Protective effects of crude garlic by reducing iron-mediated oxidative stress, proliferation and autophagy in rats

Journal of Molecular Histology

Volumn 41, Issue 4-5, 2010, Pages 233-245

  Nahdi, Afef ^a   Hammami, Imen ^a   Kouidhi, Wided ^a   Chargui, Abderrahman ^a   Ben Ammar, Awatef ^a   Hamdaoui, Mohamed Hédi ^b   El May, Ahmed ^c   El May, Michèle ^a  

^a UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

^b University of Tunis El Manar   (Tunisia)

^c SALAH AZAIEZ INSTITUTE   (Tunisia)

Author keywords

Autophagy; Electron microscopy; Garlic; Iron supplementation; Oxidative stress; Proliferation

Indexed keywords

FERROUS SULFATE; GARLIC OIL; IRON; MALONALDEHYDE; SCAVENGER; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BODY WEIGHT; CELL ASSAY; CELL PROLIFERATION; CELL PROTECTION; CELL TRANSFORMATION; CELL VACUOLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG POTENCY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; IRON BLOOD LEVEL; IRON INTAKE; IRON STORAGE; IRON THERAPY; LIPID PEROXIDATION; LIVER CELL NUCLEUS; LIVER LYSOSOME; LIVER PARENCHYMA; LIVER STRUCTURE; MALE; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TISSUE LEVEL; TREATMENT DURATION;

ANIMALS; APOPTOSIS; AUTOPHAGY; BODY WEIGHT; CELL PROLIFERATION; COMPLEX MIXTURES; DIETARY SUPPLEMENTS; FEEDING BEHAVIOR; GARLIC; IRON; LIVER; MALE; MALONDIALDEHYDE; ORGAN SPECIFICITY; OXIDATIVE STRESS; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

ALLIUM SATIVUM; RATTUS;

EID: 77958494723     PISSN: 15672379     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10735-010-9283-5     Document Type: Article

References (61)

