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Volumn 8, Issue 5, 2013, Pages

Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; KU ANTIGEN; RECQ HELICASE; RECQ1 HELICASE; UNCLASSIFIED DRUG; CELL NUCLEUS ANTIGEN; DNA; DNA BINDING PROTEIN; OLIGONUCLEOTIDE; PROTEIN BINDING; RECQL PROTEIN, HUMAN;

EID: 84877082340     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062481     Document Type: Article
Times cited : (46)

References (78)
  • 1
    • 0035839840 scopus 로고    scopus 로고
    • DNA double strand break repair and chromosomal translocation: lessons from animal models
    • Ferguson DO, Alt FW, (2001) DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene 20: 5572-5579.
    • (2001) Oncogene , vol.20 , pp. 5572-5579
    • Ferguson, D.O.1    Alt, F.W.2
  • 2
    • 33747188326 scopus 로고    scopus 로고
    • Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation
    • Keeney S, Neale MJ, (2006) Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation. Biochem Soc Trans 34: 523-525.
    • (2006) Biochem Soc Trans , vol.34 , pp. 523-525
    • Keeney, S.1    Neale, M.J.2
  • 3
    • 34249794280 scopus 로고    scopus 로고
    • Evolution of the immunoglobulin heavy chain class switch recombination mechanism
    • Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, et al. (2007) Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol 94: 157-214.
    • (2007) Adv Immunol , vol.94 , pp. 157-214
    • Chaudhuri, J.1    Basu, U.2    Zarrin, A.3    Yan, C.4    Franco, S.5
  • 4
    • 34249945536 scopus 로고    scopus 로고
    • DNA double-strand break repair: from mechanistic understanding to cancer treatment
    • Helleday T, Lo J, van Gent DC, Engelward BP, (2007) DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) 6: 923-935.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 923-935
    • Helleday, T.1    Lo, J.2    van Gent, D.C.3    Engelward, B.P.4
  • 5
    • 84870218426 scopus 로고    scopus 로고
    • Mutations Arising During Repair of Chromosome Breaks
    • Haber JE, Malkova A (2012) Mutations Arising During Repair of Chromosome Breaks. Annual Review of Genetics 46: null.
    • (2012) Annual Review of Genetics , vol.46
    • Haber, J.E.1    Malkova, A.2
  • 6
    • 81955161844 scopus 로고    scopus 로고
    • DNA double-strand break repair pathways, chromosomal rearrangements and cancer
    • Kasparek TR, Humphrey TC, (2011) DNA double-strand break repair pathways, chromosomal rearrangements and cancer. Seminars in Cell & Developmental Biology 22: 886-897.
    • (2011) Seminars in Cell & Developmental Biology , vol.22 , pp. 886-897
    • Kasparek, T.R.1    Humphrey, T.C.2
  • 7
    • 70350088548 scopus 로고    scopus 로고
    • Mechanisms of double-strand break repair in somatic mammalian cells
    • Hartlerode AJ, Scully R, (2009) Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J 423: 157-168.
    • (2009) Biochem J , vol.423 , pp. 157-168
    • Hartlerode, A.J.1    Scully, R.2
  • 8
    • 3242886313 scopus 로고    scopus 로고
    • Homologous recombination-mediated double-strand break repair
    • Wyman C, Ristic D, Kanaar R, (2004) Homologous recombination-mediated double-strand break repair. DNA Repair (Amst) 3: 827-833.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 827-833
    • Wyman, C.1    Ristic, D.2    Kanaar, R.3
  • 9
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber MR, (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79: 181-211.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 10
    • 0032530658 scopus 로고    scopus 로고
    • Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    • Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, et al. (1998) Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 17: 5497-5508.
    • (1998) EMBO J , vol.17 , pp. 5497-5508
    • Takata, M.1    Sasaki, M.S.2    Sonoda, E.3    Morrison, C.4    Hashimoto, M.5
  • 11
    • 77955841149 scopus 로고    scopus 로고
    • Collaboration and competition between DNA double-strand break repair pathways
    • Kass EM, Jasin M, (2010) Collaboration and competition between DNA double-strand break repair pathways. FEBS Lett 584: 3703-3708.
    • (2010) FEBS Lett , vol.584 , pp. 3703-3708
    • Kass, E.M.1    Jasin, M.2
  • 12
    • 33645288259 scopus 로고    scopus 로고
    • Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
    • Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, et al. (2006) Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J 25: 1305-1314.
