SMET: Systematic multiple enzyme targeting - a method to rationally design optimal strains for target chemical overproduction

Biotechnology Journal

Volumn 8, Issue 5, 2013, Pages 605-618

  Flowers, David ^a   Thompson, R Adam ^b   Birdwell, Douglas ^a   Wang, Tsewei ^a   Trinh, Cong T ^a,b  

^a University of Tennessee Knoxville   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Elementary mode analysis; Ensemble metabolic modeling; Minimal cut set; Rational strain design; Systematic multiple enzyme targeting (SMET)

Indexed keywords

CELLULAR METABOLISM; CONCEPT DEMONSTRATION; ELEMENTARY MODE ANALYSIS; ITERATIVE SEQUENCES; METABOLIC MODELING; MINIMAL CUTSETS; RATE-LIMITING REACTION; SYSTEMATIC MULTIPLE ENZYME TARGETING (SMET);

AMINO ACIDS; CHEMICAL ANALYSIS; DESIGN; ESCHERICHIA COLI; ITERATIVE METHODS; METABOLISM; OPTIMIZATION; PRODUCTIVITY; STRAIN;

ENZYMES;

AROMATIC AMINO ACID;

ANALYTIC METHOD; ARTICLE; CELL METABOLISM; CHEMICAL COMPOSITION; CHEMICAL REACTION; ENZYME SYNTHESIS; ESCHERICHIA COLI; METABOLIC ENGINEERING; MOLECULAR MODEL; PRIORITY JOURNAL; STEADY STATE; SYSTEMIC MULTIPLE ENZYME TARGETING METHOD;

AMINO ACIDS, AROMATIC; COMPUTATIONAL BIOLOGY; ENZYMES; ESCHERICHIA COLI; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; SUGAR ACIDS;

EID: 84877149255     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200233     Document Type: Article

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