Marijuana smoke and Δ9-tetrahydrocannabinol promote necrotic cell death but inhibit fas-mediated apoptosis

Toxicology and Applied Pharmacology

Volumn 174, Issue 3, 2001, Pages 264-272

  Sarafian, Theodore A ^a   Tashkin, Donald P ^a   Roth, Michael D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

A549; Apoptosis; Caspase 3; Fas; Flow cytometry; Marijuana; Necrosis

Indexed keywords

CANNABIS; CASPASE 3; DRONABINOL; FAS ANTIGEN; LIPOCORTIN 5; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; TAR;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LUNG CANCER; OXIDATIVE STRESS; PARTICULATE MATTER; SMOKE; TOBACCO; TOXICOKINETICS;

CANNABIS SATIVA; NICOTIANA TABACUM;

EID: 0035420404     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9224     Document Type: Article

References (62)

1. Cannabis: Pharmacology and toxicology in animals and humans
2. Gene expression and the thiol redox state
3. The effect of subacute marijuana smoke inhalation on experimentally induced dermonecrosis by S. aureus infection
4. Smokeless tobacco, oxidative stress, apoptosis, and antioxidants in human oral keratinocytes
5. Marijuana and cocaine impair alveolar macrophage function and cytokine production
6. Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco
7. The human costs of tobacco use (1)
8. Molecular epidemiology of human cancer risk: Gene - Environment interactions and p53 mutation spectrum in human lung cancer
9. Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells
10. Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle
11. Apoptotic cell death and nitric oxide: Activating and antagonistic transducing pathways
12. Cell death by apoptosis and its protective role against disease
13. High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy
14. Caspases: The executioners of apoptosis
15. Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites
16. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53
17. Dietary antioxidants and cigarette smoke-induced biomolecular damage: A complex interaction
18. Cigarette smoking, emphysema, and damage to alpha 1-proteinase inhibitor
19. Probing the molecular program of apoptosis by cancer chemopreventive agents
20. Apoptosis in cancer therapy: Crossing the threshold
21. Tracheobronchial histopathology in habitual smokers of cocaine, marijuana, and/or tobacco
22. The epidemiology of lung cancer
23. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
24. Redox regulation of the caspases during apoptosis
25. Recognition of apoptotic cells by phagocytes
26. Tobacco smoke carcinogens and lung cancer
27. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells
28. Redox regulation of cellular signalling
29. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species
30. Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells
31. Cannabinoid receptors and immunity
32. Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice
33. Bcl-2 protooncogene expression in cervical carcinoma cell lines containing inactive p53
34. Synergistic induction of hydroxyl radical-induced DNA single-strand breaks by chromium(VI) compound and cigarette smoke solution
35. Apoptosis in cancer
36. Nitric oxide inhibits Fas-induced apoptosis
37. Fractionation and capillary gas chromatographic-mass spectrometric characterization of the neural components in marijuana and tobacco smoke condensates
38. Redox regulation of genes that protect against carcinogens
39. Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity
40. Oxidative stress in chronic obstructive pulmonary disease
41. Airway inflammation in young marijuana and tobacco smokers
42. 9-tetrahydrocannabinol
43. Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism
44. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
45. Molecular abnormalities in lung cancer
46. Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells
47. Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids
48. Apoptosis and the nervous system
49. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
50. Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite
51. Health effects of cigarette smoking
52. Spin trapping of nitric oxide in aqueous solutions of cigarette smoke
53. The ESR properties, DNA nicking, and DNA association of aged solutions of catechol versus aqueous extracts of tar from cigarette smoke
54. Oxidants as stimulators of signal transduction
55. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: Protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA
56. The role of oxygen free radicals in occupational and environmental lung diseases
57. Tobacco smoke induces both apoptosis and necrosis in mammalian cells: Differential effects of HSP70
58. Oxidative stress disrupts glucocorticoid hormone-dependent transcription of the amiloride-sensitive epithelial sodium channel alpha-subunit in lung epithelial cells through ERK-dependent and thiore-doxin-sensitive pathways
59. N-Acetylcysteine protects lymphocytes from nitrogen mustard-induced apoptosis
60. Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas
61. Enhanced expression of anti-apoptotic proteins in human papillomavirus-immortalized and cigarette smoke condensate-transformed human endocervical cells: Correlation with resistance to apoptosis induced by DNA damage
62. Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: Involvement of Bcl-2 and caspase-1