    • (2006) EMBO J , vol.25 , pp. 1305-1314
    • Hochegger, H.1    Dejsuphong, D.2    Fukushima, T.3    Morrison, C.4    Sonoda, E.5
  • 13
    • 0037133699 scopus 로고    scopus 로고
    • DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
    • Allen C, Kurimasa A, Brenneman MA, Chen DJ, Nickoloff JA, (2002) DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc Natl Acad Sci U S A 99: 3758-3763.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3758-3763
    • Allen, C.1    Kurimasa, A.2    Brenneman, M.A.3    Chen, D.J.4    Nickoloff, J.A.5
  • 14
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • Shrivastav M, De Haro LP, Nickoloff JA, (2008) Regulation of DNA double-strand break repair pathway choice. Cell Res 18: 134-147.
    • (2008) Cell Res , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 15
    • 69249209608 scopus 로고    scopus 로고
    • RecQ helicases: multifunctional genome caretakers
    • Chu WK, Hickson ID, (2009) RecQ helicases: multifunctional genome caretakers. Nat Rev Cancer 9: 644-654.
    • (2009) Nat Rev Cancer , vol.9 , pp. 644-654
    • Chu, W.K.1    Hickson, I.D.2
  • 16
    • 33748744378 scopus 로고    scopus 로고
    • Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability
    • Sharma S, Doherty KM, Brosh RM Jr, (2006) Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J 398: 319-337.
    • (2006) Biochem J , vol.398 , pp. 319-337
    • Sharma, S.1    Doherty, K.M.2    Brosh Jr., R.M.3
  • 17
    • 23044517287 scopus 로고    scopus 로고
    • Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1
    • Sharma S, Sommers JA, Choudhary S, Faulkner JK, Cui S, et al. (2005) Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem 280: 28072-28084.
    • (2005) J Biol Chem , vol.280 , pp. 28072-28084
    • Sharma, S.1    Sommers, J.A.2    Choudhary, S.3    Faulkner, J.K.4    Cui, S.5
  • 18
    • 49649099084 scopus 로고    scopus 로고
    • The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities
    • Popuri V, Bachrati CZ, Muzzolini L, Mosedale G, Costantini S, et al. (2008) The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. J Biol Chem 283: 17766-17776.
    • (2008) J Biol Chem , vol.283 , pp. 17766-17776
    • Popuri, V.1    Bachrati, C.Z.2    Muzzolini, L.3    Mosedale, G.4    Costantini, S.5
  • 19
    • 50649118135 scopus 로고    scopus 로고
    • RECQ1 possesses DNA branch migration activity
    • Bugreev DV, Brosh RM Jr, Mazin AV, (2008) RECQ1 possesses DNA branch migration activity. J Biol Chem 283: 20231-20242.
    • (2008) J Biol Chem , vol.283 , pp. 20231-20242
    • Bugreev, D.V.1    Brosh Jr., R.M.2    Mazin, A.V.3
  • 20
    • 33646843592 scopus 로고    scopus 로고
    • Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase
    • Bachrati CZ, Borts RH, Hickson ID, (2006) Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase. Nucleic Acids Res 34: 2269-2279.
    • (2006) Nucleic Acids Res , vol.34 , pp. 2269-2279
    • Bachrati, C.Z.1    Borts, R.H.2    Hickson, I.D.3
  • 22
    • 43549099977 scopus 로고    scopus 로고
    • Unique and important consequences of RECQ1 deficiency in mammalian cells
    • Sharma S, Brosh RM Jr, (2008) Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle 7: 989-1000.
    • (2008) Cell Cycle , vol.7 , pp. 989-1000
    • Sharma, S.1    Brosh Jr., R.M.2
  • 23
    • 76749101923 scopus 로고    scopus 로고
    • Distinct roles of RECQ1 in the maintenance of genomic stability
    • Wu Y, Brosh RM Jr, (2010) Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst) 9: 315-324.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 315-324
    • Wu, Y.1    Brosh Jr., R.M.2
  • 24
    • 33847228012 scopus 로고    scopus 로고
    • RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability
    • Sharma S, Stumpo DJ, Balajee AS, Bock CB, Lansdorp PM, et al. (2007) RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol 27: 1784-1794.
