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Volumn 38, Issue 3, 2013, Pages 337-347

Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells

Author keywords

Apoptosis; Marijuana smoke condensate; P53 gene; Reactive oxygen species

Indexed keywords

CANNABIS SMOKE CONDENSATE; CASPASE 3; CATALASE; CIGARETTE SMOKE; MESSENGER RNA; PROTEIN BAX; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

EID: 84877725189     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.38.337     Document Type: Article
Times cited : (6)

References (75)
  • 1
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams, J.M. and Cory, S. (1998): The Bcl-2 protein family: arbiters of cell survival. Science, 281, 1322-1326.
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 4
    • 0018765281 scopus 로고
    • Mutagenic activity of marihuana smoke condensates
    • Busch, F.W., Seid, D.A. and Wei, E.T. (1979): Mutagenic activity of marihuana smoke condensates. Cancer Lett., 6, 319-324.
    • (1979) Cancer Lett , vol.6 , pp. 319-324
    • Busch, F.W.1    Seid, D.A.2    Wei, E.T.3
  • 5
    • 0042009909 scopus 로고    scopus 로고
    • Impact of proapoptotic proteins Bax and Bak in tumor progression and response to treatment
    • Carton, P.F., Juin, P., Oliver, L., Meflah, K. and Vallette, F.M. (2003): Impact of proapoptotic proteins Bax and Bak in tumor progression and response to treatment. Expert Rev. Anticancer Ther., 3, 563-570.
    • (2003) Expert. Rev. Anticancer Ther , vol.3 , pp. 563-570
    • Carton, P.F.1    Juin, P.2    Oliver, L.3    Meflah, K.4    Vallette, F.M.5
  • 6
    • 30344436719 scopus 로고    scopus 로고
    • Association between marijuana use and transitional cell carcinoma
    • Chacko, J.A., Heiner, J.G., Siu, W., Macy, M. and Terris, M.K. (2006): Association between marijuana use and transitional cell carcinoma. Urology, 67, 100-104.
    • (2006) Urology , vol.67 , pp. 100-104
    • Chacko, J.A.1    Heiner, J.G.2    Siu, W.3    Macy, M.4    Terris, M.K.5
  • 7
    • 0025571466 scopus 로고
    • Chemical and biological analysis of marijuana smoke condensate
    • Charles, M.S., Patricia, A.H. and Thomas, J.H. (1990): Chemical and biological analysis of marijuana smoke condensate. NIDA Res. Monogr., 99, 121-140.
    • (1990) NIDA Res. Monogr , vol.99 , pp. 121-140
    • Charles, M.S.1    Patricia, A.H.2    Thomas, J.H.3
  • 8
    • 0034046970 scopus 로고    scopus 로고
    • Cannabinoids protect cells from oxidative cell death: A receptor-independent mechanism
    • Chen, Y. and Buck, J. (2000): Cannabinoids protect cells from oxidative cell death: a receptor-independent mechanism. J. Pharmacol. Exp. Ther., 293, 807-812.
    • (2000) J. Pharmacol. Exp. Ther , vol.293 , pp. 807-812
    • Chen, Y.1    Buck, J.2
  • 10
    • 0032694302 scopus 로고    scopus 로고
    • The broad spectrum of responses to oxidants in proliferating cells: A new paradigm for oxidative stress
    • Davies, K. (1999): The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life, 48, 41-47.
    • (1999) IUBMB Life , vol.48 , pp. 41-47
    • Davies, K.1
  • 11
    • 0033970795 scopus 로고    scopus 로고
    • Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells
    • Davis, M.A., Flaws, J.A., Young, M., Collins, K. and Colburn, N.H. (2000): Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells. Toxicol. Sci., 53, 48-55.
