Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line

Toxicology in Vitro

Volumn 19, Issue 4, 2005, Pages 481-489

  Fotakis, George ^a   Cemeli, Eduardo ^b   Anderson, Diana ^b   Timbrell, John A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Cadmium; DNA damage; Lysosomes; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; CADMIUM CHLORIDE; DICHLOROFLUORESCEIN; DNA; GLUTATHIONE; LACTATE DEHYDROGENASE; NEUTRAL RED; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CELL CYCLE; CELL DAMAGE; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; FLUORESCENCE MICROSCOPY; HEPATOMA CELL; INCUBATION TIME; LIVER LYSOSOME; MITOCHONDRIAL RESPIRATION; NONHUMAN; RAT; STATISTICAL SIGNIFICANCE;

EID: 17044395830     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2005.02.001     Document Type: Article

References (57)

1. E.W. Achanzar, B.K. Achanzar, G.J. Lewis, M.M. Webber, and P.M. Waalkes Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis Toxicology and Applied Pharmacology 164 2000 291 300
2. G. Banfalvi, N. Littlefield, B. Hass, M. Mikhailova, I. Csuka, E. Szepessy, and W. Chou Effect of cadmium on the relationship between replicative and repair DNA synthesis in synchronized CHO cells European Journal of Biochemistry 267 2000 6580 6585
3. 2+-induced dysfunction of isolated rat liver mitochondria: doubts no more Archives of Biochemistry and Biophysics 405 2002 252 264
4. D. Beyersmann, and S. Hechtenberg Cadmium, gene regulation, and cellular signalling in mammalian cells Toxicology and Applied Pharmacology 144 1997 247 261
5. E. Borenfreund, and J.A. Puerner A simple quantitative procedure using monolayer culture for toxicity assays Journal of Tissue Culture Methods 9 1984 7 9
6. P. Boscolo, G. Logroscino-Sacchettoni, O.F. Ranelletti, A. Gioia, and M. Carmignani Effects of long-term cadmium exposure on the testis of rabbits: ultrastructural study Toxicology Letters 24 1985 145 149
7. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding Analytical Biochemistry 72 1976 248 254
8. O.M. Bradley, I.V. Taylor, J.M. Armstrong, and M.S. Galloway Relationship among cytotoxicity, lysosomal breakdown, chromosome aberrations, and DNA double-strand breaks Mutation Research/Genetic Toxicology 189 1987 69 79
9. K. Cain, and E.D. Holt Studies of cadmium-thionein induced nephropathy: time course of cadmium-thionein uptake and degradation Chemico-Biological Interactions 43 1983 223 237
10. J. Chao, and J. Yang Alteration of cadmium-induced mutational spectrum by catalase depletion in Chinese hamster ovary-K1 cells Mutation Research 498 2001 7 18
11. H.V. Cohn, and J. Lyle A fluorometric assay for glutathione Analytical Biochemistry 14 1966 434 440
12. P.T. Coogan, M.R. Bare, and P.M. Waalkes Cadmium-induced DNA strand damage in cultured liver cells: reduction in cadmium genotoxicity following zinc pretreatment Toxicology and Applied Pharmacology 113 1992 227 233
13. W. Ding, and M.D. Templeton Activation of parallel mitogen-activated protein kinase cascades and induction of c-fos by cadmium Toxicology and Applied Pharmacology 162 2000 93 99
14. E.R. Dudley, J.D. Svoboda, and D.C. Klaassen Acute exposure to cadmium causes severe liver injury in rats Toxicology and Applied Pharmacology 65 1982 302 313
15. E.R. Dudley, M.L. Gammal, and D.C. Klaassen Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium-metallothionein in nephrotoxicity Toxicology and Applied Pharmacology 77 1985 414 426
