances in alcoholic liver disease II Minireview: molecular mechanisms of alcoholic fatty liver Am J Physiol Gastrointest Liver Physiol 287 2004 G1 G6
5. M. Lafontan, J. Girard Impact of visceral adipose tissue on liver metabolism Part I: heterogeneity of adipose tissue and functional properties of visceral adipose tissue Diabetes Metab 34 2008 317 327
6. K. Cusi The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes Curr Diab Rep 10 2010 306 315
7. A. Wree, A. Kahraman, G. Gerken, A. Canbay Obesity affects the liver: the link between adipocytes and hepatocytes Digestion 83 2011 124 133
8. M.Y. Wang, P. Grayburn, S. Chen, M. Ravazzola, L. Orci, R.H. Unger Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome Proc Natl Acad Sci U S A 105 2008 6139 6144
9. J.Y. Kim, E. van de Wall, M. Laplante, A. Azzara, M.E. Trujillo, S.M. Hofmann, T. Schraw, J.L. Durand, H. Li, G. Li, L.A. Jelicks, M.F. Mehler, D.Y. Hui, Y. Deshaies, G.I. Shulman, G.J. Schwartz, P.E. Scherer Obesity-associated improvements in metabolic profile through expansion of adipose tissue J Clin Invest 117 2007 2621 2637
10. G. Addolorato, E. Capristo, A.V. Greco, G.F. Stefanini, G. Gasbarrini Energy expenditure, substrate oxidation, and body composition in subjects with chronic alcoholism: new findings from metabolic assessment Alcohol Clin Exp Res 21 1997 962 967
11. G. Addolorato, E. Capristo, A.V. Greco, G.F. Stefanini, G. Gasbarrini Influence of chronic alcohol abuse on body weight and energy metabolism: is excess ethanol consumption a risk factor for obesity or malnutrition J Intern Med 244 1998 387 395
12. L. Kang, X. Chen, B.M. Sebastian, B.T. Pratt, I.R. Bederman, J.C. Alexander, S.F. Previs, L.E. Nagy Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation J Biol Chem 282 2007 28465 28473
13. X. Kang, W. Zhong, J. Liu, Z. Song, C.J. McClain, Y.J. Kang, Z. Zhou Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha Hepatology 50 2009 1241 1250
14. S.L. Zhou, R.E. Gordon, M. Bradbury, D. Stump, C.L. Kiang, P.D. Berk Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells Hepatology 27 1998 1064 1074
15. P.D. Berk, S. Zhou, M.W. Bradbury Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings Trans Am Clin Climatol Assoc 116 2005 335 344
16. E. Pouteau, C. Beysen, N. Saad, S. Turner Dynamics of adipose tissue development by 2H2O labeling Methods Mol Biol 579 2009 337 358
17. B.M. Bolstad, R.A. Irizarry, M. Astrand, T.P. Speed A comparison of normalization methods for high density oligonucleotide array data based on variance and bias Bioinformatics 19 2003 185 193
18. A. Xu, Y. Wang, H. Keshaw, L.Y. Xu, K.S. Lam, G.J. Cooper The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice J Clin Invest 112 2003 91 100
19. M. You, R.V. Considine, T.C. Leone, D.P. Kelly, D.W. Crabb Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice Hepatology 42 2005 568 577
20. M. You, C.Q. Rogers Adiponectin: a key adipokine in alcoholic fatty liver Exp Biol Med (Maywood) 234 2009 850 859
21. V. Large, O. Peroni, D. Letexier, H. Ray, M. Beylot Metabolism of lipids in human white adipocyte Diabetes Metab 30 2004 294 309
22. L. Kang, L.E. Nagy Chronic ethanol feeding suppresses beta-adrenergic receptor-stimulated lipolysis in adipocytes isolated from epididymal fat Endocrinology 147 2006 4330 4338
23. K. Jaworski, E. Sarkadi-Nagy, R.E. Duncan, M. Ahmadian, H.S. Sul Regulation of triglyceride metabolism IV. Hormonal regulation of lipolysis in adipose tissue Am J Physiol Gastrointest Liver Physiol 293 2007 G1 G4
24. D.W. Crabb, A. Galli, M. Fischer, M. You Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha Alcohol 34 2004 35 38
25. M. You, D.W. Crabb Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins Alcohol 34 2004 39 43
26. M.S. Sozio, S. Liangpunsakul, D. Crabb The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis Semin Liver Dis 30 2010 378 390
27. M.A. Abrams, C. Cooper Quantitative analysis of metabolism of hepatic triglyceride in ethanol-treated rats Biochem J 156 1976 33 46
28. E. Baraona, M.A. Leo, S.A. Borowsky, C.S. Lieber Alcoholic hepatomegaly: accumulation of protein in the liver Science 190 1975 794 795
29. M. Febbraio, D.P. Hajjar, R.L. Silverstein CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism J Clin Invest 108 2001 785 791
30. M.R. Lakshmanan, M.E. Felver, R.L. Veech Alcohol and very low density lipoprotein synthesis and secretion by isolated hepatocytes Alcohol Clin Exp Res 4 1980 361 365
31. S. Venkatesan, R.J. Ward, T.J. Peters Effect of chronic alcohol feeding on the hepatic secretion of very-low-density lipoproteins Biochim Biophys Acta 960 1988 61 66
32. M. Fischer, M. You, M. Matsumoto, D.W. Crabb Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice J Biol Chem 278 2003 27997 28004
33. K.K. Kharbanda, S.L. Todero, B.W. Ward, J.J. Cannella 3rd, D.J. Tuma Betaine administration corrects ethanol-induced defective VLDL secretion Mol Cell Biochem 327 2009 75 78
34. M.M. Hussain, J. Shi, P. Dreizen Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly J Lipid Res 44 2003 22 32
35. M. Tahara, K. Matsumoto, T. Nukiwa, T. Nakamura Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats J Clin Invest 103 1999 313 320
36. K. Tomita, T. Azuma, N. Kitamura, J. Nishida, G. Tamiya, A. Oka, S. Inokuchi, T. Nishimura, M. Suematsu, H. Ishii Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met Gastroenterology 26 2004 873 885