    • (2000) Toxicol. Sci , vol.53 , pp. 48-55
    • Davis, M.A.1    Flaws, J.A.2    Young, M.3    Collins, K.4    Colburn, N.H.5
  • 12
    • 4043179097 scopus 로고    scopus 로고
    • Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: Novel role for endogenous and exogenous cannabinoids in immunoregulation
    • Do, Y., McKallip, R.J., Nagarkatti, M. and Nagarkatti, P.S. (2004): Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. J. Immunol., 173, 2373-2382.
    • (2004) J. Immunol , vol.173 , pp. 2373-2382
    • Do, Y.1    McKallip, R.J.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 13
    • 0029918901 scopus 로고    scopus 로고
    • Role of oxygen free radicals in cancer development
    • Dreher, D. and Junod, A. (1996): Role of oxygen free radicals in cancer development. Eur. J. Cancer, 32A, 30-38.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 30-38
    • Dreher, D.1    Junod, A.2
  • 14
    • 80053405518 scopus 로고    scopus 로고
    • Marijuana smoke condensate chemistry and pharmacology
    • Humana Press Inc, Totowa, New Jersey
    • ElSohly, H.N. and ElSohly, M.A. (2007): Marijuana smoke condensate chemistry and pharmacology. In: Forensic Science and Medicine: Marijuana and the Cannabinoids (Elsholy M.A., ed.), pp.67-96, Humana Press Inc., Totowa, New Jersey.
    • (2007) Forensic Science and Medicine: Marijuana and The Cannabinoids , pp. 67-96
    • Elsohly, H.N.1    Elsohly, M.A.2
  • 15
    • 0015599216 scopus 로고
    • Identification of noncannabinoid phenols in marihuana smoke condensate using chemical ionization mass spectrometry
    • Fentiman Jr., A.F., Foltz, R.L. and Kinser, G.W. (1973): Identification of noncannabinoid phenols in marihuana smoke condensate using chemical ionization mass spectrometry. Anal. Chem., 45, 580-582.
    • (1973) Anal. Chem , vol.45 , pp. 580-582
    • Fentiman Jr., A.F.1    Foltz, R.L.2    Kinser, G.W.3
  • 16
    • 17044395830 scopus 로고    scopus 로고
    • Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line
    • Fotakis, G., Cemeli, E., Anderson, D. and Timbrell, J.A. (2005): Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line. Toxicol. In Vitro, 19, 481-489.
    • (2005) Toxicol. In Vitro , vol.19 , pp. 481-489
    • Fotakis, G.1    Cemeli, E.2    Anderson, D.3    Timbrell, J.A.4
  • 17
    • 0021740546 scopus 로고
    • Mannitol as an OH· scavenger in aqueous solutions and biological systems
    • Goldstein, S. and Czapski, G. (1984): Mannitol as an OH· scavenger in aqueous solutions and biological systems. Int. J. Radiat. Biol., 46, 725-729.
    • (1984) Int. J. Radiat. Biol , vol.46 , pp. 725-729
    • Goldstein, S.1    Czapski, G.2
  • 18
    • 23444431657 scopus 로고    scopus 로고
    • Δ9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress
    • Goncharov, I., Weiner, L. and Vogel, Z. (2005): Δ9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress. Neuroscience, 134, 567-574.
    • (2005) Neuroscience , vol.134 , pp. 567-574
    • Goncharov, I.1    Weiner, L.2    Vogel, Z.3
  • 19
    • 0032493197 scopus 로고
    • Cannabidiol and (-)delta 9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson, A.J., Grimaldi, M., Axelrod, J. and Wink, D. (1988): Cannabidiol and (-)delta 9-tetrahydrocannabinol are neuroprotective antioxidants. Proc. Natl. Acad. Sci. USA, 95, 8268-8273.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 21
    • 31844447033 scopus 로고    scopus 로고
    • Determination of 1-nitropyrene metabolites by high-performance liquid chromatography with chemiluminescence detection
    • Hayakawa, K., Lu, C., Mizukami, S., Toriba, A. and Tang, N. (2006): Determination of 1-nitropyrene metabolites by high-performance liquid chromatography with chemiluminescence detection. J. Chromatogr. A., 1107, 286-289.
