Effect of binding affinity for siRNA on the invivo antitumor efficacy of polyplexes

Biomaterials

Volumn 34, Issue 21, 2013, Pages 5317-5327

  Han, Lu ^a   Tang, Cui ^a   Yin, Chunhua ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Antitumor efficacy; Binding affinity; Extracellular stability; Intracellular dissociation; SiRNA delivery

Indexed keywords

ANTI-TUMOR EFFICACY; BINDING AFFINITIES; EXTRACELLULAR; INTRACELLULAR DISSOCIATION; SIRNA DELIVERY;

AMINO ACIDS; CELL DEATH; DISSOCIATION; ENZYME ACTIVITY; FUNCTIONAL POLYMERS; GENES; TUMORS; ZETA POTENTIAL;

BINDING ENERGY;

CYSTEINE DERIVATIVE; GALACTOSE MODIFIED TRIMETHYL CHITOSAN CYSTEINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL VIABILITY; CELLULAR DISTRIBUTION; DNA FRAGMENTATION; DRUG CONJUGATION; ENCAPSULATION; ENDOCYTOSIS; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MOUSE; NONHUMAN; PARTICLE SIZE; PINOCYTOSIS; POLYMERIZATION; PRIORITY JOURNAL; TUMOR REGRESSION; ZETA POTENTIAL;

ANIMALS; ANTIGENS, CD31; ANTINEOPLASTIC AGENTS; APOPTOSIS; BODY WEIGHT; CELL LINE, TUMOR; CHITOSAN; CYSTEINE; FEMALE; GALACTOSE; GENE SILENCING; HUMANS; INTRACELLULAR SPACE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON, SCANNING; NEOPLASMS; PARTICLE SIZE; POLYMERS; RNA, SMALL INTERFERING; STATIC ELECTRICITY; TISSUE DISTRIBUTION; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS;

EID: 84877055871     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.03.060     Document Type: Article

References (32)