1. Adrian J, Rabache M, Frangne R (1981) Techniques d'analyse nutritionnelle. In: Association pour la promotion Industrie Agriculture (ed) Techniques d'analyse et de contrôle dans les industries agro-alimentaires. Technique et documentation, Paris, pp 393-420
2. KC Agarwal 1996 Therapeutic action of garlic constituents Med Res Rev 16 111 124 1:CAS:528:DyaK28XhtFyls7o%3D 10.1002/(SICI)1098-1128(199601)16:1<111: :AID-MED4>3.0.CO;2-5 8788216 (Pubitemid 26037077)
3. MK Agarwal M Iqbal M Athar 2007 Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: Implications for cancer prevention Food Chem Toxicol 45 1634 1640 1:CAS:528:DC%2BD2sXot12lu70%3D 10.1016/j.fct.2007.02.029 17512651 (Pubitemid 47102500)
4. M Anoush MA Eghbal F Fathiazad H Hamzeiy NS Kouzehkonani 2009 The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion Pak J Biol Sci 12 10 765 771 1:STN:280:DC%2BD1Mnnt1yhug%3D%3D 10.3923/pjbs.2009.765.771 19806806
5. F Antunes E Cadenas UT Brunk 2001 Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture Biochem J 356 549 555 1:CAS:528:DC%2BD3MXks1alurc%3D 10.1042/0264-6021:3560549 11368784 (Pubitemid 32532368)
6. S Arivazhagan S Balasenthil S Nagini 2000 Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats Phytother Res 14 4 291 293 1:STN:280:DC%2BD3cvgt12jtQ%3D%3D 10.1002/1099-1573(200006)14:4<291::AID-PTR570>3.0.CO;2-Y 10861977 (Pubitemid 30410062)
7. S Balasenthil S Arivazhagan CR Ramachandran S Nagini 1999 Effects of garlic on 7, 12-Dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis Cancer Detect Prev 23 6 534 538 1:CAS:528:DyaK1MXnvVGlsLc%3D 10.1046/j.1525-1500.1999.99050.x 10571664 (Pubitemid 29536885)
8. S Balasenthil S Arivazhagan S Nagini 2000 Effect of garlic on circulatory oxidant and antioxidant status during 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis Nutr Res 20 11 1581 1589 1:CAS:528:DC%2BD3MXit12l 10.1016/S0271-5317(00)00242-6
9. SK Banerjee M Maulik SC Mancahanda AK Dinda SK Gupta SK Maulik 2002 Dose-dependent induction of endogenous antioxidants in rat heart by chronic administration of garlic Life Sci 70 1509 1518 1:CAS:528:DC%2BD38XhvFKns7k%3D 10.1016/S0024-3205(01)01514-4 11895102 (Pubitemid 34164545)
10. F Blachier P Vaugelade V Robert B Kibangou F Canonne-Hergaux S Delpal F Bureau H Blottière D Bouglé 2007 Comparative capacities of the pig colon and duodenum for luminal iron absorption Can J Physiol Pharmacol 85 2 185 192 1:CAS:528:DC%2BD2sXmsVWnt7Y%3D 10.1139/Y07-007 17487259 (Pubitemid 46846429)
11. B Borch-Iohnsen K Thorstensen 2009 Iron distribution in the liver and duodenum during seasonal iron overload in Svalbard Reindeer J Comp Path 141 27 40 1:CAS:528:DC%2BD1MXmvFaju78%3D 10.1016/j.jcpa.2009.02.001 19344912
12. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254 1:CAS:528:DyaE28XksVehtrY%3D 10.1016/0003-2697(76)90527- 3 942051
13. RS Britton 1996 Metal-induced hepatotoxicity Semin Liver Dis 16 1 3 12 1:STN:280:DyaK28zgtVKisw%3D%3D 10.1055/s-2007-1007214 8723319
14. KE Brown MM Mathahs KA Broadhurst J Weydert 2006 Chronic iron overload stimulates hepatocyte proliferation and cyclin D1 expression in rodent liver Transl Res 148 2 55 62 1:CAS:528:DC%2BD28Xps1ClsLc%3D 10.1016/j.trsl.2006.03.002 16890145 (Pubitemid 44142352)
15. JA Buege SD Aust 1978 Microsomal lipid peroxidation Methods Enzymol 52 302 310 1:CAS:528:DyaE1MXltVajsw%3D%3D 10.1016/S0076-6879(78)52032-6 672633
16. JW Eaton M Qian 2002 Molecular bases of cellular iron toxicity Free Radic Biol Med 32 9 833 840 1:CAS:528:DC%2BD38XjtVeju7g%3D 10.1016/S0891-5849(02) 00772-4 11978485 (Pubitemid 34439254)