    • (2007) Mol Cell Biol , vol.27 , pp. 1784-1794
    • Sharma, S.1    Stumpo, D.J.2    Balajee, A.S.3    Bock, C.B.4    Lansdorp, P.M.5
  • 25
    • 40249083431 scopus 로고    scopus 로고
    • Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges
    • Sharma S, Brosh RM Jr, (2007) Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS ONE 2: e1297.
    • (2007) PLoS ONE , vol.2
    • Sharma, S.1    Brosh Jr., R.M.2
  • 28
    • 0037166306 scopus 로고    scopus 로고
    • Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation
    • Karmakar P, Piotrowski J, Brosh RM Jr, Sommers JA, Miller SP, et al. (2002) Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem 277: 18291-18302.
    • (2002) J Biol Chem , vol.277 , pp. 18291-18302
    • Karmakar, P.1    Piotrowski, J.2    Brosh Jr., R.M.3    Sommers, J.A.4    Miller, S.P.5
  • 29
    • 23044461827 scopus 로고    scopus 로고
    • RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination
    • Doherty KM, Sharma S, Uzdilla LA, Wilson TM, Cui S, et al. (2005) RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem 280: 28085-28094.
    • (2005) J Biol Chem , vol.280 , pp. 28085-28094
    • Doherty, K.M.1    Sharma, S.2    Uzdilla, L.A.3    Wilson, T.M.4    Cui, S.5
  • 31
    • 14844292557 scopus 로고    scopus 로고
    • DNA-dependent Protein Kinase and XRCC4-DNA Ligase IV Mobilization in the Cell in Response to DNA Double Strand Breaks
    • Drouet J, Delteil C, Lefrançois J, Concannon P, Salles B, et al. (2005) DNA-dependent Protein Kinase and XRCC4-DNA Ligase IV Mobilization in the Cell in Response to DNA Double Strand Breaks. Journal of Biological Chemistry 280: 7060-7069.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 7060-7069
    • Drouet, J.1    Delteil, C.2    Lefrançois, J.3    Concannon, P.4    Salles, B.5
  • 32
    • 34247245102 scopus 로고    scopus 로고
    • A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
    • Kanno S-i, Kuzuoka H, Sasao S, Hong Z, Lan L, et al. (2007) A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J 26: 2094-2103.
    • (2007) EMBO J , vol.26 , pp. 2094-2103
    • Kanno, S.-I.1    Kuzuoka, H.2    Sasao, S.3    Hong, Z.4    Lan, L.5
  • 34
    • 0027468265 scopus 로고
    • Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks
    • Blier PR, Griffith AJ, Craft J, Hardin JA, (1993) Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. Journal of Biological Chemistry 268: 7594-7601.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 7594-7601
    • Blier, P.R.1    Griffith, A.J.2    Craft, J.3    Hardin, J.A.4
  • 35
    • 0037449803 scopus 로고    scopus 로고
    • Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A
    • Cui S, Klima R, Ochem A, Arosio D, Falaschi A, et al. (2003) Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A. J Biol Chem. 278: 1424-1432.
    • (2003) J Biol Chem , vol.278 , pp. 1424-1432
    • Cui, S.1    Klima, R.2    Ochem, A.3    Arosio, D.4    Falaschi, A.5
  • 36
    • 33846941210 scopus 로고    scopus 로고
    • Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity
    • Muzzolini L, Beuron F, Patwardhan A, Popuri V, Cui S, et al. (2007) Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity. PLoS Biol 5: e20.
    • (2007) PLoS Biol , vol.5
    • Muzzolini, L.1    Beuron, F.2    Patwardhan, A.3    Popuri, V.4    Cui, S.5
  • 37
    • 0024356877 scopus 로고
    • HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex
    • de Vries E, van Driel W, Bergsma WG, Arnberg AC, van der Vliet PC, (1989) HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. Journal of Molecular Biology 208: 65-78.
    • (1989) Journal of Molecular Biology , vol.208 , pp. 65-78
    • de Vries, E.1    van Driel, W.2    Bergsma, W.G.3    Arnberg, A.C.4    van der Vliet, P.C.5
  • 38
    • 0032518680 scopus 로고    scopus 로고
    • Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks
    • Ramsden DA, Gellert M, (1998) Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks. EMBO J 17: 609-614.