16. M. Etxeberria, L. Sastre, M.P. Cajaraville, and I. Marigomez Digestive lysosome enlargement induced by experimental exposure to metals (Cu, Cd, and Zn) in mussels collected from a zinc-polluted site Archives of Environmental Contamination and Toxicology 27 1994 338 345
17. T. Fatur, M. Tusck, I. Falnoga, J. Scancar, T.T. Lah, and M. Filipic DNA damage and metallothionein synthesis in human hepatoma cells (HepG2) exposed to cadmium Food and Chemical Toxicology 40 2002 1069 1076
18. B.A. Fowler Intracellular compartmentation of metals in aquatic organisms: roles in mechanism of cell injury Environmental Health Perspectives 71 1987 121 128
19. H. Fujimaki, M. Ishido, and K. Nohara Induction of apoptosis in mouse thymocytes by cadmium Toxicology Letters 115 2000 99 105
20. A. Galan, A. Troyano, E.N. Vilaboa, C. Fernandez, E. De Blas, and P. Aller Modulation of the stress response during apoptosis and necrosis induction in cadmium-treated U-937 human promonocytic cells Biochimica et Biophysica Acta 1538 2001 38 46
21. H.S. Garrett, V. Phillips, S. Somji, A.M. Sens, R. Dutta, S. Park, D. Kim, and A.D. Sens Transient induction of metallothionein isoform 3 (MT-3), c-fos, c-jun and c-myc in human proximal tubule cells exposed to cadmium Toxicology Letters 126 2002 69 80
22. G.S. George, and J.S.B. Pirie The occurrence of cadmium in sub-cellular particles in the kidney of the marine mussel, Mytillus edulis, exposed to cadmium Biochimica et Biophysica Acta-Protein Structure 580 1979 234 244
23. Z. Gregus, and D.C. Klaassen Mechanism of toxicity D.C. Klaassen Casarett & Doull's toxicology, the basic science of poisons 1996 McGraw-Hill Health London 65
24. U. Gubrela, A. Mehta, M. Singh, and S.J. Flora Comparative and renal toxicity of cadmium in male and female rats Journal of Environmental Biology 25 1 2004 65 73
25. A.B. Hart, H.C. Lee, S.G. Shukla, A. Shukla, M. Osier, D.J. Eneman, and J.F. Chiu Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress Toxicology 133 1999 43 58
26. A. Hartwig Role of DNA repair inhibition in lead- and cadmium-induced genotoxicity: a review Environmental Health Perspectives 102 1994 45 50
27. A.E. Hassoun, and J.S. Stohs Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures Toxicology 112 1996 219 226
28. W.J. Heinecke Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins Toxicology 177 2002 11 22
29. J.P. Hissin, and R. Hilf A fluorometric method for determination of oxidized and reduced glutathione in tissues Analytical Biochemistry 74 1976 214 226
30. B. Hultberg, A. Andersson, and A. Isaksson Alterations of thiol metabolism in human cell lines induced by low amounts of copper, mercury or cadmium ions Toxicology 126 1998 203 212
31. IARC, 1993. Monograph 58: beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. International Agency for Research on Cancer
32. P. Irano, G. Santovito, E. Piccini, and V. Albergoni Oxidative burst and metallothionein as a scavenger in macrophages Immunology and Cell Biology 79 2001 251 254
33. T. Ishikawa, T. Igarashi, K. Hata, and T. Fujita c-fos Induction by heat, arsenitek, and cadmium is mediated by a heat shock element in its promoter Biochemical and Biophysical Research Communications 254 1999 566 571
34. T. Jin, G. Nordberg, X. Wu, T. Ye, Q. Kong, Z. Wang, F. Zhuang, and S. Cai Urinary N-acetyl-β-d-glucosaminidase isoenzymes as biomarker of renal dysfunction caused by cadmium in a general population Environmental Research Section 81 1999 167 173
35. K. Kagedal, U. Johansson, and K. Ollinger The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress The FASEB Journal 13 2001 1392 1394