17. H El Hajji E Nkhili V Tomao O Dangles 2006 Interactions of quercetin with iron and copper ions: complexation and autoxidation Free Radic Res 40 303 320 1:CAS:528:DC%2BD28XhsVSlt7k%3D 10.1080/10715760500484351 16484047 (Pubitemid 43245446)
18. F Farinati R Cardin M Fiorentino A D'errico W Grigioni A Cecchetto R Naccarato 2001 Imbalance between cytoproliferation and apoptosis in hepatitis C virus related chronic liver disease J Viral Hepat 8 1 34 40 1:STN:280: DC%2BD3M3ktlSlsw%3D%3D 10.1046/j.1365-2893.2001.00267.x 11155150 (Pubitemid 32115912)
19. T Furutani H Hino M Okuda T Gondo S Nishina A Kitase M Korenaga S-Y Xiao SA Weinman SM Lemon I Sakaida K Okita 2006 Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein Gastroenterology 130 2087 2098 1:CAS:528:DC%2BD28XntVWit78%3D 10.1053/j.gastro.2006.02.060 16762631 (Pubitemid 43816966)
20. F Gaboriau C Laupen-Chassay N Pasdeloup JL Pierre P Brissot G Lescoat 2005 Modulation de la prolifération cellulaire dans des cultures de cellules hépatiques de rat par le chélateur du fer O-trensox: une relation possible avec le métabolisme des polyamines Gastroen Clin Biol 29 8-9 900 10.1016/S0399-8320(05)86398-5
21. L Galluzzi MC Maiuri I Vitale H Zischka M Castedo L Zitvogel G Kroemer 2007 Cell death modalities: classification and pathophysiological implications Cell Death Differ 14 7 1237 1243 1:CAS:528:DC%2BD2sXms1Sqsrk%3D 10.1038/sj.cdd.4402148 17431418 (Pubitemid 46969863)
22. X Gao JL Campian M Qian XF Sun JW Eaton 2009 Mitochondrial DNA damage in iron overload J Biol Chem 284 4767 4775 1:CAS:528:DC%2BD1MXhvVSgtbg%3D 10.1074/jbc.M806235200 19095657
23. B Garner W Li K Roberg UT Brunk 1997 On the cytoprotective role of ferritin in macrophages and its ability to enhance lysosomal stability Free Radic Res 27 5 487 500 1:CAS:528:DyaK1cXisVClsrk%3D 10.3109/10715769709065788 9518065
24. B Garner K Roberg UT Brunk 1998 Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress Free Radic Res 29 2 103 114 1:CAS:528:DyaK1cXmtlGjtLk%3D 10.1080/10715769800300121 9790512 (Pubitemid 28451389)
25. M Glei A Klinder GO Latunde-Dada TW Becker U Hermann K Voigt BL Pool-Zobel 2002 Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19A Mutat Res 519 151 161 1:CAS:528: DC%2BD38XlvVeqsbw%3D 12160900
26. L Gutiérrez FJ Lázaro AR Abadía MS Romero C Quintana MP Morales C Patiño R Arranz 2006 Bioinorganic transformations of liver iron deposits observed by tissue magnetic characterisation in a rat model J of Inorg Biochem 100 1790 1799 10.1016/j.jinorgbio.2006.06.010 (Pubitemid 44537404)
27. L Gutiérrez C Quintana C Patiño J Bueno H Coppin MP Roth FJ Lázaro 2009 Iron speciation study in Hfe knockout mice tissues: Magnetic and ultrastructural characterisation Biochim Biophys Acta 1792 6 541 547 19348938
28. MH Hamdaoui A Chahed S Ellouze-Chabchoub N Marouani Z Ben Abid A Hédhili 2005 Effect of green tea decoction on long-term iron, zinc and selenium status of rats Ann Nutr Metab 49 118 124 1:CAS:528:DC%2BD2MXksVOjsLw%3D 10.1159/000084745 15802907 (Pubitemid 40827634)
29. PM Harrison P Arosio 1996 The ferritins: molecular properties, iron storage function and cellular regulation Biochim Biophys Acta 1275 161 203 10.1016/0005-2728(96)00022-9 8695634 (Pubitemid 26248989)
30. ALM Heath SJ Fairweather-Tait 2003 Health implications of iron overload: the role of diet and genotype Nutr Rev 61 2 45 62 10.1301/nr.2003.febr.45-62 12674437 (Pubitemid 37264958)
31. TC Iancu 1992 Ferritin and hemosiderin in pathological tissues Electron Microsc Rev 5 209 229 1:STN:280:DyaK383ls1Oksw%3D%3D 10.1016/0892-0354(92)90011- E 1581551
