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Volumn 98, Issue 2, 2013, Pages 240-247

'Ryanopathy': Causes and manifestations of RyR2 dysfunction in heart failure

Author keywords

Arrhythmia; Ca2+ release; Heart failure; Ryanodine receptor; Sarcoplasmic reticulum

Indexed keywords

REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR 2; XANTHINE OXIDASE;

EID: 84877256978     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt024     Document Type: Review
Times cited : (59)

References (80)
  • 1
    • 17944398302 scopus 로고
    • Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum
    • Fabiato A. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol 1983;245:C1-C14.
    • (1983) Am J Physiol , vol.245
    • Fabiato, A.1
  • 4
    • 0034943174 scopus 로고    scopus 로고
    • Molecular basis of Ca2+ activation of the mouse cardiac Ca2+ release channel (ryanodine receptor)
    • Li P, Chen SR. Molecular basis of Ca2+ activation of the mouse cardiac Ca2+ release channel (ryanodine receptor). J Gen Physiol 2001;118:33-44.
    • (2001) J Gen Physiol , vol.118 , pp. 33-44
    • Li, P.1    Chen, S.R.2
  • 6
    • 84876300508 scopus 로고    scopus 로고
    • Store-dependent deactivation: Cooling the chain-reaction of myocardial calcium signaling
    • Advance Access published October 27 doi: 10.1016/j.yjmcc.2012.10.008
    • Radwanski PB, Belevych AE, Brunello L, Carnes CA, Gyorke S. Store-dependent deactivation: cooling the chain-reaction of myocardial calcium signaling. J Mol Cell Cardiol. Advance Access published October 27, 2012, doi: 10.1016/j.yjmcc.2012.10.008.
    • (2012) J Mol Cell Cardiol
    • Radwanski, P.B.1    Belevych, A.E.2    Brunello, L.3    Carnes, C.A.4    Gyorke, S.5
  • 7
    • 0037031486 scopus 로고    scopus 로고
    • Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes
    • Terentyev D, Viatchenko-Karpinski S, Valdivia HH, Escobar AL, Gyorke S. Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes. Circ Res 2002;91:414-420.
    • (2002) Circ Res , vol.91 , pp. 414-420
    • Terentyev, D.1    Viatchenko-Karpinski, S.2    Valdivia, H.H.3    Escobar, A.L.4    Gyorke, S.5
  • 8
    • 6344290044 scopus 로고    scopus 로고
    • Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle
    • Szentesi P, Pignier C, Egger M, Kranias EG, Niggli E. Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circ Res 2004;95:807-813.
    • (2004) Circ Res , vol.95 , pp. 807-813
    • Szentesi, P.1    Pignier, C.2    Egger, M.3    Kranias, E.G.4    Niggli, E.5
  • 9
    • 0036283045 scopus 로고    scopus 로고
    • Termination of cardiac Ca2+ sparks: An investigative mathematical model of calcium-induced calcium release
    • Sobie EA, Dilly KW, dos Santos Cruz J, Lederer WJ, Jafri MS. Termination of cardiac Ca2+ sparks: an investigative mathematical model of calcium-induced calcium release. Biophys J 2002;83:59-78.
    • (2002) Biophys J , vol.83 , pp. 59-78
    • Sobie, E.A.1    Dilly, K.W.2    Dos Santos Cruz, J.3    Lederer, W.J.4    Jafri, M.S.5
  • 10
    • 38849091360 scopus 로고    scopus 로고
    • Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease
    • Gyorke S, Terentyev D. Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovasc Res 2008;77:245-255.
    • (2008) Cardiovasc Res , vol.77 , pp. 245-255
    • Gyorke, S.1    Terentyev, D.2
  • 11
    • 0036835665 scopus 로고    scopus 로고
    • Regulation of mammalian ryanodine receptors
    • Meissner G. Regulation of mammalian ryanodine receptors. Front Biosci 2002;7: d2072-d2080.
    • (2002) Front Biosci , vol.7
    • Meissner, G.1
  • 13
    • 33646771721 scopus 로고    scopus 로고
    • Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts
    • Xiao B, Zhong G, Obayashi M, Yang D, Chen K, Walsh MP et al. Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts. Biochem J 2006;396:7-16.