36. H. Koyama, H. Satoh, S. Suzuki, and C. Tohyama Increased urinary cadmium excretion and its relationship to urinary N-acetyl-beta-d-glucosaminidase activity in smokers Archives of Toxicology 66 1992 598 601
37. K.R. Kuester, P.M. Waalkes, L.P. Goering, L.B. Fisher, S.R. McCuskey, and G.I. Sipes Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats Toxicological Sciences 65 2002 151 159
38. X. Lekube, P.M. Cajaraville, and I. Marigomez Use of polyclonal antibodies for the detection of changes by cadmium in lysosomes of aquatic organisms The Science of the Total Environment 247 2000 201 212
39. J.J. Lemasters, and R.C. Hackenbrock Firefly luciferase assay for ATP production by mitochondria Methods in Enzymology 57 1978 36 50
40. R.A. Lockshin, and Z. Zakeri Caspase-independent cell deaths Current Opinion in Cell Biology 14 2002 727 733
41. J.C. Merrill, J.J.P. Morton, and S.D. Soileau Metals: cadmium A.W. Hayes Principles and methods of toxicology 2001 Taylor and Francis London 665 667
42. K.S. Min, T. Nakatsubo, Y. Fujita, S. Onosaka, and K. Tanaka Degradation of cadmium metallothionein in vitro by lysosomal proteases Toxicology and Applied Pharmacology 113 1992 299 305
43. A.S. Mouron, D.C. Golijow, and N.F. Dulout DNA damage by cadmium and arsenic salts assessed by the single cell gel electrophoresis assay Mutation Research 498 2001 47 55
44. OECD, 1994. Risk reduction monograph no: 5. Cadmium. Environment Monograph Series No. 104, Paris
45. T.N.D. Pham, J.A. Segui, C. Fortin, P.G.C. Campbell, F. Denizeau, and C. Jumarie Cadmium uptake in rat hepatocytes in relation to speciation and to complexation with Metallothionein and albumin Journal of Cellular Physiology 201 2004 320 330
46. D. Pitt Lysosomes and cell function 1975 Longman New York pp. 146-151
47. +2 Toxicology 143 2000 263 273
48. C.D. Ramirez, M.C. Riera, and S.M. Gimenez Modulation of arachidonic acid turnover in macrophages by cadmium Toxicology Letters 122 2001 9 19
49. C. Risso-de Faverney, A. Devaux, M. Lafaurie, P.J. Girard, B. Bailly, and R. Rahmani Cadmium induces apoptosis and genotoxicity in rainbow trout hepatocytes through generation of reactive oxygen species Aquatic Toxicology 53 2001 65 76
50. M. Sato, and Y. Nagai Form of cadmium in rat liver subcellular particle Toxicology Letters 7 1980 119 123
51. I.A. Seoane, and N.F. Dulout Genotoxic ability of cadmium, chromium and nickel salts studied by kinetochore staining in the cytokinesis-blocked micronucleus assay Mutation Research 490 2001 99 106
52. A.Z. Shaikh, K. Zaman, W. Tang, and T. Vu Treatment of chronic cadmium nephrotoxicity by N-acetylcysteine Toxicology Letters 104 1999 137 142
53. V. Stoka, B. Turk, L.S. Schendel, T. Kim, T. Cirman, J.S. Snipas, M.L. Ellerby, D. Bredesen, H. Freeze, M. Abrahamson, D. Bromme, S. Kvajewski, C.J. Reed, X. Yint, V. Turk, and S.G. Salvesen Lysosomal protease pathways to apoptosis The Journal of Biological Chemistry 276 2001 3149 3157
54. S. Sunitha, M. Nagaraj, and P. Varalakshmi Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmium-induced hepatotoxicity in rats Fitoterapia 72 2001 516 523
55. R.R. Tice, E. Agurell, D. Anderson, B. Burlinson, A. Hartmann, H. Kobayashi, Y. Miyamae, E. Rojas, J.C. Ryu, and F.Y. Sasaki Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing Environmental and Molecular Mutagenesis 35 2000 206 221
56. M. Webb, and T.A. Etienne Studies on the toxicity and metabolism of cadmium-thionein Biochemical Pharmacology 26 1977 25 30
57. H. Zheng, J. Liu, A. Choo, E.A. Michalska, and D.C. Klaassen Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53 Toxicology and Applied Pharmacology 136 1996 229 235