32. H Inoue I Shimizu GM Lu M Itonaga XZ Cui Y Okamura M Shono H Honda S Inoue M Muramatsu S Ito 2003 Idoxifene and estradiol enhance antiapoptotic activity through estrogen receptor-β in cultured rat hepatocytes Dig Dis Sci 48 570 580 1:CAS:528:DC%2BD3sXhsVGjs78%3D 10.1023/A:1022553119715 12757172 (Pubitemid 36324167)
33. ZI Cabantchik W Breuer G Zanninelli P Cianciulli 2005 LPI-labile plasma iron in iron overload Best Pract Res Clin Haematol 18 277 287 1:CAS:528:DC%2BD2MXhvVSmtb0%3D 10.1016/j.beha.2004.10.003 15737890 (Pubitemid 40298370)
34. M Iqbal M Athar 1998 Attenuation of iron-nitrilotriacetate (Fe-NTA)-mediated renal oxidative stress, toxicity and hyperproliferative response by the prophylactic treatment of rats with garlic oil Food Chem Toxicol 36 485 495 1:CAS:528:DyaK1cXksFSlsbg%3D 10.1016/S0278-6915(98)00008-8 9674956 (Pubitemid 28293745)
35. DJ Klionsky H Abeliovich P Agostinis, et al. 2008 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy 4 2 151 175 1:CAS:528:DC%2BD1cXksFGrtLg%3D 18188003
36. T Kurz A Terman UT Brunk 2007 Autophagy, ageing and apoptosis: The role of oxidative stress and lysosomal iron Arch Biochem Biophys 462 220 230 1:CAS:528:DC%2BD2sXmt1ygsrc%3D 10.1016/j.abb.2007.01.013 17306211 (Pubitemid 46856317)
37. S Lafay E Gueux Y Rayssiguier A Mazur C Rémésy A Scalbert 2005 Caffeic acid inhibits oxidative Stress and reduces hypercholesterolemia induced by iron overload in rats Int J Vitam Nutr Res 75 119 125 1:CAS:528:DC%2BD2MXktlyns78%3D 10.1024/0300-9831.75.2.119 15929632 (Pubitemid 40637738)
38. NT Le DR Richardson 2002 The role of iron in cell cycle progression and the proliferation of neoplastic cells Biochim Biophys Acta 1603 1 31 46 1:CAS:528:DC%2BD38XntVWrsbo%3D 12242109
39. Levine SA, Kidd PM (1996) Antioxidant adaptation. Its role in free radical pathology. A. Biocurrents division, Allergy Research Group. San Leandro, California
40. Y Liu I Shimizu T Omoya S Ito XS Gu J Zuo 2002 Protective effect of estradiol on hepatocytic oxidative damage World J Gastroentero 8 363 366 1:CAS:528:DC%2BD38Xjs1Kns7s%3D
41. OA Lukianova SS David 2005 A role for iron-sulfur clusters in DNA repair Curr Opin Chem Biol 9 2 145 151 1:CAS:528:DC%2BD2MXivFSmu7c%3D 10.1016/j.cbpa.2005.02.006 15811798 (Pubitemid 40467576)
42. EK Lund SG Wharf SJ Fairweather-Tait IT Johnson 1999 Oral ferrous sulphate supplements increase the free radical-generating capacity of feces from healthy volunteers Am J Clin Nutr 69 250 255 1:CAS:528:DyaK1MXovVKhsg%3D%3D 9989688
43. S Lyoumi M Abitbol V Andrieu D Henin E Robert C Schmitt L Gouya H de Verneuil JC Deybach X Montagutelli C Beaumont H Puy 2007 Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice Blood 109 811 818 1:CAS:528: DC%2BD2sXivVyrsb8%3D 10.1182/blood-2006-04-014142 17003376 (Pubitemid 46105986)
44. P Mena M Maynar JM Guttierez J Maynar J Timon JE Campillo 1991 Erythorcyte free radical scavenger enzymes in bicycle professional racers. Adaptation to training Int J Sports Med 12 563 566 1:STN:280: DyaK387osVCitw%3D%3D 10.1055/s-2007-1024734 1797698
45. I Morel G Lescoat J Gillard N Pasdeloup P Brissot P Cillard 1990 Kinetic evaluation of free malondialdehyde and enzyme leakage as indices of iron damage in rat hepatocyte cultures. Involvement of free radicals Biochem Pharmacol 39 1647 1655 1:CAS:528:DyaK3cXksFeqsbk%3D 10.1016/0006-2952(90)90107-V 2344365 (Pubitemid 20166612)
46. MY Moridani J Pourahmad H Bui A Siraki PJ O'Brien 2003 Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers Free Radic Biol Med 34 243 253 1:CAS:528:DC%2BD3sXotVal 10.1016/S0891-5849(02)01241-8 12521606 (Pubitemid 36084327)