    • (2006) Biochem J , vol.396 , pp. 7-16
    • Xiao, B.1    Zhong, G.2    Obayashi, M.3    Yang, D.4    Chen, K.5    Walsh, M.P.6
  • 14
    • 84861587093 scopus 로고    scopus 로고
    • Ryanodine receptor phosphorylation and heart failure: Phasing out S2808 and criminalizing S2814
    • Valdivia HH. Ryanodine receptor phosphorylation and heart failure: phasing out S2808 and "criminalizing" S2814. Circ Res 2012;110:1398-1402.
    • (2012) Circ Res , vol.110 , pp. 1398-1402
    • Valdivia, H.H.1
  • 15
    • 0034640113 scopus 로고    scopus 로고
    • PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts
    • Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 2000;101:365-376.
    • (2000) Cell , vol.101 , pp. 365-376
    • Marx, S.O.1    Reiken, S.2    Hisamatsu, Y.3    Jayaraman, T.4    Burkhoff, D.5    Rosemblit, N.6
  • 16
    • 0942290432 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase IId associates with the ryanodine receptor complex and regulates channel function in rabbit heart
    • Currie S, Loughrey CM, Craig MA, Smith GL. Calcium/calmodulin-dependent protein kinase IId associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochem J 2004;377:357-366.
    • (2004) Biochem J , vol.377 , pp. 357-366
    • Currie, S.1    Loughrey, C.M.2    Craig, M.A.3    Smith, G.L.4
  • 17
    • 79954992084 scopus 로고    scopus 로고
    • Modulation of cardiac ryanodine receptor activity by ROS and RNS
    • Donoso P, Sanchez G, Bull R, Hidalgo C. Modulation of cardiac ryanodine receptor activity by ROS and RNS. Front Biosci 2011;16:553-567.
    • (2011) Front Biosci , vol.16 , pp. 553-567
    • Donoso, P.1    Sanchez, G.2    Bull, R.3    Hidalgo, C.4
  • 18
    • 33745198418 scopus 로고    scopus 로고
    • Redox regulation of cardiac calcium channels and transporters
    • Zima AV, Blatter LA. Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 2006;71:310-321.
    • (2006) Cardiovasc Res , vol.71 , pp. 310-321
    • Zima, A.V.1    Blatter, L.A.2
  • 19
    • 0032103768 scopus 로고    scopus 로고
    • The control of Ca release from the cardiac sarcoplasmic reticulum: Regulation versus autoregulation
    • Eisner DA, Trafford AW, Diaz ME, Overend CL, O'Neill SC. The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation. Cardiovasc Res 1998;38:589-604.
    • (1998) Cardiovasc Res , vol.38 , pp. 589-604
    • Eisner, D.A.1    Trafford, A.W.2    Diaz, M.E.3    Overend, C.L.4    O'Neill, S.C.5
  • 20
    • 36849013016 scopus 로고    scopus 로고
    • Enhanced ryanodine receptor-mediated calcium leak determines reduced sarcoplasmic reticulum calcium content in chronic canine heart failure
    • Belevych A, Kubalova Z, Terentyev D, Hamlin RL, Carnes CA, Gyorke S. Enhanced ryanodine receptor-mediated calcium leak determines reduced sarcoplasmic reticulum calcium content in chronic canine heart failure. Biophys J 2007;93:4083-4092.
    • (2007) Biophys J , vol.93 , pp. 4083-4092
    • Belevych, A.1    Kubalova, Z.2    Terentyev, D.3    Hamlin, R.L.4    Carnes, C.A.5    Gyorke, S.6
  • 21
    • 0036702666 scopus 로고    scopus 로고
    • Calcium cycling in congestive heart failure
    • Hasenfuss G, Pieske B. Calcium cycling in congestive heart failure. J Mol Cell Cardiol 2002;34:951-969.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 951-969
    • Hasenfuss, G.1    Pieske, B.2
  • 22
    • 84859902405 scopus 로고    scopus 로고
    • Remodeling of calcium handling in human heart failure
    • Lou Q, Janardhan A, Efimov IR. Remodeling of calcium handling in human heart failure. Adv Exp Med Biol 2012;740:1145-1174.
