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Volumn 27, Issue 9, 2013, Pages 975-979

RB goes mitochondrial

Author keywords

Apoptosis; Cancer; MOMP; pRB; Retinoblastoma protein

Indexed keywords

PROTEIN BAK; PROTEIN BAX; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 84877270895     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.219451.113     Document Type: Article
Times cited : (16)

References (40)
  • 1
    • 18144403123 scopus 로고    scopus 로고
    • Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis
    • Adegbola O, Pasternack GR. 2005 Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis. J Biol Chem 280: 15497-15502
    • (2005) J Biol Chem , vol.280 , pp. 15497-15502
    • Adegbola, O.1    Pasternack, G.R.2
  • 3
    • 50149120366 scopus 로고    scopus 로고
    • Cellular mechanisms of tumour suppression by the retinoblastoma gene
    • Burkhart DL, Sage J. 2008 Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 8: 671-682
    • (2008) Nat Rev Cancer , vol.8 , pp. 671-682
    • Burkhart, D.L.1    Sage, J.2
  • 4
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles C, Helmberg A, Karin M. 1994. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370: 220-223
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 5
    • 84857184365 scopus 로고    scopus 로고
    • DNA damage signals through differentially modified E2F1 molecules to induce apoptosis
    • Carnevale J, Palander O, Seifried LA, Dick FA. 2012 DNA damage signals through differentially modified E2F1 molecules to induce apoptosis. Mol Cell Biol 32: 900-912
    • (2012) Mol Cell Biol , vol.32 , pp. 900-912
    • Carnevale, J.1    Palander, O.2    Seifried, L.A.3    Dick, F.A.4
  • 7
    • 2942574955 scopus 로고    scopus 로고
    • Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma
    • Chen D, Livne-Bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. 2004 Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 5: 539-551
    • (2004) Cancer Cell , vol.5 , pp. 539-551
    • Chen, D.1    Livne-Bar, I.2    Vanderluit, J.L.3    Slack, R.S.4    Agochiya, M.5    Bremner, R.6
  • 11
    • 0141927097 scopus 로고    scopus 로고
    • pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities
    • Dick FA, Dyson N. 2003. pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Mol Cell 12: 639-649
    • (2003) Mol Cell , vol.12 , pp. 639-649
    • Dick, F.A.1    Dyson, N.2
  • 12
    • 0033786378 scopus 로고    scopus 로고
    • Rb function in cell-cycle regulation and apoptosis
    • Harbour JW, Dean DC. 2000 Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2: E65-E67
    • (2000) Nat Cell Biol , vol.2
    • Harbour, J.W.1    Dean, D.C.2
  • 13
    • 1542305653 scopus 로고    scopus 로고
    • Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis
    • Hershko T, Ginsberg D. 2004 Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis. J Biol Chem 279: 8627-8634
    • (2004) J Biol Chem , vol.279 , pp. 8627-8634
    • Hershko, T.1    Ginsberg, D.2
  • 17
    • 40449096674 scopus 로고    scopus 로고
    • Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation
    • Julian LM, Palander O, Seifried LA, Foster JE, Dick FA. 2008 Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation. Oncogene 27: 1572-1579
    • (2008) Oncogene , vol.27 , pp. 1572-1579
    • Julian, L.M.1    Palander, O.2    Seifried, L.A.3    Foster, J.E.4    Dick, F.A.5
  • 18
    • 84870508046 scopus 로고    scopus 로고
    • A transcriptionally active pRb-E2F1-P/CAF signaling pathway is central to TGFb-mediated apoptosis
    • Korah J, Falah N, Lacerte A, Lebrun JJ. 2012 A transcriptionally active pRb-E2F1-P/CAF signaling pathway is central to TGFb-mediated apoptosis. Cell Death Dis 3: e407
    • (2012) Cell Death Dis , vol.3
    • Korah, J.1    Falah, N.2    Lacerte, A.3    Lebrun, J.J.4
  • 19
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu JI, Dumont P, Hafey M, Murphy ME, George DL. 2004 Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 6: 443-450
    • (2004) Nat Cell Biol , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 20
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod KF, Hu Y, Jacks T. 1996 Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J 15: 6178-6188
    • (1996) EMBO J , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 21
    • 0034717014 scopus 로고    scopus 로고
    • Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
    • Marchenko ND, Zaika A, Moll UM. 2000 Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 275: 16202-16212
    • (2000) J Biol Chem , vol.275 , pp. 16202-16212
    • Marchenko, N.D.1    Zaika, A.2    Moll, U.M.3
  • 22
    • 33644775511 scopus 로고    scopus 로고
    • Phosphorylation site mutated RB exerts contrasting effects on apoptotic response to different stimuli
    • Masselli A, Wang JY. 2006 Phosphorylation site mutated RB exerts contrasting effects on apoptotic response to different stimuli. Oncogene 25: 1290-1298