47. A Nahdi I Hammami C Brasse-Lagnel N Pilard MH Hamdaoui C Beaumont M El May 2010 Influence of garlic or its main active component diallyl disulfide on iron bioavailability and toxicity Nutr Res 30 85 95 1:CAS:528: DC%2BC3cXjt1ersrc%3D 10.1016/j.nutres.2010.01.004 20226993
48. G Papanikolaou K Pantopoulos 2005 Iron metabolism and toxicity Toxicol Appl Pharmacol 202 2 199 211 1:CAS:528:DC%2BD2MXjvF2g 10.1016/j.taap.2004.06.021 15629195 (Pubitemid 40040559)
49. J Pedraza-Chaverri P Yam-Canul YI Chirino DJ Sánchez- González CM Martínez-Martínez C Cruz ON Medina-Campos 2008 Protective effects of garlic powder against potassium dichromate-induced oxidative stress and nephrotoxicity Food Chem Toxicol 46 2 619 627 1:CAS:528:DC%2BD2sXhsVOksLrL 10.1016/j.fct.2007.09.088 17950512
50. HL Persson Z Yu O Tirosh JW Eaton UT Brunk 2003 Prevention of oxidant-induced cell death by lysosomotropic iron chelators Free Radic Biol Med 34 10 1295 1305 1:CAS:528:DC%2BD3sXjt1KgsLg%3D 10.1016/S0891-5849(03)00106-0 12726917 (Pubitemid 36513971)
51. P Senesse S Meance V Cottet J Faivre M-C Boutron-Ruault 2004 High dietary iron and copper and risk of colorectal cancer: a case-control study in Burgundy, France Nutr Cancer 49 1 66 71 1:CAS:528:DC%2BD2cXps1aht70%3D 10.1207/s15327914nc4901-9 15456637
52. U Rauen F Petrat R Sustmann H de Groot 2004 Iron-induced mitochondrial permeability transition in cultured hepatocytes J Hepatol 40 4 607 615 1:CAS:528:DC%2BD2cXitFKhsL8%3D 10.1016/j.jhep.2003.12.021 15030976 (Pubitemid 38367782)
53. DR Richardson P Ponka 1997 The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells Biochim Biophys Acta 1331 1 1 40 1:CAS:528:DyaK2sXhsFKmt7g%3D 9325434 (Pubitemid 27168147)
54. G Saravanan J Prakash 2004 Effect of garlic (Allium sativum) on lipid peroxidation in experimental myocardial infarction in rats J Ethnopharmacol 94 1 155 158 1:STN:280:DC%2BD2czlvFGhtg%3D%3D 10.1016/j.jep.2004.04.029 15261977 (Pubitemid 38949817)
55. G Sener H Satiroglu AO Sehirli A Kacmaz 2003 Protective effect of aqueous garlic extract against oxidative organ damage in a rat model of thermal injury Life Sci 73 81 91 1:CAS:528:DC%2BD3sXjt1Kgtrw%3D 10.1016/S0024-3205(03)00236-4 12726889 (Pubitemid 36515137)
56. EH Temme PG Van Hoydonck 2002 Tea consumption and iron status Eur J Clin Nutr 56 379 386 1:CAS:528:DC%2BD38XktlOluro%3D 10.1038/sj.ejcn.1601309 12001007
57. PB Walter MD Knutson A Paler-Martinez S Lee Y Xu FE Viteri BN Ames 2002 Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats Proc Natl Acad Sci 99 4 2264 2269 1:CAS:528:DC%2BD38XitVSrtbw%3D 10.1073/pnas.261708798 11854522 (Pubitemid 34169049)
58. JI Wurzelmann A Silver DM Schreinemachers RS Sandler RB Everson 1996 Iron intake and the risk of colorectal cancer Cancer Epidemiol Biomarkers Prev 5 7 503 507 1:STN:280:DyaK28visV2jsA%3D%3D 8827353
59. Z Xie DJ Klionsky 2007 Autophagosome formation: core machinery and adaptations Nat Cell Biol 9 10 1102 1109 1:CAS:528:DC%2BD2sXhtFSntbzJ 10.1038/ncb1007-1102 17909521 (Pubitemid 47500484)
60. Z Yajun C Hongshan S Baoxi Y Dengbing S Jianhua G Xinshun Y Li C Yi 2005 Translocation of Bax in rat hepatocytes cultured with ferric nitrilotriacetate Life Sci 76 24 2763 2772 10.1016/j.lfs.2004.07.035 15808878 (Pubitemid 40460323)
61. Z Yu HL Persson JW Eaton UT Brunk 2003 Intralysosomal iron: a major determinant of oxidant-induced cell death Free Radic Biol Med 34 10 1243 1252 1:CAS:528:DC%2BD3sXjt1KgsL8%3D 10.1016/S0891-5849(03)00109-6 12726912 (Pubitemid 36513967)