    • (2012) Adv Exp Med Biol , vol.740 , pp. 1145-1174
    • Lou, Q.1    Janardhan, A.2    Efimov, I.R.3
  • 23
    • 33845296446 scopus 로고    scopus 로고
    • Altered cardiac myocyte Ca regulation in heart failure
    • Bers DM. Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda) 2006;21:380-387.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 380-387
    • Bers, D.M.1
  • 24
    • 1542613385 scopus 로고    scopus 로고
    • Cellular basis of triggered arrhythmias in heart failure
    • Pogwizd SM, Bers DM. Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med 2004;14:61-66.
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 61-66
    • Pogwizd, S.M.1    Bers, D.M.2
  • 25
    • 0345861903 scopus 로고    scopus 로고
    • Electrophysiological changes in heart failure and their relationship to arrhythmogenesis
    • Janse MJ. Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. Cardiovasc Res 2004;61:208-217.
    • (2004) Cardiovasc Res , vol.61 , pp. 208-217
    • Janse, M.J.1
  • 26
    • 78349303787 scopus 로고    scopus 로고
    • Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium
    • Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T et al. Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res 2010;107:1150-1161.
    • (2010) Circ Res , vol.107 , pp. 1150-1161
    • Sossalla, S.1    Fluschnik, N.2    Schotola, H.3    Ort, K.R.4    Neef, S.5    Schulte, T.6
  • 27
    • 79957481291 scopus 로고    scopus 로고
    • The relationship between arrhythmogenesis and impaired contractility in heart failure: Role of altered ryanodine receptor function
    • Belevych AE, Terentyev D, Terentyeva R, Nishijima Y, Sridhar A, Hamlin RL et al. The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function. Cardiovasc Res 2011;90:493-502.
    • (2011) Cardiovasc Res , vol.90 , pp. 493-502
    • Belevych, A.E.1    Terentyev, D.2    Terentyeva, R.3    Nishijima, Y.4    Sridhar, A.5    Hamlin, R.L.6
  • 28
    • 77953356086 scopus 로고    scopus 로고
    • Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca2+-calmodulin-dependent protein kinase II
    • Curran J, Brown KH, Santiago DJ, Pogwizd S, Bers DM, Shannon TR. Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca2+-calmodulin-dependent protein kinase II. J Mol Cell Cardiol 2010;49:25-32.
    • (2010) J Mol Cell Cardiol , vol.49 , pp. 25-32
    • Curran, J.1    Brown, K.H.2    Santiago, D.J.3    Pogwizd, S.4    Bers, D.M.5    Shannon, T.R.6
  • 29
    • 84859755460 scopus 로고    scopus 로고
    • Cardiac ryanodine receptor in metabolic syndrome: Is JTV519 (K201)
    • Dincer UD. Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy Diabetes Metab Syndr Obes 2012;5:89-99.
    • (2012) Future Therapy Diabetes Metab Syndr Obes , vol.5 , pp. 89-99
    • Dincer, U.D.1
  • 30
    • 84877292962 scopus 로고    scopus 로고
    • Up-regulation of sarcoplasmic reticulum Ca2+ uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2
    • Kalyanasundaram A, Lacombe VA, Belevych AE, Brunello L, Carnes CA, Janssen PM et al. Up-regulation of sarcoplasmic reticulum Ca2+ uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2. Cardiovasc Res 2013;98:297-306.
    • (2013) Cardiovasc Res , vol.98 , pp. 297-306
    • Kalyanasundaram, A.1    Lacombe, V.A.2    Belevych, A.E.3    Brunello, L.4    Carnes, C.A.5    Janssen, P.M.6
  • 31
    • 77950470200 scopus 로고    scopus 로고
    • Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model
    • van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG et al. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension 2010;55:932-938.
    • (2010) Hypertension , vol.55 , pp. 932-938
    • Van Oort, R.J.1    Respress, J.L.2    Li, N.3    Reynolds, C.4    De Almeida, A.C.5    Skapura, D.G.6
  • 32
    • 34248186991 scopus 로고    scopus 로고
    • Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel
    • Yamaguchi N, Takahashi N, Xu L, Smithies O, Meissner G. Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest 2007;117:1344-1353.