    • (2006) J. Chromatogr. A , vol.1107 , pp. 286-289
    • Hayakawa, K.1    Lu, C.2    Mizukami, S.3    Toriba, A.4    Tang, N.5
  • 25
    • 0028452962 scopus 로고
    • Iron enhances uptake of mineral particles and increases lipid peroxidation in tracheal epithelial cells
    • Keeling, B., Li, K.Y. and Churg, A. (1994): Iron enhances uptake of mineral particles and increases lipid peroxidation in tracheal epithelial cells. Am. J. Respir. Cell. Mol. Biol., 19, 683-688.
    • (1994) Am. J. Respir. Cell. Mol. Biol , vol.19 , pp. 683-688
    • Keeling, B.1    Li, K.Y.2    Churg, A.3
  • 26
    • 0032863928 scopus 로고    scopus 로고
    • Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADPribose) polymerase-mediated cell death
    • Kiningham, K.K., Oberley, T.D., Lin, S., Mattingly, C.A. and St Clair, K.D. (1999): Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADPribose) polymerase-mediated cell death. FASEB. J., 13, 1601-1610.
    • (1999) FASEB. J , vol.13 , pp. 1601-1610
    • Kiningham, K.K.1    Oberley, T.D.2    Lin, S.3    Mattingly, C.A.4    St Clair, K.D.5
  • 27
    • 0031857216 scopus 로고
    • Organochlorine pesticide-induced oxidative stress and immune suppression in rats
    • Koner, B.C., Banerjee, B.D. and Ray, A. (1988): Organochlorine pesticide-induced oxidative stress and immune suppression in rats. Indian. J. Exp. Biol., 36, 395-398.
    • (1988) Indian. J. Exp. Biol , vol.36 , pp. 395-398
    • Koner, B.C.1    Banerjee, B.D.2    Ray, A.3
  • 29
    • 0017275817 scopus 로고
    • Gas chromatography/mass spectrometric and nuclear magnetic resonance spectrometric studies of carcinogenic polynuclear aromatic hydrocarbons in tobacco and marijuana smoke condensates
    • Lee, M.L., Novotny, M. and Bartle, K.D. (1976): Gas chromatography/mass spectrometric and nuclear magnetic resonance spectrometric studies of carcinogenic polynuclear aromatic hydrocarbons in tobacco and marijuana smoke condensates. Anal. Chem., 48, 405-416.
    • (1976) Anal. Chem , vol.48 , pp. 405-416
    • Lee, M.L.1    Novotny, M.2    Bartle, K.D.3
  • 30
    • 29944444765 scopus 로고    scopus 로고
    • Antiestrogenic effects of marijuana smoke condensate and cannabinoid compounds
    • Lee, S.Y., Oh, S.M., Lee, S.K. and Chung, K.H. (2005): Antiestrogenic effects of marijuana smoke condensate and cannabinoid compounds. Arch. Pharm. Res., 28, 1365-1375.
    • (2005) Arch. Pharm. Res , vol.28 , pp. 1365-1375
    • Lee, S.Y.1    Oh, S.M.2    Lee, S.K.3    Chung, K.H.4
  • 31
    • 0015811487 scopus 로고
    • Effects of marijuana and tobacco smoke on DNA and chromosomal complement in human lung explants
    • Leuchtenberger, C., Leuchtenberger, R., Ritter, U. and Inui, N. (1973): Effects of marijuana and tobacco smoke on DNA and chromosomal complement in human lung explants. Nature, 242, 403-404.
    • (1973) Nature , vol.242 , pp. 403-404
    • Leuchtenberger, C.1    Leuchtenberger, R.2    Ritter, U.3    Inui, N.4
  • 32
    • 0031774592 scopus 로고    scopus 로고
    • Observations on the compensatory effects of superoxide dismutase under hypoxic or ischaemic stress in rats and rabbits
    • Liu, S.L., Shi, D.Y., Pan, J.H. and Yao, S.K. (1998): Observations on the compensatory effects of superoxide dismutase under hypoxic or ischaemic stress in rats and rabbits. Med. Sci. Res., 26, 741-743.