1. Yang X.Z., Du J.Z., Dou S., Mao C.Q., Long H.Y., Wang J. Sheddable ternary nanoparticles for tumor acidity-targeted siRNA delivery. ACS Nano 2012, 6:771-781.
2. Castanotto D., Rossi J.J. The promises and pitfalls of RNA-interference-based therapeutics. Nature 2009, 457:426-433.
3. Oh Y.K., Park T.G. siRNA delivery systems for cancer treatment. Adv Drug Deliv Rev 2009, 61:850-862.
4. Bumcrot D., Manoharan M., Koteliansky V., Sah D.W.Y. RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol 2006, 2:711-719.
5. Varkouhi A.K., Verheul R.J., Schiffelers R.M., Lammers T., Storm G., Hennink W.E. Gene silencing activity of siRNA polyplexes based on thiolated N, N, N-trimethylated chitosan. Bioconjug Chem 2010, 21:2339-2346.
6. Ping Y., Liu C.D., Zhang Z.X., Liu K.L., Chen J.H., Li J. Chitosan-graft-(PEI-β-cyclodextrin) copolymers and their supramolecular PEGylation for DNA and siRNA delivery. Biomaterials 2011, 32:8328-8341.
7. Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 8:129-138.
8. Ozpolat B., Sood A.K., Lopez-Berestein G. Nanomedicine based approaches for the delivery of siRNA in cancer. JIntern Med 2010, 267:44-53.
9. Nimesh S., Gupta N., Chandra R. Strategies and advances in nanomedicine for targeted siRNA delivery. Nanomedicine 2011, 6:729-746.
10. Liao Z.X., Ho Y.C., Chen H.L., Peng S.F., Hsiao C.W., Sung H.W. Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly(γ-glutamic acid). Biomaterials 2010, 31:8780-8788.
11. Mao S.R., Sun W., Kissel T. Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 2010, 62:12-27.
12. Vandenbroucke R.E., De Geest B.G., Bonné S., Vinken M., Van Haecke T., Heimberg H., et al. Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(β-amino esters). JGene Med 2008, 10:783-794.
13. Xue H.Y., Wong H.L. Tailoring nanostructured solid-lipid carriers for time-controlled intracellular siRNA kinetics to sustain RNAi-mediated chemosensitization. Biomaterials 2011, 32:2662-2672.
14. Zhang J., Tang C., Yin C. Galactosylated trimethyl chitosan-cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages. Biomaterials 2013, 34:3667-3677.
15. van der Merwe S.M., Verhoef J.C., Verheijden J.H.M., Kotze A.F., Junginger H.E. Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. Eur J Pharm Biopharm 2004, 58:225-235.
16. Jiang H.L., Kwon J.T., Kim Y.K., Kim E.M., Arote R., Jeong H.J., et al. Galactosylated chitosan-graft-polyethylenimine as a gene carrier for hepatocyte targeting. Gene Ther 2007, 14:1389-1398.
17. Marschütz M.K., Bernkop-Schnürch A. Thiolated conjugates: self-crosslinking properties of thiolated 450kDa poly(acrylic acid) and their influence on mucoadhesion. Eur J Pharm Sci 2002, 15:387-394.
18. Zhao Y., Gao J., Sun X., Chen H., Wu L., Liang W. Enhanced nuclear delivery and cytotoxic activity of hydroxycamptothecin using o/w emulsions. JPharm Sci 2007, 10:61-70.
19. Gratton S.E.A., Ropp P.A., Pohlhaus P.D., Luft J.C., Madden V.J., Napier M.E., et al. The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A 2008, 105:11613-11618.
20. Khalil I.A., Kogure K., Akita H., Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006, 58:32-45.
21. Xiong X.B., Lavasanifar A. Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin. ACS Nano 2011, 5:5202-5213.
22. Zhu C., Jung S., Luo S., Meng F., Zhu X., Park T.G., et al. Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA-PCL-PDMAEMA triblock copolymers. Biomaterials 2010, 31:2408-2416.
23. Zhang X.Q., Wang X.L., Zhang P.C., Liu Z.L., Zhuo R.X., Mao H.M., et al. Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes. JControl Release 2005, 102:749-763.
24. Katas H., Alpar H.O. Development and characterisation of chitosan nanoparticles for siRNA delivery. JControl Release 2006, 115:216-225.
25. Gaspar V.M., Sousa F., Queiroz J.A., Correia I.J. Formulation of chitosan-TPP-pDNA nanocapsules for gene therapy applications. Nanotechnology 2011, 22:015101.
26. Ruenraroengsak P., Cook J.M., Florence A.T. Nanosystem drug targeting: facing up to complex realities. JControl Release 2010, 141:265-276.
27. Peng S.F., Tseng M.T., Ho Y.C., Wei M.C., Liao Z.X., Sung H.W. Mechanisms of cellular uptake and intracellular trafficking with chitosan/DNA/poly(γ-glutamic acid) complexes as a gene delivery vector. Biomaterials 2011, 32:239-248.
28. Park K., Lee M.Y., Kim K.S., Hahn S.K. Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine-hyaluronic acid conjugate. Biomaterials 2010, 31:5258-5265.
29. Christie R.J., Matsumoto Y., Miyata K., Nomoto T., Fukushima S., Osada K., et al. Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano 2012, 6:5174-5189.
30. Minai-Tehrani A., Jiang H.L., Kim Y.K., Chung Y.S., Yu K.N., Kim J.E., et al. Suppression of tumor growth in xenograft model mice by small interfering RNA targeting osteopontin delivery using biocompatible poly(amino ester). Int J Pharm 2012, 431:197-203.
31. Noh S.M., Han S.E., Shim G., Lee K.E., Kim C.W., Han S.S., et al. Tocopheryloligo chitosan-based self-assembling oligomersomes for siRNA delivery. Biomaterials 2011, 32:849-857.
32. Noh S.M., Park M.O., Shim G., Han S.E., Lee H.Y., Huh J.H., et al. Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA. JControl Release 2010, 145:159-164.