    • (2007) J Clin Invest , vol.117 , pp. 1344-1353
    • Yamaguchi, N.1    Takahashi, N.2    Xu, L.3    Smithies, O.4    Meissner, G.5
  • 33
    • 76349084460 scopus 로고    scopus 로고
    • Phospholamban ablation rescues sarcoplasmic reticulum Ca2+ handling but exacerbates cardiac dysfunction in CaMKIIdC transgenic mice
    • Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL et al. Phospholamban ablation rescues sarcoplasmic reticulum Ca2+ handling but exacerbates cardiac dysfunction in CaMKIIdC transgenic mice. Circ Res 2010;106:354-362.
    • (2010) Circ Res , vol.106 , pp. 354-362
    • Zhang, T.1    Guo, T.2    Mishra, S.3    Dalton, N.D.4    Kranias, E.G.5    Peterson, K.L.6
  • 34
    • 0141752833 scopus 로고    scopus 로고
    • Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure
    • Shannon TR, Pogwizd SM, Bers DM. Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ Res 2003;93:592-594.
    • (2003) Circ Res , vol.93 , pp. 592-594
    • Shannon, T.R.1    Pogwizd, S.M.2    Bers, D.M.3
  • 35
    • 31444444347 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure
    • Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM. Ca2+/calmodulin- dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res 2005;97:1314-1322.
    • (2005) Circ Res , vol.97 , pp. 1314-1322
    • Ai, X.1    Curran, J.W.2    Shannon, T.R.3    Bers, D.M.4    Pogwizd, S.M.5
  • 37
    • 84858652117 scopus 로고    scopus 로고
    • Ryanodine receptor S2808 phosphorylation in heart failure: Smoking gun or red herring
    • Bers DM. Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring. Circ Res 2012;110:796-799.
    • (2012) Circ Res , vol.110 , pp. 796-799
    • Bers, D.M.1
  • 38
    • 70450211189 scopus 로고    scopus 로고
    • Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure
    • Domeier TL, Blatter LA, Zima AV. Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure. J Physiol 2009; 587:5197-5209.
    • (2009) J Physiol , vol.587 , pp. 5197-5209
    • Domeier, T.L.1    Blatter, L.A.2    Zima, A.V.3
  • 41
    • 0033607667 scopus 로고    scopus 로고
    • Upregulation of Na+/Ca2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure
    • Pogwizd SM, Qi M, Yuan W, Samarel AM, Bers DM. Upregulation of Na+/Ca2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 1999;85:1009-1019.
    • (1999) Circ Res , vol.85 , pp. 1009-1019
    • Pogwizd, S.M.1    Qi, M.2    Yuan, W.3    Samarel, A.M.4    Bers, D.M.5
  • 45
    • 0035827719 scopus 로고    scopus 로고
    • Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness
    • Pogwizd SM, Schlotthauer K, Li L, YuanW, Bers DM. Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res 2001;88: 1159-1167.
    • (2001) Circ Res , vol.88 , pp. 1159-1167
    • Pogwizd, S.M.1    Schlotthauer, K.2    Li, L.3    Yuan, W.4    Bers, D.M.5
  • 46
    • 33847058737 scopus 로고    scopus 로고
    • Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase
    • Curran J, Hinton MJ, Rios E, Bers DM, Shannon TR. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res 2007;100:391-398.
    • (2007) Circ Res , vol.100 , pp. 391-398
    • Curran, J.1    Hinton, M.J.2    Rios, E.3    Bers, D.M.4    Shannon, T.R.5
  • 47
    • 85047679986 scopus 로고
    • Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart
    • Lakatta EG. Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart. Cardiovasc Res 1992;26:193-214.