    • (1998) EMBO J , vol.17 , pp. 609-614
    • Ramsden, D.A.1    Gellert, M.2
  • 40
    • 0037099520 scopus 로고    scopus 로고
    • Deficient Nonhomologous End-Joining Activity in Cell-free Extracts from Brca1-null Fibroblasts
    • Zhong Q, Boyer TG, Chen P-L, Lee W-H, (2002) Deficient Nonhomologous End-Joining Activity in Cell-free Extracts from Brca1-null Fibroblasts. Cancer Research 62: 3966-3970.
    • (2002) Cancer Research , vol.62 , pp. 3966-3970
    • Zhong, Q.1    Boyer, T.G.2    Chen, P.-L.3    Lee, W.-H.4
  • 41
    • 35348821296 scopus 로고    scopus 로고
    • A Backup DNA Repair Pathway Moves to the Forefront
    • Nussenzweig A, Nussenzweig MC, (2007) A Backup DNA Repair Pathway Moves to the Forefront. Cell 131: 223-225.
    • (2007) Cell , vol.131 , pp. 223-225
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 42
    • 77649225150 scopus 로고    scopus 로고
    • Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells
    • Fattah F, Lee EH, Weisensel N, Wang Y, Lichter N, et al. (2010) Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells. PLoS Genet 6: e1000855.
    • (2010) PLoS Genet , vol.6
    • Fattah, F.1    Lee, E.H.2    Weisensel, N.3    Wang, Y.4    Lichter, N.5
  • 43
    • 79956215808 scopus 로고    scopus 로고
    • Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways
    • Mladenov E, Iliakis G, (2011) Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mutat Res 711: 61-72.
    • (2011) Mutat Res , vol.711 , pp. 61-72
    • Mladenov, E.1    Iliakis, G.2
  • 44
    • 84864499620 scopus 로고    scopus 로고
    • RecQ helicases in DNA double strand break repair and telomere maintenance
    • Singh DK, Ghosh AK, Croteau DL, Bohr VA, (2012) RecQ helicases in DNA double strand break repair and telomere maintenance. Mutat Res 736: 15-24.
    • (2012) Mutat Res , vol.736 , pp. 15-24
    • Singh, D.K.1    Ghosh, A.K.2    Croteau, D.L.3    Bohr, V.A.4
  • 45
    • 0026045833 scopus 로고
    • Analysis of the mechanism of interaction of simian Ku protein with DNA
    • Paillard S, Strauss F, (1991) Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucleic Acids Res 19: 5619-5624.
    • (1991) Nucleic Acids Res , vol.19 , pp. 5619-5624
    • Paillard, S.1    Strauss, F.2
  • 46
    • 74049134920 scopus 로고    scopus 로고
    • Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex
    • Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, et al. (2010) Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex. Journal of Biological Chemistry 285: 1414-1423.
    • (2010) Journal of Biological Chemistry , vol.285 , pp. 1414-1423
    • Hammel, M.1    Yu, Y.2    Mahaney, B.L.3    Cai, B.4    Ye, R.5
  • 47
    • 84862776819 scopus 로고    scopus 로고
    • BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair
    • Bunting Samuel F, Callén E, Kozak Marina L, Kim Jung M, Wong N, et al. (2012) BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair. Molecular Cell 46: 125-135.
    • (2012) Molecular Cell , vol.46 , pp. 125-135
    • Bunting Samuel, F.1    Callén, E.2    Kozak Marina, L.3    Kim Jung, M.4    Wong, N.5
  • 48
    • 84865364870 scopus 로고    scopus 로고
    • Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
    • Chapman JR, Taylor Martin RG, Boulton Simon J, (2012) Playing the End Game: DNA Double-Strand Break Repair Pathway Choice. Molecular Cell 47: 497-510.
    • (2012) Molecular Cell , vol.47 , pp. 497-510
    • Chapman, J.R.1    Taylor Martin, R.G.2    Boulton Simon, J.3
  • 49
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington LS, Gautier J, (2011) Double-strand break end resection and repair pathway choice. Annu Rev Genet 45: 247-271.
    • (2011) Annu Rev Genet , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 50
    • 80053447704 scopus 로고    scopus 로고
    • Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks
    • Langerak P, Mejia-Ramirez E, Limbo O, Russell P, (2011) Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet 7: e1002271.