    • (2006) Oncogene , vol.25 , pp. 1290-1298
    • Masselli, A.1    Wang, J.Y.2
  • 24
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser SD, Williams BO, Jacks T, DePinho RA. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371: 72-74
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    Depinho, R.A.4
  • 27
    • 0032160407 scopus 로고    scopus 로고
    • Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
    • Pan H, Yin C, Dyson NJ, Harlow E, Yamasaki L, Van Dyke T. 1998 Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol Cell 2: 283-292
    • (1998) Mol Cell , vol.2 , pp. 283-292
    • Pan, H.1    Yin, C.2    Dyson, N.J.3    Harlow, E.4    Yamasaki, L.5    van Dyke, T.6
  • 28
    • 0037194579 scopus 로고    scopus 로고
    • pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation
    • Pucci B, Claudio PP, Masciullo V, Bellincampi L, Terrinoni A, Khalili K, Melino G, Giordano A. 2002. pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation. Oncogene 21: 5897-5905
    • (2002) Oncogene , vol.21 , pp. 5897-5905
    • Pucci, B.1    Claudio, P.P.2    Masciullo, V.3    Bellincampi, L.4    Terrinoni, A.5    Khalili, K.6    Melino, G.7    Giordano, A.8
  • 29
    • 34249074239 scopus 로고    scopus 로고
    • DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans
    • Reddien PW, Andersen EC, Huang MC, Horvitz HR. 2007 DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175: 1719-1733
    • (2007) Genetics , vol.175 , pp. 1719-1733
    • Reddien, P.W.1    Andersen, E.C.2    Huang, M.C.3    Horvitz, H.R.4
  • 30
    • 28944437358 scopus 로고    scopus 로고
    • Structure of the Rb C-terminal domain bound to E2F1-DP1: A mechanism for phosphorylation-induced E2F release
    • Rubin SM, Gall AL, Zheng N, Pavletich NP. 2005 Structure of the Rb C-terminal domain bound to E2F1-DP1: A mechanism for phosphorylation-induced E2F release. Cell 123: 1093-1106
    • (2005) Cell , vol.123 , pp. 1093-1106
    • Rubin, S.M.1    Gall, A.L.2    Zheng, N.3    Pavletich, N.P.4
  • 31
    • 36148979346 scopus 로고    scopus 로고
    • C. elegans orthologs of components of the RB tumor suppressor complex have distinct proapoptotic functions
    • Schertel C, Conradt B. 2007 C. elegans orthologs of components of the RB tumor suppressor complex have distinct proapoptotic functions. Development 134: 3691-3701
    • (2007) Development , vol.134 , pp. 3691-3701
    • Schertel, C.1    Conradt, B.2
  • 32
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr CJ, McCormick F. 2002 The RB and p53 pathways in cancer. Cancer Cell 2: 103-112
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 34
    • 27544490654 scopus 로고    scopus 로고
    • Mitochondrially targeted p53 has tumor suppressor activities in vivo
    • Talos F, Petrenko O, Mena P, Moll UM. 2005 Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res 65: 9971-9981
    • (2005) Cancer Res , vol.65 , pp. 9971-9981
    • Talos, F.1    Petrenko, O.2    Mena, P.3    Moll, U.M.4
  • 35
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai KY, Hu Y, Macleod KF, Crowley D, Yamasaki L, Jacks T. 1998 Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell 2: 293-304
    • (1998) Mol Cell , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 36
    • 84862675016 scopus 로고    scopus 로고
    • p53 opens the mitochondrial permeability transition pore to trigger necrosis
    • Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM. 2012. p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 149: 1536-1548
    • (2012) Cell , vol.149 , pp. 1536-1548
    • Vaseva, A.V.1    Marchenko, N.D.2    Ji, K.3    Tsirka, S.E.4    Holzmann, S.5    Moll, U.M.6
  • 37
    • 14844316300 scopus 로고    scopus 로고
    • Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf
    • Wagner S, Roemer K. 2005 Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. Biochem Pharmacol 69: 1059-1067
    • (2005) Biochem Pharmacol , vol.69 , pp. 1059-1067
    • Wagner, S.1    Roemer, K.2
  • 38
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • Wang X. 2001 The expanding role of mitochondria in apoptosis. Genes Dev 15: 2922-2933
    • (2001) Genes Dev , vol.15 , pp. 2922-2933
    • Wang, X.1
  • 39
    • 0029819994 scopus 로고    scopus 로고
    • pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis
    • Zacksenhaus E, Jiang Z, Chung D, Marth JD, Phillips RA, Gallie BL. 1996. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev 10: 3051-3064
    • (1996) Genes Dev , vol.10 , pp. 3051-3064
    • Zacksenhaus, E.1    Jiang, Z.2    Chung, D.3    Marth, J.D.4    Phillips, R.A.5    Gallie, B.L.6
  • 40
    • 0035118893 scopus 로고    scopus 로고
    • E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
    • Ziebold U, Reza T, Caron A, Lees JA. 2001 E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev 15: 386-391.
    • (2001) Genes Dev , vol.15 , pp. 386-391
    • Ziebold, U.1    Reza, T.2    Caron, A.3    Lees, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.