    • (1992) Cardiovasc Res , vol.26 , pp. 193-214
    • Lakatta, E.G.1
  • 48
    • 42949133930 scopus 로고    scopus 로고
    • Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca2+ signal integrators
    • Colella M, Grisan F, Robert V, Turner JD, Thomas AP, Pozzan T. Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: role of calcineurin/NFAT as Ca2+ signal integrators. Proc Natl Acad Sci USA 2008;105:2859-2864.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2859-2864
    • Colella, M.1    Grisan, F.2    Robert, V.3    Turner, J.D.4    Thomas, A.P.5    Pozzan, T.6
  • 49
    • 79960044552 scopus 로고    scopus 로고
    • CaMKII in myocardial hypertrophy and heart failure
    • Anderson ME, Brown JH, Bers DM. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol 2011;51:468-473.
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 468-473
    • Anderson, M.E.1    Brown, J.H.2    Bers, D.M.3
  • 50
    • 0024218960 scopus 로고
    • Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: Mechanisms and consequences
    • Stern MD, Capogrossi MC, Lakatta EG. Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences. Cell Calcium 1988;9:247-256.
    • (1988) Cell Calcium , vol.9 , pp. 247-256
    • Stern, M.D.1    Capogrossi, M.C.2    Lakatta, E.G.3
  • 51
    • 33846117456 scopus 로고    scopus 로고
    • Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves: Threshold sarcoplasmic reticulum calcium content is required
    • Venetucci LA, Trafford AW, Eisner DA. Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves: threshold sarcoplasmic reticulum calcium content is required. Circ Res 2007;100:105-111.
    • (2007) Circ Res , vol.100 , pp. 105-111
    • Venetucci, L.A.1    Trafford, A.W.2    Eisner, D.A.3
  • 52
    • 0035916903 scopus 로고    scopus 로고
    • Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure
    • Hobai IA, O'Rourke B. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation 2001;103:1577-1584.
    • (2001) Circulation , vol.103 , pp. 1577-1584
    • Hobai, I.A.1    O'Rourke, B.2
  • 53
    • 44949209661 scopus 로고    scopus 로고
    • Arrhythmogenic effects of b2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load
    • Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM et al. Arrhythmogenic effects of b2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res 2008;102:1389-1397.
    • (2008) Circ Res , vol.102 , pp. 1389-1397
    • Desantiago, J.1    Ai, X.2    Islam, M.3    Acuna, G.4    Ziolo, M.T.5    Bers, D.M.6
  • 54
    • 84857645169 scopus 로고    scopus 로고
    • Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death
    • Belevych AE, Terentyev D, Terentyeva R, Ho HT, Gyorke I, Bonilla IM et al. Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death. Circ Res 2012;110:569-577.
    • (2012) Circ Res , vol.110 , pp. 569-577
    • Belevych, A.E.1    Terentyev, D.2    Terentyeva, R.3    Ho, H.T.4    Gyorke, I.5    Bonilla, I.M.6
  • 55
    • 35448984962 scopus 로고    scopus 로고
    • Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor
    • Benkusky NA, Weber CS, Scherman JA, Farrell EF, Hacker TA, John MC et al. Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor. Circ Res 2007;101:819-829.
    • (2007) Circ Res , vol.101 , pp. 819-829
    • Benkusky, N.A.1    Weber, C.S.2    Scherman, J.A.3    Farrell, E.F.4    Hacker, T.A.5    John, M.C.6
  • 56
    • 0038643583 scopus 로고    scopus 로고
    • Transgenic CaMKIIdC overexpression uniquely alters cardiac myocyte Ca2+ handling: Reduced SR Ca2+ load and activated SR Ca2+ release
    • Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers DM. Transgenic CaMKIIdC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res 2003;92:904-911.
    • (2003) Circ Res , vol.92 , pp. 904-911
    • Maier, L.S.1    Zhang, T.2    Chen, L.3    Desantiago, J.4    Brown, J.H.5    Bers, D.M.6
  • 57
    • 0038643573 scopus 로고    scopus 로고
    • The dC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
    • Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J Jr, Bers DM et al. The dC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res 2003;92:912-919.
    • (2003) Circ Res , vol.92 , pp. 912-919
    • Zhang, T.1    Maier, L.S.2    Dalton, N.D.3    Miyamoto, S.4    Ross Jr., J.5    Bers, D.M.6
  • 58
    • 0037015257 scopus 로고    scopus 로고
    • Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy
    • Wu Y, Temple J, Zhang R, Dzhura I, Zhang W, Trimble R et al. Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation 2002;106: 1288-1293.