    • (2011) PLoS Genet , vol.7
    • Langerak, P.1    Mejia-Ramirez, E.2    Limbo, O.3    Russell, P.4
  • 51
    • 34948872046 scopus 로고    scopus 로고
    • Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous Recombination
    • Limbo O, Chahwan C, Yamada Y, de Bruin RAM, Wittenberg C, et al. (2007) Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous Recombination. Molecular Cell 28: 134-146.
    • (2007) Molecular Cell , vol.28 , pp. 134-146
    • Limbo, O.1    Chahwan, C.2    Yamada, Y.3    de Bruin, R.A.M.4    Wittenberg, C.5
  • 52
    • 58149289464 scopus 로고    scopus 로고
    • Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
    • Hartsuiker E, Neale MJ, Carr AM, (2009) Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA. Molecular Cell 33: 117-123.
    • (2009) Molecular Cell , vol.33 , pp. 117-123
    • Hartsuiker, E.1    Neale, M.J.2    Carr, A.M.3
  • 53
    • 53649090109 scopus 로고    scopus 로고
    • DNA helicases Sgs1 and BLM promote DNA double-strand break resection
    • Gravel S, Chapman JR, Magill C, Jackson SP, (2008) DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev 22: 2767-2772.
    • (2008) Genes Dev , vol.22 , pp. 2767-2772
    • Gravel, S.1    Chapman, J.R.2    Magill, C.3    Jackson, S.P.4
  • 54
    • 77957805302 scopus 로고    scopus 로고
    • Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
    • Mimitou EP, Symington LS, (2010) Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO J 29: 3358-3369.
    • (2010) EMBO J , vol.29 , pp. 3358-3369
    • Mimitou, E.P.1    Symington, L.S.2
  • 55
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou EP, Symington LS, (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774.
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 56
    • 79951688343 scopus 로고    scopus 로고
    • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
    • Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, et al. (2011) BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev 25: 350-362.
    • (2011) Genes Dev , vol.25 , pp. 350-362
    • Nimonkar, A.V.1    Genschel, J.2    Kinoshita, E.3    Polaczek, P.4    Campbell, J.L.5
  • 58
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z, Chung WH, Shim EY, Lee SE, Ira G, (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134: 981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 59
    • 84859004905 scopus 로고    scopus 로고
    • Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions
    • Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, et al. (2012) Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst) 11: 441-448.
    • (2012) DNA Repair (Amst) , vol.11 , pp. 441-448
    • Tomimatsu, N.1    Mukherjee, B.2    Deland, K.3    Kurimasa, A.4    Bolderson, E.5
  • 60
    • 84863152463 scopus 로고    scopus 로고
    • Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex
    • Sun J, Lee KJ, Davis AJ, Chen DJ, (2012) Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J Biol Chem 287: 4936-4945.
    • (2012) J Biol Chem , vol.287 , pp. 4936-4945
    • Sun, J.1    Lee, K.J.2    Davis, A.J.3    Chen, D.J.4
  • 61
    • 9744241712 scopus 로고    scopus 로고
    • A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining
    • Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, et al. (2004) A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining. Molecular Cell 16: 701-713.
    • (2004) Molecular Cell , vol.16 , pp. 701-713
    • Ma, Y.1    Lu, H.2    Tippin, B.3    Goodman, M.F.4    Shimazaki, N.5
  • 62
    • 78049446968 scopus 로고    scopus 로고
    • The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
    • Mansour WY, Rhein T, Dahm-Daphi J (2010) The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies. Nucleic Acids Research.
    • (2010) Nucleic Acids Research
    • Mansour, W.Y.1    Rhein, T.2    Dahm-Daphi, J.3
  • 63
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • Wang M, Wu W, Rosidi B, Zhang L, Wang H, et al. (2006) PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 34: 6170-6182.
    • (2006) Nucleic Acids Res , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Rosidi, B.3    Zhang, L.4    Wang, H.5
  • 65
    • 34248157719 scopus 로고    scopus 로고
    • APLF (C2orf13) Is a Novel Human Protein Involved in the Cellular Response to Chromosomal DNA Strand Breaks
    • Iles N, Rulten S, El-Khamisy SF, Caldecott KW, (2007) APLF (C2orf13) Is a Novel Human Protein Involved in the Cellular Response to Chromosomal DNA Strand Breaks. Molecular and Cellular Biology 27: 3793-3803.