    • (1998) Med. Sci. Res , vol.26 , pp. 741-743
    • Liu, S.L.1    Shi, D.Y.2    Pan, J.H.3    Yao, S.K.4
  • 33
    • 0242552555 scopus 로고    scopus 로고
    • Influence of induced reactive oxygen species in p53-mediated cell fate decisions
    • Macip, S., Igarashi, M., Berggren, P., Yu, J., Lee, S.W. and Aaronson, S.A. (2003): Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol. Cell. Biol., 23, 8576-8585.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 8576-8585
    • Macip, S.1    Igarashi, M.2    Berggren, P.3    Yu, J.4    Lee, S.W.5    Aaronson, S.A.6
  • 34
    • 0032478694 scopus 로고    scopus 로고
    • Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death
    • Majima, H.J., Oberley, T.D., Furukawa, K., Mattson, M.P., Yen, H.C., Szweda, L.I. and St Clair, D.K. (1998): Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death. J. Biol. Chem., 273, 8217-8224.
    • (1998) J. Biol. Chem , vol.273 , pp. 8217-8224
    • Majima, H.J.1    Oberley, T.D.2    Furukawa, K.3    Mattson, M.P.4    Yen, H.C.5    Szweda, L.I.6    St Clair, D.K.7
  • 35
    • 0036488182 scopus 로고    scopus 로고
    • Neuroprotective properties of cannabinoids against oxidative stress: Role of the cannabinoid receptor CB1
    • Marsicano, G., Moosmann, B., Hermann, H., Lutz, B. and Behl, C. (2002): Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J. Neurochem., 80, 448-456.
    • (2002) J. Neurochem , vol.80 , pp. 448-456
    • Marsicano, G.1    Moosmann, B.2    Hermann, H.3    Lutz, B.4    Behl, C.5
  • 36
    • 33748492117 scopus 로고    scopus 로고
    • The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
    • Massi, P., Vaccani, A., Bianchessi, S., Costa, B., Macchi, P. and Parolaro, D. (2006): The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell. Mol. Life. Sci., 63, 2057-2066.
    • (2006) Cell. Mol. Life. Sci , vol.63 , pp. 2057-2066
    • Massi, P.1    Vaccani, A.2    Bianchessi, S.3    Costa, B.4    Macchi, P.5    Parolaro, D.6
  • 37
    • 0036074054 scopus 로고    scopus 로고
    • Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo
    • McKallip, R.J., Lombard, C., Martin, B.R., Nagarkatti, M. and Nagarkatti, P.S. (2002): Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. J. Pharmacol. Exp. Ther., 302, 451-465.
    • (2002) J. Pharmacol. Exp. Ther , vol.302 , pp. 451-465
    • McKallip, R.J.1    Lombard, C.2    Martin, B.R.3    Nagarkatti, M.4    Nagarkatti, P.S.5
  • 39
    • 0042413982 scopus 로고    scopus 로고
    • Transitional cell carcinoma in a young heavy marihuana smoker
    • Moiche, B.P., Atxa de la Presa, M.A. and Guesta, A. (2001): Transitional cell carcinoma in a young heavy marihuana smoker. Arch. Esp. Urol., 54, 165-167.
    • (2001) Arch. Esp. Urol , vol.54 , pp. 165-167
    • Moiche, B.P.1    Atxa de la Presa, M.A.2    Guesta, A.3
  • 40
    • 0026599895 scopus 로고
    • The human toxicity of marihuana: A review
    • Nahas, G. and Latour, G. (1992): The human toxicity of marihuana: a review. Med. J. Aust., 156, 495-497.