    • (2002) Circulation , vol.106 , pp. 1288-1293
    • Wu, Y.1    Temple, J.2    Zhang, R.3    Dzhura, I.4    Zhang, W.5    Trimble, R.6
  • 59
    • 78650701435 scopus 로고    scopus 로고
    • Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure
    • van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL et al. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation 2010;122:2669-2679.
    • (2010) Circulation , vol.122 , pp. 2669-2679
    • Van Oort, R.J.1    McCauley, M.D.2    Dixit, S.S.3    Pereira, L.4    Yang, Y.5    Respress, J.L.6
  • 60
    • 74249087588 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure
    • Sag CM, Wadsack DP, Khabbazzadeh S, Abesser M, Grefe C, Neumann K et al. Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail 2009;2:664-675.
    • (2009) Circ Heart Fail , vol.2 , pp. 664-675
    • Sag, C.M.1    Wadsack, D.P.2    Khabbazzadeh, S.3    Abesser, M.4    Grefe, C.5    Neumann, K.6
  • 61
    • 84863513714 scopus 로고    scopus 로고
    • Disease mutations in the ryanodine receptor central region: Crystal structures of a phosphorylation hot spot domain
    • Yuchi Z, Lau K, Van Petegem F. Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain. Structure 2012;20: 1201-1211.
    • (2012) Structure , vol.20 , pp. 1201-1211
    • Yuchi, Z.1    Lau, K.2    Van Petegem, F.3
  • 62
    • 58149387380 scopus 로고    scopus 로고
    • Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure
    • Terentyev D, Gyorke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y et al. Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure. Circ Res 2008;103:1466-1472.
    • (2008) Circ Res , vol.103 , pp. 1466-1472
    • Terentyev, D.1    Gyorke, I.2    Belevych, A.E.3    Terentyeva, R.4    Sridhar, A.5    Nishijima, Y.6
  • 63
    • 77956520622 scopus 로고    scopus 로고
    • Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure
    • Gonzalez DR, Treuer AV, Castellanos J, Dulce RA, Hare JM. Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure. J Biol Chem 2010;285:28938-28945.
    • (2010) J Biol Chem , vol.285 , pp. 28938-28945
    • Gonzalez, D.R.1    Treuer, A.V.2    Castellanos, J.3    Dulce, R.A.4    Hare, J.M.5
  • 64
    • 0032498185 scopus 로고    scopus 로고
    • Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation
    • Xu L, Eu JP, Meissner G, Stamler JS. Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 1998;279:234-237.
    • (1998) Science , vol.279 , pp. 234-237
    • Xu, L.1    Eu, J.P.2    Meissner, G.3    Stamler, J.S.4
  • 65
    • 42949085382 scopus 로고    scopus 로고
    • A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation
    • Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV et al. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell 2008;133:462-474.
    • (2008) Cell , vol.133 , pp. 462-474
    • Erickson, J.R.1    Joiner, M.L.2    Guan, X.3    Kutschke, W.4    Yang, J.5    Oddis, C.V.6
  • 66
    • 0034902242 scopus 로고    scopus 로고
    • Dynamic regulation of sarcoplasmic reticulum Ca2+ content and release by luminal Ca2+-sensitive leak in rat ventricular myocytes
    • Lukyanenko V, Viatchenko-Karpinski S, Smirnov A, Wiesner TF, Gyorke S. Dynamic regulation of sarcoplasmic reticulum Ca2+ content and release by luminal Ca2+-sensitive leak in rat ventricular myocytes. Biophys J 2001;81:785-798.
    • (2001) Biophys J , vol.81 , pp. 785-798
    • Lukyanenko, V.1    Viatchenko-Karpinski, S.2    Smirnov, A.3    Wiesner, T.F.4    Gyorke, S.5
  • 68
    • 77950360868 scopus 로고    scopus 로고
    • K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum
    • Toischer K, Lehnart SE, Tenderich G, Milting H, Korfer R, Schmitto JD et al. K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Res Cardiol 2010;105:279-287.