    • (2007) Molecular and Cellular Biology , vol.27 , pp. 3793-3803
    • Iles, N.1    Rulten, S.2    El-Khamisy, S.F.3    Caldecott, K.W.4
  • 66
    • 37549023517 scopus 로고    scopus 로고
    • APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation
    • Macrae CJ, McCulloch RD, Ylanko J, Durocher D, Koch CA, (2008) APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair 7: 292-302.
    • (2008) DNA Repair , vol.7 , pp. 292-302
    • Macrae, C.J.1    McCulloch, R.D.2    Ylanko, J.3    Durocher, D.4    Koch, C.A.5
  • 67
    • 0033575278 scopus 로고    scopus 로고
    • Poly(ADP-ribose) Polymerase and Ku Autoantigen Form a Complex and Synergistically Bind to Matrix Attachment Sequences
    • Galande S, Kohwi-Shigematsu T, (1999) Poly(ADP-ribose) Polymerase and Ku Autoantigen Form a Complex and Synergistically Bind to Matrix Attachment Sequences. Journal of Biological Chemistry 274: 20521-20528.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 20521-20528
    • Galande, S.1    Kohwi-Shigematsu, T.2
  • 68
  • 69
    • 0242721664 scopus 로고    scopus 로고
    • Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage
    • von Kobbe C, Harrigan JA, May A, Opresko PL, Dawut L, et al. (2003) Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol Cell Biol 23: 8601-8613.
    • (2003) Mol Cell Biol , vol.23 , pp. 8601-8613
    • von Kobbe, C.1    Harrigan, J.A.2    May, A.3    Opresko, P.L.4    Dawut, L.5
  • 70
    • 0037102588 scopus 로고    scopus 로고
    • Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus
    • Karmakar P, Snowden CM, Ramsden DA, Bohr VA, (2002) Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. Nucleic Acids Res 30: 3583-3591.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3583-3591
    • Karmakar, P.1    Snowden, C.M.2    Ramsden, D.A.3    Bohr, V.A.4
  • 71
    • 0035971076 scopus 로고    scopus 로고
    • Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex
    • Li B, Comai L, (2001) Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. J Biol Chem 276: 9896-9902.
    • (2001) J Biol Chem , vol.276 , pp. 9896-9902
    • Li, B.1    Comai, L.2
  • 72
    • 3843101621 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein
    • von Kobbe C, Harrigan JA, Schreiber V, Stiegler P, Piotrowski J, et al. (2004) Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein. Nucleic Acids Res 32: 4003-4014.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4003-4014
    • von Kobbe, C.1    Harrigan, J.A.2    Schreiber, V.3    Stiegler, P.4    Piotrowski, J.5
  • 73
    • 1842791545 scopus 로고    scopus 로고
    • Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1
    • Li B, Navarro S, Kasahara N, Comai L, (2004) Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem 279: 13659-13667.
    • (2004) J Biol Chem , vol.279 , pp. 13659-13667
    • Li, B.1    Navarro, S.2    Kasahara, N.3    Comai, L.4
  • 74
    • 0037081095 scopus 로고    scopus 로고
    • Lack of WRN results in extensive deletion at nonhomologous joining ends
    • Oshima J, Huang S, Pae C, Campisi J, Schiestl RH, (2002) Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res 62: 547-551.
    • (2002) Cancer Res , vol.62 , pp. 547-551
    • Oshima, J.1    Huang, S.2    Pae, C.3    Campisi, J.4    Schiestl, R.H.5
  • 75
    • 77954374334 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells
    • Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, et al. (2010) Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. Cancer Res 70: 5389-5398.
    • (2010) Cancer Res , vol.70 , pp. 5389-5398
    • Gottipati, P.1    Vischioni, B.2    Schultz, N.3    Solomons, J.4    Bryant, H.E.5
  • 76
    • 51649128895 scopus 로고    scopus 로고
    • Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks
    • Sallmyr A, Tomkinson AE, Rassool FV, (2008) Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks. Blood 112: 1413-1423.
    • (2008) Blood , vol.112 , pp. 1413-1423
    • Sallmyr, A.1    Tomkinson, A.E.2    Rassool, F.V.3
  • 77
    • 34547589577 scopus 로고    scopus 로고
    • Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70
    • Weinstock DM, Brunet E, Jasin M, (2007) Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat Cell Biol 9: 978-981.
    • (2007) Nat Cell Biol , vol.9 , pp. 978-981
    • Weinstock, D.M.1    Brunet, E.2    Jasin, M.3


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