    • (1992) Med. J. Aust , vol.156 , pp. 495-497
    • Nahas, G.1    Latour, G.2
  • 41
    • 30344467869 scopus 로고    scopus 로고
    • Transitional cell carcinoma associated with marijuana: Case report and review of the literature
    • 200.e5-200.e6
    • Nieder, A.M., Lipke, M.C. and Madjar, S. (2006): Transitional cell carcinoma associated with marijuana: case report and review of the literature. Urology, 67, 200.e5-200.e6.
    • (2006) Urology , vol.67
    • Nieder, A.M.1    Lipke, M.C.2    Madjar, S.3
  • 42
    • 36049002543 scopus 로고    scopus 로고
    • Levels of particulate air pollution, its elemental composition, determinants and health effects in metro systems
    • Nieuwenhuijsen, M.J., Gò;mez-Perales, J.E. and Colvile, R.N. (2007): Levels of particulate air pollution, its elemental composition, determinants and health effects in metro systems. Atmos. Environ., 41, 7995-8006.
    • (2007) Atmos. Environ , vol.41 , pp. 7995-8006
    • Nieuwenhuijsen, M.J.1    2    mez-Perales, J.E.3    Colvile, R.N.4
  • 44
    • 0019954480 scopus 로고
    • Fractionation and capillary gas chromatographic-mass spectrometric characterization of the neutral components in marijuana and tobacco smoke condensates
    • Novotny, M., Merli, F., Wiesler, D., Fencl, M. and Saeed, T. (1982): Fractionation and capillary gas chromatographic-mass spectrometric characterization of the neutral components in marijuana and tobacco smoke condensates. J. Chromatogr., 238, 141-150.
    • (1982) J. Chromatogr , vol.238 , pp. 141-150
    • Novotny, M.1    Merli, F.2    Wiesler, D.3    Fencl, M.4    Saeed, T.5
  • 45
    • 79959795029 scopus 로고    scopus 로고
    • Organic extracts of urban air pollution particulate matter (PM2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells)
    • Oh, S.M., Kim, H.R., Park, Y.U., Lee, S.Y. and Chung, K.H. (2011): Organic extracts of urban air pollution particulate matter (PM2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells). Mutat. Res., 723, 142-151.
    • (2011) Mutat. Res , vol.723 , pp. 142-151
    • Oh, S.M.1    Kim, H.R.2    Park, Y.U.3    Lee, S.Y.4    Chung, K.H.5
  • 46
    • 0032078035 scopus 로고    scopus 로고
    • DNA single strand breaks and adenine nucleotide depletion as indices of oxidant effects on human lung cells
    • Ollikainen, T.R., Linnainmaa, K.I., Raivio, K.O. and Kinnula, V.L. (1998): DNA single strand breaks and adenine nucleotide depletion as indices of oxidant effects on human lung cells. Free. Radic. Biol. Med., 24, 1088-1096.
    • (1998) Free. Radic. Biol. Med , vol.24 , pp. 1088-1096
    • Ollikainen, T.R.1    Linnainmaa, K.I.2    Raivio, K.O.3    Kinnula, V.L.4
  • 47
    • 17644378047 scopus 로고    scopus 로고
    • Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells
    • Ostrakhovitch, E.A. and Cherian, M.G. (2005): Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. Apoptosis, 10, 111-121.
    • (2005) Apoptosis , vol.10 , pp. 111-121
    • Ostrakhovitch, E.A.1    Cherian, M.G.2
  • 49
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives, C. and Hall, P.A. (1999): The p53 pathway. J. Pathol., 187, 112-126.
    • (1999) J. Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 53
    • 0345435976 scopus 로고    scopus 로고
    • Reactive oxygen species activate human peripheral blood dendritic cells
    • Rutault, K., Alderman, C., Chain, B.M. and Katz, D.R. (1999): Reactive oxygen species activate human peripheral blood dendritic cells. Free Radic. Biol. Med., 26, 232-238.
    • (1999) Free Radic. Biol. Med , vol.26 , pp. 232-238
    • Rutault, K.1    Alderman, C.2    Chain, B.M.3    Katz, D.R.4
  • 55
    • 0035420404 scopus 로고    scopus 로고
    • 9 -tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis
    • 9 -tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicol. Appl. Pharmacol., 174, 264-272.