    • (2010) Basic Res Cardiol , vol.105 , pp. 279-287
    • Toischer, K.1    Lehnart, S.E.2    Tenderich, G.3    Milting, H.4    Korfer, R.5    Schmitto, J.D.6
  • 69
    • 34247150261 scopus 로고    scopus 로고
    • Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure
    • Mochizuki M, Yano M, Oda T, Tateishi H, Kobayashi S, Yamamoto T et al. Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure. J Am Coll Cardiol 2007; 49:1722-1732.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1722-1732
    • Mochizuki, M.1    Yano, M.2    Oda, T.3    Tateishi, H.4    Kobayashi, S.5    Yamamoto, T.6
  • 70
    • 79961153702 scopus 로고    scopus 로고
    • Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release
    • Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A et al. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med 2011;17:1003-1009.
    • (2011) Nat Med , vol.17 , pp. 1003-1009
    • Zhou, Q.1    Xiao, J.2    Jiang, D.3    Wang, R.4    Vembaiyan, K.5    Wang, A.6
  • 71
    • 20244362095 scopus 로고    scopus 로고
    • Calmodulin kinase II inhibition protects against structural heart disease
    • Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G et al. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med 2005;11:409-417.
    • (2005) Nat Med , vol.11 , pp. 409-417
    • Zhang, R.1    Khoo, M.S.2    Wu, Y.3    Yang, Y.4    Grueter, C.E.5    Ni, G.6
  • 72
    • 0035856508 scopus 로고    scopus 로고
    • Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy
    • Cappola TP, Kass DA, Nelson GS, Berger RD, Rosas GO, Kobeissi ZA et al. Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation 2001;104:2407-2411.
    • (2001) Circulation , vol.104 , pp. 2407-2411
    • Cappola, T.P.1    Kass, D.A.2    Nelson, G.S.3    Berger, R.D.4    Rosas, G.O.5    Kobeissi, Z.A.6
  • 74
    • 12944332074 scopus 로고    scopus 로고
    • Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure
    • Miyamoto MI, del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T et al. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci USA 2000;97:793-798.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 793-798
    • Miyamoto, M.I.1    Del Monte, F.2    Schmidt, U.3    Disalvo, T.S.4    Kang, Z.B.5    Matsui, T.6
  • 76
    • 79961032369 scopus 로고    scopus 로고
    • Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure
    • Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B et al. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation 2011;124:304-313.
    • (2011) Circulation , vol.124 , pp. 304-313
    • Jessup, M.1    Greenberg, B.2    Mancini, D.3    Cappola, T.4    Pauly, D.F.5    Jaski, B.6
  • 77
    • 80052342152 scopus 로고    scopus 로고
    • SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure
    • Lyon AR, Bannister ML, Collins T, Pearce E, Sepehripour AH, Dubb SS et al. SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circ Arrhythm Electrophysiol 2011;4: 362-372.
    • (2011) Circ Arrhythm Electrophysiol , vol.4 , pp. 362-372
    • Lyon, A.R.1    Bannister, M.L.2    Collins, T.3    Pearce, E.4    Sepehripour, A.H.5    Dubb, S.S.6
  • 79
    • 2442501143 scopus 로고    scopus 로고
    • Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model
    • Janczewski AM, Zahid M, Lemster BH, Frye CS, Gibson G, Higuchi Y et al. Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model. Cardiovasc Res 2004;62:468-480.
    • (2004) Cardiovasc Res , vol.62 , pp. 468-480
    • Janczewski, A.M.1    Zahid, M.2    Lemster, B.H.3    Frye, C.S.4    Gibson, G.5    Higuchi, Y.6
  • 80
    • 57349157738 scopus 로고    scopus 로고
    • Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo
    • O'Donnell JM, Fields A, Xu X, Chowdhury SA, Geenen DL, Bi J. Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo. Am J Physiol Heart Circ Physiol 2008;295:H2483-H2494.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • O'Donnell, J.M.1    Fields, A.2    Xu, X.3    Chowdhury, S.A.4    Geenen, D.L.5    Bi, J.6


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