    • (2001) Toxicol. Appl. Pharmacol , vol.174 , pp. 264-272
    • Sarafian, T.A.1    Tashkin, D.P.2    Roth, M.D.3
  • 56
    • 0033957359 scopus 로고    scopus 로고
    • Morphologic and biochemical hallmarks of apoptosis
    • Saraste, A. and Pulkki, K. (2000): Morphologic and biochemical hallmarks of apoptosis. Cardiovasc. Res., 45, 528-537.
    • (2000) Cardiovasc. Res , vol.45 , pp. 528-537
    • Saraste, A.1    Pulkki, K.2
  • 58
    • 0029077743 scopus 로고
    • Effects of smoking marijuana, tobacco or cocaine alone or in combination on DNA damage in human alveolar macrophages
    • Sherman, M.P., Aeberhard, E.E., Wong, V.Z., Simmons, M.S., Roth, M.D. and Tashkin, D.P. (1995): Effects of smoking marijuana, tobacco or cocaine alone or in combination on DNA damage in human alveolar macrophages. Life. Sci., 56, 2201-2207.
    • (1995) Life. Sci , vol.56 , pp. 2201-2207
    • Sherman, M.P.1    Aeberhard, E.E.2    Wong, V.Z.3    Simmons, M.S.4    Roth, M.D.5    Tashkin, D.P.6
  • 59
    • 33645805643 scopus 로고    scopus 로고
    • Oxidative ability and toxicity of n-hexane insoluble fraction of diesel exhaust particles
    • Shima, H., Koike, E., Shinohara, R. and Kobayashi, T. (2006): Oxidative ability and toxicity of n-hexane insoluble fraction of diesel exhaust particles. Toxicol. Sci., 91, 218-226.
    • (2006) Toxicol. Sci , vol.91 , pp. 218-226
    • Shima, H.1    Koike, E.2    Shinohara, R.3    Kobayashi, T.4
  • 62
    • 0023104697 scopus 로고
    • Respiratory symptoms and lung function in habitual heavy smokers of marijuana alone, smokers of marijuana and tobacco, smokers of tobacco alone, and nonsmokers
    • Tashkin, D.P., Coulson, A.H., Clark, V.A., Simmons, M., Bourque, L.B., Duann, S., Spivey, G.H. and Gong, H. (1987): Respiratory symptoms and lung function in habitual heavy smokers of marijuana alone, smokers of marijuana and tobacco, smokers of tobacco alone, and nonsmokers. Am. Rev. Respir. Dis., 135, 209-216.
    • (1987) Am. Rev. Respir. Dis , vol.135 , pp. 209-216
    • Tashkin, D.P.1    Coulson, A.H.2    Clark, V.A.3    Simmons, M.4    Bourque, L.B.5    Duann, S.6    Spivey, G.H.7    Gong, H.8
  • 63
    • 23844510064 scopus 로고    scopus 로고
    • Smoked marijuana as a cause of lung injury
    • Tashkin, D.P. (2005): Smoked marijuana as a cause of lung injury. Monaldi. Arch. Chest. Dis., 63, 93-100.
    • (2005) Monaldi. Arch. Chest. Dis , vol.63 , pp. 93-100
    • Tashkin, D.P.1
  • 64
    • 0024150906 scopus 로고
    • Marijuana as a potential respiratory tract carcinogen: A retrospective analysis of a community hospital population
    • Taylor, F.M.3rd
    • Taylor, F.M.3rd. (1988): Marijuana as a potential respiratory tract carcinogen: a retrospective analysis of a community hospital population. South. Med. J., 81, 1213-1216.
    • (1988) South. Med. J , vol.81 , pp. 1213-1216
  • 65
    • 0036716260 scopus 로고    scopus 로고
    • Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism
    • Tithof, P.K., Elgayyar, M., Cho, Y., Guan, W., Fisher, A.B. and Peter-golden, M. (2002): Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. FASEB J. 16, 1463-1464.
    • (2002) FASEB J , vol.16 , pp. 1463-1464
    • Tithof, P.K.1    Elgayyar, M.2    Cho, Y.3    Guan, W.4    Fisher, A.B.5    Peter-Golden, M.6
  • 67
    • 0033829708 scopus 로고    scopus 로고
    • The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation
    • Wang, S., Leonard, S.S., Ye, J., Ding, M. and Shi, X. (2000): The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. Am. J. Physiol. Cell. Physiol., 279, C868-C875.
    • (2000) Am. J. Physiol. Cell. Physiol , vol.279
    • Wang, S.1    Leonard, S.S.2    Ye, J.3    Ding, M.4    Shi, X.5
  • 68
    • 0035055046 scopus 로고    scopus 로고
    • Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications
    • Wattanapitayakul, S.K. and Bauer, J.A. (2001): Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications. Pharmacol. Ther., 89, 187-206.
    • (2001) Pharmacol. Ther , vol.89 , pp. 187-206
    • Wattanapitayakul, S.K.1    Bauer, J.A.2
  • 69
    • 38649110505 scopus 로고    scopus 로고
    • Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8
    • Wu, H.Y., Chu, R.M., Wang, C.C., Lee, C.Y., Lin, S.H. and Jan, T.R. (2008): Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8. Toxicol. Appl. Pharmacol., 226, 260-270.
    • (2008) Toxicol. Appl. Pharmacol , vol.226 , pp. 260-270
    • Wu, H.Y.1    Chu, R.M.2    Wang, C.C.3    Lee, C.Y.4    Lin, S.H.5    Jan, T.R.6
  • 70
    • 0033404866 scopus 로고    scopus 로고
    • Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells
    • Xu, A., Wu, L.J., Santella, R.M. and Hei, T.K. (1999): Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells. Cancer Res., 59, 5922-5926.
    • (1999) Cancer Res , vol.59 , pp. 5922-5926
    • Xu, A.1    Wu, L.J.2    Santella, R.M.3    Hei, T.K.4
  • 71
    • 0031926177 scopus 로고    scopus 로고
    • A new approach to iden tifying genotoxic carcinogens: P53 induction as an indicator of genotoxic damage
    • Yang, J. and Duerksen-Hughes, P. (1998): A new approach to iden tifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 1117-1125.
    • (1998) Carcinogenesis , vol.19 , pp. 1117-1125
    • Yang, J.1    Duerksen-Hughes, P.2
  • 72
    • 0029781555 scopus 로고    scopus 로고
    • The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice
    • Yen, H.C., Oberley, T.D., Bichitbandha, S., He, Y.S. and St Clair, D.K. (1996): The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J. Clin. Invest., 98, 1253-1260.
    • (1996) J. Clin. Invest , vol.98 , pp. 1253-1260
    • Yen, H.C.1    Oberley, T.D.2    Bichitbandha, S.3    He, Y.S.4    St Clair, D.K.5
  • 73
    • 58149196248 scopus 로고    scopus 로고
    • Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line
    • Yun, Y.P., Lee, J.Y., Ahn, E.K., Lee, K.H., Yoon, H.K. and Lim, Y. (2009): Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line. Toxicol. In Vitro., 23, 21-28.
    • (2009) Toxicol. In Vitro , vol.23 , pp. 21-28
    • Yun, Y.P.1    Lee, J.Y.2    Ahn, E.K.3    Lee, K.H.4    Yoon, H.K.5    Lim, Y.6
  • 75
    • 0032219623 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: Involvement of Bcl-2 and caspase-1
    • Zhu, W., Friedman, H. and Klein, T.W. (1998): Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of Bcl-2 and caspase-1. J. Pharmacol. Exp. Ther., 286, 1103-1109.
    • (1998) J. Pharmacol. Exp. Ther , vol.286 , pp. 1103-1109
    • Zhu, W.1    Friedman, H.2    Klein, T.W.3


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